scholarly journals Safety and Preliminary Efficacy of a Novel Host-Modulatory Therapy for Reducing Gingival Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Hatice Hasturk ◽  
Fabian Schulte ◽  
Melissa Martins ◽  
Homa Sherzai ◽  
Constantinos Floros ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Periodontal Pocket ◽  
Lipid Mediator ◽  
Control Group ◽  
Gingival Inflammation ◽  
Lipoxin A4 ◽  
Resolution Of Inflammation ◽  
Oral Rinse

BackgroundPeriodontal disease is among the sixth most common inflammatory diseases worldwide with high risk to promote complications from other inflammatory diseases including diabetes, cardiovascular disease and Alzheimer’s Disease. Failure of active resolution of inflammation pathways is implicated in pathogenesis of periodontal diseases, including gingivitis. Lipoxin A4 (LXA4), a member of the specialized pro-resolving lipid mediators (SPMs) that drive resolution of inflammation via GPC-receptor mediated pathways, offered therapeutic advantages in preclinical models of periodontitis.MethodsWe conducted a randomized, placebo-controlled, parallel-group Phase 1 clinical trial to determine the safety and preliminary efficacy of an LXA4 analog in patients with gingival inflammation. One hundred twenty-seven (127) individuals were randomized to daily use of an oral rinse containing a LXA4 mimetic, methyl ester-benzo-lipoxin A4 (BLXA4), placebo rinse or a no-rinse control group for 28 days. Treatment emergent adverse events (TEAEs) were assessed for safety, the primary outcome. Secondary outcomes included the change in the level of gingival inflammation and periodontal pocket depth (PD). Serum SPMs were monitored using targeted lipid mediator lipidomics to assess potential systemic impact of BLXA4.ResultsThe frequency of TEAEs was similar in BLXA4 and placebo-treated groups with no study-related SAEs. Once-daily rinsing with BLXA4 for 28-days resulted in a greater decrease in gingival inflammation compared to placebo rinse and no-rinse control groups (mean change: 0.26 GI unit vs 0.21 and 0.17, respectively). PD reduction was also greater with BLXA4 oral rinse compared to placebo and no-rinse groups (mean reduction: 1.23 mm vs. 0.71 mm and 0.46 mm, respectively). Topical application of BLXA4 increased serum levels of SPMs.ConclusionTreatment with BLXA4 reduces local inflammation, and increases abundance of pro-resolution molecules systemically, which may dampen inflammation that can mediate progression and course of inflammatory diseases beyond periodontitis.Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT02342691).

scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals Comparative evaluation of satranidazole and ornidazole effectiveness in the treatment of chronic periodontal diseases along with mechanical debridement

2018 ◽  
Vol 6 (5) ◽  
pp. 1579
Author(s):  
Bharat Bhushan Awasthi ◽  
Saurabh Singh
Keyword(s):  
Periodontal Diseases ◽  
Periodontal Pocket ◽  
Gingival Inflammation ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Microbial Infections ◽  
Microbiological Parameters ◽  
Substantial Progress ◽  
Pre Treatment ◽  
Root Planning

Background: Periodontitis is a common chronic inflammatory dental disease, which occurs due to the existence of pathogenic microorganisms within the gingival plaque and lead to the formation of periodontal pocket. This study was aimed to evaluate the effectiveness of satranidazole and ornidazole in the treatment of chronic periodontal diseases along with mechanical debridement.Methods: Forty subjects were randomly selected to access the effectiveness of selected drugs on the basis of clinical and microbiological investigations over a period of 14 days. Six Ramfjord teeth (i.e. 16, 21, 24, 36, 41 and 44) were examined for investigating clinical parameters such as gingival inflammation, pocket depth and bleeding on probing. Microbiological investigations were carried out to examine the presence of gram positive (cocci and bacilli), gram negative (cocci and bacilli) and spirochaetes.Results: A substantial progress was recorded in treating gingival inflammation, pocket depth and bleeding on probing. The results of microbiological investigations suggest that the satranidazole and ornidazole were equally effective when used alone and with scaling and root planning in reducing microbial infections. The results indicated a significant (p <0.0001) effect of model drugs on clinical and microbiological parameters in different study subjects at baseline (pre-treatment), and 7 days and 14 days post treatment.Conclusions: The results concluded that ornidazole is better than satranidazole in treating periodontal diseases.

