scholarly journals THE EFFECT OF SUPPLEMENTATION PROBIOTIC Lactobacillus casei STRAIN Shirota L AGAINST COLONIZATION OF Staphylococcus aureus Nasal Swab ISOLATES FROM PATIENTS WITH ALLERGIC RHINITIS

2015 ◽  
Vol 2 (1) ◽  
pp. 124
Author(s):  
Lilis Suryani
Keyword(s):  
Staphylococcus Aureus ◽  
Allergic Rhinitis ◽  
Lactobacillus Casei ◽  
Nasal Swab ◽  
Intestinal Flora ◽  
Control Group ◽  
School Of Medicine ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Lactobacillus ◽  
Quasi Experimental

<p>Staphylococcus aureus is the most important type of bacteria causing infections in humans. There are several potential factors for Staphylococcus aureus nasal careers in healthy adults, i.e. chronic sinusitis, the long-term skin trauma, respiratory allergies, asthma, allergen injection therapy. Probiotics are life microorganisms which have a positive effect on prevention or treatment of certain disease conditions when consumed. Manipulation of intestinal flora with probiotics for the prevention and treatment of rhinitis allergy should be developed. This study aims to determine the effect of supplementation probiotic Lactobacillus casei Shirota strain against colonization Staphylococcus aureus nasal swab isolates from patients with allergic rhinitis. <br />This research was quasi-experimental case-control design with a control group pretest-postest design. The study was conducted at the Microbiology and Research Laboratory School of Medicine Muhammadiyah Yogyakarta University, on February-July 2011. Fourty two students school of medicine Muhammadiyah Yogyakarta University, with the inclusion criteria suspect allergic rhinitis based on history. Volunteers who have a history of allergic rhinitis were taken nasal swab to check the number of S.aureus bacteria. Volunters consumed milk containing Lactobacillus casei strain Shirota daily for a month, then taken to be examined nasal swab S.aureus bacteria numbers. <br />The results showed that the average number of bacteria nasal swab isolates before supplementation about 92 CFU. After given the probiotic Lactobacillus casei Shirota strain during a month, the average number of S.aureus about 27 CFU. It can be concluded that supplementation with Lactobacillus casei strain Shirota probiotics can reduce Staphylococcus aureus colonization in patients with allergic rhinitis.</p><p><br /><strong>Keywords</strong>: Staphylococcus aureus, Lactobacillus casei, allergic rhinitis</p>

scholarly journals Pengaruh suplementasi probiotik Lactobacillus casei L shirota strain terhadap kadar IgE penderita rinitis alergi

2011 ◽  
Vol 41 (1) ◽  
pp. 60
Author(s):  
Asti Widuri ◽  
Lilis Suryani
Keyword(s):  
Allergic Rhinitis ◽  
Lactobacillus Casei ◽  
Immunoglobulin E ◽  
T Test ◽  
Mucosal Barrier ◽  
Inflammatory Reactions ◽  
Lactobacillus Casei Shirota ◽  
Significant Difference ◽  
Quasi Experimental ◽  
Paired T Test

