scholarly journals Homogeneity of Mycoplasma agalctiae vaccine strains in an agalaxy- high-burden environment

2019 ◽  
Author(s):  
Khatereh Kabiri ◽  
Seyyed Ali Ali Pourbakhsh ◽  
Jamileh Norouzi ◽  
Mohammad Sekhavati ◽  
Keyvan Tadayon
Keyword(s):  
Disease Control ◽  
Structure Analysis ◽  
Laboratory Strain ◽  
Sequence Type ◽  
Control Measures ◽  
High Burden ◽  
Mlst Analysis ◽  
Mycoplasma Agalactiae ◽  
Identical Nucleotide

Background and Objectives: Interrogation of the genomic relations between Iranian Mycoplasma agalactiae vaccine strains of Taliqan, Lorestan and Shiraz. Materials and Methods: Two MLVA (covering VNTR loci of 5, 9, 17 and 19) and MLST (comprising dnaA, gltX, gyrB, C, tufA genes) genotyping systems plus nucleotide structure analysis of P80 gene, was conducted. Results: The shared MLVA pattern represented by the three strains differed to that of the Mag PG2 laboratory strain, only at locus VNTR19 where the PG2 genome hold a 3 bp longer stretch. In MLST analysis, at dnaA, gltX, gyrB, metS and tufA loci, the three strains displayed alleles 1, 21, 2, 2 and 1, respectively. At, gltX locus a new allele (21) was detected where a new sequence type (ST33) was identified. Besides, the trio strains hold an identical nucleotide structure in their ma-mp81 gene. Conclusion: In explanation, lack of efficient disease control measures, has possibly contributed in evolution of a clone or a few clones that gradually overwhelmed the population over the time. Besides, the similarity between the Iranian and the PG2 strains, might be due to homoplasy or farming exercises such as animal importation. Inclusion of further local isolates in next studies will help to assess these assumptions.

scholarly journals COVID-19 in South Korea: Proper timing for Easing Mask mandates after COVID-19 Vaccination

2021 ◽  
pp. 1-9
Author(s):  
Yun-Jung Kang
Keyword(s):  
South Korea ◽  
Disease Control ◽  
Prevention And Control ◽  
Control Measures ◽  
Social Distancing ◽  
Proper Timing ◽  
Control And Prevention ◽  
Prevention And Control Measures ◽  
And Control

Abstract As of 25 July 2021, the Korea Disease Control and Prevention Agency reported 1,422 new COVID-19 cases, 188,848 total cases, and 2.073 total deaths (1.10% fatality rates). Since the first SARS-CoV-2 case was reported, efforts to find a treatment and vaccine against COVID-19 have been widespread. Four vaccines are on the WHO’s emergency use listing and are approved of their usage; BNT162b2, mRNA-1273, AZD1222, and Ad26.COV2.S. Vaccines against SARS-CoV-2 need at least 14 days to achieve effectiveness. Thus, people should abide by prevention and control measures, including wearing masks, washing hands, and social distancing. However, a lot of new cases were reported after vaccinations, as many people did not follow the prevention control measures before the end of the 14 days period. There is no doubt we need to break free from mask mandates. But let us not decide the timing in haste. Even if the mask mandates are eased, they should be changed depending on the number of reported cases, vaccinations, as well as prevention and control measures on how circumstances are changing under the influence of mutant coronavirus.

scholarly journals Interhospital Transmission of Vancomycin-resistant Enterococcus Faecium in Aomori, Japan

2021 ◽  
Author(s):  
Norihiro Saito ◽  
Junichi Kitazawa ◽  
Hiroko Horiuchi ◽  
Takeo Yamamoto ◽  
Masahiko Kimura ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Continuous Monitoring ◽  
Clonal Propagation ◽  
Sequence Type ◽  
Control Measures ◽  
Vancomycin Resistant Enterococcus ◽  
Infection Control Measures ◽  
Vancomycin Resistant ◽  
Aomori Prefecture ◽  
Hospital Transmission