scholarly journals EVALUATION OF LOCAL IMMUNITY OF MORBIDITY OF THE MUTUAL IN THE TRADITIONAL THERAPY OF INFLAMMATORY DISEASES OF THE PARODONT

2018 ◽  
Vol 14 (3) ◽  
pp. 11-16 ◽  
Author(s):  
Надежда Васильева ◽  
Nadezhda Vasil'eva ◽  
Альбина Булгакова ◽  
Al'bina Bulgakova ◽  
Эльмира Имельбаева ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Effective Means ◽  
Immunoglobulin A ◽  
Control Group ◽  
Total Protein Content ◽  
Total Production ◽  
Local Immunity ◽  
Traditional Therapy ◽  
Mixed Saliva

Subject. The state of local immunity before and with the use of traditional therapy is considered. As a material for assessing local immunity, the quantitative and qualitative characteristics of mixed saliva and the migration test of leukocytes were used, reflecting the severity of inflammatory phenomena in the periodontium and to determine the effectiveness of treatment. The purpose is an evaluation of local immunity of the oral cavity in the traditional therapy of inflammatory periodontal diseases. Methodology. Local immunity was studied in 204 patients with periodontal inflammatory diseases according to the test of leukocyte migration, quantitative and qualitative content of spontaneously secreted mixed saliva: the total protein content, secretory immunoglobulin A (sIgA), lysozyme. All patients underwent traditional therapy. Results. The study revealed an imbalance of local immunity and was characterized by a decrease in total production of mixed saliva in all groups of CDW patients in comparison with the control group. The level of protein was reduced in the group of moderate hippocampus, sIgA in mixed saliva in all patients, especially in cases of severe HCV. The amount of lysozyme is increased in patients with gingivitis, in mild to moderate HGP it corresponds to the content of the control group, it is decreased in patients with moderate and severe periodontitis. In the course of traditional treatment, all patients showed a tendency to normalization of these parameters and was characterized by preservation of reduced production of mixed saliva in all CDW patients, increased lysozyme content and sIgA. However, the restoration of sIgA level in CDW patients to the control group level was not observed. In the group of severe hCG, the level of lysozyme was lower than in control. Conclusions. The use of traditional therapy indicates the preservation of the intensity of immune response in patients with CDW and requires further research and more effective means of action on inflammatory mediators.

scholarly journals The Antimicrobial Effect of Pomegranate Peel Extract versus Chlorhexidine in High Caries Risk Individuals Using Quantitative Real-Time Polymerase Chain Reaction: A Randomized Triple-Blind Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Benoy Jacob ◽  
Nivedhitha Malli Sureshbabu ◽  
Manish Ranjan ◽  
Aishwarya Ranganath ◽  
Riluwan Siddique
Keyword(s):  
Clinical Trial ◽  
Control Group ◽  
Caries Risk ◽  
Chain Reaction ◽  
Pomegranate Peel ◽  
Oral Rinse ◽  
High Caries Risk ◽  
Polymerase Chain ◽  
Pomegranate Peel Extract ◽  
Peel Extract

The aim of the present study was to compare the antibacterial effectiveness of chlorhexidine and PPE oral rinse on S. mutans, Lactobacilli, and Veillonella, in clinical salivary samples of patients with advanced stages of dental caries at baseline and two and four weeks with PCR technique. This triple-blind randomized clinical trial involved 60 high caries risk adult patients, 19–59 years of age, randomly allocated into two groups of 30 subjects each. The intervention group received pomegranate peel extract mouthwash, whereas the control group received chlorhexidine mouthwash. Unstimulated pooled saliva was collected from the floor of the mouth before and after the intervention. The quantitative real-time polymerase chain reaction was employed to analyze the bacterial copies of each salivary sample at baseline and two and four weeks. The significance level was fixed at 5% (α = 0.05). Overall comparison of antimicrobial effectiveness across both groups revealed insignificant outcomes. The control group evinced a significant reduction in S. mutans between a specific time, i.e., baseline and 4 weeks ( p = 0.043 ). PPE oral rinse as a natural product or ecological alternative was effective in disrupting activity across all microorganisms tested in this triple-blind RCT; however, the nutraceutical, when compared to chlorhexidine, was not as effective against S. mutans.

scholarly journals Eugenia uniflora Dentifrice for Treating Gingivitis in Children: Antibacterial Assay and Randomized Clinical Trial

