Not always a distant metastasis: Can be a double maliganancy too

The incidence of double malignancy reported are between 0.3% and 4.3%. The second primary lesion is identified either simultaneously with the primary lesion (synchronous) or after a period of time (metachronous). We report a case in a 63-year-old male presenting with double malignancy with adenocarcinoma of the ascending colon and a pre- sacral Chordoma of which the latter was detected accidentally on imaging. The patient underwent surgical excision of the pre-sacral mass and an exploratory laparotomy with Right Hemicolectomy. The increasing incidence of multiple malignant tumors is a real challenge to both clinicians and pathologists and close attention should be paid to imaging and histologic findings to avoid a misdiagnosis. In addition an early diagnosis is essential to achieve optimal treatment. We believe that the treatment modalities should be carefully tailored for each individual patient diagnosed with a double malignancy.

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EFFECTS OF SMOKING ON THE DISEASE PROGNOSIS IN CANCER PATIENTS

Problems in oncology ◽

10.37469/0507-3758-2019-65-3-321-329 ◽

2019 ◽

Vol 65 (3) ◽

pp. 321-329

Author(s):

David Zaridze ◽

Anush Mukeriya

Keyword(s):

Smoking Cessation ◽

Cancer Patients ◽

Malignant Tumors ◽

Scientific Data ◽

Second Primary ◽

Primary Tumors ◽

Smoking Intensity ◽

Risk Of Death ◽

Disease Prognosis ◽

Increased Risk

Smoking not only increases the risk of the development of malignant tumors (MT), but affects the disease prognosis, mortality and survivability of cancer patients. The link between the smoking of cancer patients and increased risk of death by all diseases and oncological causes has been established. Mortality increases with the growth of the smoking intensity, i.e. the number of cigarettes, smoked per day. Smoking is associated with the worst general and oncological survivability. The statistically trend-line between the smoking intensity and survivability was observed: each additional unit of cigarette consumption (pack/year) leads to the Overall Survival Reduction by 1% (p = 0.002). The link between smoking and the risk of developing second primary tumors has been confirmed. Smoking increases the likelihood of side effects of the antitumor therapy both drug therapy and radiation therapy and reduces the treatment efficacy. The smoking cessation leads to a significant improvement in the prognosis of a cancer patient. Scientific data on the negative effect of smoking on the prognosis of cancer patients have a major clinical importance. The treatment program for cancer patients should include science-based methods for the smoking cessation. The latter is fundamentally important, taking into account that the smoking frequency among cancer patients is much higher than in the population.

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Management of extra-abdominal fibromatosis in a musculoskeletal tumour centre in Hong Kong

Journal of Orthopaedics Trauma and Rehabilitation ◽

10.1177/2210491721989082 ◽

2021 ◽

pp. 221049172198908

Author(s):

Lam Wei Sze Yvette ◽

Fong Sin Tak ◽

Mak Ka Lok

Keyword(s):

Watchful Waiting ◽

Surgical Excision ◽

Treatment Modalities ◽

Management Approach ◽

Conservative Approach ◽

Management Options ◽

Musculoskeletal Tumour ◽

Female Predominance ◽

Tumour Location ◽

Marginal Status

Introduction: Fibromatosis is a benign disease yet prone to recurrence. The best treatment option remains controversial. The purpose of this study was to analyse the management approach in our musculoskeletal tumour centre. Materials and Methods: Thirty-four patients with extra-abdominal fibromatosis referred to our centre between 2000 to 2018 were included. Patients’ demographics, tumour location and size, year of diagnosis, treatment modalities, surgical margins, recurrence, and subsequent management were analysed. Results: Patients mostly presented in the second and third decade, with female predominance. Twenty-seven patients underwent excision. Other management options included ‘watchful waiting’, pharmacological treatment and radiotherapy. Recurrence rate was 51.9%. There was no statistically significant relationship between marginal status and recurrence. Conclusion: We report our experiences on management of fibromatosis, with strategy shifted from early excision to a conservative approach over the years. Surgical excision is still indicated in some situations. Tumour recurrence is not rare but second excision is not always necessary.

