Results of integrated treatment of herpetic stomatitis with the inclusion of lipid concentrate of ERYX biomass

Aim. The study of the effectiveness of the use of the biologically active additive Reptin-plant in the complex treatment of patients with herpetic stomatitis.Materials and methods. We examined 189 patients with a diagnosis of herpetic stomatitis, which were divided into 2 groups depending on the receipt of complex antiviral therapy with the inclusion of ERYX biomass lipid concentrate in the treatment regimen and without it. The following were assessed: clinical status, index assessment of the state of the oral cavity, state of local immunity, frequency of relapses and duration of the latency period.Results. 57 (30.2%) patients were identified with a mild form of herpetic stomatitis (HS), the average severity of HS was determined in 93 (49.2%) and a severe course of the disease was diagnosed in 39 (20.6%) patients. Analysis of the index assessment of the state of the oral cavity (OHIS, PMA), molecular genetic parameters, immunological studies (lysozyme titer, phagocytosis, concentration of sIg A in saliva) showed a statistically significant difference when included in the complex treatment of Reptin-plant, demonstrating the benefits of using it.Conclusions. The use of ERYX biomass lipid concentrate in the complex treatment of herpetic stomatitis effectively affects the dynamics of the course of the disease, improves the quality of life of patients.

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DENTAL STATUS FEATURES OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA

The actual problems in dentistry ◽

10.18481/2077-7566-20-16-4-71-76 ◽

2021 ◽

Vol 16 (4) ◽

pp. 71-76

Author(s):

Kamilla Yanbuhtina ◽

Milyausha Kabirova ◽

Bulat Kabirov

Keyword(s):

Chronic Myeloid Leukemia ◽

Oral Cavity ◽

Myeloid Leukemia ◽

Dental Treatment ◽

Clinical Symptoms ◽

The State ◽

Dental Status ◽

Malignant Neoplasms ◽

Local Immunity ◽

Oral Symptoms

Subject. At the present stage of society development cancer incidence remains among the most pressing medical and social problems. In the structure of oncopathology a special place is occupied by malignant neoplasms of lymphoid and hematopoietic tissues which include chronic myeloid leukemia (CML). In some patients, the disease can appear with dental symptoms associated with a decrease in local immunity of the oral cavity — the appearance of aphthae, plaque on the oral mucosa, angular cheilosis, bleeding gums, dry mouth. It is diagnostically significant that such oral symptoms may precede general clinical symptoms, that is, they can be considered as early symptoms of CML. In addition, their severity often prompts a patient with CML to see a dentist. Thus, the importance of the professional knowledge of the dentist in general clinical and dental symptomatology of CML, the correct routing of the patient for further clinical and laboratory examination, treatment and observation by a hematologist is undeniably high. The goal is to study and identify the features of the dental status of patients with chronic myeloid leukemia. Methodology. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment of patients with chronic myeloid leukemia in which patients with preserved systemic status and patients with chronic myeloid leukemia took part. Results. According to the results of a complex dental examination and the calculation of the main dental indices, patients with CML were found to have serious disorders in the state of their oral health. Conclusions. Patients with CML showed a high need for various types of dental care, primarily in conservative oral cavity sanitation, periodontal treatment and rationalization of oral hygiene protocols (professional and individual).

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Microbiocenoses and the State of Local Mucosal Immunity of the Oral Cavity of Children and Adolescents with Liver Diseases

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs06.05.316 ◽

2021 ◽

Vol 6 (5) ◽

pp. 316-321

Author(s):

O. V. Khmil ◽

◽

D. O. Khmil ◽

L. F. Kaskova ◽

O. V. Silkova ◽

...