2016 ◽  
Vol 27 (4) ◽  
pp. 387-392 ◽  
Author(s):  
Vanessa de Carvalho Jovito ◽  
Irlan Almeida Freires ◽  
Danilo Augusto de Holanda Ferreira ◽  
Marçal de Queiroz Paulo ◽  
Ricardo Dias de Castro
Keyword(s):  
Clinical Trial ◽  
Periodontal Diseases ◽  
Clinical Signs ◽  
School Age Children ◽  
Secondary Outcome ◽  
Control Group ◽  
Eugenia Uniflora ◽  
Gingival Bleeding ◽  
And Control

Abstract School-age children are frequently at high risk for the onset of biofilm-dependent conditions, including dental caries and periodontal diseases. The objective of this study was to evaluate the clinical efficacy of a dentifrice containing Eugenia uniflora Linn. (Surinam cherry) extract versus a triclosan-based comparator in treating gingivitis in children aged 10-12 years. The in vitro antibacterial potential of the dentifrice was tested against oral pathogens (Streptococcus mutans, Streptococcus oralis and Lactobacillus casei). Then a phase-II clinical trial was conducted with 50 subjects aged 10-12 years, with clinical signs of gingivitis. The subjects were randomly assigned to the experimental group (n=25) and control group (n=25), in which participants used the experimental dentifrice and a triclosan-based fluoridated dentifrice (Colgate Total 12(r)), respectively. Clinical examinations assessed the presence of gingivitis (primary outcome) and biofilm accumulation (secondary outcome) using the Gingival-Bleeding Index (GBI) and Simplified Oral Hygiene Index (OHI-S), respectively, at baseline and after seven days of tooth brushing 3x/day. The data were analyzed using paired and unpaired t-test (GBI) and Wilcoxon and Mann-Whitney (OHI-S), with p≤0.05. The experimental dentifrice showed efficient antibacterial activity in vitro. In the clinical trial, a significant reduction in gingival bleeding was observed in both experimental and control groups (p<0.0001), with no statistical difference between them (p=0.178), although a small size effect was observed. Biofilm accumulation was only reduced in the control group (p=0.0039). In conclusion, E. uniflora dentifrice showed anti-gingivitis properties in children aged 10-12 years. Thus, it may be a potentially efficient and safe product to be used alternatively in preventive dental practice

scholarly journals METHOD FOR TREATING CHRONIC GENERALIZED PERIODONTITIS OF LIGHT AND MEDIUM GRAPES

2020 ◽  
Vol 16 (2) ◽  
pp. 53-58
Author(s):  
Karen Karakov ◽  
Emilia Khachaturyan ◽  
Marat Uzdenov ◽  
Laura Uzdenoba ◽  
Nelli Vanchenko ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Regimen ◽  
Treatment Time ◽  
Periodontal Diseases ◽  
Periodontal Pocket ◽  
Control Group ◽  
Moderate Severity ◽  
Affected Area ◽  
Periodontal Tissues ◽  
Complex Therapy

Subject. The article presents the data of a comparative analysis of the traditional method of treating chronic generalized periodontitis of mild to moderate severity and with the use of periodontal dressings in combination with an antibacterial photodynamic system. The goal is to study the effectiveness of the methodology of complex therapy for the treatment of periodontal diseases using periodontal dressings and antibacterial photodynamic therapy. Methodology. We observed 120 patients with inflammatory periodontal diseases aged 18 to 55 years (men ― 52, women ― 68), who were divided into the control and main groups. In the control group, treatment was carried out according to the traditional scheme of drug therapy, in the main ― according to the method of complex therapy. The treatment regimen according to this technique included the use of periodontal dressings and an antibacterial photodynamic therapy system: photosynthesis was applied to the affected area of the periodontal pocket, after which the pathogenic microorganisms were stained for 1-3 minutes, then the liquid was thoroughly washed from the periodontal pockets and the laser affected the affected area for 60 seconds. Results. The proposed treatment regimen using an antibacterial photodynamic system in combination with periodontal dressings allows to achieve a pronounced and prolonged anti-inflammatory effect in periodontal tissues without local and systemic use of antibiotics, reduces treatment time for mild periodontitis by 29, average ― by 57 %, reduces the likelihood recurrence, lengthens the duration of remission. Findings. The use of complex treatment of periodontitis of mild to moderate severity allows the method to accelerate the restoration of periodontal tissues, relieve inflammation, saturate the tissues with oxygen, reduce the rate of relapse by 2.6 times and reduce the duration of relapse of this disease within 24 months. Our data allow us to implement this treatment regimen in practical healthcare.

