scholarly journals EVALUATION OF LOCAL IMMUNITY OF MORBIDITY OF THE MUTUAL IN THE TRADITIONAL THERAPY OF INFLAMMATORY DISEASES OF THE PARODONT

2018 ◽  
Vol 14 (3) ◽  
pp. 11-16 ◽  
Author(s):  
Надежда Васильева ◽  
Nadezhda Vasil'eva ◽  
Альбина Булгакова ◽  
Al'bina Bulgakova ◽  
Эльмира Имельбаева ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Effective Means ◽  
Immunoglobulin A ◽  
Control Group ◽  
Total Protein Content ◽  
Total Production ◽  
Local Immunity ◽  
Traditional Therapy ◽  
Mixed Saliva

Subject. The state of local immunity before and with the use of traditional therapy is considered. As a material for assessing local immunity, the quantitative and qualitative characteristics of mixed saliva and the migration test of leukocytes were used, reflecting the severity of inflammatory phenomena in the periodontium and to determine the effectiveness of treatment. The purpose is an evaluation of local immunity of the oral cavity in the traditional therapy of inflammatory periodontal diseases. Methodology. Local immunity was studied in 204 patients with periodontal inflammatory diseases according to the test of leukocyte migration, quantitative and qualitative content of spontaneously secreted mixed saliva: the total protein content, secretory immunoglobulin A (sIgA), lysozyme. All patients underwent traditional therapy. Results. The study revealed an imbalance of local immunity and was characterized by a decrease in total production of mixed saliva in all groups of CDW patients in comparison with the control group. The level of protein was reduced in the group of moderate hippocampus, sIgA in mixed saliva in all patients, especially in cases of severe HCV. The amount of lysozyme is increased in patients with gingivitis, in mild to moderate HGP it corresponds to the content of the control group, it is decreased in patients with moderate and severe periodontitis. In the course of traditional treatment, all patients showed a tendency to normalization of these parameters and was characterized by preservation of reduced production of mixed saliva in all CDW patients, increased lysozyme content and sIgA. However, the restoration of sIgA level in CDW patients to the control group level was not observed. In the group of severe hCG, the level of lysozyme was lower than in control. Conclusions. The use of traditional therapy indicates the preservation of the intensity of immune response in patients with CDW and requires further research and more effective means of action on inflammatory mediators.

LOCAL IMMUNE STATUS AND ETIOLOGICAL FACTORS IN PARATONSILLITIS

2019 ◽  
Vol 25 (3) ◽  
pp. 78-86
Author(s):  
T.V. Zolotova ◽  
◽  
A.G. Volkov ◽  
P.A. Kondrashov ◽  
◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Immunoglobulin A ◽  
Secretory Iga ◽  
Control Group ◽  
Local Immunity ◽  
Immunomodulatory Agents ◽  
Etiological Factors ◽  
Streptolysin O ◽  
Bacterial Lysates ◽  
Antigenic Load

Paratonsillitis is one of the most common purulent inflammatory diseases, considered as a manifestation of chronic tonsillitis. The aim of the work is to study the state of local immunity by the level of immunoglobulin A in saliva in patients with paratonsillitis and its changes in the treatment process, to determine the level of antistreptolysin-O in serum, as well as to study the etiological factors of paratonsillites in the microbiological assessment of the species composition of flora in smears from the cavity of paratonsillar abscess. Under our observation there were 152: 32 healthy people and 120 patients with paratonsillitis under abecedarian or abscess stage. It was found that in patients with paratonsillitis there is a significant (p<0.001) decrease in the level of secretory immunoglobulin A in saliva, which indicates a violation of local immunity and requires correction. The level of antibodies to streptolysin-O in the serum of patients with paratonsillitis was significantly - 10.25 times higher than in healthy individuals in the control group, which confirms the high streptococcal antigenic load. The results of microbiological examination of smears from the abscess cavity indicated the release of the most frequent pathogens of paratonsillites - Streptococcus β-haemolythicus, Streptococcus Pneumoniae and Staphylococcus Aureus, with bacterial associations prevailing (63.5%). After a course of antimicrobial therapy, supplemented with immunomodulatory agents in the form of bacterial lysates, there was an increase in the level of secretory IgA in saliva in 10-30 days in 3.3-4.5 times. At the same time, the level of antistreptolysin-O significantly decreased. In patients receiving immunomodulatory therapy in the form of bacterial lysates in the complex treatment of paratonsillitis, for the period of observation of 6 months, there was a decrease in the frequency of relapses of the disease by 2 times.