Abstract A series of vancomycin-resistant Enterococcus faecium (VREf) outbreaks caused by clonal propagation due to inter-hospital transmission occurred in six general hospitals in Aomori prefecture, Japan. This was the first multi-jurisdictional outbreak of VREf sequence type 1421 in Japan. It took almost three years for VREf prevalence to return to pre-outbreak levels. The duration and size of outbreaks differed between hospitals according to the countermeasures available at each hospital. Prompt and strong countermeasures including patient isolation and repetitive screening of all inpatients were required to control the outbreaks. In addition to strict infection control measures, continuous monitoring of VREf prevalence in local medical regions and smooth and immediate communication among hospitals are required to prevent VREf outbreaks.

scholarly journals Mycoplasma agalactiae in Dairy Goat Flocks Bred in State of Ceará in Association with Caprine Arthritis Encephalitis Virus

2018 ◽  
Vol 46 (1) ◽  
pp. 7
Author(s):  
Renato Mesquita Peixoto ◽  
Alice Andrioli ◽  
Raymundo Rizaldo Pinheiro ◽  
Francisco Selmo Fernandes Alves ◽  
Vanderlan Warlington Souza Dos Santos ◽  
...  
Keyword(s):  
Milk Production ◽  
Clinical Signs ◽  
Small Ruminants ◽  
The State ◽  
Encephalitis Virus ◽  
Control Measures ◽  
Dairy Goat ◽  
Economic Losses ◽  
Caprine Arthritis Encephalitis Virus ◽  
Mycoplasma Agalactiae

Background: Contagious agalactia is an infectious disease caused by Mycoplasma agalactiae (M. agalactiae) that occurs in small ruminants leading to productive and economic losses. Due to the similarity of clinical signs presented in Caprine Arthritis Encephalitis (CAE), which is a viral disease, a differential diagnosis is important. Therefore, this study aimed to investigate the presence of anti-Mycoplasma agalactiae antibodies in dairy goat flocks in Ceará State and possible correlation with CAE.Materials, Methods & Results: The research was performed in four mesoregions in Ceará State (Metropolitan Region of Fortaleza-MRF; Northeast Ceará - NeC; North Ceará - NC; Sertões in Ceará - SC), from which 16 productions located in 10 cities with the highest representativeness for goat milk production within the State or mesoregion were sampled. A total of 417 females and 69 males (486 animals) of breeds with dairy production aptitude, pure or crossbreed, maintained in semi-intensive or intensive systems, were tested. Blood serum was obtained by venipuncture of the jugular vein with vacuum pressure syringe followed by centrifugation at 1,500 g for 10min. Antibodies against the caprine arthritis encephalitis virus (CAEV) were detected with micro technique of agarose gel immunodiffusion (AGID) and Western Blot (WB). The anti-Mycoplasma agalactiae antibodies were detected with commercial kit of enzymatic immunoassay (IDEXX Laboratories™). Seroprevalence of M. agalactiae in dairy goat flocks in Ceará State was 0.62% (3/486). From the total of 16 visited productions, 18.75% (3/16) had seropositive animals for M. agalactiae located in MRF, NC and SC mesoregions. CAE was diagnosed in 56.25% (9/16) of productions with AGID and in 81.25% (13/16) with WB. In addition, 5.2% (25/486) of animals were seropositive for CAE with AGID and 16.6% (80/486) with WB. Animals that reacted positive for M. agalactiae were all females of pure breed with milk production aptitude in distinct mesoregions submitted to intensive rearing system. None of these animals was positive in neither test (AGID or WB) for CAE. Therefore, no correlation of results obtained in diagnosis of M. agalactiae by ELISA and CAEV by AGID or WB (P < 0.05) was identified. However, two out of three productions that were positive for M. agalactiae presented positive results for CAEV with frequencies of 10% and 20%.Discussion: Seroprevalence of M. agalactiae in Ceará State was low in comparison with other Brazilian states and even other countries. However, the presence of the pathogen in more than one mesoregion indicates that the disease occurs in different locations within the State. Therefore, flocks in Ceará are susceptible to the infection, which may be favored by uncontrolled commerce that occurs with deficient surveillance, associated with the importation of animals to improve flock genetic quality. The presence of the pathogen in dairy goats may contribute to significant losses in the local production. On the other hand, CAE was diagnosedin nearly all productions proving the dissemination of this lentivirus infection among dairy goat flocks in Ceará State. Although an association between these diseases was not identified, the presence of a retrovirus in the organism may favor co-infection with another micro-organism, promoting the deficiency in the immune system of the host. In conclusion, M. agalactiae is present in different mesoregions of the Ceará State and control measures should be adopted in short term to prevent pathogen dissemination and, consequently reduce economic and productive losses in the local dairy goat production. No correlation was identified between the prevalence of infection by CAEV and M. agalactiae in this study.Keywords: correlation, diagnosis, caprine lentivirus, mycoplasmosis.

