scholarly journals Comparative study of localised intradermal microinjection of tranexamic acid and oral tranexamic acid for the treatment of melasma

2018 ◽  
Vol 4 (3) ◽  
pp. 363 ◽  
Author(s):  
Vinma H. Shetty ◽  
Monisha Shetty
Keyword(s):  
Tranexamic Acid ◽  
Comparative Study ◽  
Subjective Assessment ◽  
Therapeutic Modality ◽  
Treatment Modalities ◽  
Before And After ◽  
The Face ◽  
Group A ◽  
Good Improvement ◽  
Group B

<p class="abstract"><strong>Background:</strong> Melasma is an acquired hypermelanosis affecting the sun- exposed areas of the skin, most commonly the face and neck. Different treatment modalities have been utilized in different studies with varying, not so satisfactory outcomes. The aim of the study was to compare the efficacy of localized intradermal microinjection of tranexamic acid with oral tranexamic acid in melasma patients.</p><p class="abstract"><strong>Methods:</strong> It is a prospective comparative study. All patients enrolled in the study were divided into 2 groups - twenty in each treatment group. In group A, patients were given intradermal injections of tranexamic acid (4 mg/ml) once at three week intervals (0, 3, 6, 9, 12 weeks) for 12 weeks. Group B patients were given oral tranexamic acid 250 mg twice a day for 12 weeks. Following parameters were evaluated before and after 12 weeks of treatment: a) digital photographs b) MASI score c) patient subjective assessment d) dermoscopic photographs. Software (SPSS, version 16.0 statistical packages) was used.<strong></strong></p><p class="abstract"><strong>Results:</strong> Clinical efficacy of the treatment in 2 different groups showed higher efficacy with intradermal microinjection (35.6%) compare to oral tranexamic acid (21.7%). Patient's subjective assessment showed good improvement in 63.15% of cases in group A, whereas in group B 27.8% of cases showed good improvement.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional localized microinjection of tranexamic acid is a promising new therapeutic modality for the treatment of resistant melasma.</p>

A Comparative Study of Epidemiology, Clinicopathologic Features and Outcome of Colorectal Cancer Patients between Ain Shams University Hospitals and Luxor International Hospital

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Tarek Hussein Kamel ◽  
Amr Lotfy Farag ◽  
Dr/Sherif Hassanin Ahmed ◽  
Chresteen Talaat Samy Hanna
Keyword(s):  
Colorectal Cancer ◽  
Comparative Study ◽  
Disease Free Survival ◽  
University Hospital ◽  
Treatment Modalities ◽  
Clinicopathologic Features ◽  
Free Survival ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is the third most common malignancy after lung & breast and the fourth leading cause of cancer-related deaths worldwide, accounting for approximately 1,400,000 new cases and about 700,000 deaths worldwide. Objectives The aim of this retrospective study is to compare the epidemiology, clinicopathologic features, different treatment modalities and outcomes regarding disease free survival (DFS), progression free survival (PFS) & overall survival (OS) of colorectal cancer disease between cases presented to Ain shams university hospital & to Luxor international hospital in 3 consecutive years. Patients and Methods The study is retrospective comparative study. Clinical oncology department in Ain Shams University Hospital and Luxor International Hospital. The data Collected from January 2013 to December 2015. This study analyzed hospital records of patients who diagnosed with colorectal cancer (CRC) and allocated into two groups: Group A: CRC patients presented to Ain-Shams University Hospital from January 2013 to December 2015, group B: CRC patients presented to Luxor International Hospital from January 2013 to December 2015. Results There was no statistically significant difference regarding age parameter in LIH when compared to ASU, but the study was consistent with higher incidence in patients who were aged more than forty- accounted about 70.5% in all CRC cases. Cases less than 40 years old, in group A were 35.2%, while in Group B were 23.5%. Even there was no statistically significant difference but it may be attributable to more westernization in Lower Egypt. Other explanation may be due to decreased low socioeconomic status and different lifestyle factors in more developing region what increase risk of colorectal cancer. Among our cases, there is no statistically significant difference regarding gender between the two hospitals. Both sexes almost were affected equally, females appeared to be at a slightly higher risk of developing CRC cancer with current prevalence 1.3:1 in ASU group, and 1.1:1 in LIH group. Conclusion The need to increase awareness about CRC in Egypt especially upper Egypt, is recommended. An awareness campaign should be performed to promote detection of CRC at its earliest and most curable stage by recognizing early symptoms and enabling early referrals for colonoscopy. Those at higher risk should be offered more intensive surveillance. Similarity of the data from different centers suggests that this is the picture of colorectal cancer typical of Egypt.

scholarly journals Comparison of septoplasty with and without packing and splints.

