scholarly journals Relapse of varicose veins of lower extremities

2018 ◽  
Vol 11 (3) ◽  
pp. 183-185
Author(s):  
Galina Viktorovna Yarovenko ◽  
Alexey Vitalievich Fesun
Keyword(s):  
Varicose Veins ◽  
Statistical Significance ◽  
Young Patients ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Group I ◽  
Venous Diseases ◽  
Varicose Disease ◽  
Group Ii

According to modern data, there are no signs of chronic venous disease in only 15.9% of people. Observing the clinical data of recent years, there is a tendency to increase the number of people with venous diseases and, unfortunately, the number of young patients is increasing (there are data that schoolchildren of the senior classes have signs of varicose transformation in 10-15%). Polymorphism of matrix metalloproteinase-12 is a key link in the pathogenesis of varicose veins.We conducted surveys of 50 patients. The average age is 43.7 ± 15.9 years, of them women 32, men 18 people. All patients with the class C2-C6 varicose veins (CEAP-classifier) ​​were divided into two groups by the method of serial sampling: group I (n = 20) - with relapse of varicose veins; Group II (n = 30) - patients treated with varicose disease for the first time. The only exception was patients with deferred vein thrombosis. Ultrasound diagnosis of the main veins of the lower extremities and genomic analysis of blood samples of patients was used.The obtained results confirm that in patients of the I group the MMP-12 gene occurs in 80% of cases (homo- and heterozygous variation), whereas in group II only in 33.3% of cases. The Pearson consensus criterion is 10.4 (the critical value of the criterion is 6.63). The significance level of this relationship corresponds to p <0.01. The statistical significance of the frequency of recurrence of varicose disease and the MMP-12 gene was established using the Spearman rank correlation coefficient, which is equal to 1,000 (criterion value is 0.398). Dependence of signs is statistically significant, with p <0.05

scholarly journals Interrelation of venous and osteoarticular pathology in patients with Giacomini's vein

2021 ◽  
Author(s):  
G. V. Yarovenko ◽  
A. I. Zhdanova
Keyword(s):  
Soft Tissues ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Stasis ◽  
Venous Disease ◽  
Pearson Criterion ◽  
The Third ◽  
Group I ◽  
Venous Diseases ◽  
The Relationship

Objective: To establish a possible relationship between the Giacomini vein and osteoarticular pathology of the lower extremities in chronic venous diseases (CVD).Materials and methods. In 115 examined patients (out of 321), we identified the Giacomini vein (92 women, 23 men). The average age of men was 44.82 ± 1.62 years; women – 45.36 ± 3.31 years. All patients were divided into 3 groups by anatomical randomization. The first group was without pathology, the second group of patients had only CVD, and the third group included patients with CVD and osteoarticular pathology. The criteria for inclusion in the groups were: the presence of Giacomini vein in patients, chronic venous disease and osteoarticular pathology on one or both lower extremities. Exclusion criteria: age of patients less than 18 years, the presence of CVD C5-C6 according to the CEAP classification, post-traumatic changes in the osteoarticular system, post-thrombotic transformation of the veins of the lower extremities. Using triplex angioscanning, the anatomical features of the structure of the venous system of the lower extremities were assessed. The study of the condition of the foot was carried out using the Friedland method.Results. Group I with an absolute norm of the venous and osteoarticular systems included 30 people (26 %). The second group consisted of 45 patients (39.22 %) with CVD C0-C4 according to CEAP, and the third group consisted of 40 patients (34.78 %) who, in addition to venous, osteoarticular pathology. Chronic venous diseases in patients of groups II and III were distributed as follows: C0 – 25.6 %; C1 – 16.4 %; C2 – 49.4 %; C3 – 4.3 %; C4 – 4.3 % on the CEAP scale. Among the osteoarticular pathology, the most numerous group consisted of changes in the configuration of the foot, non-traumatic deformities – 32 (27.81 %) cases. To confirm the relationship between venous and osteoarticular pathology, we used the Pearson criterion. We found a significant correlation in the presence of nontraumatic deformities of the foot in the group of patients with CVD (Pearson's criterion 0.749642; p < 0.22). A strong correlation was established between the age of patients and changes in the venous and osteoarticular systems of the lower extremities (Pearson's criterion 0.7677696; p < 0.22), which confirms the relationship between the development of nontraumatic changes in the foot and CVD in patients with Giacomini vein with age.Conclusion. It was found that the presence of an altered Giacomini vein leads to an aggravation of venous stasis in the lower extremities, which in turn increases the likelihood of developing venous pathology. Chronic diseases of the veins of the lower extremities contribute to dystrophic changes in soft tissues, most pronounced in the distal part of the extremity and, as a consequence, predispose to the development of osteoarticular pathology. 