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Zosteriform Nevus Comedonicus

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4565 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 2609-2612

Author(s):

Babbita S ◽

Thillaikkarasi A ◽

Sathyanarayanana R ◽

Narasimhalu CRV ◽

Sulochana Sonti

Keyword(s):

Topical Therapy ◽

Treatment Options ◽

Neck Region ◽

Surgical Excision ◽

Hair Follicles ◽

Treatment Modalities ◽

Developmental Defect ◽

Linear Distribution ◽

Head And Neck Region ◽

Typical Morphology

Nevus comedonicus is an uncommon cutaneous developmental defect of follicular apparatus characterized by unilateral and linear distribution of bundles of dilated hair follicles filled with keratin plugs. It is usually seen on the head and neck region, trunk and upper arm. This condition may be present at birth or can occur later in life. The term nevus comedonicus is a misnomer as there are no true comedones and is better termed as follicular keratotic nevus. It is also known as nevus zoniforme or nevus acneiformis unilateralis. There are two types of nevus comedonicus, namely inflammatory and non-inflammatory (non-pyogenic). When nevus comedonicus is manifested with other extracutaneous symptoms, it is termed as nevus comedonicus syndrome. Diagnosis is mainly clinical, based on history and typical morphology. As the disease runs a benign course, no aggressive treatment is required. Patients seek treatment, especially for cosmetic purposes and inflammatory type of lesions. Various treatment modalities like topical therapy, surgical excision, lasers are available and treatment options are individualized based on the size and extent of the lesion. We herein present a case of unilateral nevus comedonicus with no systemic associations in a 30-year-old female on her lower limb which is not a common site of occurrence.

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Efficacy of Different Treatment Modalities for Eye Cancer in Bovines

Indian Journal of Animal Research ◽

10.18805/ijar.b-4149 ◽

2021 ◽

Author(s):

M. Prasanna Lakshmi ◽

P. Veena ◽

R.V. Suresh Kumar ◽

D. Rani Prameela ◽

K. Jagan Mohan Reddy

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factor ◽

Cell Carcinoma ◽

Squamous Cell ◽

Dietary Habits ◽

Growth Factor Receptor ◽

Surgical Excision ◽

Treatment Modalities ◽

Treatment Protocols ◽

Hereditary Factors

Background: Bovine ocular squamous cell carcinoma also called cancer eye, represents the most economically important neoplasm in large animals. Hereditary factors, environmental factors (e.g: latitude, altitude, exposure to sunlight), lack of eyelid pigmentation, age and dietary habits have all been reported to play a role in the etiopathogenesis of bovine ocular squamous cell carcinoma. In addition, in cattle the etiology has been linked to a number of viral agents, especially bovine papilloma virus and bovine herpes virus type 1 and 5. Nevertheless, ultraviolet light, viruses and circumocular pigmentation are the major epidemiologic risk factors for the development of the tumor. The efficacy of different treatment modalities for eye cancer in bovines was studied.Methods: All the animals were divided in to four groups of six animals each. Surgical excision, intra lesion BCG vaccine, surgery with auto vaccine and surgery with mitomycin was the treatment protocols followed. Immunohistochemical studies were conducted to know the rate of proliferation of bovine ye cancer. Immunopositive reaction was observed against Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptor in all the cases.Result: The benefits of different treatment modalities depended on nature, type, location and extensiveness of tumor. Early detection and aggressive treatment were essential in the successful management of these tumors. A multimodal treatment approach was recommended with surgery, immunotherapy and chemotherapy in providing 100% disease free interval.

