scholarly journals Does Diabetic Microvascular Complications Affect Gastrointestinal Symptoms?

2019 ◽  
Author(s):  
Akram Ghadiri-Anari ◽  
Somayeh Gholami ◽  
Elham Sheyda ◽  
Shadab Kharazmi ◽  
Nasim Namiranian
Keyword(s):  
Microvascular Complications ◽  
Gastrointestinal Symptoms ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Gi Symptoms ◽  
High Prevalence ◽  
Rome Iii ◽  
Diabetic Microvascular Complications ◽  
Sample Method

Abstract- Due to high prevalence of diabetes in our region (16.3%) and no data on the frequency of gastrointestinal (GI) symptoms in this population, we performed a cross-sectional study to evaluate the frequency of GIsymptoms in diabetic patients and its association between microvascular complications (retinopathy and nephropathy) and gastrointestinal symptoms in diabetic subjects.This analytical crosssectional study was conducted from 2014 to 2016 on 233 patients with type 2 diabetes mellitus (T2DM), 3065-year, referred to Yazd diabetic research center. They were selected by convenient sample method. A questionnaire according to Rome III Criteria was used to collect digestive information related to diabetes. Last HbA1c (Since 2-3 months ago) was available in the patient's medical folder. Diabetic nephropathy defines to increased excretion rate of albumin in the urine in the range of above 30 mg/g creatinine. Diabetic retinopathy was examined by an expert ophthalmologist (retinal specialist). For the current study, 233 patients (age 30-65 years with mean age of 57.43±10.49 years, 102 (43.8%) males and 131 (56.2%) females) were included. Among 233 patients, 91 cases (39.1%) had nephropathy,and 111(47.6%) subjects had different degrees of retinopathy. Bloating and early satiety and upper GI symptoms were higher in the subjects with retinopathy than another group. In summary, this study provides evidence that GI symptoms in diabetic subjects are independently linked to diabetic complications, particularly to retinopathy.

The Correlation Between the Vitamin D Level and Glycemic Control Status Among Diabetic Patients - A Clinical Observational Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Nasser Alqahtani ◽  
Eisa Ghazwani ◽  
Awad Alqahtani ◽  
Mohammed Helaly
Keyword(s):  
Vitamin D ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
High Hba1c ◽  
Sugar Levels ◽  
Diabetic Microvascular Complications

Background: Vitamin D deficiency is widespread and coexisted with diabetes. However, the relation between Vitamin D level and glycemic control is not yet fully understood. This study examines the correlation between vitamin D level and glycemia indicators and diabetic microvascular complications.Methods: The study is a cross-sectional study, had been done at the outpatient department in Najran university hospital, Saudi Arabia from May 2019 to February 2020. 220 patients recruited by simple random sampling.Results: 60% of diabetes (n-130) had been using oral anti-glycemic medications, though most of them had uncontrolled glycemic status and had got microvascular complications. It is notable that among diabetes having a low vitamin D level; 55.5% had high FBS, 45.6% had high RBS and 65% had high HBA1C. Besides,17% have retinopathy, 16.6% have nephropathy, 26.2% have peripheral neuropathy and 1.9% have a diabetic foot.Conclusion: The clinical and laboratory assessments are essential to control the glycemic state in diabetes. The study noted that an inverse relationship between the level of vitamin D with blood sugar levels and diabetic microvascular complications. To assure the feasibility of the prediction of vitamin D level in assessing the progress of diabetes further studies are needed.

scholarly journals The management of upper gastrointestinal symptoms: A study on community pharmacies in Italy

Pharmacia ◽  
2021 ◽  
Vol 68 (2) ◽  
pp. 401-409
Author(s):  
Enrico Keber ◽  
Paolo Rocco ◽  
Umberto M. Musazzi ◽  
Antonio M. Morselli-Labate ◽  
Nicolina P. Floris ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Cross Sectional Study ◽  
Community Pharmacies ◽  
Medication History ◽  
Self Medication ◽  
Cross Sectional ◽  
Therapeutic Class ◽  
Gi Symptoms ◽  
History Of ◽  
Upper Gastrointestinal