Association between obesity and the aggravation of limited range of ankle mobility in chronic venous disease

2021 ◽  
pp. 026835552110553
Author(s):  
Sergio Q Belczak ◽  
Rubiana Neves Ramos ◽  
Jose Maria Pereira de Godoy
Keyword(s):  
Varicose Veins ◽  
Limited Range ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Limited Joint Mobility ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Ankle Mobility

Aim The aim of the present study was to show that an increase in weight leads to the aggravation of limited joint mobility. Method One hundred sixteen patients with varicose veins of the lower limbs and body mass index (BMI) higher than 30 kg/m2 were evaluated at the Belczak Clinic in Maringá, Brazil. All patients were evaluated by the same physician, and the goniometric readings were performed on all patients by a physiotherapist. The participants were then divided into three groups based on BMI: Group I—BMI between 30 and 40. Group II—BMI between 40 and 50, and Group III—BMI > 50. Results There is a significant difference between the groups detected. Conclusion The present findings show that an increased BMI in obese individuals with chronic venous disease is associated with a progressive limitation of ankle mobility.

Thermal Diagnostics in Chronic Venous Disease

2017 ◽  
pp. 34-54
Author(s):  
Armand Cholewka ◽  
Karolina Sieroń-Stołtny ◽  
Joanna Kajewska ◽  
Agnieszka Cholewka ◽  
Zofia Drzazga ◽  
...  
Keyword(s):  
Lower Limb ◽  
Thermal Imaging ◽  
Screening Method ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Venous Diseases ◽  
Diagnostic Usefulness ◽  
Thermovision Diagnostics ◽  
Thermal Diagnostics

The aim of the study was to determine the diagnostic usefulness of thermal imaging as tool to find quantitative parameters in lower-limb primary chronic venous diseases and insufficiency of superficial veins. There were significant differences obtained in thermal maps of lower extremities between patients and healthy. The correlations were obtained between temperature parameters counted from thermal imaging and duplex scanning. Such results also suggest that thermovision diagnostics may be useful as a complementary and first of all objective method that can be used in the diagnosis of chronic venous diseases in the lower extremities. It may suggest that thermovision may be used as a screening method or together with an ultrasound diagnosis in different superficial veins disorders.

scholarly journals Features of structural and functional parameters of superficial veins of lower extremities in men with arterial hypertension

2019 ◽  
Vol 1 (16) ◽  
pp. 18-21
Author(s):  
T. F. Vagapov ◽  
V. M. Baev ◽  
L. N. Druzhina ◽  
C. V. Letyagina
Keyword(s):  
Blood Flow ◽  
Arterial Hypertension ◽  
Varicose Veins ◽  
Venous Blood ◽  
Lower Extremities ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Venous Blood Flow ◽  
Cardiovascular Risks ◽  
Functional Parameters

The aim of the work was to assess the structural and functional parameters of the superficial veins of the lower extremities in men with arterial hypertension. A comparative analysis of the results of the angioscanning of the superficial veins of the lower extremities between 60 men with arterial hypertension and 27 men with normal blood pressure at the age of 30–50 years was performed. In hypertension, an increased rate of venous blood flow and signs of chronic vein diseases are recorded — an increased diameter and area of the lumen of the veins; abnormal venous reflux marked in 10 % of men; in 3 % — varicose veins and thrombotic masses, signs of postrombotic lesion of the superficial veins.Conclusion. For men with hypertension aged 30–50 years, there is an increased rate of venous blood flow and signs of chronic venous disease of the lower extremities: chronic venous insufficiency, varicose and postrombotic venous disease, which must be considered when stratifying cardiovascular risks and treating hypertension.

scholarly journals Biological necrectomy and vacuum-therapy in complex treatment of decompensated chronic venous insufficiency of the lower extremities

2019 ◽  
Vol 86 (7) ◽  
pp. 32-35
Author(s):  
V. I. Rusyn ◽  
V. V. Korsak ◽  
O. A. Nosenko ◽  
V. V. Rusyn ◽  
S. S. Kalinich
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Combined Treatment ◽  
Lower Extremities ◽  
Vacuum Therapy ◽  
Working Capacity ◽  
Group I ◽  
Varicose Disease ◽  
Group Ii ◽  
The Impact

