scholarly journals EVALUATION OF THE RESULTS OF COMPLEX TREATMENT OF LICHEN PLANUS OF THE ORAL MUCOSA WITH THE USE OF AUTOLOGOUS PLASMA OR HUMAN PLACENTA EXTRACT

2019 ◽  
Vol 15 (2) ◽  
pp. 37-44
Author(s):  
Ирина Усманова ◽  
Irina Usmanova ◽  
Лариса Герасимова ◽  
Larisa Gerasimova ◽  
Зухра Хисматуллина ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Human Placenta ◽  
Preventive Measures ◽  
The State ◽  
Complex Treatment ◽  
Autologous Plasma ◽  
Local Immunity ◽  
Somatic Status

Subject. On the basis of a comprehensive dental examination, the clinical condition of the oral mucosa was assessed. With the use of laboratory research methods, the parameters of the microta state from the surface of erosion, the state of local immunity of the oral fluid, as well as anamnesis data with the assessment of somatic status, clinical blood analysis, ultrasound examination of the state of internal organs, the tactics of the complex of phased local and General therapy were studied. In clinical conditions, the analysis of minimizing pain, the nature of the epithelialization of erosive elements and regeneration of the oral mucosa. Using the analysis of laboratory methods, the pronounced antibacterial effect, increase of local immunity factors of the oral cavity, a qualitative decrease in chronic inflammation in the oral mucosa and in the body as a whole, as well as a decrease in the depressive state of the patient were evaluated. Proven and proved the efficiency of application of this complex treatment in the early and late periods. The purpose ― is to draw the attention of practicing dentists and related specialists to the need for an effective phased scheme of diagnostic and therapeutic and preventive measures in patients with lichen planus. Material and methods. The article is based on the description of clinical observation of a patient with erosive-ulcerative form of lichen planus. Results. The use of the proposed complex of step-by-step local injection methods on the oral mucosa and General measures by dermatologists, therapists, gastroenterologists in the erosive and ulcerative form of lichen planus contributes to a better acceleration of the epithelialization process, regeneration, reducing the signs of chronic inflammation, qualitative improvement of the somatic status and quality of life of patients. Summary. The inclusion in the scheme of the complex of local and General therapeutic and preventive measures of erosive-ulcerative form of lichen planus by injection of autologous plasma (AP) and human placenta hydrolysate (HRH) is a more effective method of therapy in these patients.

scholarly journals Results of integrated treatment of herpetic stomatitis with the inclusion of lipid concentrate of ERYX biomass

2020 ◽  
Vol 18 (3) ◽  
pp. 26-31
Author(s):  
K. P. Kamilov ◽  
G. I. Lukina ◽  
F. A. Shokirova ◽  
G. I. Sharipova
Keyword(s):  
Oral Cavity ◽  
Clinical Status ◽  
Molecular Genetic ◽  
Latency Period ◽  
Integrated Treatment ◽  
The State ◽  
Biologically Active ◽  
Complex Treatment ◽  
Local Immunity ◽  
Significant Difference

Aim. The study of the effectiveness of the use of the biologically active additive Reptin-plant in the complex treatment of patients with herpetic stomatitis.Materials and methods. We examined 189 patients with a diagnosis of herpetic stomatitis, which were divided into 2 groups depending on the receipt of complex antiviral therapy with the inclusion of ERYX biomass lipid concentrate in the treatment regimen and without it. The following were assessed: clinical status, index assessment of the state of the oral cavity, state of local immunity, frequency of relapses and duration of the latency period.Results. 57 (30.2%) patients were identified with a mild form of herpetic stomatitis (HS), the average severity of HS was determined in 93 (49.2%) and a severe course of the disease was diagnosed in 39 (20.6%) patients. Analysis of the index assessment of the state of the oral cavity (OHIS, PMA), molecular genetic parameters, immunological studies (lysozyme titer, phagocytosis, concentration of sIg A in saliva) showed a statistically significant difference when included in the complex treatment of Reptin-plant, demonstrating the benefits of using it.Conclusions. The use of ERYX biomass lipid concentrate in the complex treatment of herpetic stomatitis effectively affects the dynamics of the course of the disease, improves the quality of life of patients.

METHOD FOR DETERMINING THE DEGREE OF BLEEDING OF THE GINGIVAL SULCUS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH CHRONIC GENERALIZED PERIODONTITIS, COMPLICATED BY PARTIAL SECONDARY ADENTIA

2021 ◽  
pp. 43-47
Author(s):  
Наталия Александровна Полушкина ◽  
Наталия Владимировна Чиркова ◽  
Наталья Владимировна Примачева ◽  
Елена Александровна Лещева ◽  
Ольга Игоревна Олейник
Keyword(s):  
Oral Mucosa ◽  
The State ◽  
The Body ◽  
Microbial Flora ◽  
Individual Species ◽  
Quantitative Composition ◽  
Entire Body ◽  
Local Immunity ◽  
Removable Denture ◽  
The Relationship