Upper gastrointestinal (GI) symptoms are usual complaints among patients presenting to Italian community pharmacies. However, information on treatment history of those patients is often lacking. This descriptive, cross-sectional study aims at exploring the medication history of individuals with upper GI tract symptoms visiting one of the 20 enrolled community pharmacies, over a period of 7 months, based on the administration of a questionnaire. Of 1,020 interviewees, 62.1% had asked for a medical consultation. The most frequent symptom was epigastric burning (31.8%), followed by acid regurgitation (14.6%) and post-prandial fullness (12.0%). Of the 1,609 therapies, proton pump inhibitors constituted the most represented therapeutic class (35.6%) followed by antacids (17.5%) and alginate-based products (17.2%). In treating symptoms, 38.1% of the patients do not seek medical advice, while 42.0% rely on non-prescription therapies. As findings suggest, support to patients with GI disorders in community pharmacies can be enhanced for a safer self-medication.

scholarly journals Prevalence of depression among type2 diabetes mellitus in Pakistani population

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Abid Naeem ◽  
Muhammad Shuaib ◽  
Subtain-Ul- Hassan Abid ◽  
Muhammad Huzaifa Abid ◽  
Muhammad Imran
Keyword(s):  
Diabetes Mellitus ◽  
Severe Depression ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Type2 Diabetes ◽  
High Prevalence ◽  
Prevalence Of Depression ◽  
Type2 Diabetes Mellitus

Introduction: Diabetes is a very prevalent problem in Pakistan. Depression along with diabetes affects not only quality of life but compliance and management of patient. Various studies have found high prevalence of depression among T2DM depression. In our study we shall determine the prevalence of depression among T2DM patients in Pakistan. Period: May 2017 to December 2017. Objectives: The objective of this study was to find out the prevalence of depression in Type2 diabetes mellitus patients. Study Design: A cross-sectional study. Setting: Jinnah Post Graduate Medical Centre Karachi. Results: Mean PHQ- Score is 10.83±5.6. 81.9% had PHQ Score > 4. According to PHQ-9 scale, 18.1% (n=30) had no depression, 26.5% (n=44) had moderately severe depression and 3.6% (n=6) had severe depression. In our study females had more severe depression in comparison with male (5.2% vs. 0%). Conclusion: Depression is very common in Pakistan among Type 2 Diabetic patients. Antidepressant has key role to break the vicious cycle of depression and type2 diabetes mellitus diabetes.

Relationship between Stress Perceived and Gastrointestinal Symptoms in Intensive Care Nurses During COVID-19 Pandemic: A Cross-Sectional Study

2022 ◽  
Vol 8 (4) ◽  
pp. 217-230
Author(s):  
Tuğba Menekli ◽  
Runida Doğan ◽  
Erman Yıldız
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Perceived Stress ◽  
Stress Level ◽  
Gastrointestinal Symptoms ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Intensive Care Nurses ◽  
Gi Symptoms

The purpose of this study is to determine the relationship between perceived stress and gastrointestinal (GI) symptoms during the COVID-19 outbreak in the intensive care unit (ICU) nurses. This cross-sectional study was conducted with 170 nurses working in the ICUs of a hospital in eastern Turkey. Descriptive, chi-square and multiple linear regression analyses were used to analyze data. In the last three months, 48.2% of the nurses had complaints such as heartburn, 44.1% abdominal distension, 41.7% diarrhea/ constipation. The mean perceived stress level experienced by the nurses was found to be 29.30±5.73. Results from regression analysis included perceived stress score, gender, perceived health status, diet, having been infected with COVID-19 before and risk degree of the ICU in question in terms of COVID-19 revealed a statistically significant associated with scores obtained from GI symptoms. Perceived stress level, health perception status, having been infected with COVID-19 before and the high-risk status of the intensive care unit in question for COVID-19 were predictive factors for the occurrence of gastrointestinal symptoms. These findings may provide a basis for creating a healthy work environment where factors contributing to work-related stress are reduced and coping strategies are developed. Keywords: gastrointestinal symptoms, intensive care, nurses, stress

scholarly journals Comparative Intraocular Pressure Study among Diabetic and Non-Diabetic Patients

