Age and body mass index as factors of female infertility and negative results of assisted reproductive technologies

2021 ◽  
Vol 2_2021 ◽  
pp. 21-26
Author(s):  
Ruziguli A. Ruziguli ◽  
Rukhliada N.N. Rukhliada ◽  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Female Infertility ◽  
Negative Results

scholarly journals Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies

2009 ◽  
Vol 18 (6) ◽  
pp. 856-863 ◽  
Author(s):  
Hind A Beydoun ◽  
Laurel Stadtmauer ◽  
May A Beydoun ◽  
Helena Russell ◽  
Yueqin Zhao ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Assisted Reproductive Technologies ◽  
Polycystic Ovary ◽  
Reproductive Technologies ◽  
Ovary Syndrome

scholarly journals Effects of Vaginal Misoprostol after Intrauterine Insemination IUI

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Zahraa H. Mohan ◽  
◽  
Nadia M. Al-Hilli ◽  
Mohammad Oda Selman ◽  
◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Assisted Reproductive Technologies ◽  
Positive Impact ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
Control Group ◽  
Infertile Couples ◽  
Vaginal Misoprostol

Intrauterine insemination has an important role in the treatment of infertile couples. Usage of vaginal misoprostol therapy at the time of intrauterine insemination has been investigated, and its tolerability and effects on clinical pregnancy rates still questionable. To assess the effectiveness of vaginal misoprostol on some demographic characteristics and hormones level with a success rate of Intrauterine Insemination. the period of collection of patients extended from Sep. 2018 until May 2019. Eighty- one infertile couples who attended Al Nahrain University, High Institute for Diagnostic Infertility and Assisted Reproductive Technologies, and private fertility clinics were enrolled through this study. Divided into two groups, the next group received 100 μg vaginal misoprostol immediately after completion of the IUI procedure, while the control group was subjected to ordinary IUI procedure without adjunctive therapy. The mean of demographic data of body mass index, age, and duration of infertility was statistically insignificant in control, Misoprostol post- intrauterine insemination. The percentage of pregnancy rate in the control group 5.0% and it 19.5% in the Misoprostol post-intrauterine insemination group. Moreover, there are significant differences in pregnancy rates among all study groups. According to this study, there is no significant result of pregnancy occurrences correlated with, female age, male age, and body mass index, duration of infertility or type of infertility, hormone levels. Misoprostol use after intrauterine insemination has a positive impact on pregnancy outcome in the control group 5.0% and it 19.5% in Misoprostol post- intrauterine insemination group. Smaller doses (100 μg) of misoprostol can decrease side effects without affecting the outcome.

Anesthetic impact of body mass index in patients undergoing assisted reproductive technologies

2008 ◽  
Vol 20 (5) ◽  
pp. 356-363 ◽  
Author(s):  
Brian Egan ◽  
Catherine Racowsky ◽  
Mark D. Hornstein ◽  
Ramon Martin ◽  
Lawrence C. Tsen
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies

scholarly journals Reproductive technologies, female infertility, and the risk of imprinting-related disorders

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Patricia Fauque ◽  
Jacques De Mouzon ◽  
Aviva Devaux ◽  
Sylvie Epelboin ◽  
Marie-José Gervoise-Boyer ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Assisted Reproductive Technologies ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Female Infertility ◽  
Global Risk ◽  
Vitro Fertilization ◽  
Increased Risk ◽  
Genomic Imprints