scholarly journals Results of study of local immunity of the oral cavity in patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases

2016 ◽  
Vol 97 (3) ◽  
pp. 363-367
Author(s):  
I R Shafeev ◽  
A I Bulgakova ◽  
I V Valeev ◽  
G Sh Zubairova
Keyword(s):  
Oral Cavity ◽  
Oral Fluid ◽  
Periodontal Diseases ◽  
Immunoglobulin A ◽  
Main Group ◽  
Interleukin 4 ◽  
Control Group ◽  
Interferon Α ◽  
Local Immunity ◽  
Dental Prostheses

Aim. To study the state of local immunity of the oral cavity in patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases.Methods. 90 patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases (main group) and 21 patients without dental prostheses and inflammatory periodontal disease (control group) were examined. Immunoglobulin A, sA, G, M, E classes, interleukin-4, -6 and -1β, interferon α contents in oral liquid were determined using enzyme immunoassay.Results.. As a result of our study of immunoglobulins level in saliva in patients of the main and control groups an increase in the immunoglobulin A level, compared with the normal value, statistically significant increase in secretory immunoglobulin A were revealed; difference in the immunoglobulin G level was not determined. The increase in immunoglobulin E level in patients of the main group was determined. When studying the interleukins content in the oral fluid a statistically significant decrease in the concentration of IL-4 and increase in interleukin-6 and -1β content in patients of the main group were determined. The tendency to decrease in the interferon α content in the main group compared to the control group was registered.Conclusion. In patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases humoral immunity imbalance was identified, manifesting in changes of the immunoglobulin classes A, sA and E, interleukin-4, -6 and -1β contents in oral fluid.

The effect of probiotics on the level of immunoglobulin A in women with violation of the biocenosis of the vagina

2017 ◽  
pp. 85-88
Author(s):  
O.I. Ostapenko ◽  
◽  
V.P. Kvashenko ◽  
I.K. Akimova ◽  
I.N. Nosova ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Lactobacillus Rhamnosus ◽  
Test System ◽  
Main Group ◽  
Reproductive Age ◽  
Local Action ◽  
Serum Immunoglobulin ◽  
Control Group ◽  
Local Immunity ◽  
Serum Iga

The objective: the study of immunomodulatory effects of a probiotic, which contains lyophilized Lactobacillus (Lactobacillus rhamnosus) – 13 mg (2,0ґ109 CFU) and lyophilized bifidobacteria (Bifidobacterium lactis) – 4 mg (2,0ґ109 CFU) the level of serum immunoglobulin IgA as a marker of local immunity in the plasma of women of reproductive age with the violation of the biocenosis of the vagina. Patients and methods. The study involved 86 patients of reproductive age with the violation of the vaginal biocenosis, which were divided into two groups according to received treatment. A survey was conducted for all patients in both groups: determine the level of serum IgA, measuring pH of vaginal environment and the quantification of lactobacilli and pathogenic flora with the help of test-system «Florotsenoz» before treatment and in 6 weeks after treatment. The state of vaginal microbiocenosis in both groups before treatment was homogeneous. Patients in both groups as therapy at the first stage of treatment received, if necessary antimicrobial therapy depending on the selected flora. In the second stage (restoration of microflora) patient of the main group received systemic probiotic combined with a complex prebiotic local action, patients in the control group, the probiotic localy in the form of the vaginal candles or tablets. Results. The research stated the increasing level of serum IgA in blood plasma of patients of the main group compared to control group at 20%, normalizing the pH of the vaginal environment in the main group in 94% of cases, which indicates an increase of immunity in mucosal. Conclusion. The inclusion of the systemic probiotic in the scheme of treatment of disorders of biocenosis of the vagina system enhances the increasing of immunity of the mucous membranes, and the vaginal tablets prebiotic of local action restores the own normal microflora of the vagina. Key words: serum immunoglobulin A, local immunity, vaginal dysbiosis, probiotics, prebiotics, vaginal microbiocenosis, the pH of the vaginal environment.

scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals IMMUNOLOGICAL AND PATHOPHYSIOLOGICAL LAWS OF LOCAL IMMUNITY ORAL CAVITY PREVENTION OF INFLAMMATORY COMPLICATIONS OF TREATMENT OF DENTOALVEOLAR ANOMALIES