Background: Allergic rhinitis is a nasal mucosal inflammatory reactions mediated by immunoglobulin E (IgE), after allergen exposure. Probiotics is considered has strong influence on the regulation of primary immunophysiology in intestinal mucosal barrier and might be useful to prevent allergy attacks.Purpose: To study the benefits of Lactobacillus casei Shirota strain L in preventing allergy attacks through the mechanism  of immunomodulatory systems that inhibit the production of IgE. Methods:The study was quasi-experimental  with pretest-posttest design. The subjects were 45 students with history of allergic rhinitis. Serum IgE levels were measured before and after given milk containing probiotics for one month. Results: With a paired t test, there was significant difference of the average IgE levels between before (291.88 IU/L) and after one month. Probiotic supplementation (141.43 IU/L),p<0.05. Conclusion: Supplementation of probiotic Lactobacillus casei Shirota strain L is useful in preventing allergy attacks.  Keywords: allergic rhinitis, probiotics, immunoglobulin E (IgE) Abstrak :  Latar belakang: Rinitis alergi adalah reaksi peradangan mukosa hidung yang diperantarai oleh imunoglobulin E (IgE) setelah terjadi pajanan alergen. Pemberian probiotik dianggap mempunyai pengaruh yang kuat terhadap regulasi imunofisiologi primer dalam barier mukosa usus. Tujuan:Mengkaji manfaat suplemen probiotik Lactobacillus casei L shirota strain dalam mencegah serangan alergi melalui mekanisme sistem imunomodulator yang menghambat produksi IgE. Metode: Desain penelitian adalah eksperimental kuasi case control dengan rancangan pretest-postest design. Subjek penelitian adalah 45 orang yang mempunyai riwayat rinitis alergi, diambil darah sampel untuk diperiksa kadar IgE sebelum dan setelah diberi susu yang mengandung probiotik selama satu bulan. Hasil: Dengan paired t test, terdapat perbedaan bermakna antara rata-rata kadar IgE sebelum suplementasi (291,88 IU/L) dan setelah diberi suplementasi probiotik Lactobacillus casei Lshirota strain selama satu bulan (141,43 IU/L), p<0,05. Kesimpulan: Suplementasi probiotikLactobacillus casei L shirota strain bermanfaat dalam mencegah serangan alergi melalui mekanisme imunomodulator yang menghambat produksi IgE. Kata kunci: rinitis alergi, probiotik, imunogobulin E (IgE)

Effect of a moustache on nasal Staphylococcus aureus colonisation and nasal cytology results in men

2015 ◽  
Vol 129 (2) ◽  
pp. 155-158 ◽  
Author(s):  
E Soylu ◽  
I Orhan ◽  
A Cakir ◽  
A Istanbullu ◽  
G Altin ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Control Group ◽  
Study Group ◽  
Left Nasal Cavity ◽  
Adult Men ◽  
Nasal Cytology ◽  
Non Allergic Rhinitis

AbstractObjective:This study compared the results of nasal Staphylococcus aureus carriage and nasal cytology in men with and without a moustache.Methods:The study group comprised 118 adult men with a moustache, and the control group consisted of 123 adult men without a moustache. Samples were taken from the participants' right nasal cavity for cytology and from the left nasal cavity for microbiology.Results:The results for S aureus were positive in 19.5 per cent (n = 23) of participants with a moustache and in 20.3 per cent (n = 25) of men without a moustache. This difference was not significant (p > 0.05). However, nasal cytology revealed rich eosinophil clusters in participants with a moustache.Conclusion:The presence or absence of a moustache had no effect on nasal S aureus colonisation. However, further research is needed to understand whether the presence of a moustache increases the risk of allergic or non-allergic rhinitis.

The probiotic Lactobacillus casei Shirota attenuates symptoms of vestibular migraine: a randomised placebo-controlled double-blind clinical trial

2020 ◽  
Vol 11 (5) ◽  
pp. 469-476
Author(s):  
X. Qi ◽  
G. Fan ◽  
H. Jia
Keyword(s):  
Depressive Symptoms ◽  
Lactobacillus Casei ◽  
Daily Basis ◽  
Vestibular Migraine ◽  
Double Blind ◽  
Beneficial Effects ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Lactobacillus ◽  
Vestibular Symptoms

