scholarly journals Prognosis and surgical tactics in obliterating atherosclerosis of lower extremities

2011 ◽  
Vol 4 (1) ◽  
pp. 71-78
Author(s):  
Alexander Viktorovich Kazantsev ◽  
Evgeny Anatolievich Korymasov
Keyword(s):  
Multivariate Analysis ◽  
Endothelial Dysfunction ◽  
Lipid Profile ◽  
Lower Extremities ◽  
Prediction System ◽  
Surgical Tactics ◽  
Atherosclerosis Obliterans

We studied the prognostic significant clinical, hemodynamic, hemostasiological, immunological characteristics, markers of endothelial dysfunction, changes in lipid profile in patients with atherosclerosis obliterans of the femoral-femoralpopliteal-tibial localization. As a result, multivariate analysis the pathogenetically substantiated prediction system with the calculation of the index of the disease. When the index of less than 13 points for obliterative atherosclerosis assessed as non progressive, at index 13 points, and more-progressive.

scholarly journals OBLITERATING ATHEROSCLEROSIS OF THE LOWER EXTREMITIES: COURSE PROGNOSIS AND TREATMENT

2018 ◽  
Vol 3 (4) ◽  
pp. 41-45
Author(s):  
A V Kazantsev
Keyword(s):  
Multivariate Analysis ◽  
Endothelial Dysfunction ◽  
Lipid Profile ◽  
Lower Extremities ◽  
Disease Index ◽  
Prediction System ◽  
Index Calculation

Objectives - to develop a course prognosis method for obliterating atherosclerosis of femoropopliteal and tibial localization. Material and methods. We studied a group of patients with obliterating atherosclerosis of femoropopliteal and tibial localization. The subjects for analysis were significant prognostic clinical, hemodynamic, hemostasiological, immunological characteristics, markers of endothelial dysfunction, changes in lipid profile. Results. As a result of multivariate analysis the pathogenetically substantiated prediction system with the disease index calculation was developed. The obliterative atherosclerosis course with index less than 13 points is assessed as non progressive, with index 13 points and more - as progressive.

scholarly journals SURGICAL TREATMENT OF CHRONIC VENOUS DEFICIENCY OF LOWER EXTREMITIES

2020 ◽  
pp. 68-73
Author(s):  
I. B. Babynkina ◽  
A. A. Novikova ◽  
G. P. Babynkina
Keyword(s):  
Surgical Treatment ◽  
Lower Extremities ◽  
Outpatient Basis ◽  
Perforating Veins ◽  
Results Of Treatment ◽  
Cosmetic Effect ◽  
Modern Economic ◽  
Surgical Tactics ◽  
Tissue Trauma ◽  
Standard Operations

Summary. The aim. Improving the results of treatment of patients with decompensated forms of chronic venous insufficiency in post-thrombophlebitic and varicose diseases based on the use of differentiated pathogenetically substantiated surgical tactics. Materials and methods. The basis of the work is the study of the results of surgical treatment of 102 patients not previously operated on with postthrombophlebitic disease of the lower extremities in the decompensated stage of CVI. All patients underwent combined surgical treatment, including the elimination of perforating insufficiency and various modifications of the operation on the superficial veins to eliminate vertical reflux. Results and discussion. The combined operation for clipping perforating veins allows the operation to interrupt blood circulation through insolvent perforating veins, including on an outpatient basis, minimizing tissue trauma during puncture rather than sectional access to a vein. The cosmetic effect of the operation is significantly increased, which is especially important in the treatment of women. Since the operation can be performed on an outpatient basis, the number of days of incapacity for work is significantly reduced compared to standard operations on perforating veins, which is a particularly important circumstance in modern economic conditions. Conclusion. Using the proposed method allows to achieve optimal conditions for the restoration of trophism of affected tissues, leading to a decrease in the number of complications and a reduction in hospitalization.

Abstract 3698: Decreased Circulating Endothelial Progenitor Cells and Endothelial Dysfunction: a Novel Mechanism of Atherogenesis in Obesity.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Paulo F Leite ◽  
Claudia R Andrade ◽  
Santa Poppe ◽  
Luiz A Cesar ◽  
Silmara Coimbra ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Multivariate Analysis ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Obese Patients ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Morbid Obese

Underlying mechanisms of endothelial dysfunction in obesity are not fully understood. Circulating Endothelial Progenitor Cells (EPCs) are known to promote endothelial repair. Our aim was to assess the number/function of EPCs in morbid obese individuals and its correlation with endothelial function and inflammatory markers. EPCs were isolated from 33 morbid obese patients (age 47±1.8 y; men=34%; BMI=49±2.1 kg/m 2 , metabolic syndrome=84%) and 20 lean controls. Peripheral blood EPC number was significantly reduced in obese patients both with flow cytometry (KDR + /CD34 + ; 0.041±0.04 vs 0.074±0.05 %events, p<0.001) and fluorescence analysis after short-term culture (49±4 vs 28±2 cells/field, p<0.001). The plasma number of primitive CD 133 + cells, and concentrations of VEGF (Elisa) and nitrogen oxides (which potentially recruit EPCs), were similar to control, suggesting that reduction of EPCs occurs distally to early cell differentiation. Importantly, C-Reactive Protein (CRP), robustly increased in obese patients (0.15±0.04 vs 1.3±0.3; p=0.003), was a strong predictor of reduced EPC number at multivariate analysis (r=0.623; p < 0.001). Likewise, the migratory response of EPCs to VEGF in vitro was significantly impaired in obese vs controls, despite similar VEGF receptor numbers. Multivariate analysis suggested potential roles of metabolic syndrome and leptin in such effect. Endothelial function at flow-mediated brachial artery reactivity was markedly reduced (by 60%) in obese patients, and had a significant inverse correlation with EPC number (r= 0.678; p< 0.001). Carotid intimal thickness was also increased in obese patients (0.68±0.02 vs 0.58±0.08; p=0.001). On the other hand, the number of circulating endothelial cells (CD31 + /CD106 + ) was similar in both groups, suggesting that apoptosis was not enhanced in the obese. These results suggest for the first time that reduced number and migratory capacity of EPCs correlate with endothelial dysfunction or increased CRP and may be a key underlying mechanism of vascular complications and atherosclerosis in obesity.