2018 ◽  
Vol 22 (1) ◽  
pp. 25-28
Author(s):  
Pavel Aleksandrovich Zheleznyi ◽  
K. S Shchelkunov ◽  
S. P Zheleznyi ◽  
A. P Zheleznaia ◽  
Y. N Belousov
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Immunoglobulin A ◽  
Interleukin 4 ◽  
Activity Levels ◽  
Local Immunity ◽  
Immunomodulatory Agents ◽  
Periodontal Tissues ◽  
Mixed Saliva ◽  
Secretory Immunoglobulin

The state of local immunity oral factors in orthodontic treatment with fixed structures in 192 people aged 18-25 years. The mixed saliva was determined lysozyme activity levels of secretory immunoglobulin A, interleukin 1в and interleukin 4 dynamics. It was found that orthodontic treatment leads to activation of the inflammatory process in periodontal tissues, effective therapy which should be based on the integrated use of antimicrobial agents and immunomodulatory agents.

scholarly journals Dynamics of clinical and immunological parameters in the integrated management of endo-­periodontal lesions, including laser therapy

2021 ◽  
Vol 102 (3) ◽  
pp. 322-328
Author(s):  
S L Blashkova ◽  
E V Krikun ◽  
I G Mustafin ◽  
I Kh Valeeva ◽  
Ju V Blashkova
Keyword(s):  
Diode Laser ◽  
Immunoglobulin A ◽  
Interleukin 10 ◽  
Main Group ◽  
Control Group ◽  
Immunological Parameters ◽  
Necrosis Factor Alpha ◽  
Periodontal Index ◽  
Factor Alpha ◽  
Mixed Saliva

Aim. To determine the dynamics of clinical changes and indicators of local immunity in integrating the diode laser into the treatment of the endo-periodontal lesion. Methods. We performed a prospective study of 110 patients of both sexes aged 2555 years with endo-periodontal lesions. The patients were randomized into two groups the main group (n=54), whose received root canal treatment and periodontal pockets with a diode laser in addition to standard therapy, which included endodontic and periodontal treatment, and control group (n=56), whose patients received only standard treatment. The GreenVermillion oral hygiene index and Russells periodontal index, as well as the levels of immunoglobulin (Ig) A, tumor necrosis factor-alpha (TNF-alpha) and cytokine interleukin-10 (IL-10) in the mixed saliva of patients, were determined during the study. Quantitative data were described using median, lower and upper quartiles. These data were visualized using boxplots. The MannWhitney U test was used to compare differences between an independent set of quantitative data. Differences were considered significant at a confidence level of p 0.05. Results. The median oral hygiene index decreased from 2.9 to 1.0 (p 0.001) in the main group and from 2.9 to 1.6 (p 0.001) in the control group. The median Russell's periodontal index decreased from 3.38 to 1.3 (p 0.001) in the main group and from 3.95 to 2.0 (p 0.001) in the control group. The median immunoglobulin A content decreased from 5.25 to 3.13 mg/L (p 0.001) in the main group and from 5.23 to 4.21 mg/L (p 0.001) in the control group. The tumor necrosis factor-alpha level decreased from 16.65 pg/ml in the main group and 18.28 pg/ml in the control group to 3.96 and 8.44 pg/ml (p 0.001), respectively. The median cytokine interleukin-10 levels increased from 0.83 to 2.94 pg/ml (p 0.001) in the main group and from 1.29 to 2.13 pg/ml (p 0.001) in the control group. Conclusion. The use of a diode laser in the treatment of endo-periodontal lesions has a positive effect on the dynamics of clinical and immunological parameters, as evidenced by a statistically significant decrease in clinical indices, as well as the normalization of the immunoglobulin A and cytokine levels in mixed saliva.

scholarly journals Safety and Preliminary Efficacy of a Novel Host-Modulatory Therapy for Reducing Gingival Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Hatice Hasturk ◽  
Fabian Schulte ◽  
Melissa Martins ◽  
Homa Sherzai ◽  
Constantinos Floros ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Periodontal Pocket ◽  
Lipid Mediator ◽  
Control Group ◽  
Gingival Inflammation ◽  
Lipoxin A4 ◽  
Resolution Of Inflammation ◽  
Oral Rinse