Further studies on epidemiological factors influencing control of banana bunchy top disease and evaluation of control measures by computer simulation

1987 ◽  
Vol 38 (2) ◽  
pp. 373
Author(s):  
RN Allen
Keyword(s):  
Disease Control ◽  
Control Measure ◽  
Significant Loss ◽  
Control Measures ◽  
Disease Spread ◽  
Disease Symptoms ◽  
Control Disease ◽  
Banana Leaves ◽  
Time Required ◽  
Apparently Healthy

The basic infection rate of bunchy top disease in established bananas averaged 0.0342 new infections per infectious plant per day, but varied seasonally with a maximum in summer. The mean distance of spread for the aphid vector was 15.2 m. The latent period was 59.8 days and correlated with the time required for the growth of 3.7 new banana leaves. A microcomputer program was written to simulate spread of banana bunchy top disease in space and time. In the absence of disease control, disease spread from an initial primary infection in July or January to 124 or 153 infected plants, respectively, in one year. When disease control was maintained by removing diseased plants whenever the number of infected plants exceeded a given threshold, the numbers of diseased plants detected each inspection were positively correlated with the infection threshold, but the numbers of inspections required to maintain control increased markedly as the infection threshold was decreased. A practice of removing apparently healthy plants within 5 m of plants detected with bunchy top disease symptoms in five or more leaves was found to locate about 30% of the remaining undetected infected plants when disease was first detected in a plantation. However, its use as a routine control measure was ineffective in reducing the number of inspections required to maintain control or in reducing the risk of disease spreading to adjoining plantations. Removal of apparently healthy plants within 5 m had some bearing on disease control when applied around plants with disease symptoms in two leaves or less, but also caused a significant loss of healthy plants.

scholarly journals Socially vs. Privately Optimal Control of Livestock Diseases: A Case for Integration of Epidemiology and Economics

2020 ◽  
Vol 7 ◽  
Author(s):  
Ângelo J. Mendes ◽  
Daniel T. Haydon ◽  
Emma McIntosh ◽  
Nick Hanley ◽  
Jo E. B. Halliday
Keyword(s):  
Optimal Control ◽  
Disease Control ◽  
Low Income ◽  
Disease Risk ◽  
Control Measures ◽  
Low Income Countries ◽  
Control Effort ◽  
Optimal Behavior ◽  
Wide Range ◽  
Livestock Diseases