scholarly journals Specific characteristics of rapid diagnosis in periodontology

2021 ◽  
Vol 18 (2) ◽  
pp. 196-203
Author(s):  
S. P. Rubnikovich ◽  
L. N. Dedova ◽  
P. A. Semizhon ◽  
Yu. L. Denisova ◽  
O. V. Kandrukevich
Keyword(s):  
Periodontal Diseases ◽  
Genetic Material ◽  
Clinical Signs ◽  
Rapid Test ◽  
Laboratory Diagnosis ◽  
Periodontal Pocket ◽  
Control Group ◽  
Treponema Denticola ◽  
Microbiological Diagnosis ◽  
Laboratory Measures

Currently, the advanced studies have been justified and implemented in the Republic of Belarus that enable the production and a practical use of a domestic rapid test and allow dentists to apply microbiological diagnosis methods.The objective of the study was to develop a domestic rapid test for periodontology, indicating the procedure for preparatory clinical and laboratory measures using PCR and trypsin-like activity of periopathogenic microflora (Treponema denticola, Porphyromonas gingivalis, Bacteroides forsythus)Dental examination was performed in 60 patients with clinical signs of generalized periodontitis and a 5‒6 mm deep pathological dentogingival pocket (PDGP), aged 35–44 (the main group), and 140 patients without signs of periodontal diseases, aged 20–24 (the control group). These patients were selected among the visitors of Chair No. 3 of the Belarusian State Medical University. The laboratory diagnosis was made using PCR and evaluating the trypsin-like activity of periopathogenic microflora.The algorithm of preparatory clinical and laboratory measures was suggested for diagnosis of periodontal diseases, including material sampling and identification of periopathogenic microorganisms in the sample using a biochemical method; sampling, preservation and storage of material for quantitative PRC testing; and the identification of the genetic material of periopathogenic microorganisms by means of a real-time quantitative PRC method.The basic principles of microbiological diagnosis in periodontology enable making a true diagnosis, planning treatment and assessing the treatment results.We examined the content of the gingival sulcus and/or the periodontal pocket in patients who have periodontal diseases. It was noted that the most rational tools for removing the periodontal pocket content in patients with periodontal diseases was a paper pin.The development of a domestic express test in periodontology demonstrated the need of preparatory clinical and laboratory activities using PCR and trypsin-like activity of periopathogenic microflora (Treponema denticola, Porphyromonas gingivalis, Bacteroides forsythus).

scholarly journals The effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis

2018 ◽  
Author(s):  
A. I. Furdychko ◽  
A. Yu. Buchkovska ◽  
M. A. Pasichnyk
Keyword(s):  
Periodontal Disease ◽  
Comparison Group ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Hepatobiliary System ◽  
The Difference ◽  
Calculous Cholecystitis

Summary. Inflammatory periodontal diseases continue to be one of the pressing problems of modern dentistry [1]. It is known that there is a close relationship between general-somatic pathology and diseases of the oral cavity [2]. The aim of the study – to learn the effectiveness of the use of anti-dysbiotic hepatoprotector in the complex treatment of patients with periodontal inflammatory diseases on the background of chronic non-calculous cholecystitis. Materials and Methods. The main (group 1) group consisted of 106 people who suffered from inflammatory periodontal disease (IPD) with concomitant chronic non-calculous cholecystitis (CNC). The comparison group included 92 patients with IPD without concomitant pathology (group 2). To compare the research results of the patients with IPD, 30 healthy teethed individuals without periodontal pathology and without somatic diseases (group 3 or the control group) were involved. The state of the hepatobiliary system in patients of the main group was assessed by the doctors of the Gastroenterology Department of Zolochiv District Hospital of Lviv region. Results and Discussion. The symptomatic HCG and the presence of solid and soft dental deposits were diagnosed in all patients. The Green-Vermillion’s index was the highest in patients from the main group (1.67±0.01); it was probably (p <0.05) higher than that in the comparison group (1.54±0.04), as well as in the control group (0.44±0.07). The PMA index in the subgroup 1A immediately after treatment decreased by 9.7 (p <0.001) times. The index of bleeding in the subgroup 1A decreased by 10.7 (p <0.001) times. The PMA index in the subgroup 1A immediately after treatment decreased by 10.4 (p <0.001) times. The index of bleeding in the subgroup 1A under the influence of the proposed therapy decreased by 6.5 (p <0.001) times.The difference regarding the data before treatment remained lower by 2.2 times and 2.0 (p <0.001) times, however, the difference between the subgroups 1A and 1B in 3 months and 6 months was already 2.1 times in both cases. Conclusions. It was found that the clinical course of inflammatory periodontal diseases was much more difficult in these patients. The presence of pathology in the hepatobiliary system in patients increases the risk of periodontal disease. Therefore, in order to improve the efficacy of treatment, it is advisable to use this antidysbiotic drug in the complex treatment, and the results obtained in 3 and 6 months after treatment indicate a long-lasting positive effect.