BackgroundPeriodontal disease is among the sixth most common inflammatory diseases worldwide with high risk to promote complications from other inflammatory diseases including diabetes, cardiovascular disease and Alzheimer’s Disease. Failure of active resolution of inflammation pathways is implicated in pathogenesis of periodontal diseases, including gingivitis. Lipoxin A4 (LXA4), a member of the specialized pro-resolving lipid mediators (SPMs) that drive resolution of inflammation via GPC-receptor mediated pathways, offered therapeutic advantages in preclinical models of periodontitis.MethodsWe conducted a randomized, placebo-controlled, parallel-group Phase 1 clinical trial to determine the safety and preliminary efficacy of an LXA4 analog in patients with gingival inflammation. One hundred twenty-seven (127) individuals were randomized to daily use of an oral rinse containing a LXA4 mimetic, methyl ester-benzo-lipoxin A4 (BLXA4), placebo rinse or a no-rinse control group for 28 days. Treatment emergent adverse events (TEAEs) were assessed for safety, the primary outcome. Secondary outcomes included the change in the level of gingival inflammation and periodontal pocket depth (PD). Serum SPMs were monitored using targeted lipid mediator lipidomics to assess potential systemic impact of BLXA4.ResultsThe frequency of TEAEs was similar in BLXA4 and placebo-treated groups with no study-related SAEs. Once-daily rinsing with BLXA4 for 28-days resulted in a greater decrease in gingival inflammation compared to placebo rinse and no-rinse control groups (mean change: 0.26 GI unit vs 0.21 and 0.17, respectively). PD reduction was also greater with BLXA4 oral rinse compared to placebo and no-rinse groups (mean reduction: 1.23 mm vs. 0.71 mm and 0.46 mm, respectively). Topical application of BLXA4 increased serum levels of SPMs.ConclusionTreatment with BLXA4 reduces local inflammation, and increases abundance of pro-resolution molecules systemically, which may dampen inflammation that can mediate progression and course of inflammatory diseases beyond periodontitis.Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT02342691).

Role of antimicrobial peptides system in inflammatory periodontal diseases non-specific oral cavity protection

2021 ◽  
Vol 66 (7) ◽  
pp. 422-427
Author(s):  
N. V. Davidovich ◽  
N. V. Solovieva ◽  
A. S. Galieva ◽  
S. Yu. Lepeshkin ◽  
E. N. Bashilova ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Antimicrobial Peptides ◽  
Chronic Periodontitis ◽  
Pathogenic Bacteria ◽  
Periodontal Diseases ◽  
Control Group ◽  
Periodontal Pathogens ◽  
Local Immunity ◽  
Microbial Invasion

The system of antimicrobial peptides (AMP) is one of the most ancient mechanisms of the macroorganism resistance to infectious pathogens invasion. The aim of the study was to determine the role of the antimicrobial peptides system and periodontal pathogenic markers in the development and progression of inflammatory periodontal diseases. Gingival pocket washes (91 samples in total) for the research were received from patients with inflammatory periodontal diseases (chronic periodontitis and gingivitis) and intact periodontium. Using ELISA, the content of antimicrobial peptides was determined: human alpha-defensin (HNP 1-3), beta-defensin (HBD 1-3) and cathelicidin (LL-37). Periodontal pathogenic markers were isolated during RT-PCR. The study revealed differences in AMP concentrations by groups: level of HBD 2 in patients with chronic periodontitis was 1,36 times higher than those in the group of patients with chronic gingivitis (p=0,023) and 2,39 times higher than those in the control group (p<0,001), the content of HNP 1-3 in the group of patients with chronic periodontitis was reduced by 1,23 times compared with the indicators of the group of patients with gingivitis (p=0,045) and by 1,97 times compared with the indicators of the control group (p<0,001). The frequency of detection of periodontal pathogenic bacteria genes was 88,0% in patients with periodontitis, 76,92% in patients with gingivitis and 33,3% in the group with intact periodontium. HBD 2 content moderately correlated with the definition of P. gingivalis (r=0,612; p=0,022), T. forsythensis (r= 0,434; p=0,015), A. actinomycetemcomitans (r=0,483; p=0,006), a moderate negative correlation was detected between the content of HNP 1-3 and the release of periodontal pathogens in associations (P. gingivalis with T. forsythensis and T. denticola) (r=-0,388; p=0,031) in the group of patients with chronic periodontitis. Thus, the revealed relationships and correlations indicate shifts in the processes of reparative regeneration of the oral cavity and the regulation of local immunity in response to microbial invasion.

scholarly journals The effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis

2018 ◽  
Author(s):  
A. I. Furdychko ◽  
A. Yu. Buchkovska ◽  
M. A. Pasichnyk
Keyword(s):  
Periodontal Disease ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Hepatobiliary System ◽  
The Difference ◽  
Calculous Cholecystitis