Objective. To improve the results of treatment in patients, suffering decompensated forms of chronic venous insufficiency (CHVI) of the lower extremities, using introduction of biological necrectomy and vacuum-therapy in combination with complex of optimal surgical interventions, depending on state of venous hemodynamics of the lower extremities. Materials and methods. In 2015-2018 yrs in Surgical Clinic of the Zakarpattya Regional Clinical Hospital named after Andriy Novak 147 patients, ageing 40 yrs old and older, suffering CHVI Category C6 in accordance to the CEAP Classification, were treated. All the patients were divided into two groups: the Group I consisted of 76 patients, suffering CHVI in decompensated stage on background of varicose disease, and the Group II - 71 patients, suffering trophic ulcers (TU) on background of postthrombophlebitic syndrome (PTHPHS). Results. There was established, that the TU clearance under the action of maggot-therapy in patients, suffering decompensated course of CHVI, is significantly more effective, than under the impact of vacuum-therapy. Autodermoplasty must be performed in all the patients, having TU with 4 cm in diameter, Good and satisfactory results were observed in 75 (98.7%) patients of Group I and in 63 (88.7%) patients of Group II, while poor results - in 8 (11.3%) patients of Group II. The working capacity of patients, suffering CHVI in decompensated stage of varicose genesis, have enhanced in 16.5 times, while in the patients, suffering TU on background of PTHPHS – in 1.25 times. Conclusion. Combined treatment of CHVI in decompensated stage, occurring on background of varicose disease includes the TU clearance, using vacuum-therapy or biological necrectomy with subsequent elimination of vertical reflux. In the patients, suffering TU on the PTHPHS background the biologic necrectomy with elimination of horizontal reflux is advantageous. The working capacity in patients with CHVI in decompensated stage of varicose genesis have enhanced in 16.5 times, while in the patients with TU on the PTHPHS background - in 1.25 times.

The method for determining the degree of venous pathology depending on the index of erythrocytes deformability

2021 ◽  
Vol 22 (1) ◽  
pp. 36-40
Author(s):  
L. N. Komarova ◽  
◽  
K. U. Nabiyeva ◽  
M. A. Kisileva ◽  
N. V. Bruvskaya ◽  
...  
Keyword(s):  
Varicose Veins ◽  
Clinical Stage ◽  
Venous Blood ◽  
Lower Extremities ◽  
Blood Parameters ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Clinical Form ◽  
Venous Outflow ◽  
Deformability Of Erythrocytes

Aim. To study the ability of erythrocytes to deformability in patients with chronic diseases of the veins of the lower extremities. Materials and methods. From March to July 2019, we conducted a study of the deformability of erythrocytes in 271 railway workers using the method of laser diffractometry. The study of blood samples was carried out at the Department of Human and Animal Anatomy and Physiology of the Institute of Biology. At the same time, there were 182 people with varicose veins of the lower extremities, which was confirmed by the data of ultrasound angioscanning of the veins. Results. Studying the deformability of red blood cells of venous blood in patients with chronic venous disease of the lower extremities, we have identified certain patterns. With the increase in the clinical stage (form) of the disease of varicose veins of the lower extremities, the deformability of erythrocytes decreases, the deterioration of blood parameters is determined, which is confirmed by the data of a small coagulogram and a general blood test. The deformability index in the range from 0.12 to 0.42 indicates a violation of venous outflow in the subcutaneous venous system of the lower extremities, the deformability index from 0.42 and above indicates the presence of a thrombotic process in the deep veins of the lower extremities. Conclusion. With an increase in the erythrocyte deformability index, venous insufficiency increases, and venous outflow worsens. The higher the severity of the disease (clinical form C4-6), the lower the deformability of erythrocytes. In patients with VBLK, as the disease progresses, there is a decrease in the deformability of erythrocytes (i. e., in patients with the clinical form according to CEAP C2-3, the deformability is higher than in C3-4; in patients with C3-4, it is higher than in С4-5 … etc.).

scholarly journals Generation of reactive oxygen species by a sufficient, insufficient and varicose vein wall.