Факторами, способствующими возникновению гипертрофического воспаления слизистой оболочки полости рта при пользовании конструкциями съемных протезов, являются механическая травма, плохая гигиена рта и ослабление резистентности организма. Отмечено, что при устранении причины, а именно при отказе от пользования съемными пластиночными протезами, воспалительные явления исчезают. Анализ литературы показал, что тяжесть течения воспалительных заболеваний тканей полости рта зависит от различных факторов, в том числе от состояния иммунологической резистентности и обсемененности тканей микроорганизмами. Учеными была установлена взаимосвязь между клиническими параметрами, иммунологическими показателями ротовой жидкости и состоянием микробиоценоза рта. Доказано, что для полости рта, как и для всего организма, свойственна микробная флора, которая отличается постоянством качественного и количественного состава флоры. Известно, что она поддерживается физиологическими процессами, обеспечивающими оптимальное функционирование слизистой оболочки и слюнных желез, взаимоотношениями между микробными видами, что является следствием биологического равновесия за счет феномена «бактериального взаимодействия», как между организмом и адаптированной флорой, так и между отдельными ее видами. Учеными доказано, что нормальная микробная флора, осуществляя функции биологического барьера и постоянного стимулятора локального иммунитета, оказывает положительное влияние на организм. Однако при изменении соотношения отдельных видов под влиянием разнообразных причин, микробная флора утрачивает свои защитные свойства и часто становится источником аутоинфекции. Доказано, что травма, возникающая при ношении съемных протезов, влияет на эту среду и способствует росту патогенной флоры, которая является причиной возникновения заболеваний слизистой оболочки рта, таких как протезный стоматит, кандидоз Factors contributing to the occurrence of hypertrophic inflammation of the oral mucosa when using removable denture structures are mechanical trauma, poor oral hygiene and weakening of the body's resistance. It is noted that when the cause is eliminated, namely, when refusing to use removable plate prostheses, inflammatory phenomena disappear. The analysis of the literature showed that the severity of the course of inflammatory diseases of the oral tissues depends on various factors, including the state of immunological resistance and the contamination of the tissues with microorganisms. Scientists have established the relationship between clinical parameters, immunological parameters of oral fluid and the state of oral microbiocenosis. It is proved that the oral cavity, as well as the entire body, is characterized by microbial flora, which is characterized by a constant qualitative and quantitative composition of the flora. It is known that it is supported by physiological processes that ensure optimal functioning of the mucous membrane and salivary glands, the relationship between microbial species, which is a consequence of the biological balance due to the phenomenon of "bacterial interaction", both between the organism and the adapted flora, and between its individual species. Scientists have proven that the normal microbial flora, performing the functions of a biological barrier and a permanent stimulator of local immunity, has a positive effect on the body. However, when the ratio of individual species changes under the influence of various causes, the microbial flora loses its protective properties and often becomes a source of auto-infection. It is proved that the trauma that occurs when wearing removable dentures affects this environment and promotes the growth of pathogenic flora, which is the cause of diseases of the oral mucosa, such as prosthetic stomatitis, candidiasis

scholarly journals INFLUENCE OF TYPE 2 DIABETES MELLITUS ON THE PREVENTION AND TREATMENT OF PROSTHETIC STOMATITIS

2021 ◽  
Vol 77 (3) ◽  
pp. 14-23
Author(s):  
Robert Badalov ◽  
Irina Chernyavskaya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Dental Treatment ◽  
Statistical Significance ◽  
The State ◽  
Local Immunity

Purpose: to study the effect of type 2 diabetes mellitus on the state of the mucous membrane and tissues of the oral cavity to optimize the prevention and increase the effectiveness of dentition defects complex treatment in this contingent of patients. Materials and methods. We examined 112 patients with type 2 diabetes mellitus aged 35 to 64 years, who were further divided into three groups. The state of the oral mucosa, morphological changes, local immunity, lysozyme were determined. The work used morphological, microscopic methods, enzyme immunoassay and spectrophotometry. To test the statistical significance of intergroup differences, the nonparametric Mann- Whitney test was used. Results. Oral use in patients with diabetes mellitus type 2, applications of 1% Clotrimazole cream and Echinacea Compositum S had a positive preventive and therapeutic effect, which was accompanied by an increase in capillary resistance, a decrease in the degree of migration of leukocytes, an increase in the functional activity of immune system cells and an increase in the level of regenerative processes. In patients with defects in the dentition against the background of type 2 diabetes mellitus, violations of the oral cavity local immunity were revealed, characterized by a significant increase in the S-IgA content and a decrease in lysozyme.Orthopedic treatment with partial removable denturesled to a significant decrease in the concentration of S-IgA and an increase in the bactericidal activity of saliva due to increased lysozyme synthesis. It was concluded that type 2 diabetes mellitus affects the state of the oral mucosa, which must be taken into account when providing orthopedic and dental treatment.

scholarly journals MODERN ASPECTS OF ETIOPATHOGENESIS, CLINICS AND TREATMENT OF PATHOLOGY MUCOUS MEMBRANE OF MOUTH IN PATIONS WITH GASTROINTESTINAL TRACT DISEASES