Vestibular migraine (VM) has emerged as one of the major vestibular syndromes. Although probiotics have exhibited beneficial effects on migraine headache, its effect on VM is not clear. This trial aimed to investigate the treatment efficacy of the probiotic Lactobacillus casei Shirota (LcS) on symptoms of VM. 247 VM patients were enrolled, of which 204 eligible patients receiving either LcS or placebo on a daily basis completed the 4 month study. They were re-visited at 2 and 4 months after study initiation to assess treatment outcomes. The primary endpoints were vestibular symptoms, evaluated by the number of vertiginous attacks during the past week, the Vertigo Severity Score (VSS), and Dizziness Handicap Inventory (DHI) scores. The secondary endpoints were anxiety and depressive symptoms, evaluated using Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores. Efficacy of LcS over placebo was not obvious at 2 month follow-up. At 4 month follow-up, while both LcS and placebo groups of VM patients displayed alleviated symptoms, the extents of the improvements were significantly better in LcS group than those of placebo group, with regard to vestibular symptoms using DHI and VSS, as well as anxiety and depressive symptoms using BAI and BDI. Although placebo effect cannot be ignored in intervention for VM patients, the probiotic LcS still exhibits considerable efficacy against VM symptoms over a 4 month study period, supporting further clinical study of a larger and more diverse cohort.

scholarly journals Probiotic Lactobacillus casei: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1150 ◽  
Author(s):  
Hung-Hsiang Lai ◽  
Cheng-Hsun Chiu ◽  
Man-Shan Kong ◽  
Chee-Jen Chang ◽  
Chien-Chang Chen
Keyword(s):  
Body Weight ◽  
Abdominal Pain ◽  
Acute Diarrhea ◽  
Inflammatory Markers ◽  
Lactobacillus Casei ◽  
Clinical Symptoms ◽  
Control Group ◽  
Childhood Diarrhea ◽  
Fecal Lactoferrin ◽  
Probiotic Lactobacillus

Background: Acute diarrhea is a major cause of childhood morbidity and an economic burden for families. The aim of this study is to explore the effect of probiotics on clinical symptoms, intestinal microbiota, and inflammatory markers during childhood diarrhea. Methods: Children (n = 81) aged six months to six years (mean age 2.31 years) hospitalized for acute diarrhea were randomized to receive probiotics (Lactobacillus casei variety rhamnosus; n = 42) or no probiotics (n = 39) orally twice daily for seven days. Feces samples were also collected to evaluate microbial content using a traditional agar plate and next-generation sequencing. Immunoglobulin A (IgA), lactoferrin, and calprotectin were determined by enzyme-linked immunosorbent assay (ELISA) and compared in different groups. Other clinical symptoms or signs, including fever, vomiting, diarrhea, abdominal pain, bloated abdomen, daily intake, appetite, and body weight were also assessed. Results: Data were collected from 81 individuals across three different time points. Total fecal IgA levels in fecal extracts of the probiotics group were higher than those in the control group, reaching statistical significance (p < 0.05). Concentrations of fecal lactoferrin and calprotectin were significantly downregulated in patients with probiotic Lactobacillus casei variety rhamnosus (Lc) consumption compared to those of the control (p < 0.05). Probiotic Lc administration may be beneficial for gut-microbiota modulation, as shown by the data collected at one week after enrollment. Counts of Bifidobacteria and Lactobacillus species were elevated in stool culture of the probiotic group. Appetite and oral intake, body-weight gain, abdominal pain, bloating, as well as bowel habits (diarrhea) were much better in children receiving probiotics compared with those in the control group. Conclusion: Fecal IgA increased during acute diarrhea under Lc treatment; in contrast, fecal lactoferrin and calprotectin were downregulated during acute diarrhea under Lc treatment. Probiotic Lc may be a useful supplement for application in children during acute diarrhea to reduce clinical severity and intestinal inflammatory reaction.