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Chondrosarcoma of the Nasal Septum—A Rare Subsite: Case Report with Review of Literature

Indian Journal of Medical and Paediatric Oncology ◽

10.1055/s-0041-1736210 ◽

2021 ◽

Vol 42 (05) ◽

pp. 506-509

Author(s):

Nidhi Gupta ◽

Awadhesh Kumar Pandey ◽

Kislay Dimri ◽

Surinder K Singhal ◽

Neeraj Rathee ◽

...

Keyword(s):

Nasal Septum ◽

Malignant Tumors ◽

Surgical Excision ◽

Metastatic Potential ◽

Young Female ◽

Resection Margins ◽

Diagnostic Dilemma ◽

Complete Surgical Excision ◽

Grade Ii ◽

Common Primary Malignant Bone

AbstractChondrosarcomas are the second most common primary malignant bone tumors. Head and neck chondrosarcomas constitute less than 10% of these tumors, rarely arising from the nasal septum. These are locally aggressive malignant tumors arising from the cartilaginous framework of the nasal septum. Rarity of the tumor coupled with nonspecific symptoms makes it a diagnostic dilemma. Diagnosis requires endoscopy, radiology, and final histopathology for confirmation. Treatment is mainly surgical, requiring complete surgical excision with clear margins. Radiation has a role in unresectable tumors or for tumors with positive margins after surgery. Survival depends on the grade of tumor that predicts the metastatic potential of the tumor. We present a rare case of chondrosarcoma arising from the nasal septum in a 29-year-old young female presenting with complaints of nasal obstruction. Computed tomography was suggestive of a calcified cartilaginous tumor arising from the nasal septum. Endoscopic excision was done and postoperative histopathology showed grade II chondrosarcoma with clear margins. No adjuvant treatment was given to our patient and 2 years post-excision patient is disease free.To conclude, chondrosarcoma of the nasal septum is a rare tumor, with nonspecific symptoms. Surgery with clear margins remains the treatment of choice. Prognosis depends on the extent of tumor at presentation, resection margins, and grade of tumor.

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A rare cause of right iliac fossa lump: contained fish bone perforation of caecum

International Surgery Journal ◽

10.18203/2349-2902.isj20204161 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3476

Author(s):

Washim F. Khan ◽

Sandeep Jain ◽

Yashwant S. Rathore ◽

Sunil Chumber

Keyword(s):

Foreign Body ◽

Foreign Bodies ◽

Iliac Fossa ◽

Exploratory Laparotomy ◽

Right Hemicolectomy ◽

Fish Bone ◽

Rare Entity ◽

Radiological Findings ◽

Generalized Peritonitis ◽

High Index Of Suspicion

Ingested foreign bodies usually pass uneventfully through the gastrointestinal tract but few of them can cause symptoms. They can get stuck at acute angulations or narrow part of intestine and can perforate leading to localized to generalized peritonitis, collection or abscess formation. We describe a case of 59 year old gentleman who presented with pain in right iliac fossa with fever and a hard, tender lump. Initial investigation revealed a mass in right iliac fossa adherent to anterior abdominal was in right iliac fossa region with a foreign body inside. Patient was managed with exploratory laparotomy, removal of a fish bone from cacecum and limited right hemicolectomy. Fishbone perforation of caecum is a rare entity. Careful corroboration between patient’s presentation and radiological findings with a high index of suspicion is needed for pre-operative diagnosis.

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Giant Ocular Surface Squamous Neoplasia Wrapping Almost the Whole Cornea: A Case Report

Journal of Institute of Medicine ◽

10.3126/jiom.v42i2.37548 ◽

2020 ◽

Vol 42 (2) ◽

pp. 94-96

Author(s):

Poonam Shrestha ◽

Mukesh Pandey

Keyword(s):

Ocular Surface ◽

Histopathological Examination ◽

Promising Result ◽

Intraepithelial Neoplasia ◽

Surgical Excision ◽

Treatment Modalities ◽

Ocular Surface Squamous Neoplasia ◽

History Of ◽

Grade 3 ◽

Clinical Pictures

Ocular surface squamous neoplasia (OSSN) includes the dysplastic lesions involving the epithelium of conjunctiva and cornea with various clinical pictures. Histopathological examination of the excised tissue is the benchmark for diagnosis. Surgery, chemotherapy, immunotherapy are the various treatment modalities which in combination shows promising result. We present here a case of 83 years old female patient with history of fleshy mass covering the cornea and the patient was diagnosed clinically as ocular surface squamous neoplasia. Patient underwent surgical excision of the mass followed by cryotherapy. Histopathological examination revealed conjunctival intraepithelial neoplasia of grade 3. Six months after treatment the patient is completely tumor free with no recurrence.