Abstract Background Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints. However, little is currently known about the risk of imprinting defects according to the type of ART or the type of underlying female infertility. From the French national health database, a cohort of 3,501,495 singletons born over a 5-year period (2013–2017) following fresh embryo or frozen embryo transfers (fresh-ET or FET from in vitro fertilization), intrauterine insemination, or natural conception was followed up to early childhood. Based on clinical features, several syndromes/diseases involving imprinted genes were monitored. The effects of ART conception and the underlying cause of female infertility were assessed. Results Compared with infants conceived naturally, children born after fresh-ET had a higher prevalence of imprinting-related diseases, with an aOR of 1.43 [95% CI 1.13–1.81, p = 0.003]. Namely, we observed an increased risk of neonatal diabetes mellitus (1.96 aOR [95% CI 1.43–2.70], p < 0.001). There was an overall independent increase in risk of imprinting diseases for children with mothers diagnosed with endometriosis (1.38 aOR [95% CI 1.06–1.80], p = 0.02). Young and advanced maternal age, primiparity, obesity, smoking, and history of high blood pressure or diabetes were also associated with high global risk. Conclusions This prospective epidemiological study showed that the risk of clinically diagnosed imprinting-related diseases is increased in children conceived after fresh embryo transfers or from mothers with endometriosis. The increased perturbations in genomic imprinting could be caused by controlled ovarian hyperstimulation and potentially endometriosis through the impairment of endometrial receptivity and placentation, leading to epigenetic feto-placental changes. Further studies are now needed to improve understanding of the underlying molecular mechanisms (i.e. genetic or epigenetic causes).

Not Yet a Woman: The Influence of Socio-Political Constructions of Motherhood on Experiences of Female Infertility

2019 ◽  
Vol 50 (3) ◽  
pp. 890-907
Author(s):  
Hannah Wells ◽  
Milena Heinsch
Keyword(s):  
Social Work ◽  
Scoping Review ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Female Infertility ◽  
Support Needs ◽  
Infertile Women ◽  
Interdisciplinary Knowledge ◽  
Systemic Factors ◽  
Feminine Ideals

AbstractIn contemporary pronatalist societies, motherhood and childbearing are constructed as inevitable fulfilments of the female identity, resulting in the stigmatisation of women who do not conform to these feminine ‘ideals’. This article reports on the findings of a scoping review, which explored constructions of women and motherhood in Western societies, and how they influence women’s experiences of infertility. Three key themes were identified: (i) the ‘women as mothers’ discourse; (ii) medicalisation and the ‘female biological fault’; and (iii) ‘deviant’ mothers and infertility. While these themes facilitate a deeper understanding of the ways social ideologies can influence the identity and life-course of infertile women, the current literature was found to be overwhelmingly medical in focus, centred on the concept of Assisted Reproductive Technologies. This article aims to expand narrow discourses on female infertility by exploring women’s support needs and the socio-political impacts on their experience. It extends the interdisciplinary knowledge base in this area by considering the contributions social work can make in addressing these systemic factors.

Medical-biological and social significance of female infertility

2020 ◽  
pp. 29-38
Author(s):  
Essedulla M. OSMANOV ◽  
Aleksey Yu. PROKOPOV
Keyword(s):  
Birth Rate ◽  
Family Income ◽  
Assisted Reproductive Technologies ◽  
Pension System ◽  
Reproductive Technologies ◽  
Female Infertility ◽  
High Rate ◽  
Sexual Life ◽  
Social Significance ◽  
Demographic Situation

As a result of the decline in the population, Russia has faced a number of economic and social problems related to the reduction of the working-age population, as well as the need to reform the existing pension system, one of the measures aimed at improving the demographic situation is the increase in the birth rate. The aim of the study is to study the medical, biological and social significance of female infertility on the basis of a literary review. The results of the review showed a high level of infertility both in Russia and around the world. Among the main medical and biological risk factors for female infertility are the high prevalence of harmful habits, the earlier age of entry into sexual life of the high rate of sexually transmitted infections, gynaecological incidence, the high rate of abortion, the postponement of the birth of children to an older age. Social factors include low family income, poor quality of life, poor relationships with spouses and dissatisfaction with sexual intimacy. The increase in the number of families with infertility indicates an increasing need for assisted reproductive technologies. In developed countries, assisted reproductive technologies produce between 0.4 and 4.0 % children. In Russia, 160836 children were born with assisted reproductive technologies from 2007 to 2013, and the contribution of assisted reproductive technologies to annual fertility increased almost 40 times (from 0.04 to 1.55 %). The conclusion: the restoration of women's reproductive health is one of the promising directions in raising the birth rate and restoring the demographic situation.

scholarly journals A Case-Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria)

2015 ◽  
Vol 6 (3) ◽  
pp. 103-107 ◽  
Author(s):  
Hichem Abdessalem MAÏ ◽  
Abbassia Demmouche
Keyword(s):  
Body Mass Index ◽  
Confidence Interval ◽  
Body Mass ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Female Infertility ◽  
Prevalence Of Obesity ◽  
Control Study

