The influence of salivary pH and calcium/phosphate ions concentration on salivary gland stones' formation

Objective: The sialendoscopy era in the treatment of salivary gland stones has reduced the use of classical surgical methods. However, the miniature ducts and tools may cause difficulties in removing large sialoliths. Therefore, invasive combined oral surgeries or gland resection may be considered. We searched for the most suitable method in order to stay in line with the minimally invasive approach that preserves the ductus anatomy, and that can reduce the surgical fears of patients. Materials and Methods: The study included 84 cases (23 parotid and 61 submandibular) in whom stones were fragmented by pneumatic lithotripsy and removed between January 2015 and January 2020. The parotid cases comprised 7 females and 16 males, and the submandibular cases comprised 25 females and 36 males. Intraductal lithotripsy was performed using pneumatic lithotripter. This study has fourth level of evidence. Results: Based on total number of cases (n = 84), success rate was 67/84 (79.7%) immediately after sialendoscopy, and overall success rate was 77/84 (91.6%). Based on number of stones treated (n = 111), our immediate success rate was 94/111 (84.6%), and overall success rate was 104/111 (93.7%). The success criteria were complete removal of the stone and fragments in a single sialendoscopy procedure and resolution of symptoms. Conclusions: We successfully treated salivary gland stones, including L3b stones, in our patient cohort with sialendoscopy combined with pneumatic lithotripsy. The lithotripsy method that we have adapted seems to be more useful and cost-effective compared to its alternatives. We were also able to preserve the ductus anatomy and relieve patients’ concerns. Level of Evidence: Level IV

Download Full-text

Study of Bio-Mineralization of BCP with Compensation of Calcium and Phosphate Ions

Materials Science Forum ◽

10.4028/www.scientific.net/msf.610-613.1391 ◽

2009 ◽

Vol 610-613 ◽

pp. 1391-1394

Author(s):

Hua De Zheng ◽

Ying Jun Wang ◽

Qiang Ma ◽

Cheng Yun Ning ◽

Xiao Feng Chen

Keyword(s):

Free Energy ◽

Calcium Phosphate ◽

Calcium Ions ◽

Biphasic Calcium Phosphate ◽

Porous Ceramic ◽

Apatite Layer ◽

Apatite Formation ◽

Phosphate Ions

In the present study, an Intelligent Multi-parameter Simulated Evaluation in vitro （IMSE system） was used to study the deposition properties of apatite formation on the surface of biphasic calcium phosphate porous ceramic (BCP) from static and dynamic r-SBF. Results showed that apatite formed on the surface of BCP from static and dynamic r-SBF differed between each other. In static r-SBF, ions were transferred by diffusion, which could not compensate the consuming of calcium ions, and mist apatite layer was formed on the surface of samples. But in the dynamic r-SBF, simulated fluid was adjusted precisely and flowed forcedly, the concentrations of ions were homogeneous; with the compensation of ions, calcium and phosphate were supersaturated, and the free energy of apatite formation was negative, bone-like apatite sheets were formed on the surface of samples.

Download Full-text

Salivary gland stones – evaluation and treatment

Therapeutische Umschau ◽

10.1024/0040-5930.60.2.119 ◽

2003 ◽

Vol 60 (2) ◽

pp. 119-122

Author(s):

Reimers

Keyword(s):

Salivary Gland ◽

Salivary Gland Stones

Die Ätiologie der Sialolithiasis als eines der häufigsten Speicheldrüsenleiden ist immer noch unklar. Bei anamnestisch verdächtigen Beschwerden kann die Diagnose häufig bereits klinisch gestellt werden, bedarf aber vor therapeutischen Maßnahmen meist einer bildgebenden Diagnostik mittels Sonographie oder MR-Sialographie. Die konventionelle Sialographie wird von uns nicht mehr verwendet. In der Therapie der symptomatischen Speichelsteine haben sich in den letzten Jahren neben den chirurgischen Maßnahmen zunehmend auch konservative Therapieverfahren wie etwa die extrakorporelle Speichelsteinlithotripsie oder die interventionelle Sialendoskopie bewährt.