scholarly journals Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1710 ◽  
Author(s):  
Diego Estrada-Luna ◽  
Elizabeth Carreón-Torres ◽  
Rocío Bautista-Pérez ◽  
Gabriel Betanzos-Cabrera ◽  
Alan Dorantes-Morales ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Lipid Profile ◽  
High Density ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Plasma Samples ◽  
Postprandial Period ◽  
Coronary Syndrome

(1) Background: the composition of high-density lipoproteins (HDL) becomes altered during the postprandial state, probably affecting their functionality vis-à-vis the endothelium. Since acute coronary syndrome (ACS) in women is frequently associated with endothelial dysfunction, it is likely that HDL are unable to improve artery vasodilation in these patients. Therefore, we characterized HDL from women with ACS in fasting and postprandial conditions. We also determined whether microencapsulated pomegranate (MiPo) reverts the HDL abnormalities, since previous studies have suggested that this fruit improves HDL functionality. (2) Methods: Eleven women with a history of ACS were supplemented daily with 20 g of MiPo, for 30 days. Plasma samples were obtained during fasting and at different times, after a lipid load test to determine the lipid profile and paraoxonase–1 (PON1) activity. HDL were isolated by sequential ultracentrifugation to determine their size distribution and to assess their effect on endothelial function, by using an in vitro model of rat aorta rings. (3) Results: MiPo improved the lipid profile and increased PON1 activity, as previously reported, with fresh pomegranate juice. After supplementation with MiPo, the incremental area under the curve of triglycerides decreased to half of the initial values. The HDL distribution shifted from large HDL to intermediate and small-size particles during the postprandial period in the basal conditions, whereas such a shift was no longer observed after MiPo supplementation. Consistently, HDL isolated from postprandial plasma samples hindered the vasodilation of aorta rings, and this endothelial dysfunction was reverted after MiPo consumption. (4) Conclusions: MiPo exhibited the same beneficial effects on the lipid profile and PON1 activity as the previously reported fresh pomegranate. In addition, MiPo supplementation reverted the negative effects of HDL on endothelial function generated during the postprandial period in women with ACS.

Effects of diosgenin and its derivatives on atherosclerosis

2019 ◽  
Vol 10 (11) ◽  
pp. 7022-7036 ◽  
Author(s):  
Fang-Chun Wu ◽  
Jian-Guo Jiang
Keyword(s):  
Endothelial Dysfunction ◽  
Lipid Profile ◽  
Foam Cell ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
Macrophage Foam Cell

The effects of diosgenin are discussed with respect to endothelial dysfunction, lipid profile, macrophage foam cell formation, VSMC viability, thrombosis and inflammation during the formation of atherosclerosis.

Hyaluronidase Alters the Lipid Profile of Cumulus Cells as Detected by MALDI-TOF MS and Multivariate Analysis

Lipids ◽  
2014 ◽  
Vol 49 (9) ◽  
pp. 957-962 ◽  
Author(s):  
Daniela Antunes Montani ◽  
Thaís Regiani ◽  
Amanda Begati Victorino ◽  
Jacqueline Camillo ◽  
Eduardo Jorge Pilau ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lipid Profile ◽  
Cumulus Cells ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Echography analysis altered in musculoskeletal, heart and liver associated with endothelial dysfunction of obese rat

2020 ◽  
Author(s):  
Alejandra Martínez Coria ◽  
Norma Angélica Estrada-Cruz ◽  
María Inés Pérez Ordoñez ◽  
Daniel H. Montes-Cortes ◽  
Leticia Manuel-Apolinar
Keyword(s):  
Body Weight ◽  
Endothelial Dysfunction ◽  
Adhesion Molecules ◽  
Musculoskeletal System ◽  
Lower Extremities ◽  
Abdominal Ultrasound ◽  
Control Group ◽  
Standard Diet ◽  
Sprague Dawley ◽  
Distal Joint

Abstract Background: Modern imaging plays a central role in the care of obese patients, with an integral focus on its use and accessibility in individuals into this condition with alterations of various organs. Objective. To perform an echographical analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle in obese rats. Methods. Sprague Dawley rats (250±5 g) were used and divided in two groups: control group (C) fed with a standard diet, and the obese group (Ob) fed with a hyper caloric diet of high fructose-fat for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities.Results. Body weight in the Ob group was increased compared to the control group, (p <0.001); in addition, increased glucose, cholesterol and triglycerides were found in the Ob group vs the C group, (p<0.05), and as well as increased adhesion molecules ICAM-1 and, VCAM-1 (p<0.01). On ultrasound, 75% of the Ob group presented, showed 75% fatty liver and distal joint abnormalities. Conclusion. Endothelial dysfunction and changes at the level of the musculoskeletal system with the presence of joint cysts in the posterior region of the distal joint of the lower extremities and fat liver were observed in obese rodents.

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