scholarly journals Collagen and Use Its in the Treatment of Wounds

2021 ◽  
Vol 14 (1) ◽  
pp. 85-90
Author(s):  
Anton Petrovich Ostroushko ◽  
Alexander Alexeyevich Andreev ◽  
Anastasiya Yurievna Laptiyova ◽  
Alexander Anatolievich Glukhov

Wounds take the main places of among surgical diseases, and the problem of developing new methods of their treatment remains relevant today. In recent years, the use of collagen has been widely used in the treatment of wounds. Collagen modulates the flow of fluid from the wound, facilitates the migration of fibroblasts and the formation of microvessels, helps in the synthesis of neodermal collagen matrices, forms complexes with biologically active substances and minimizes the formation of scars.Currently, collagen is used in the treatment of soft tissue wounds in the form of several pharmaceutical forms. Collagen sponges are used in the treatment of thermal and mechanical wounds, for local delivery of medicines. Collagen gels can be used for injections. Collagen can also be implemented in the form of a collagen shield. There are also collagen granules that have been developed for various compounds.Thus, the use of collagen is promising in the development of new medicinal preparation. However, for a wider disclosure of its clinical potential, it is necessary to thoroughly study all types of collagen and reveal their role at different stages of soft tissue repair.

2021 ◽  
Author(s):  
D. Abdullina ◽  
K. Valeev ◽  
R. Safin

As know, all wood material is recycled only half, and the rest of it remains unused. In practice, wood waste is most often plowed or burned, at a time when such wood is a valuable natural raw material that can compensate for the needs of a number of sectors of the economy. In this regard, the problem of recycling waste from the woodworking industry is very relevant today. Wood waste contains a large amount of substances capable of exhibiting biological activity. In particular, such biologically active substances include betulin, which is found in birch bark, which, due to its many advantages, has found wide application in medical, perfumery, cosmetic, food and other industries. For the rational use of wood and wood materials, it is necessary to develop new technologies and equipment for processing wood into products that are in demand for mankind. The paper provides an overview of the processing of birch bark. The relevance and prospects of birch species as a raw material for the chemical industry have been established. An installation for obtaining biologically active substances from wood waste is presented.


2020 ◽  
pp. 10-16
Author(s):  
S.I. Melnik ◽  
V.D. Torikashvili ◽  
K.D. Yakuta ◽  
S.A. Lebedeva

Collagen is a promising auxiliary substance in the manufacture of soft dosage forms (DF). Wound dressings and gels based on collagen are of great interest, as they allow speeding up the healing process, are completely utilized by the body, and can serve as a carrier for various medicinal and biologically active substances. An important advantage of using collagen is a large number of sources of its acquisition, which minimizes the risks of missing the necessary basis for the production of new medicines.


2019 ◽  
Vol 65 (4) ◽  
Author(s):  
Katarzyna Janda ◽  
Aleksandra Taukin ◽  
Justyna Kałduńska ◽  
Karolina Jakubczyk

The increasing incidence of cancer is driving research into new methods of cancer prevention. Chemoprevention is the use of natural or synthetic substances to slow down, stop or delay carcinogenesis. Increased intake of cruciferous plants may have a beneficial effect on reducing the incidence of human cancers. This is related to the presence of glucosinolates, i.e. biologically active substances whose enzymatic degradation products have a detoxifying effect, inhibiting neoplastic processes and adhesion, and intensifying tumour cell apoptosis.


2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.


2020 ◽  
Vol 62 (1-2) ◽  
pp. 49-68
Author(s):  
T. O. Kondratiuk ◽  
T. V. Beregova ◽  
I. Yu. Parnikoza ◽  
S. Y. Kondratyuk ◽  
A. Thell

The identification of the diversity of microscopic fungi of lithobiont communities of the Argentine Islands in specimens collected during the 22nd Ukrainian Antarctic Expedition was the purpose of this work. Samples of rock, soil, mosses and lichens of rock micro-habitats of “Crustose lichen sub-formation and fruticose lichen and moss cushion sub-formation” were used in the work. These samples were used for extracting and cultivation of filamentous fungi on dense nutrient media. Determination of physiological and biochemical characteristics and identification of yeast-like fungi were performed using a microbiological analyser ‘Vitek-2’ (‘Bio Merieux’, France). Cultivation of microorganisms was carried out at temperatures from +2 to +37 °C. In results cultures of microscopic fungi of Zygomycota (Mucor circinelloides), Ascomycota (species of the genera cf. Tlielebolus, Talaromyces), representatives of the Anamorphic fungi group (Geomyces pannorum, species of the genera Alternaria, Acremonium, Aspergillus, Penicillium, and Cladosporium) were isolated from Antarctic samples. Microscopic fungi Penicillium spp. were dominated after the frequency in the studied samples (54.5%). Rhodotorula rubra and Candida sp. among isolated yeast fungi, and dark pigmented fungi represented by Aureobasidium pulhdans and Exophiala spp. were identified. The biological properties of a number of isolated fungi (the potential ability to synthesise important biologically active substances: melanins, carotenoids, lipids) are characterised. Mycobiota of rock communities of Argentine Islands is rich on filamentous and yeast fungi similarly to other regions of Antarctica. A number of fungi investigated are potentially able to synthesise biologically active substances. The dark pigmented species of the genera Cladosporium, Exophiala, Aureobasidium pulhdans, capable of melanin synthesis; ‘red’ yeast Rhodotorula rubra (carotenoid producers and resistant to toxic metals); Mucor circinelloides and Geomyces pannorum, lipid producers, are among these fungi. Yeast-like fungi assimilated a wide range of carbohydrates, which will allow them to be further used for cultivation in laboratory and process conditions. The collection of technologically promising strains of microorganisms, part of the Culture Collection of Fungi at Taras Shevchenko National University of Kyiv (Ukraine), is updated with isolated species (strains) of filamentous fungi and yeast – potential producers of biologically active substances, obtained within this study.


Author(s):  
Chernichkina A.D.

A large number of biologically active substances, organic acids, tannins, and pectin substances were detected during the study of fruits, leaves, and pulp of the fruits of mountain Ash. The content of these substances in leaves and pulp will significantly expand the arsenal of medicinal plant raw materials used. Given the wide distribution of mountain Ash in the territory of the Russian Federation, harvesting leaves from the same plants after harvesting the fruit and using pulp will make it possible to obtain new phytopreparations.


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