This paper aims to illustrate the interdependencies between key epidemiological and economic factors that influence the control of many livestock infectious diseases. The factors considered here are (i) farmer heterogeneity (i.e., differences in how farmers respond to a perceived disease risk), (ii) off-farm effects of farmers' actions to control a disease (i.e., costs and benefits borne by agents that are external to the farm), and (iii) misalignment between privately and socially optimal control efforts (i.e., privately optimal behavior not conducive to a socially optimal outcome). Endemic chronic diseases cause a wide range of adverse social and economic impacts, particularly in low-income countries. The actions taken by farmers to control livestock diseases minimize some of these impacts, and heterogeneity in those actions leads to variation in prevalence at the farm level. While some farmers respond to perceived disease risks, others free-ride on the actions of these individuals, thereby compromising the potential benefits of collective, coordinated behavior. When evaluating a plausible range of disease cost to price of control ratios and assuming that farmers choose their privately optimal control effort, we demonstrate that achievement of a socially optimal disease control target is unlikely, occurring in &lt;25% of all price-cost combinations. To achieve a socially optimal disease control outcome (reliant on farmers' voluntary actions), control policies must consider farmer heterogeneity, off-farm effects, and the predicted uptake of control measures under the assumption of optimized behavior.

An Outbreak of Chancroid in Orange County, California: Descriptive Epidemiology and Disease-Control Measures

1985 ◽  
Vol 151 (5) ◽  
pp. 840-844 ◽  
Author(s):  
C. A. Blackmore ◽  
K. Limpakarnjanarat ◽  
J. G. Rigau-Perez ◽  
W. L. Albritton ◽  
J. R. Greenwood
Keyword(s):  
Disease Control ◽  
Orange County ◽  
Control Measures ◽  
Descriptive Epidemiology

scholarly journals Infant Case of Co-infection with SARS-CoV-2 and Citrobacter koseri Urinary Infection

2020 ◽  
Author(s):  
Hyppolite K Tchidjou ◽  
Bernard Romeo
Keyword(s):  
Mortality Rate ◽  
Infection Control ◽  
Disease Control ◽  
Urinary Infection ◽  
Severe Disease ◽  
Control Measures ◽  
University Hospital ◽  
Infection Control Measures ◽  
Control And Prevention ◽  
Infant Case

Abstract Since 2019 coronavirus disease (COVID-19) is highly contagious with a high mortality rate. France has taken strict infection control measures. According to the report by the Center for Disease Control and Prevention, children are less affected with COVID-19 and seem to have less severe disease than adults. We reported the first confirmed infant case of co-infection with SARS-CoV-2 and Citrobacter koseri urinary infection in 6-week-old child admitted on 25 March 2020 with mild symptoms in the Pediatric COVID Unit of Amiens University Hospital, France.

scholarly journals The impact of contact structure on infectious disease control: influenza and antiviral agents

2007 ◽  
Vol 135 (7) ◽  
pp. 1124-1132 ◽  
Author(s):  
H.-P. DUERR ◽  
M. SCHWEHM ◽  
C. C. LEARY ◽  
S. J. De Vlas ◽  
M. EICHNER
Keyword(s):  
Disease Control ◽  
Contact Structure ◽  
Influenza Pandemic ◽  
Antiviral Treatment ◽  
Antiviral Agents ◽  
Emerging Infectious Diseases ◽  
Control Measures ◽  
Variable Degree ◽  
Contact Patterns ◽  
The Impact

SUMMARYPlanning adequate public health responses against emerging infectious diseases requires predictive tools to evaluate the impact of candidate intervention strategies. With current interest in pandemic influenza very high, modelling approaches have suggested antiviral treatment combined with targeted prophylaxis as an effective first-line intervention against an emerging influenza pandemic. To investigate how the effectiveness of such interventions depends on contact structure, we simulate the effects in networks with variable degree distributions. The infection attack rate can increase if the number of contacts per person is heterogeneous, implying the existence of high-degree individuals who are potential super-spreaders. The effectiveness of a socially targeted intervention suffers from heterogeneous contact patterns and depends on whether infection is predominantly transmitted to close or casual contacts. Our findings imply that the various contact networks' degree distributions as well as the allocation of contagiousness between close and casual contacts should be examined to identify appropriate strategies of disease control measures.

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