Keyword(s):

Oral Cavity ◽

Children And Adolescents ◽

Oral Hygiene ◽

Mucosal Immunity ◽

Liver Diseases ◽

Oral Fluid ◽

The State ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Local Immunity

The purpose of the study was to study the relationship between the state of the oral cavity microbiocenosis and the level of local immunity in children and adolescents with chronic liver diseases. Materials and methods. 45 children aged 10 to 16 years, who were treated in the public utility "City Children's Clinical Dental Hospital of the Poltava City Council" were examined. All children were divided into 2 groups: the main group – children and adolescents with chronic hepatitis (n = 26) with diseases of concomitant oral mucosa and periodontal disease; control group – children of the same age without concomitant somatic pathology (n = 20). In all observation groups, the state of oral hygiene was recorded using the simplified oral hygiene index (Green-Vermillion, 1964) and the intensity of the inflammatory process in the periodontal tissues, which was assessed by the papillary-marginal-alveolar index modified by Parma (1960). The degree of dysbiosis in the oral cavity was determined using the enzymatic method of A. P. Levitsky by the ratio of the relative activity of urease and lysozyme. The state of local immunity was investigated by the level of immunoglobulins IgA, IgM, IgG and secretory immunoglobulin sIgA. Results and discussion. It was found that the majority of patients with chronic hepatitis had an unsatisfactory and even poor state of oral hygiene, according to the Green-Vermillion simplified oral hygiene index, in combination with moderate and severe gingivitis (according to the papillary-marginal-alveolar index). The most negative results were registered in children 9-13 years old. The effect of the low level of oral hygiene in children and adolescents with chronic liver diseases, which is accompanied by increased dysbiosis, was studied, which indicates a drop in the level of antimicrobial protection, suppression of local mucosal immunity, a decrease in lysozyme activity and a decrease in the content of secretory sIgA in the oral fluid. The mediated mechanism of sIgA action through the phagocyte activation system with subsequent lysis of pathogenic microorganisms is considered. Conclusion. Chronic liver diseases reliably lead to changes in the body's immunobiological reactivity, and also cause suppression of the protective mechanisms of the oral cavity and its local immunity, characterized by a decrease in the activity of lysozyme and secretory IgA in the oral fluid of sick children and adolescents

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INFLUENCE OF TYPE 2 DIABETES MELLITUS ON THE PREVENTION AND TREATMENT OF PROSTHETIC STOMATITIS

PROBLEMS OF ENDOCRINE PATHOLOGY ◽

10.21856/j-pep.2021.3.02 ◽

2021 ◽

Vol 77 (3) ◽

pp. 14-23

Author(s):

Robert Badalov ◽

Irina Chernyavskaya

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Oral Cavity ◽

Oral Mucosa ◽

Dental Treatment ◽

Statistical Significance ◽

The State ◽

Local Immunity

Purpose: to study the effect of type 2 diabetes mellitus on the state of the mucous membrane and tissues of the oral cavity to optimize the prevention and increase the effectiveness of dentition defects complex treatment in this contingent of patients. Materials and methods. We examined 112 patients with type 2 diabetes mellitus aged 35 to 64 years, who were further divided into three groups. The state of the oral mucosa, morphological changes, local immunity, lysozyme were determined. The work used morphological, microscopic methods, enzyme immunoassay and spectrophotometry. To test the statistical significance of intergroup differences, the nonparametric Mann- Whitney test was used. Results. Oral use in patients with diabetes mellitus type 2, applications of 1% Clotrimazole cream and Echinacea Compositum S had a positive preventive and therapeutic effect, which was accompanied by an increase in capillary resistance, a decrease in the degree of migration of leukocytes, an increase in the functional activity of immune system cells and an increase in the level of regenerative processes. In patients with defects in the dentition against the background of type 2 diabetes mellitus, violations of the oral cavity local immunity were revealed, characterized by a significant increase in the S-IgA content and a decrease in lysozyme.Orthopedic treatment with partial removable denturesled to a significant decrease in the concentration of S-IgA and an increase in the bactericidal activity of saliva due to increased lysozyme synthesis. It was concluded that type 2 diabetes mellitus affects the state of the oral mucosa, which must be taken into account when providing orthopedic and dental treatment.