2020 ◽  
Vol 16 (2) ◽  
pp. 5-10
Author(s):  
Irina Galimova ◽  
Irina Usmanova ◽  
Zarema Hismatullina ◽  
Yigal Granot ◽  
Olga Guryevskaya ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Oral Cavity ◽  
Mucous Membrane ◽  
Oral Mucosa ◽  
Defense Mechanisms ◽  
Local Treatment ◽  
Underlying Disease ◽  
Local Immunity ◽  
Treatment And Prevention ◽  
Somatic Status

Subject. Despite the many pathogenetic links in the lesions of the gastrointestinal tract and oral mucosa, unresolved issues related to their etiopathogenesis, diagnosis and high-quality therapeutic and preventive measures. Among the various pathological processes manifesting on the oral mucosa, recurrent aphthous stomatitis is a chronic disease characterized by the appearance of secondary pathomorphological elements (aphthae) in response to the development of acute proliferative inflammation. The goal is the analysis and systematization of literature data on the problem of damage to the oral mucosa in acid-dependent diseases of the gastrointestinal tract. Methodology. Recurrent aphthae of the oral cavity belong to the chronic pathology of the oral mucosa, are characterized by a prolonged course and periodic relapses, which are most often associated with the state of somatic status, including the presence of acid-dependent diseases of the gastrointestinal tract. Results. The main pathomorphological element inherent in this pathology is aphtha. Its localization is the mucous membrane of the vestibule of the oral cavity, cheeks, and lateral surface of the tongue, visually oval or round, covered with a dirty white fibrinous coating. Treatment of recurrent aphthae of the oral cavity includes a complex consisting of general systemic therapy of the underlying disease. Local treatment includes the use of antihistamines, immunocorrection, drugs that increase nonspecific hypersensitivity, normalization of cellular metabolism and stimulate nonspecific defense mechanisms, vitamin therapy and physiotherapy methods. Conclusions. This treatment should ultimately be aimed at eliminating not only pain, but also at increasing local immunity factors, combating pathogenic microflora and promoting the epithelization of pathological processes on the oral mucosa. Of great importance in the treatment and prevention of recurrent aphthae is a comprehensive examination of the patient in order to identify risk factors.

The dynamics of the clinical picture in the treatment of patients with severe forms of oral lichen planus and vermillion border using physical methods

2021 ◽  
Vol 26 (1) ◽  
pp. 44-51
Author(s):  
O. V. Serikova ◽  
B. R. Shumilovich ◽  
Z. A. Filippova ◽  
O. I. Shcherbachenko
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Topical Steroid ◽  
Clinical Problem ◽  
Complex Treatment ◽  
Ozone Therapy ◽  
Physical Methods ◽  
Red Led ◽  
Traditional Drug

Relevance. Lichen planus is a chronic recurring dermatosis, characterized by unspecified etiopathogenesis, a variety of trigger factors, a severe, often permanent course, a tendency to malignancy of the lesion elements, and often refractory to the treatment. The most difficult clinical problem is the search for effective methods of treating continuously recurring severe forms of lichen planus and red border of the lips, refractory to corticosteroids. Objective – to improve the quality of treatment for severe forms of lichen planus of the oral mucosa and red border of the lips based on the use of various physical methods in complex therapy. Materials and methods. Depending on the complex of medical procedures, all patients were divided into four groups, the patients of which respectively underwent traditional drug treatment; complex treatment using ozone therapy; complex treatment using photophoresis of red LED radiation and a topical steroid, as well as complex treatment using combined physiotherapy and ozone therapy in combination with photophoresis. Results. The inclusion of physical methods in the complex treatment of patients with severe forms of lichen planus of the mucous membrane of the mouth and lips made it possible to accelerate the time of epithelization of erosive-ulcerative elements and achieve a stable remission of the disease. Conclusion. The obtained clinical data allowed us to draw conclusions about the appropriateness of using physical methods in the treatment of severe forms of lichen planus of the oral mucosa and lips using the effectiveness of combined physiotherapy.

Dynamics of indicators of reparative regeneration of the oral mucosa in patients with lichen planus

2019 ◽  
Vol 24 (3) ◽  
pp. 264-268
Author(s):  
I. V. Firsova ◽  
S. V. Poroiskiy ◽  
Yu. A. Makedonova ◽  
Yu. M. Fedotova
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Laboratory Data ◽  
Reparative Regeneration ◽  
Layer By Layer ◽  
Qualitative And Quantitative Analysis ◽  
Cytological Examination ◽  
Sandwich Technique ◽  
Ulcerative Lesions ◽  
Chronic Course

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite difficult to differentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic effects that help accelerate the healing of the oral mucosa.Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.Materials and methods: all patients were divided into two groups using simple randomization: in patients of the first group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a film, which fixed betamethasone B in the lesion area.Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.  

Malignant development of lichen planus-affected oral mucosa

1988 ◽  
Vol 17 (5) ◽  
pp. 219-225 ◽  
Author(s):  
P. Holmstrup ◽  
J. J. Thorn ◽  
J. Rindum ◽  
J. J. Pindborg
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa
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