2021 ◽  
pp. 229-233
Author(s):  
Asadullah Jatoi ◽  
Noman Ahmed Shaikh ◽  
Mona Liza Mahesar
Keyword(s):  
Intraocular Pressure ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
Rank Test ◽  
Diabetic Patients ◽  
Health Issues ◽  
Cross Sectional ◽  
Clinical Investigations ◽  
Spearman Correlation Test ◽  
The Difference

Background: Diabetes mellitus is one of the major health issues in the world. Its microvascular complications contribute to ocular complications including increased intraocular pressure (IOP) which is a risk factor of glaucoma. Identification of factors responsible for glaucoma is a mainstay in the early detection and prevention of blindness. Aim and Objectives: The objective of the study was to compare IOP among diabetic and non-diabetic patients and to assess the correlation between age and IOP. Materials and Methods: The cross-sectional study was performed on 104 participants. Patients were divided into two groups based on diabetes (case, n = 52) and non-diabetes (control, n = 52). The detailed history and routine clinical investigations were performed. Three consecutive readings of IOP of the left and right eye were recorded separately using Goldmann applanation tonometer. Wilcox sign-rank test and Spearman-correlation test was used to find the difference between the IOP and correlation between age and IOP, respectively. Results: A significantly higher IOP was observed in diabetic patients than non-diabetic patients. (0.0001). There was no sex difference in IOP was observed in diabetic and non-diabetic patients. Age of the patient was not correlated with IOP (r = –0.02197219, P = 0.824). Conclusion: Diabetic patients are prone to higher IOP; therefore, diabetic patients should be regularly assessed for IOP for diagnosis glaucoma.

scholarly journals Level of VEGF-A and interleukin 6 in lacrimal fluid of patients with diabetic retinopathy

2020 ◽  
Vol 14 (3) ◽  
pp. 664-673
Author(s):  
Christelle Domngang ◽  
Armelle Lowe Noutchie ◽  
Pascal Djamen Chuisseu ◽  
Freddy Nemg Simo ◽  
Borris Tietche Galani ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Interleukin 6 ◽  
Microvascular Complications ◽  
Cross Sectional Study ◽  
Elisa Test ◽  
Diabetic Patients ◽  
Vascular Endothelial ◽  
Cross Sectional ◽  
The Mean ◽  
Endothelial Growth Factor

Diabetic retinopathy (DR) is an ocular manifestation characterized by microvascular complications. The aim of this study was to investigate the relationship between diabetic retinopathy (DR) and two lacrimal angiogenic cytokines, interleukin-6 (Il-6) and vascular endothelial growth factor-A (VEGF-A). A cross-sectional study was conducted at Yaoundé Central Hospital from February,1 to June, 15, 2019. Twenty-six diabetic patients with retinopathy and 55 diabetics without retinopathy were enrolled. Tears were collected with Schirmer strips. The concentrations of VEGF-A and Il-6 were determined by the ELISA test. Statistical analysis was performed using Epi Data version 7.1.5.2. and GraphPad 5.0. The mean VEGF-A concentration was 163.4 ± 45.1 and 149± 81.8 pg/ml in patients with and without DR respectively (p= 0.292) while tear Il-6 level was 118.5±103 and 119±79.43 pg/ml in patients with and without DR respectively (p= 0.497). The mean tear VEGF level was 165.2 ± 76.10 and 153.50 ± 57.94 pg/mL in patients with and without diabetic maculopathy (DM) respectively (p=0.343) while tear Il-6 level was significantly lower in DM (54.92±32.68) compared to patients without DM (159.10±89.78) (p=0.047). Tear Il-6 level was significantly low in patients with DM. There was no association between the 2 lacrimal biomarkers and diabetic retinopathy. Further analysis is needed for this type of screening in diabetic patients.Keywords: eye, retina, tear, diabetes, biomarker; cytokine.

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