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EVALUATION OF THE RESULTS OF COMPLEX TREATMENT OF LICHEN PLANUS OF THE ORAL MUCOSA WITH THE USE OF AUTOLOGOUS PLASMA OR HUMAN PLACENTA EXTRACT

The actual problems in dentistry ◽

10.18481/2077-7566-2019-15-2-37-44 ◽

2019 ◽

Vol 15 (2) ◽

pp. 37-44

Author(s):

Ирина Усманова ◽

Irina Usmanova ◽

Лариса Герасимова ◽

Larisa Gerasimova ◽

Зухра Хисматуллина ◽

...

Keyword(s):

Chronic Inflammation ◽

Lichen Planus ◽

Oral Mucosa ◽

Human Placenta ◽

Preventive Measures ◽

The State ◽

Complex Treatment ◽

Autologous Plasma ◽

Local Immunity ◽

Somatic Status

Subject. On the basis of a comprehensive dental examination, the clinical condition of the oral mucosa was assessed. With the use of laboratory research methods, the parameters of the microta state from the surface of erosion, the state of local immunity of the oral fluid, as well as anamnesis data with the assessment of somatic status, clinical blood analysis, ultrasound examination of the state of internal organs, the tactics of the complex of phased local and General therapy were studied. In clinical conditions, the analysis of minimizing pain, the nature of the epithelialization of erosive elements and regeneration of the oral mucosa. Using the analysis of laboratory methods, the pronounced antibacterial effect, increase of local immunity factors of the oral cavity, a qualitative decrease in chronic inflammation in the oral mucosa and in the body as a whole, as well as a decrease in the depressive state of the patient were evaluated. Proven and proved the efficiency of application of this complex treatment in the early and late periods. The purpose ― is to draw the attention of practicing dentists and related specialists to the need for an effective phased scheme of diagnostic and therapeutic and preventive measures in patients with lichen planus. Material and methods. The article is based on the description of clinical observation of a patient with erosive-ulcerative form of lichen planus. Results. The use of the proposed complex of step-by-step local injection methods on the oral mucosa and General measures by dermatologists, therapists, gastroenterologists in the erosive and ulcerative form of lichen planus contributes to a better acceleration of the epithelialization process, regeneration, reducing the signs of chronic inflammation, qualitative improvement of the somatic status and quality of life of patients. Summary. The inclusion in the scheme of the complex of local and General therapeutic and preventive measures of erosive-ulcerative form of lichen planus by injection of autologous plasma (AP) and human placenta hydrolysate (HRH) is a more effective method of therapy in these patients.

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PECULIARITIES OF TREATMENT OF CHANGES IN PERIODONTAL TISSUES IN CHILDREN LIVING IN POLLUTED PRECARPATHIAN REGIONS

Art of Medicine ◽

10.21802/artm.2021.3.19.64 ◽

2021 ◽

pp. 64-68

Author(s):

M. M. Rozhko ◽

M. V. Pavlishin

Keyword(s):

