Synthesis and Characterization of a Novel Niosome System Containing Adiantum Capillus-Veneris for Breast Cancer Therapy

2020 ◽  
Author(s):  
Mojtaba Ansari ◽  
Sanaz Hasani
Keyword(s):  
Side Effects ◽  
Loading Rate ◽  
Mcf7 Cell ◽  
Cell Survival Rate ◽  
Iranian Traditional Medicine ◽  
Anti Cancer ◽  
Adiantum Capillus Veneris ◽  
Mcf7 Cell Line ◽  
Film Method

Background: Due to the increase in cancer and side effects of common therapies, researchers are looking for treatments with the least side effects, which is why medicinal plants have become so important. Adiantum capillus-veneris L. plant commonly called southern maidenhair fern, and also named as “Pare-siavashan” in medical and pharmaceutical textbooks of Iranian Traditional Medicine, contains triterpenoid compounds that have anti-tumor properties. It is a perennial fern with narrow stems and small leaves that grows in hot and humid places. This study aims to make biocompatible nanosystems carrying Adiantum capillus-veneris extract with an appropriate loading rate and to compare the anti-tumor properties of the extract-carrying system with its free state. Materials and Methods: After Extracting by Soxhlet, the resulting extract was loaded in the nano-niosome system by thin-film method and was subjected to physical, chemical, and cellular characterization. Results: The results of this study showed that the loading rate of Adiantum capillus-veneris extract in niosomic formulation is 50.74% and the resulting particles are spherical with a size of 325.7nm and anionic. No chemical interactions were found between niosome and extract and the resulting system was chemically stable. Conclusion: Based on acquired results, the designed system has acceptable anti-cancer properties on MCF7 cell line. It is notable that the cell survival rate was about 19 %.

scholarly journals DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sinem Şimşek ◽  
Ayça Aktaş Şüküroğlu ◽  
Derya Yetkin ◽  
Belma Özbek ◽  
Dilek Battal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Carbon Dots ◽  
Mcf7 Cell ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Mcf7 Cell Line

Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

2018 ◽  
Vol 18 (15) ◽  
pp. 1275-1286 ◽  
Author(s):  
Luiz Felipe Domingues Passero ◽  
Lucas Antal Cruz ◽  
Gabriela Santos-Gomes ◽  
Eliana Rodrigues ◽  
Márcia Dalastra Laurenti ◽  
...  
Keyword(s):  
Side Effects ◽  
Visceral Leishmaniasis ◽  
Traditional Knowledge ◽  
Conventional Therapy ◽  
Pathogenic Species ◽  
Action Mechanism ◽  
In Vivo Assays ◽  
Clinical Forms

Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in most cases, are considered outdated. In addition, patients under classical treatment show serious side effects during drug administration, moreover parasites are able to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary to develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis. The present review will focus on the efficacy, side effects and action mechanism of classic drugs used in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a rational search toward the discovery and characterization of new and effective molecules (in vivo assays) from plants to be used against leishmaniasis.

Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs

2019 ◽  
Vol 19 (9) ◽  
pp. 1080-1102 ◽  
Author(s):  
Ghansham S. More ◽  
Asha B. Thomas ◽  
Sohan S. Chitlange ◽  
Rabindra K. Nanda ◽  
Rahul L. Gajbhiye
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Nitrogen Mustard ◽  
Alkylating Agents ◽  
Cross Linking ◽  
Nitrogen Mustards ◽  
Information Leaflets ◽  
Anti Cancer ◽  
Approved Drugs

Background & Objective: :Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation with DNA involving cross-linking between guanine N-7 of one strand of DNA with the other. The generated cross-linking is irreversible and leads to cell apoptosis. Hence it is of great interest to explore this class of anticancer alkylating agents.Methods::An exhaustive list of reviews, research articles, patents, books, patient information leaflets, and orange book is presented and the contents related to nitrogen mustard anti-cancer agents have been reviewed. Attempts are made to present synthesis schemes in a simplified manner. The mechanism of action of the drugs and their side effects are also systematically elaborated.Results::This review provides a platform for understanding all aspects of such drugs right from synthesis to their mechanism of action and side effects, and lists USFDA approved ANDA players among alkylating anticancer agents in the current market.Conclusion: :Perusing this article, generic scientists will be able to access literature information in this domain easily to gain insight into the nitrogen mustard alkylating agents for further ANDA development. It will help the scientific and research community to continue their pursuit for the design of newer and novel heterocyclic alkylating agents of this class in the coming future.

