scholarly journals High Myostatin Serum Related with High Prevalence of Sarcopenia Among Elderly Population in Pedawa Village, Bali, Indonesia

2019 ◽  
Vol 11 (3) ◽  
pp. 293-8
Author(s):  
I Gusti Putu Suka Aryana ◽  
I Nyoman Astika ◽  
Raden Ayu Tuty Kuswardhani ◽  
Ida Bagus Putu Putrawan ◽  
Ni Ketut Rai Purnami ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Muscle Growth ◽  
Sampling Technique ◽  
Prevalence Ratio ◽  
Serum Levels ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Significant Difference

BACKGROUND: Sarcopenia is defined as a decrease in muscle mass accompanied by a decrease in muscle strength and performance. Sarcopenia arises from the disruption of the complex balance between anabolic and catabolic factors. Myostatin strongly influences muscle growth inhibition. Deletion and function loss of myostatin causes hyperplasia and skeletal muscle hypertrophy.METHODS: This study was an analytical cross-sectional study. Seventy respondents aged ≥60 years in Pedawa Village, Bali, Indonesia were selected by using the stratified random sampling technique. Sarcopenia status was assessed according to Asian Working Group for Sarcopenia (AWGS) criteria, including muscle mass, grip strength, and walking speed. While the myostatin serum levels was measured by enzyme-linked immunosorbent assay (ELISA).RESULTS: The incidence of sarcopenia in the elderly was 45 people (64.3%). Based on the analysis, there was a significant difference between myostatin levels in sarcopenia subjects (47.59 ng/mL) and non-sarcopenia subjects (39.7 ng/mL). Based on the statistical calculations, it was determined that the cut-off range of myostatin levels was 48.91 ng/mL. The prevalence ratio of sarcopenia incidence based on the myostatin levels in the elderly was 3.84, while based on the combination of age risk and myostatin levels was 9.75.CONCLUSION: Based of the data, there are significant differences of myostatin level between elderly people with and without sarcopenia. The prevalence of high myostatin levels in elderly is almost 4 times higher than low myostatin levels in the elderly.KEYWORDS: myostatin, sarcopenia, elderly

scholarly journals Sero-Epidemiological Study of Hepatitis E Virus among Thalassemia as High Risk Patients: A Cross-Sectional Survey in Jahrom, Southern, Iran

2016 ◽  
Vol 8 (9) ◽  
pp. 245 ◽  
Author(s):  
Abdolreza Sotoodeh Jahromi ◽  
Abbas Ahmadi-vasmehjani ◽  
Hassan Zabetian ◽  
Hossein Hakimelahi ◽  
Alireza Yusefi ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Age Groups ◽  
Serum Levels ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ig G

<p>Hepatitis E virus (HEV) could be cause of viral hepatitis in the developing countries and cause severe epidemics. According to other studies, blood transfusion as a probable route of HEV infection has been suggested. An infection with hepatitis agents such as HEV causes active liver failure in multi-transfusion patients in particular thalassemia. The purpose of this study determines the seropositivity of anti-HEV antibodies in thalassemia individuals in Jahrom. In a cross-sectional study, sera from 110 thalassemia were collected between 2013 and 2014. Enzyme-linked immunosorbent assay (ELISA) method was performed to detection of anti-HEV antibodies. Individuals’ data were collected such as, demographic and clinical, for statistical analysis. Our results show that 10% and 1.8% of the enrolled patients were HEV Ig-G and Ig-M positive antibodies respectively. In addition, there was statiscally significant difference in age groups for prevalence of anti-HEV Ig-G (P = 0.01). Also the serum levels of liver enzymes such as ALT and AST in the HEV Ig-G and Ig-M positive samples were significantly higher than anti-HEV negative samples. But there were no significant difference between sex and splenectomy with anti-HEV positive samples. The results indicate more study are needed to assess HEV screening of blood products to these patients that those have a probably risk of exposure to HEV especially in higher years old. </p>

scholarly journals Investigation of IL-17A Serum Levels in Patients with Nonmelanoma Skin Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Mehdi Ghahartars ◽  
Fatemeh Sedaghat ◽  
Elham Khajavi ◽  
Amir Ali Nejat ◽  
Mahyar Malekzadeh ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Nonmelanoma Skin Cancer ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Cross Sectional ◽  
Interleukin 17A ◽  
Significant Difference

