scholarly journals The Comparative Evaluation of Liquid Based Cytology (LBC) and Conventional Pap Smear As a Screening Method of Cervical Cancer at Tertiary Care Center, Kota Rajasthan, India

2017 ◽  
Vol 05 (03) ◽  
pp. 18343-18348
Author(s):  
Badri Lal Patidar ◽  
Author(s):  
Chaitra Krishna ◽  
Savitha Chandraiah ◽  
Chandana Krishna

Background: Cervical cancer is the fourth commonest cancer affecting women worldwide and the second most common cancer in women aged 15-44 years. The Papanicolaou (Pap) smear has been the cornerstone of screening for cervical neoplasm for the last 50 years. Liquid-based cytology (LBC) was introduced in mid-1990s as an alternative technique to process cervical samples has many benefits over Pap. A new second generation technique, Liquiprep was introduced after a decade has the advantage of a much lower cost. However, the information available on second generation liquid based cytology is limited. The objective was to look for the efficacy of LBC and to compare it to that of conventional cytology.Methods: This hospital based comparative study was undertaken 100 women who attended gynaecology OPD during 2017 at a tertiary care hospital in Bengaluru. Two cervical smears were simultaneously prepared from each subject, one for Pap smear and another for LBC followed by colposcopy and biopsy.Results: Among the study subjects, 89% of Pap smear analysis and 100% of smears in LBC showed satisfactory smear. Cytological abnormality was detected in 11% and 21% in pap and LBC, respectively. The present study showed higher sensitivity and specificity of 100% and 75% by LBC when compared to Pap smear (55% and 100% respectively).Conclusions: The present study showed that liquid based cytology is better in detecting cervical lesions when compared to conventional smear. 


2019 ◽  
Vol 4 (1) ◽  
pp. 2-8
Author(s):  
Pragya Gautam Ghimire ◽  
Durga BC Rawat ◽  
Kavita Sinha ◽  
Kamar Jahan ◽  
Richa Shrestha

Introduction: Cervical cancer is a common health problem in Nepal. There is paucity of data regarding the spectrum of findings in cervical Pap in western Nepal. This study was aimed to study the cytological patterns in cervical Pap smears in patients in a tertiary hospital of Nepal. Methods: This is a prospective, cross sectional, hospital based study. Clinical features of patients who had presented with Pap smear was noted in a structured proforma. Pap smears were studied by a senior pathologist and reported based on revised Bethesda system (2014). Results: Most of the cases belonged to 31-40 years 399 (42.8%). Unsatisfactory/ inadequate sample was present in 133(14.05%) with obscuration due to inflammatory exudate being most common cause. Negative for intraepithelial lesion or malignancy rate was noted in 798 (85.54%) with 477(51.2%) being normal findings. Epithelial cell abnormalities were noted in 116 (14.5 %) smears. Low-grade squamous intraepithelial lesion constituted 321(34.5%), High grade squamous intraepithelial lesion 273(29.3 %) and Atypical squamous cells of undetermined significance 153(16.4%) of epithelial cell abnormalities. Squamous cell carcinoma was present in 9(1%) of all reviewed smears. There was no statistical significance between the age and abnormalities of Pap smear (p=0.9). Conclusions: Pap smear is pivotal in cervical cancer screening in developing countries. It also identifies various inflammatory, infective, benign and malignant pathologies at the earliest thereby decreasing the morbidity and mortality.


2018 ◽  
Vol 150 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Michelle Davis ◽  
Kyle Strickland ◽  
Sarah Rae Easter ◽  
Michael Worley ◽  
Colleen Feltmate ◽  
...  

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 92-96
Author(s):  
Varsha Reddy N ◽  
Yogesh Mohan ◽  
Charumathi B ◽  
Timsi Jain

In recent years cervical cancer has been witnessed as the second most prevalent cancer amongst females throughout the world. Sadly, regardless of the proof of methods for prevention, the majority of the females endure unscreened. The hurdles to screening include ignorance towards risk factors, manifestations, stigma, and fallacy about gynecological ailments. This research was conducted with the objective to describe the extent of awareness about cervical carcinoma and its screening among patient’s attenders who are women and are in the reproductive age group in a tertiary hospital. A cross-sectional study was conducted among patient's attenders age 15-45 years at a tertiary health care center, i.e., Saveetha Medical College and Hospital (SMCH) with a sample size of 158 and purposive sampling technique was used. Data was gathered using a semi-structured questionnaire. Data were entered in Microsoft Excel and analyzed using relevant statistical tests. Out of 158 study participants at SMCH,85 (53.7%) of them have heard about cervical cancer, 88 (55.6%) are apprised of screening of cervical carcinoma and 40 (25.3%) of them have been screened for cervical carcinoma using Pap smear. Study shows that more than half of the women have a satisfactory extent of awareness regarding cervical carcinoma. However, uptake of screening services is low. These results indicate that we need to increase awareness about cervical cancer and its screening.


2017 ◽  
Vol 9 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Uma Singh ◽  
Nisha Singh ◽  
Sabuhi Qureshi ◽  
Sakshi Foruin ◽  
Neha Negi ◽  
...  

ABSTRACT Aim To evaluate and compare the efficacy of liquid-based cytology (LBC) with conventional cytology (CS) as a screening tool for cervical cancer in postmenopausal women. Materials and methods This was an observational crosssectional study conducted over one year. Subjects were recruited from patients attending the outpatient department of the Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, Uttar Pradesh, India. Pap smear and LBC were taken in all subjects. In cases with suspected lesions, the discrepancy between Pap smear and LBC and colposcopy was found. Results Pap smear reported 14.3% inadequate smears in women with postmenopausal changes and 5% inadequate smears in women without postmenopausal changes. In contrast, LBC reported no inadequate smear. This difference was statistically significant (p = 0.011). Cervical neoplasia was ruled out in 53.6% cases by Pap smear and 75.8% cases by LBC. The difference was statistically significant (p = 0.002). Conclusion Liquid-based cytology offers better results in detecting cervical pathology when compared with Pap smear. Liquid-based cytology could be better as a screening method, especially in postmenopausal women in which the screening is challenging due to menopause-induced anatomical and hormonal changes. Clinical significance Cervical cancer is the most common genital cancer among Indian women. Postmenopausal women are at higher risk for developing cervical cancer. Low estrogenic state poses a challenge for detection of cervical cancer by CS in postmenopausal women. We investigated LBC as a better cervical cancer screening tool in this age group. How to cite this article Qureshi S, Singh U, Foruin S, Negi N, Agarwal G, Singh N. Liquid-based Cytology vs Conventional Cytology as a Screening Tool for Cervical Cancer in Postmenopausal Women. J South Asian Feder Obst Gynae 2017;9(2):159-163.


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