scholarly journals Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects

APOPTOSIS ◽  
2021 ◽  
Author(s):  
Edmond Francis O’Donnell ◽  
Hyo Sang Jang ◽  
Daniel F Liefwalker ◽  
Nancy I Kerkvliet ◽  
Siva Kumar Kolluri
Keyword(s):  
Anti Cancer

scholarly journals Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B

2021 ◽  
Vol 22 (5) ◽  
pp. 2501
Author(s):  
Sonja Hinz ◽  
Dominik Jung ◽  
Dorota Hauert ◽  
Hagen S. Bachmann
Keyword(s):  
Protein Function ◽  
Tumor Development ◽  
Cysteine Residue ◽  
Type I ◽  
Pharmacological Characterization ◽  
Anti Cancer ◽  
And Function ◽  
Caax Motif ◽  
Important Drug

Geranylgeranyltransferase type-I (GGTase-I) represents an important drug target since it contributes to the function of many proteins that are involved in tumor development and metastasis. This led to the development of GGTase-I inhibitors as anti-cancer drugs blocking the protein function and membrane association of e.g., Rap subfamilies that are involved in cell differentiation and cell growth. In the present study, we developed a new NanoBiT assay to monitor the interaction of human GGTase-I and its substrate Rap1B. Different Rap1B prenylation-deficient mutants (C181G, C181S, and ΔCQLL) were designed and investigated for their interaction with GGTase-I. While the Rap1B mutants C181G and C181S still exhibited interaction with human GGTase-I, mutant ΔCQLL, lacking the entire CAAX motif (defined by a cysteine residue, two aliphatic residues, and the C-terminal residue), showed reduced interaction. Moreover, a specific, peptidomimetic and competitive CAAX inhibitor was able to block the interaction of Rap1B with GGTase-I. Furthermore, activation of both Gαs-coupled human adenosine receptors, A2A (A2AAR) and A2B (A2BAR), increased the interaction between GGTase-I and Rap1B, probably representing a way to modulate prenylation and function of Rap1B. Thus, A2AAR and A2BAR antagonists might be promising candidates for therapeutic intervention for different types of cancer that overexpress Rap1B. Finally, the NanoBiT assay provides a tool to investigate the pharmacology of GGTase-I inhibitors.

scholarly journals Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

2021 ◽  
Vol 36 (1) ◽  
pp. 1029-1047
Author(s):  
Myriam González ◽  
María Ovejero-Sánchez ◽  
Alba Vicente-Blázquez ◽  
Manuel Medarde ◽  
Rogelio González-Sarmiento ◽  
...  
Keyword(s):  
Cell Line ◽  
Mcf7 Cell ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
Cytotoxic Compounds ◽  
Mcf7 Cell Line

scholarly journals Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review

2021 ◽  
Vol 43 (1) ◽  
pp. 127-141
Author(s):  
Matúš Čoma ◽  
Veronika Lachová ◽  
Petra Mitrengová ◽  
Peter Gál
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Biologically Active ◽  
Estrogen Receptor Modulators ◽  
Age Related ◽  
Skin Repair ◽  
Genistein Treatment ◽  
Anti Cancer ◽  
Major Factors ◽  
Promising Source

Estrogen deprivation is one of the major factors responsible for many age-related processes including poor wound healing in postmenopausal women. However, the reported side-effects of estrogen replacement therapy (ERT) have precluded broad clinical administration. Therefore, selective estrogen receptor modulators (SERMs) have been developed to overcome the detrimental side effects of ERT on breast and/or uterine tissues. The use of natural products isolated from plants (e.g., soy) may represent a promising source of biologically active compounds (e.g., genistein) as efficient alternatives to conventional treatment. Genistein as natural SERM has the unique ability to selectively act as agonist or antagonist in a tissue-specific manner, i.e., it improves skin repair and simultaneously exerts anti-cancer and chemopreventive properties. Hence, we present here a wound healing phases-based review of the most studied naturally occurring SERM.

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