ABSTRACT Introduction The prevalence of obesity and female infertility in Algeria has increased in past decades, and recent study are showing a relationship between body mass index (BMI) and the risk of female infertility, suggesting that obesity is a risk factor for infertility. In order to evaluate the risk of infertility associated with BMI, we conducted a case-control study. Materials and methods The relationship between BMI and female infertility was investigated in a case-control study of 256 infertile cases and 326 fertile control subjects. The BMI of infertile women was compared with the BMI of the control fertile group. Odds ratios (ORs) was calculated as measures of relative risk of infertility associated with BMI. Results Multiple analyses showed significant association between various measures of BMI and female infertility in this population. An association between BMI and infertility was observed for the overweight (25.00–29.99 kg/m2; odds ratio = 2.23; p = 0.021; 95% confidence interval, 1.52–3.25) and obese group (> 30 kg/m2; odds ratio = 3.26; p = 0.019; 95% confidence interval, 1.62–6.58) compared to the normal weight group. However, no association was found between underweight and infertility (BMI < 20 Kg/m2, odds ratio = 0.96; p = 0.063; 95% confidence interval, 0.57–1.63). Conclusion The present study confirms the results that the previously reported research have shown and affirm that an negative association exist between obesity and overweight with fertility, this association might be influenced by other factors, that's why larger and more research in the Algerian population are needed. How to cite this article MAÏ HA, Demmouche A. A Case-Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria). Int J Infertil Fetal Med 2015;6(3):103-107.

scholarly journals Effects of Hepatic Expression of the High-Density Lipoprotein Receptor SR-BI on Lipoprotein Metabolism and Female Fertility

Endocrinology ◽  
2006 ◽  
Vol 147 (4) ◽  
pp. 1577-1588 ◽  
Author(s):  
Ayce Yesilaltay ◽  
María Gabriela Morales ◽  
Ludwig Amigo ◽  
Silvana Zanlungo ◽  
Attilio Rigotti ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Assisted Reproductive Technologies ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Reproductive Technologies ◽  
High Density ◽  
Female Infertility ◽  
Female Fertility ◽  
Wild Type ◽  
Human Female

The etiology of human female infertility is often uncertain. The sterility of high-density lipoprotein (HDL) receptor-negative (SR-BI−/−) female mice suggests a link between female infertility and abnormal lipoprotein metabolism. SR-BI−/− mice exhibit elevated plasma total cholesterol [with normal-sized and abnormally large HDL and high unesterified to total plasma cholesterol (UC:TC) ratio]. We explored the influence of hepatic SR-BI on female fertility by inducing hepatic SR-BI expression in SR-BI−/− animals by adenovirus transduction or stable transgenesis. For transgenes, we used both wild-type SR-BI and a double-point mutant, Q402R/Q418R (SR-BI-RR), which is unable to bind to and mediate lipid transfer from wild-type HDL normally, but retains virtually normal lipid transport activities with low-density lipoprotein. Essentially wild-type levels of hepatic SR-BI expression in SR-BI−/− mice restored to nearly normal the HDL size distribution and plasma UC:TC ratio, whereas approximately 7- to 40-fold overexpression dramatically lowered plasma TC and increased biliary cholesterol secretion. In contrast, SR-BI-RR overexpression had little effect on SR-BI+/+ mice, but in SR-BI−/− mice, it substantially reduced levels of abnormally large HDL and normalized the UC:TC ratio. In all cases, hepatic transgenic expression restored female fertility. Overexpression in SR-BI−/− mice of lecithin:cholesterol acyl transferase, which esterifies plasma HDL cholesterol, did not normalize the UC:TC ratio, probably because the abnormal HDL was a poor substrate, and did not restore fertility. Thus, hepatic SR-BI-mediated lipoprotein metabolism influences murine female fertility, raising the possibility that dyslipidemia might contribute to human female infertility and that targeting lipoprotein metabolism might complement current assisted reproductive technologies.

Sign in / Sign up

Export Citation Format

Share Document