Download Full-text

Microfiltration performance: physicochemical aspects of whey pretreatment

Journal of Dairy Research ◽

10.1017/s0022029900030971 ◽

1995 ◽

Vol 62 (2) ◽

pp. 269-279 ◽

Cited By ~ 15

Author(s):

Genevieve Gesan ◽

Georges Daufin ◽

Uzi Merin ◽

Jean-Pierre Labbe ◽

Auguste Quemerais

Keyword(s):

Calcium Phosphate ◽

Membrane Surface ◽

Physicochemical Process ◽

High Shear ◽

Lower Content ◽

Phosphate Ions ◽

Complex Lipid ◽

Ionic Calcium ◽

Calcium Phosphate Particles ◽

Soluble Calcium

SUMMARYClarification of whey by microfiltration (MF) can be achieved after appropriate pretreatment of the feed. A control pretreatment consists of a physicochemical process comprising increased ionic calcium and pH accompanied by heat (50 °C, 15 min) to cause aggregation of complex lipid–calcium phosphate particles, which are then separated by MF. This pretreatment process was modified by increasing the temperature to 55 °C and by maintaining the pH constant during heat treatment. This modification resulted in larger calcium phosphate particles and a lower content of soluble calcium and phosphate ions. As a consequence, a longer period of MF operation, better whey clarification and lower calcium and phosphate content of the filtrate were achieved. This suggests that a loosely structured deposit was formed on the membrane surface which was less resistant to filtration than that resulting from the control pretreatment. During MF, it was necessary to avoid zones of high shear in the retentate compartment that might cause physical alteration of the aggregates.

Download Full-text

Detection of Posner's clusters during calcium phosphate nucleation: a molecular dynamics study

Journal of Materials Chemistry B ◽

10.1039/c7tb01199g ◽

2017 ◽

Vol 5 (35) ◽

pp. 7274-7284 ◽

Cited By ~ 24

Author(s):

Giulia Mancardi ◽

Carlos Ernesto Hernandez Tamargo ◽

Devis Di Tommaso ◽

Nora H. de Leeuw

Keyword(s):

Molecular Dynamics ◽

Calcium Phosphate ◽

Molecular Dynamics Simulations ◽

Aggregation Process ◽

Phosphate Ions ◽

Dynamics Simulations

Molecular dynamics simulations of calcium and phosphate ions in water show that Posner-like clusters originate during the aggregation process.

Download Full-text

Incorporation of Proteins with Different Isoelectric Points into Biomimetic Ca-P Coatings: A New Approach to Produce Hybrid Coatings with Tailored Properties

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.309-311.755 ◽

2006 ◽

Vol 309-311 ◽

pp. 755-758 ◽

Cited By ~ 3

Author(s):

H.S. Azevedo ◽

Isabel B. Leonor ◽

Rui L. Reis

Keyword(s):

Calcium Phosphate ◽

Bovine Serum Albumin ◽

Hybrid Coating ◽

Hybrid Coatings ◽

New Approach ◽

Phosphate Ions ◽

Preferential Interactions ◽

Isoelectric Points ◽

Different Characteristics ◽

Positively Charged

This work aims to study the effect of incorporating proteins with different isoelectric points (pI) on the structure, composition and morphology of biomimetic calcium-phosphate (Ca-P) coatings. For that, bovine serum albumin (BSA) and lysozyme, having respectively acidic and basic pIs, were used as model proteins. It was observed that the incorporation of positively charged proteins, such as lysozyme, was able to significantly change the structure of the coatings, possibly due to the preferential interactions between the protein and negatively charged phosphate ions. These results indicated that proteins with different characteristics can be incorporated into biomimetic Ca-P coatings in order to obtain a hybrid coating and at the same tailoring their properties.