Summary. Inflammatory periodontal diseases continue to be one of the pressing problems of modern dentistry [1]. It is known that there is a close relationship between general-somatic pathology and diseases of the oral cavity [2]. The aim of the study – to learn the effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis. Materials and Methods. The main (group 1) group consisted of 106 people who suffered from inflammatory periodontal disease (IPD) with concomitant chronic non-calculous cholecystitis (CNC). The comparison group included 92 patients with IPD without concomitant pathology (group 2). To compare the research results of the patients with IPD, 30 healthy teethed individuals without periodontal pathology and without somatic diseases (group 3 or the control group) were involved. The state of the hepatobiliary system in patients of the main group was assessed by the doctors of the Gastroenterology Department of Zolochiv District Hospital of Lviv region. Results and Discussion. The symptomatic HCG and the presence of solid and soft dental deposits were diagnosed in all patients. The Green-Vermillion’s index was the highest in patients from the main group (1.67±0.01); it was probably (p <0.05) higher than that in the comparison group (1.54±0.04), as well as in the control group (0.44±0.07). The PMA index in the subgroup 1A immediately after treatment decreased by 9.7 (p <0.001) times. The index of bleeding in the subgroup 1A decreased by 10.7 (p <0.001) times. The PMA index in the subgroup 1A immediately after treatment decreased by 10.4 (p <0.001) times. The index of bleeding in the subgroup 1A under the influence of the proposed therapy decreased by 6.5 (p <0.001) times.The difference regarding the data before treatment remained lower by 2.2 times and 2.0 (p <0.001) times, however, the difference between the subgroups 1A and 1B in 3 months and 6 months was already 2.1 times in both cases. Conclusions. It was found that the clinical course of inflammatory periodontal diseases was much more difficult in these patients. The presence of pathology in the hepatobiliary system in patients increases the risk of periodontal disease. Therefore, in order to improve the efficacy of treatment, it is advisable to use this antidysbiotic drug in the complex treatment, and the results obtained in 3 and 6 months after treatment indicate a long-lasting positive effect.

scholarly journals СIRCULATING SECRETORY IMMUNOGLOBULINA IN SEPTIC DISORDERS

2018 ◽  
Vol 20 (5) ◽  
pp. 711-720
Author(s):  
N. V. Mal'tseva ◽  
Т. A. Laputenko ◽  
S. V. Arkhipova ◽  
A. Sc. Smirnova ◽  
O. F. Lykova ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Systemic Infection ◽  
Individual Variability ◽  
Infectious Endocarditis ◽  
Control Group ◽  
Large Individual ◽  
Glutathione S Transferase ◽  
Local Immunity ◽  
Source Of Infection ◽  
Wide Range

Insufficiency of local immunity can play an important role in pathogenesis of sepsis, including septic (acute) infectious endocarditis (IE). The paper presents data on secretory immunoglobulin A (sIgA) contents in blood serum of patients with sepsis (26 women and 32 men), acute (11 women and 23 men) and subacute (7 women and 13 men) IE, depending on localization of the infection site (angiogenic or non-angiogenic), outcome of the disease and carriage of glutathione-S-transferase P1 gene variants (GSTP1Ile105Val). A control group consisted of 25 women and 24 men without hypertension and ischemic heart disease and lacking evidence of focal and systemic infection, was examined. Laboratory studies were performed with еnzyme immunoassay and allele-specific polymerase chain reaction. We have found that, despite large individual variability of serum sIgA concentration in sepsis and infectious endocarditis, the majority of patients had a significant (on average, 4-fold) IgA increase against controls, in both men and women, especially in acute IE (a mean of 5-fold over control values). Subacute infectious endocarditis is associated with lesser sIgA in circulation than acute IE and sepsis, which may be used for early differential diagnosis of these conditions. There were no gender differences in sIgA contents. In sepsis with non-angiogenic source of infection, the sIgA levels were higher than in angiogenic infection. There was no association of sIgA level with survival (mortality), which excludes this index from predictive markers in sepsis and IE. Carriage of heterozygous GSTP1Ile105Val genotype increases the risk of sepsis and IE development, regardless of clinical course, and homozygous genotype GSTP1Ile105Ile is associated with higher contents of circulating immunoglobulin than in carriers of GSTP1Val105Val genotype. Thus, a wide range of individual variability in of circulating sIgA levels in patients with sepsis and infective endocarditis may be connected with location of infection source and genetic factors.

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