2021 ◽  
Vol 28 (04) ◽  
pp. 459-463
Author(s):  
Amrat Kumar ◽  
Ashok Kumar ◽  
Shabir Mehar ◽  
Dileep Kumar ◽  
Muhammad Wasi Ullah Khan
Keyword(s):  
Comparative Study ◽  
Nasal Packing ◽  
Treatment Results ◽  
New Techniques ◽  
Before And After ◽  
Group A ◽  
Vas Scores ◽  
The Mean ◽  
Group B ◽  
Study Setting

Objective: During septoplasty, nasal packing is routinely used by surgeons for hemostasis and balancing the cartilage and bony skeleton of the nose. However, these new techniques are not totally mild and therefore new ways are adopted to check their efficiency and reason their value. The study was performed to compare the use of plastic intranasal splints with or without anterior nasal packing to determine the need of nasal packing after septoplasty. Study Design: Comparative Study. Setting: ISRA University Hyderabad. Period: March 2018 to April 2019. Material & Methods: A total of 50 patients presenting with nasal septum in this period were prospectively examined. For the purpose of comparative study, we divided the patients into two groups: Group A –Patients who underwent septoplasty with packing and Group-B –Patients who underwent septoplasty without packing. We recorded the pain felt using Visual analogue scale before and after the surgery and also noted the Mean Age gender wise and recorded treatment results for statistical analysis using SPSS Version-20. Results: In our data, a total fifty (50) patients comprising 28 Males (68%) and 22 Females (32%) were listed in the study. The mean± standard deviation VAS scores of Group-A was at 5.2 ±0.9 and Group-B is 2.9±0.61 showing less pain in Group B-without splints and packing. However the complication rate in patients without Splints and packing was only 18%. Conclusion: Thus we find septoplasty without nasal splints and packing is more effective and cause lesser bleeding and pain to patients.

scholarly journals A comparative study to evaluate the effects of intranasal steroid spray, isotonic saline nasal irrigation and combination therapy in patients with allergic rhinitis

2021 ◽  
Vol 7 (6) ◽  
pp. 1004
Author(s):  
Smitha Soubhagya Gangaraju ◽  
Nikitha Pillai ◽  
Vijaylaxmi Manthal
Keyword(s):  
Allergic Rhinitis ◽  
Combination Therapy ◽  
Isotonic Saline ◽  
Treatment Modalities ◽  
Nasal Irrigation ◽  
Intranasal Corticosteroids ◽  
Nasal Symptoms ◽  
Before And After ◽  
Group A ◽  
Group B

<p class="abstract"><strong>Background:</strong> Allergic rhinitis (AR) is characterized by inflammatory changes in the nasal mucosa caused by exposure to inhaled allergens. AR clinically having 2 or more symptoms of anterior or posterior rhinorrhea, sneezing, nasal blockage or itching of the nose during two or more consecutive days for more than 1 hour on most days which are caused by allergen exposure leading to an IgE mediated reaction. Nasal steroids and antihistamines are considered as gold standard treatment of choice in moderate to severe AR. This study was taken to evaluate the efficacy of intranasal steroid spray, isotonic saline nasal irrigation, combination therapy and to compare all 3 treatment modalities.</p><p class="abstract"><strong>Methods:</strong> 75 patients of AR who met inclusion criteria were sequentially divided into 3 groups. Group A was intranasal steroid spray, group B was isotonic saline nasal irrigation, group C was combination of both intranasal steroid spray and saline nasal irrigation. Total nasal symptoms score was compared before and after 1 month of treatment.</p><p class="abstract"><strong>Results:</strong> Mean total nasal symptoms score before treatment in groups A, B and C was found to be 13.72, 12.96 and 13.68 respectively and after 1 month of treatment total nasal symptoms score was seen 8.28, 8.76 and 3.72 respectively.</p><p class="abstract"><strong>Conclusions:</strong> The combined use of saline nasal irrigation along with intranasal corticosteroids is found to be more effective in reducing the symptoms of patients with allergic rhinitis when compared to individual therapies.</p>

scholarly journals A comparative study between micro needling with modified Kligman regimen versus micro needling with tranexamic acid in melasma patients