Download Full-text

New Analytical Approach for the Determination of Calcium Phosphate Dibasic and Tribasic in Processed Food by Comparison of Ion Chromatography with High-Performance Liquid Chromatography

Foods ◽

10.3390/foods9030248 ◽

2020 ◽

Vol 9 (3) ◽

pp. 248 ◽

Cited By ~ 1

Author(s):

Minjung Song ◽

Juhee Park ◽

Jihyun Lee ◽

Heejae Suh ◽

Hyunjung Lee ◽

...

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Calcium Phosphate ◽

Ion Chromatography ◽

High Performance ◽

Food Additives ◽

Food Samples ◽

Hplc Method ◽

Processed Foods ◽

Phosphate Ions

An analytical method to measure solubilized orthophosphate ions (HPO42− and PO43− ) from the water-insoluble food additives calcium phosphate dibasic (DCP) and calcium phosphate tribasic (TCP) in processed foods was optimized by comparing ion chromatography (IC) coupled with DS6 conductivity detector (Cond.) and high-performance liquid chromatography (HPLC) with Evaporative light scattering detector (ELSD) methods. The ion-pairing HPLC method could analyze calcium and phosphate ions successively. However, this method exhibited low reproducibility after approximately 48 hours of measurements. The IC method was established as an effective method of measuring orthophosphate ions with high reproducibility using distilled water and KOH solution as the mobile phase with a Dionex column. Matrix-based limit of detections (LOD) and limit of quantifications (LOQ) for snacks and cereals were estimated in the range of 0.01–0.91 µg/mL and 0.21–2.74 µg/mL, respectively. In inter-day and intra-day tests, the calculated precision (%RSD) and accuracy (recovery %) ranged from 0.5% to 6.6% and 82% to 117%, respectively, in both food samples. The levels of DCP or TCP could be analyzed in various positive food samples, and the developed IC method demonstrated good applicability in the analysis of DCP and TCP in collected processed foods.

Download Full-text

Extracorporeal Electromagnetic Shock-Wave Lithotripsy for Salivary Gland Stones

The Laryngoscope ◽

10.1097/00005537-199606000-00018 ◽

1996 ◽

Vol 106 (6) ◽

pp. 761-764 ◽

Cited By ~ 53

Author(s):

Francesco Ottaviani ◽

Pasquale Capaccio ◽

Michela Campi ◽

Antonio Ottaviani

Keyword(s):

Shock Wave ◽

Salivary Gland ◽

Shock Wave Lithotripsy ◽

Electromagnetic Shock ◽

Electromagnetic Shock Wave ◽

Salivary Gland Stones

Download Full-text

Fabrication and Characterisation of Calcium Phosphate - Liposome Composites as an Implant Coating

MRS Proceedings ◽

10.1557/proc-662-ll4.7 ◽

2000 ◽

Vol 662 ◽

Cited By ~ 1

Author(s):

Tarinee Pongsaanutin ◽

Jan T. Czernuszka

Keyword(s):

Electron Microscopy ◽

Calcium Phosphate ◽

Dark Field ◽

Electrophoretic Method ◽

Phosphate Ions ◽

Transmission Electron ◽

Stainless Steel Cathode ◽

Cathode Substrate ◽

Implant Coating ◽

Drug Delivery Devices

AbstractCalcium phosphate in the form of apatite has been successfully precipitated on the surface of liposomes. Liposome vesicles were prepared by sonication of phosphatidylcholine and this was introduced into an aqueous solution of calcium and phosphate ions supersaturated with respect to hydroxyapatite. Calcium phosphate was shown to precipitate solely on the outer layer surface of the liposome vesicles. These composite assemblies were then deposited onto a stainless steel cathode substrate using an electrophoretic method at physiological temperatures.Scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder xray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR) were used to analyse the morphology, structure and chemical composition of the composite coating. The results from PXRD and FTIR show a mixture of amorphous and poor crystalline hydroxyapatite (HAp). This was verified by electron diffraction. Dark field images confirmed that the precipitated HAp deposited solely at the outer surface of the liposomes. SEM micrographs demonstrated a thin uniform coating at the microstructure level. These results suggest that these calcium phosphateliposome composites can be formed. They have tremendous potential for use as drug delivery devices in aiding the treatments of bone disorders.

Download Full-text