scholarly journals Efficacy of a plant-based dental gel for chronic simple marginal gingivitis: a clinical trial

2020 ◽  
Vol 10 (4) ◽  
pp. 144-148
Author(s):  
Adel Isaeva ◽  
Sergey Averyanov ◽  
Ilgiz Iskhakov ◽  
Oksana Gulyaeva ◽  
Olga Gileva ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Periodontal Diseases ◽  
Control Group ◽  
High Prevalence ◽  
Complex Therapy ◽  
Long Term Consequences ◽  
The Stability ◽  
Great Damage ◽  
Periodontal Indices

High prevalence of inflammatory periodontal diseases in young people along with unfavourable outcomes and long-term consequences cause great damage to health, thereby determining the importance and urgency of this problem in modern dentistry. Herein, we introduced a gel based on sanguiritrin, medicinal extracts of calendula and yarrow, and evaluated its effectiveness in the treatment of chronic simple marginal gingivitis in the clinical study involving 45 patients aged 18 to 23 years (26 females and 19 males). In the treatment group (23 patients), after professional oral hygiene and correction of hygiene skills, the dental gel based on sanguiritrin, medicinal extracts of calendula and yarrow was applied as part of complex therapy, while in the control group (22 patients) the Cholisal gel was used. The data obtained from hygienic and periodontal indices following the treatment (OHI-S — 0.39±0.03; PBI — 1.12±0.06; PMA — 16.4±1.31%) showed clinical anti-inflammatory efficacy of the introduced dental gel in the treatment of gingivitis, while positive indices dynamics of the dental status (OHI-S — 0.64±0.03; PBI — 0.42±0.03; PMA — 9.92±1.42%) evaluated in 3rd, 6th and 12th months after the therapy indicated of the stability of obtained results.

A STUDY ON ASSOCIATION 0F TOOTH LOSS & PERIODONTAL DISEASE IN PATIENTS SUFFERING FROM DIABETES FROM BIHAR REGION

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Kumar Manish ◽  
Nikita Raman ◽  
Abhishek Gautam ◽  
Samir Jain ◽  
Prakash Chandra Jha ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Tooth Loss ◽  
Alveolar Bone ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Group ◽  
The Individual ◽  
Tissue Attachment

Diabetes is one of the common diseases of modern times and one of the most common systemic disorder that is connected to periodontal disease. Periodontal diseases are bacterially induced chronic inflammatory diseases affecting the tissues surrounding and supporting the teeth. The lesion begins as gingivitis, an inflammation of the gingival tissues only, and may progress to periodontitis, where destruction of connective tissue attachment and alveolar bone can eventually lead to tooth loss. Hence based on above reported findings the present study was planned for study of prevalence of tooth Loss in Patients Suffering from Diabetes from Bihar Region. The present study was planned in Department of Dentistry, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar. Total 100 cases were enrolled in the present study. In the enrolled patients 50 cases were Diabetic and 50 were non-diabetic cases. The data generated from the present study concludes that periodontal disease increases in diabetes group than in control group. Thus, a diabetic patient should always see that he/she maintains his/her oral hygiene by following proper tooth brushing habits. Diabetics should take care to see that they get their teeth restored as early as possible, if decayed. They should follow the instructions given by the physician or the dietician for the intake of non-cariogenic diet. The prevention of periodontal breakdown in diabetic patients is mostly based on the education of the individual. Thus, patients should be informed about the importance of oral health for diabetics, and they should be taught that the main symptom of periodontal disease is gingival bleeding. Keywords: Tooth Loss, Diabetes, periodontal disease, bihar, etc

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