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Diagnostic Dilemma of a Rare, Giant Retroperitoneal Schwannoma: A Case Report and Review of Literature

Case Reports in Oncological Medicine ◽

10.1155/2014/628538 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Mahendra Singh ◽

Lovekesh Kumar ◽

Rajkumar Chejara ◽

Om Prakash Prasad ◽

Yuvraj Kolhe ◽

...

Keyword(s):

Low Frequency ◽

Surgical Excision ◽

Abdominal Distension ◽

Exploratory Laparotomy ◽

Postoperative Recovery ◽

Cystic Mass ◽

Imaging Features ◽

Diagnostic Dilemma ◽

Complete Surgical Excision ◽

Retroperitoneal Schwannoma

Schwannoma is a benign tumour of peripheral nerve sheath. It usually arises from head, neck, and trunk. Retroperitoneal schwannoma is a rare entity, accounting for only 0.3–3% of total schwannomas. Majority of retroperitoneal schwannomas reported in literature have a diameter of 5 to 15 cm. Preoperative diagnosis is difficult due to low frequency, nonspecific clinical course, and nonspecific imaging features. Histology usually provides definitive diagnosis. Schwannomas are solitary, well-circumscribed, and noninvasive, so complete surgical excision provides good result. We report a case of a 23-year-old male, who presented with progressive abdominal distension and intermittent episodes of intestinal obstruction. CECT was suggestive of huge solid-cystic mass in abdominopelvic region. Image guided percutaneous aspiration revealed around 1 litre of frank pus and FNAC was suggestive of abscess. Exploratory laparotomy revealed a large 32 × 28 × 26 cm mass with solid and cystic components containing 1 litre of pus. Histological features of tumour were suggestive of benign schwannoma and immunohistochemistry for S-100 was positive. Postoperative recovery was uneventful. We report this case of a retroperitoneal schwannoma because of giant size, rare location, unusual presentation, and diagnostic dilemma.

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Alternative Therapeutic Approach in the Treatment of Oral Pyogenic Granuloma

Case Reports in Oncology ◽

10.1159/000441839 ◽

2015 ◽

Vol 8 (3) ◽

pp. 493-497 ◽

Cited By ~ 2

Author(s):

Amr Bugshan ◽

Harsh Patel ◽

Karen Garber ◽

Timothy F. Meiller

Keyword(s):

Oral Cavity ◽

Malignant Tumors ◽

Surgical Excision ◽

Pyogenic Granuloma ◽

Hormonal Imbalance ◽

Choice Of Treatment ◽

Chronic Irritation ◽

Multiple Recurrences ◽

And Behavior ◽

Rule Out

Pyogenic granulomas (PGs) in the oral cavity present as an inflammatory hyperplasia usually caused by trauma, hormonal imbalance, chronic irritation, or as the response to a wide variety of drugs. PGs with atypical presentation and behavior may clinically mimic malignant tumors. Thus, histological examination is required to rule out cancer development. Lesions in the oral cavity have been described to be either an isolated entity or present in multiple forms and with multiple recurrences. Conservative surgical excision is the standard choice of treatment in almost every scenario. However, the severity of the lesions and the affected sites often challenge surgical treatment. In this report, we describe the clinical scenario of a recurrent PG, where surgical excision of the lesion was questioned. As an alternative, we describe a noninvasive approach with lesional steroid injections.

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