The Effects of Probiotic Lactobacillus casei Shirota Strain in Patients with Allergic Rhinitis Symptoms

2015 ◽  
Vol 4 (4) ◽  
pp. 264
Author(s):  
Asti Widuri ◽  
Lilis Suryani
Keyword(s):  
Allergic Rhinitis ◽  
Lactobacillus Casei ◽  
Immunoglobulin E ◽  
Nasal Congestion ◽  
Rank Test ◽  
Inflammatory Reactions ◽  
Runny Nose ◽  
Before And After ◽  
Quasi Experimental ◽  
Signed Rank Test

Allergic rhinitis is inflammatory reactions mediated by immunoglobulin E, after exposure to allergens. The symptoms are sneezing, runny nose and nasal congestion. Allergic rhinitis can be alleviated by the use of specific probiotics selected to confer immune effects, which can be demonstrated in the intestinal tract prior to an allergic reaction. The specific strains used in this study were selected based on their anti-inflammatory properties and an expected effect in promoting a Th1 type of immune response. To review the benefits of probiotics of Lactobacillus casei L Shirota strain in preventing allergy attacks that inhibit the production of IgE, IL-4 and reduce the symptoms. To review the benefits of probiotics of Lactobacillus casei L Shirota strain in preventing allergy attacks that inhibit the production of IgE, IL-4 and reduce the symptoms. The study design was quasi-experimental with pre and post test design. The subject were 45 patients who had a history of allergic rhinitis and positif skin prickt test result and filled out the questionnaires to get the allergic symptoms. The blood samples were taken for examining the IgE and IL-4 levels then after giving milk containing probiotics for 1 month, the researcher did the same examination. The mean IgE and IL-4 levels decrease before and after supplementation probiotics from 291.88 IU / L and 22.48 pg/ml to 141.43 IU / L and 17.83 pg/ml. The result of the statistical analysis paired t-test test was p = 0.00 on IgE level and p=0,056 on IL-4 level. The allergic rhinitis symptoms decreased significantly, the presentage of patients who had persistent and moderate 17.78% to 0% , who had persistent and mild 44.44% to 4.44%, who had intermittent and moderate 13.33% to 2.22%,and who had intermittent and mild 24.44% to 93.33%. Based on the Wilcoxon signed rank test showed a significance value of P = 0.00. Conclusion Probiotics is useful in preventing allergy attacks that inhibit the production of IgE, IL-4 and reduce the symptoms.

scholarly journals Biotherapeutic potential of dairy beverage supplemented with lactobacillus casei shirota for the control of canine hookworm

2018 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Matheus Diniz Gonçalves Coêlho ◽  
Lívia Simões Silva ◽  
Lucas Tobias Rodrigues Maciel ◽  
Carolina Laurindo Moreira ◽  
Taís Cristina Paschoal ◽  
...  
Keyword(s):  
Protective Effect ◽  
Lactobacillus Casei ◽  
Alternative Therapy ◽  
Control Group ◽  
Lactobacillus Casei Shirota ◽  
Natural Hosts ◽  
Parasitic Load ◽  
Healthy Dogs ◽  
Probiotic Preparation ◽  
Potential Use

Domestic dogs (Canis familiaris) are present in the homes of several families around the world, and are one of the animals with greater contact with humans, either as a guard dog or just as a pet. With this, they can transmit parasites to their owners, since dogs are natural hosts of several parasites, among them the helminths of Ancylostomidae family. Ancylostomiasis presents as main symptoms abdominal pain and anemia. The treatment is performed with anthelmintics, however, it was found that these parasites are acquiring resistance to current drugs, which makes necessary the development of alternative therapies. Thus, this study aims to evaluate the therapeutic effect of a probiotic preparation containing 1x1010 CFU of Lactobacillus casei Shirota, administering 80 mL of this, for a group of four naturally infected dogs during 40 alternate days and, in parallel, administering a same volume during 30 consecutive days for a similar group of dogs. The protective effect was also evaluated by administering 80 ml of the preparation for a group of 5 healthy dogs for 30 consecutive days, which were maintained along with other infected animals. The number of eggs per gram of feces (EPG) was determined every 7 days, noting possible changes. As results, it was observed the potential use of probiotics in the treatment of hookworm in dogs as an inexpensive alternative therapy, since the assessed preparation induced significant reduction of the parasitic load of infected animals (p <0.005) in comparison with the control group, but in the other hand it was not observed protective effect, since the parasitosis have established in the dogs which were pretreated with L. casei Shirota.

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