Oral Cavity ◽

Mucous Membrane ◽

The Body ◽

Stress Disorders ◽

Local Immunity ◽

Comparative Characterization ◽

Periodontal Tissues ◽

Significant Difference ◽

Chlorhexidine Solution

Today special attention to the influence of environmental factors on the condition of the dental-maxillary system and periodontal tissues in children is paid. Scientists have proved that environmentally unfavorable conditions also change the immunological reactivity of the body, form violations of the immune status, and changes in the local immunity in the oral cavity stimulate the development of pathogenic microflora. Our research is devoted to the study of changes in periodontal tissues in children living in ecologically favorable conditions and in ecologically polluted Precarpathian regions, a comparative characterization of changes in periodontium, a treatment plan for chronic catarrhal gingivitis, supplemented with chlorhexidine dentin and quercetin. According to the results of many researches, 0.12% chlorhexidine solution provides a pronounced antimicrobial effect on pathogenic microflora; and under the action of quercetin there is a stabilization of the antioxidant system, improvement of peripheral blood circulation, improvement of rheological properties of the patient's blood. We examined 60 patients with chronic catarrhal gingivitis living in environmentally stable conditions (Ivano-Frankivsk) (1 group), 15 people with intact periodontium and 60 children with chronic catarrhal gingivitis living in contaminated Precarpathian regions (Burshtyn) (group 2). All patients were treated with a set of therapeutic measures, which are recommended for the conventional treatment of patients with chronic catarrhal gingivitis. In groups 1a and 2a, patients were treated with chlorhexidine, calendula and chamomile infusion and 1% mefenamine paste. In groups 1b and 2b we applied a quercetin gel on the mucous membrane of the patient’s gums under an individual dental-gingival cap. For the purpose of comparative characterization of the two groups, an index assessment of the condition of periodontal tissues, study of rheographic parameters of periodontal tissues and radiographic characteristics of jaw bone tissue were performed. The results of the research showed a significant difference between clinical and laboratory parameters in patients with chronic catarrhal gingivitis living in environmentally friendly conditions compared with persons living permanently in ecologically polluted Precarpathian regions (p <0.05 ). In people living in ecologically polluted areas there is a pronounced cyanosis of the gums and mild diffuse cyanosis of the oral mucosa, high rates of bleeding gums. Scientists believe that the main mechanisms of pathogenetic effects on periodontal tissues are transmitted infectious and toxic diseases, trophic and metabolic disorders, changes in neurohumoral regulation, vitamin imbalance in the body, immune disorders, hypoxia, oxidative stress, disorders of plastic processes in any tissues of the body, the mucous membrane of the oral cavity. We proved that the use of the proposed treatment regimen for chronic catarrhal gingivitis (groups 1b and 2b) shows a significantly higher effectiveness over the treatment of basic therapy in groups 1a and 2a. This treatment stimulates metabolic processes in periodontal tissues, reduces cyanosis, edema of periodontal tissues, eliminates inflammatory phenomena in periodontal tissues. The results show that the use of quercetin and 0.12% chlorhexidine solution in the complex treatment of patients with chronic catarrhal gingivitis provides a significant improvement in clinical parameters and laboratory characteristics of periodontal tissues in children living in different environmental conditions.

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Violation of Local Immunity of the Oral Cavity in Agro-Industrial Workers with Generalized Periodontitis under the Influence of Pesticides

Ukraïnsʹkij žurnal medicini bìologìï ta sportu ◽

10.26693/jmbs06.01.222 ◽

2021 ◽

Vol 6 (1) ◽

pp. 222-227

Author(s):

V. T. Dyryk ◽

◽

R. V. Shkrebniyuk ◽

O. M. Vynogradova

Keyword(s):