2020 ◽  
Vol 6 (4) ◽  
pp. 520
Author(s):  
Anjum M. Momin ◽  
Ankita A. Mistry ◽  
Jignesh B. Vaishnani
Keyword(s):  
Side Effects ◽  
Tranexamic Acid ◽  
Comparative Study ◽  
Age Group ◽  
Female Predominance ◽  
Group A ◽  
Group B ◽  
Topical Tranexamic Acid ◽  
Facial Type

<p class="abstract"><strong>Background:</strong> Melasma is common, acquired disorder of hyperpigmentation, with female predominance and occurrence of facial involvement mostly. Various modalities of treatment are available including topical, oral and procedural therapies.</p><p class="abstract"><strong>Methods:</strong> Total 46 patients of melasma were studied. They were divided in two groups A and B. Micro needling with derma roller 1.5mm was done once in a month for 3 months. Group A patients received topical Modified Kligman regimen daily at night, while group B patients were advised topical tranexamic acid daily. Topical sunscreen was advised in both group patients. Patients were evaluated clinically and by Modified MASI score, and followed up for 3 more months after completion of treatment.<strong></strong></p><p class="abstract"><strong>Results:</strong> Female predominance was noted with most common age group being 25-40 years. Epidermal type of melasma was common. Centro-facial type of distribution was found mostly in patients. Significant decrease was noted in modified MASI score (p&lt;0.05) which was more and rapid in group A patients.</p><p class="abstract"><strong>Conclusions:</strong> Modified Kligman regimen has better efficacy but tranexamic acid is safer with lesser side effects. Inspite of various treatment arms, melasma is still challenging.</p>

scholarly journals Laser for post acne scars with or without growth factors: a comparative clinical trial

2020 ◽  
Vol 6 (2) ◽  
pp. 224
Author(s):  
Lakkireddygari Sujana ◽  
Balachandra S. Ankad ◽  
Savitha L. Beergouder
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Objective Assessment ◽  
Subjective Assessment ◽  
Primary Objective ◽  
Treatment Modalities ◽  
Acne Scars ◽  
New Strategy ◽  
Group A ◽  
Group B

<p class="abstract"><strong>Background:</strong> Treatment of acne scars presents a considerable challenge to dermatologists. But with advent of fractional CO<sub>2</sub> (FCO<sub>2</sub>) laser and platelet-rich plasma (PRP), new avenues can be explored. PRP provides various growth factors, so that the healing of laser-damaged skin is accelerated. The aim of this study was to assess the efficacy and safety of FCO<sub>2</sub> laser alone and in combination with PRP in patients with post-acne scars.</p><p class="abstract"><strong>Methods:</strong> Eighty patients with acne scars were counseled and randomly assigned into two groups of 40 each. Group A was treated with FCO<sub>2</sub> laser alone, while Group B was treated with FCO<sub>2</sub> laser and PRP for 6 months. Primary objective was assessment of efficacy of both treatment modalities. Secondary objective was evaluation of safety of treatments.<strong></strong></p><p class="abstract"><strong>Results:</strong> At the end of 6 months, group A showed about 18% reduction, while group B showed about 33% reduction in acne scars on objective assessment. Patient satisfaction as assessed by subjective assessment was greater in group B than in group A. Duration of erythema, edema and crusting was lesser in group B compared to group A.</p><p class="abstract"><strong>Conclusions:</strong> Combination of FCO<sub>2</sub> and PRP was found to be more efficacious as compared to FCO<sub>2</sub> laser alone. Combining the treatment modalities can provide a new strategy for treating the post-acne scars.</p>

Prospective clinical trial in the management of Mutrashmari through Avapidaka Snehapana and Matra Basti

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr.Savita Metri ◽  
Dr.Prashanth A. S.
Keyword(s):  
Clinical Trial ◽  
Total Duration ◽  
Treatment Modalities ◽  
Single Subject ◽  
Study Group ◽  
Inclusion Criteria ◽  
Before And After ◽  
Group A ◽  
Group B