2011 ◽  
Vol 58 (1) ◽  
Author(s):  
Wirginia Krzyściak ◽  
Mariusz Kózka
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Varicose Veins ◽  
Reactive Oxygen ◽  
Chronic Venous Disease ◽  
Clinical State ◽  
Venous Disease ◽  
Oxygen Species ◽  
Vein Wall ◽  
Venous Diseases

Despite numerous theories, the etiology and pathogenesis of primary varicose veins remain unclear. The etiology of chronic venous diseases (CVDs) known as chronic venous insufficiency (CVI) is related to leukocyte trapping. Leukocyte trapping involves trapping of white cells in vessel walls followed by their activation and translocation outside the vessel. Release of reactive oxygen species (ROS) from trapped white cells has been documented. Superoxide dismutase (SOD) directly inhibits the generation of free radicals and compounds that are produced during oxidation by ROS, such as malonyldialdehyde (MDA). The aim of this study was to determine the involvement of free radicals in the etiology of venous changes. The following material was used for the study: fragments of sufficient or insufficient venous system and varices from 31 patients diagnosed with chronic venous disease in the 2nd or 3rd degree, according to clinical state, etiology, anatomy and pathophysiology (CEAP), which were qualified for surgical procedure. The levels of oxidative stress markers strongly correlated with lesions observed by USG in insufficient and varicose veins. In both a higher concentration of MDA was observed, which is a sign of lipid peroxidation. Antioxidative mechanisms, SOD activity and total antioxidative power expressed as FRAP were inversely proportional to MDA concentration. In insufficient and varicose veins both FRAP and SOD activities were significantly lower than in normal veins. The severity of clinical changes was inversely dependent on the efficiency of scavenging of ROS, which additionally proves the participation of free radicals in pathogenesis of CVDs.

scholarly journals Dysregulations of MicroRNA and Gene Expression in Chronic Venous Disease

2020 ◽  
Vol 9 (5) ◽  
pp. 1251 ◽  
Author(s):  
Daniel P. Zalewski ◽  
Karol P. Ruszel ◽  
Andrzej Stępniewski ◽  
Dariusz Gałkowski ◽  
Jacek Bogucki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mononuclear Cells ◽  
Varicose Veins ◽  
Expression Profiles ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Operating Characteristics ◽  
Potential Biomarker ◽  
Pathologic Features

Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide. Pathologic features include varicose veins, venous valves dysfunction and skin ulceration resulting from dysfunction of cell proliferation, apoptosis and angiogenesis. These processes are partly regulated by microRNA (miRNA)-dependent modulation of gene expression, pointing to miRNA as a potentially important target in diagnosis and therapy of CVD progression. The aim of the study was to analyze alterations of miRNA and gene expression in CVD, as well as to identify miRNA-mediated changes in gene expression and their potential link to CVD development. Using next generation sequencing, miRNA and gene expression profiles in peripheral blood mononuclear cells of subjects with CVD in relation to healthy controls were studied. Thirty-one miRNAs and 62 genes were recognized as potential biomarkers of CVD using DESeq2, Uninformative Variable Elimination by Partial Least Squares (UVE-PLS) and ROC (Receiver Operating Characteristics) methods. Regulatory interactions between potential biomarker miRNAs and genes were projected. Functional analysis of microRNA-regulated genes revealed terms closely related to cardiovascular diseases and risk factors. The study shed new light on miRNA-dependent regulatory mechanisms involved in the pathology of CVD. MicroRNAs and genes proposed as CVD biomarkers may be used to develop new diagnostic and therapeutic methods.

scholarly journals Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

2021 ◽  
Vol 10 (15) ◽  
pp. 3239
Author(s):  
Miguel A. Ortega ◽  
Oscar Fraile-Martínez ◽  
Cielo García-Montero ◽  
Miguel A. Álvarez-Mon ◽  
Chen Chaowen ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Current Knowledge ◽  
Varicose Veins ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Significant Loss ◽  
Venous Hypertension ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Environmental Agents

Chronic venous disease (CVD) is a multifactorial condition affecting an important percentage of the global population. It ranges from mild clinical signs, such as telangiectasias or reticular veins, to severe manifestations, such as venous ulcerations. However, varicose veins (VVs) are the most common manifestation of CVD. The explicit mechanisms of the disease are not well-understood. It seems that genetics and a plethora of environmental agents play an important role in the development and progression of CVD. The exposure to these factors leads to altered hemodynamics of the venous system, described as ambulatory venous hypertension, therefore promoting microcirculatory changes, inflammatory responses, hypoxia, venous wall remodeling, and epigenetic variations, even with important systemic implications. Thus, a proper clinical management of patients with CVD is essential to prevent potential harms of the disease, which also entails a significant loss of the quality of life in these individuals. Hence, the aim of the present review is to collect the current knowledge of CVD, including its epidemiology, etiology, and risk factors, but emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments. Furthermore, future directions will also be covered in this work in order to provide potential fields to explore in the context of CVD.

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