Immune System ◽

Oral Cavity ◽

Periodontal Diseases ◽

Main Group ◽

The State ◽

Industrial Workers ◽

Local Immunity ◽

High Biological Activity ◽

Periodontal Tissues ◽

Study Results

Among dental diseases, periodontal diseases occupy a prominent place. The polyetiology and polypathogenicity of periodontal diseases are different in nature: pathological processes at the level of the whole organism, its cells and environments, periodontal tissues, biochemically reactive substrates. The significant impact of adverse environmental factors on the state of human organs and systems is confirmed by the tendency to increase the incidence of periodontal disease in industrialized countries, which in different age groups ranges from 80% to 100%. Pesticides are one of the most important factors determining the well-being and balance of the human-environment system today. This is due to their characteristics as chemical pollutants, which deliberately and purposefully contributes to the environment pollution. The main among these features are constant and excessive scattering over large areas; high biological activity on pets, as well as on humans and other living organisms; the ability to persist in the environment and circulate in its objects; metabolized in biological objects and transformed into the environment with the formation of more toxic and dangerous, compared to the original, compounds; the ability to cause the development of long-term effects. The group of risk of periodontal tissue diseases naturally includes employees of agricultural enterprises, who in the process of work are exposed to occupational pathogens of different nature, intensity and duration of action. Continuous intake of agro-industrial xenobiotics creates a chemical load, causes the occurrence of toxic hypoxia, anemia, imbalance in the immune system, promotes the activation of endogenous intoxication, which in turn is projected on the periodontal tissues, and disease of tooth-retaining tissues. The purpose of our research was to study the state of local immunity of the oral cavity in agro-industrial workers with generalized periodontitis under the influence of pesticides. Material and methods. To determine the changes in local immunity in the oral and gingival fluid we determined the concentrations of lysozyme, sIgA, IgA and IgG in 39 patients with generalized periodontitis who were not adversely affected by greenhouse factors (comparative group) and 81 agricultural workers (41 people in open (I main group) and 40 people in closed soils) II main group), exposed to pesticides). The obtained values were compared with data in 31 dentistically healthy people not in contact with pesticides (control group). Results and discussion. The obtained results showed that generalized periodontitis marked changes in the local immune mechanisms of the oral cavity. However, the most pronounced violations were observed in patients with generalized periodontitis working in closed and open soils under the influence of pesticides, and in subjects who were exposed to toxic effects of chemicals in closed soil, this trend was more intense. Conclusion. The study results proved that agro-industrial workers in contact with pesticides in open and closed soils have significant disturbances in the local immune system, which was characterized by a decrease in the levels of immunoglobulins A, G, sIgA and lysozyme in oral and gingival fluids

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The Influence of the Thyroid Function on the Metabolic Rate of Prothrombin, Factor VII, and Factor X in the Rat

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647959 ◽

1976 ◽

Vol 35 (03) ◽

pp. 607-619 ◽

Cited By ~ 8

Author(s):

Allan T. van Oosterom ◽

Herman Mattie ◽

Wim Th Hermens ◽

Jan J. Veltkamp

Keyword(s):

Metabolic Rate ◽

Thyroid Function ◽

Coagulation Factors ◽

Biologically Active ◽

Factor Vii ◽

Synthesis Rate ◽

Apparent Difference ◽

Vitamin K1 ◽

Factor X ◽

Significant Difference

SummaryThe influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and X was studied in the rat. Disappearance rates of the three coagulation factors were measured after synthesis had been blocked with appropriate doses of warfarin, and reappearance rates were assessed upon induction of synthesis by high doses of vitamin K1 injected into rats displaying coumarin induced hypocoagulability.No statistically significant difference in the disappearance and production rates of any of the factors could be found between normal euthyroid rats and thyroxin-treated hypothyroid rats proven to be euthyroid. The differences between the two euthyroid groups and the hypothyroid group were highly significant, however: hypothyroidism results in an approximately 50% decrease of the metabolic rates of the three coagulation factors under study.The reappearance of the three factors, under euthyroid as well as hypothyroid conditions, showed a biphasic pattern: in the first two hours after vitamin K1 administration to warfarin treated rats, a rapid reappearance was observed, to the same extent for all three factors, in hypo- as well as euthyroid rats. This finding suggests that in vitamin K1 deficiency an intracellular accumulation of precursor proteins (PIVKAs) occurs, which after rapid conversion into biologically active coagulation factors by vitamin K1 are shed into circulation.The subsequent phase of reappearance is much slower and reflects the synthesis rate of coagulation enzymes. It is characteristic for each factor and clearly slower in hypothyroid rats than in euthyroid rats. From this an influence of thyroid function on the synthesis rate of the protein moiety of coagulation factors can be inferred.An apparent difference between disappearance and reappearance rate of the coagulation factors in the plasma, particularly pronounced for factors VII and X in euthyroid rats, could theoretically be explained as the consequence of the model used for derivation of these rates.

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