Background: Ashmari Roga is considered as one of the Ashta Maha Gada considered difficult to cure because of its Marma Ashrayatwa, due to the involvement of Bahu Dosha and Basti, which is one of the Tri Marma, Acharyas has specifically mentioned many treatment modalities for reducing the symptoms as well as eliminating the Ashmari from its root, in which Basti and Virechana is having prime importance. So here an attempt is made to compare and study the efficacy of Basti and Virechana in Mutrashmari. Objective: To study the effect of Avapidaka Snehapana followed by Virechana and Shamanoushadhi and Matrabasti followed by Shamanoushadhi in the management of Mutrashmari. Materials and methods: 40 patients diagnosed with Mutrashmari (urinary calculus) and fulfilling the inclusion criteria were selected and randomly divided into 2 groups. In Group A: Amapachana with Hingvastaka Churna, Avapidaka Sneha with Punarnavadi Ghrita and Virechana with Trivrut Mrudvika Rasa followed by Shuntyadi Kwatha as Shamanoushadhi, In Group B: Amapachana with Hingvastaka Churna, Varunadhya Taila Matra Basti followed by Shwadamstra Kwath as Shamanoushadhi. Pain (from loin to groin), Nausea, Dysuria, Haematuria, Burning Micturation, Number of stones, Size of stones, Site of stone, Hydroureter and Hydronephrosis were assessed before and after treatment. The total duration of the study was 60 days or up to expulsion of the stone with 45 days of follow up. Results: In this study, Group A shows statistically more significant result than Group B. Conclusion: Both Group A and Group B have shown significant outcomes in all parameters with proper diet and regimen. Reoccurrence of stone was not found in a single subject.

Efficacy of Closed-System Drainage in Treating Chronic Subdural Hematoma: A Prospective Comparative Study

Neurosurgery ◽  
1990 ◽  
Vol 26 (5) ◽  
pp. 771-773 ◽  
Author(s):  
Susumu Wakai ◽  
Kazuyoshi Hashimoto ◽  
Naofumi Watanabe ◽  
Satoshi Inoh ◽  
Chikayuki Ochiai ◽  
...  
Keyword(s):  
Comparative Study ◽  
Recurrence Rate ◽  
Closed System ◽  
Subdural Hematoma ◽  
Chronic Subdural Hematoma ◽  
Burr Hole ◽  
Treatment Modalities ◽  
Group A ◽  
Prospective Comparative Study ◽  
Group B

Abstract The authors conducted a prospective comparative study on the recurrence rate of chronic subdural hematoma after the use of two different treatment modalities: burr-hole irrigation of the hematoma cavity with (Group A) and without closed-system drainage (Group B). Thirty-eight patients were studied. Patients were assigned to groups sequentially upon admission. There were no significant differences between the two groups for age, sex, preoperative hematoma volume, and density on computed tomographic scan. One patient in Group A (5%) suffered a recurrence as opposed to 6 in Group B (33%). The difference in recurrence rate between the two groups was statistically significant (p &lt; 0.05). The authors conclude that closed-system drainage after burr-hole irrigation reduces the recurrence rate of chronic subdural hematoma.

scholarly journals Selective Fusion in Lenke 1 B/C: Before or After Menarche?

2020 ◽  
pp. 219256822092056
Author(s):  
Nestor Ricardo Davies ◽  
Carlos Tello ◽  
Lucas Piantoni ◽  
Rodrigo Remondino ◽  
Eduardo Galaretto ◽  
...  
Keyword(s):  
Comparative Study ◽  
First Year ◽  
Lumbar Curve ◽  
Significance Level ◽  
Selective Fusion ◽  
P 75 ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Retrospective Comparative Study

Study Design: A retrospective, comparative study. Objective: To determine the radiological behavior of the lumbar curve in selective fusions in premenarchal girls with adolescent idiopathic scoliosis (Lenke 1 B/C). Methods: A retrospective, comparative study was conducted. Selective fusion was performed in 21 patients younger than 18 years. The patients were divided into 2 groups: group A, after menarche (n = 12) and group B, before menarche (n = 9). Angles (preoperative, and at 1 and 2 years postoperatively) of the fused thoracic curves and the corresponding lumbar curves were measured and compared. For statistical analysis, the t test was used with a significance level of P < .05. Results: Mean preoperative angle value of the proximal/main thoracic curve was 61° in group A and 57° in group B ( P = .44), and 21° and 20°, respectively, in the first year postoperatively ( P = .61). Mean preoperative angle value of the lumbar curve was 43° in group A and 42° in group B ( P = .87), while at 1 year after surgery, this curve was 19° in both groups ( P = 0.91), and at 2 years postoperatively, the curve was 16° in group A and 17° in group B ( P = .75). Conclusions: Over a 2-year follow-up, we did not find significant radiological differences in lumbar curves between patients who underwent surgery before and after menarche.

Study the Relationship Between Estrogen Hormone and Calcium in Normal Females Before and After Menopause in Baghdad / Iraq

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Sameerah Mustafa ◽  
Asal Tawfeeq ◽  
Hadeel Hasan
Keyword(s):  
Oral Contraceptive ◽  
Healthy Controls ◽  
Serum Samples ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Menopausal Women ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Age Range

This study involved the collection of (90) samples of women serum which included (30) serum samples collected from women before menopause (reproductive women) in the age range of (22-43) years and were considered as (group A- control). While, (group B) included (30) serum samples collected from women using oral contraceptive pills between the ages of (22-43) years old. Whereas, another (30) serum samples were collected from women after menopause between the ages of (43-54) years and were considered as (group C). All of the collected serum samples were subjected to a number of serological and chemical tests for the measurement of (E2, HDL, LDL and Ca). Then, the obtained data were statistical analyzed and results showed a significant decrease (p˂ 0.05) in (E2 ,Ca and HDL) levels in menopausal women compared to that of the normal healthy controls. While, there were non-significant decrease (p> 0.05) in (E2, Ca and HDL) levels in women taking oral contraceptive when compared to the normal healthy controls. On the other hand, a significant increase (p˂ 0.05) was recorded in LDL level in menopausal women compared to that of the normal healthy controls whereas, no-significant increase (p˃ 0.05) in the LDL level in women taking oral contraceptives when compared to the control women.

COMPARATIVE STUDY IN BETWEEN INTRALESIONAL VITAMIN D3 AND INTRALESIONAL BLEOMYCIN IN THE TREATMENT OF CUTANEOUS VERRUCAE

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Shrikant . ◽  
R.D. Mehta ◽  
B.C. Ghiya
Keyword(s):  
Partial Response ◽  
Comparative Study ◽  
Recurrence Rate ◽  
Vitamin D3 ◽  
Complete Response ◽  
Recurrence Rates ◽  
Additional Advantage ◽  
Cost Effective Treatment ◽  
Group A ◽  
Group B

Background: Verruca is one of the common dermatopathologies which has multiple therapeutic options but with variable success rates, refractory cases and high recurrence rates. Nowadays, treatment with intralesional injections has gained recognition due to its effectiveness in clearing verrucae. These act by stimulating the cell-mediated immunity. Out of scores of options available for intralesional therapeutics, Vitamin D3 appears to be more promising but least evaluated. Therefore, we planned to evaluate the efficacy of intralesional Vitamin D3 in various types of cutaneous verrucae. Simultaneously the results were compared with intralesional bleomycin, also. Methods: A total of 200 patients of cutaneous verrucae with varying size and duration were included in the experimental randomized comparative study. We divided them into two groups. Group A, comprising of 100 patients, received 0.2-0.5 ml intralesional Vitamin D3 (600,000 IU, 15mg/ml) and Group B, also of hundred subjects, received intralesional Bleomycin (1 mg/ml) into the base of verrucae. A maximum of 5 verrucae were injected per session at 3 weeks interval until resolution or for a maximum of 4 sessions. Patients were followed up for 6 months after the last injection to assess the clearance status and detect any recurrence. Results: In Group A (Vitamin D3), 'Complete response', 'Partial response' and 'No response' were observed in 85.07%, 6.74% and 8.17% respectively after 4 sessions. Recurrence rate was 0.81% after 6 months. In Group B (Bleomycin), 'Complete response', 'Partial response' and 'No response' were found in 77.99%, 10.47% and 11.53% in the series. Recurrence rate was 1.71%, comparatively higher in group B. Conclusion: The efficacy of intralesional Vitamin D3 was found significantly higher as compared to intralesional Bleomycin in the treatment of cutaneous verrucae with less recurrence rates. Vitamin D3 has an additional advantage of cost-effective treatment over Bleomycin. We purpose its use, as a primary mode of treatment in various types of cutaneous verrucae. Keywords: Bleomycin, Vitamin D3, Verrucae.

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