Background. Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, some others suggest that it promotes the growth and development of different types of cancer including skin cancer by activation of STAT3. Although the function of the cytokines such as IL-17A has been extensively studied in various types of cancer, nonmelanoma skin cancer (NMSC) has not received much attention. Therefore, the present study was aimed to investigate the serum levels of IL-17A in NMSC patients. Methods. This cross-sectional study was performed on 60 patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) as well as 57 age-sex matched healthy individuals as control group. Measurement of IL-17A serum levels in both case and control groups was performed by a commercially reliable sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results. In this study, we observed that IL-17A serum levels in NMSC patients were significantly higher than the control group P < 0.001 . Also, both BCC and SCC patients had higher levels of IL-17A in their sera in comparison to the controls ( P = 0.001 and P < 0.001 , respectively). However, there was no significant difference between SCC and BCC patients regarding serum levels of IL-17A. Conclusion. According to our results, it can be concluded that IL-17A may play a role in inducing the growth and progression of NMSC and it can be used as a therapeutic target in these patients in future.

scholarly journals The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Moerbono Mochtar ◽  
Alamanda Murasmita ◽  
M. Eko Irawanto ◽  
Indah Julianto ◽  
Harijono Kariosentono ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Acne Vulgaris ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Severe Acne ◽  
Significant Difference ◽  
The Difference ◽  
Degrees Of Severity

Introduction. Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods. This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum. Result. Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. Conclusions. There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.

scholarly journals Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

2021 ◽  
Vol 43 (06) ◽  
pp. 429-435
Author(s):  
Elaine Cristina Rocha Pádua ◽  
Silvia Daher ◽  
Isa de Pádua Cintra Sampaio ◽  
Edward Araujo Júnior ◽  
Cristina Falbo Guazzelli
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Adiponectin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Pregnant Adolescents ◽  
Cross Sectional ◽  
Adolescent Group ◽  
Gestational Weight ◽  
Intergroup Comparison

Abstract Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation. Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison. Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239). Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

scholarly journals Prevalence of health services usage and associated factors in the Amazon region of Brazil: a population-based cross-sectional study

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017966 ◽  
Author(s):  
Maria Elizete A Araujo ◽  
Marcus T Silva ◽  
Tais F Galvao ◽  
Mauricio G Pereira
Keyword(s):  
Health Services ◽  
Associated Factors ◽  
Prevalence Ratio ◽  
The Elderly ◽  
Population Based ◽  
Cross Sectional Study ◽  
Metropolitan Region ◽  
Medical Attention ◽  
Cross Sectional ◽  
Physician Visits

ObjectivesTo estimate the prevalence of healthcare use and associated factors in the Manaus metropolitan region and to describe the reasons for lack of access.DesignCross-sectional population-based study.SettingA survey conducted between May and August of 2015 in eight cities from Manaus metropolitan region, Amazonas, Brazil.Participants4001 adults ≥18 years of age.Primary outcomes measuresPhysician visits, dentist visits and hospitalisations in the last 12 months were the primary outcomes. Associated factors were investigated through the calculation of prevalence ratio (PR) obtained by hierarchical Poisson regression modelling.Results4001 adults were included in the study, 53% of whom were women. The self-reported prevalence of medical visits was 77% (95% CI 75% to 77%); dentist visits, 36% (95% CI 34% to 37%) and hospital admission, 7% (95% CI 6% to 7%). Physician visits were higher in women PR=1.18 (95% CI 1.14 to 1.23), the elderly PR=1.18 (95% CI 1.10 to 1.26) and people with health insurance PR=1.14 (95% CI 1.10 to 1.19). Dentist visits declined with older age PR=0.38 (95% CI 0.30 to 0.49), lower education level PR=0.62 (95% CI 0.51 to 0.74) and lower economic class PR=0.65 (95% CI 0.57 to 0.75). Hospitalisations were found to be twice as frequent for women than for men and three times as frequent among those who reported very poor health status. Among the individuals who did not receive medical attention in the previous 2 weeks, 58% reported lack of facilities or appointment unavailable and 14% reported lack of doctors.ConclusionWhile more than half visited the doctor in the last year, a lower proportion of people with socioeconomic inequities visited the dentist. Organisational and service policies are needed to increase equity in health services in the region.

scholarly journals Study of Maternal and Fetal Outcome among Booked and Unbooked Patients at tertiary Hospital

2020 ◽  
Vol 5 (2) ◽  
pp. 1027-1030
Author(s):  
Shanti Sunuwar Subedi ◽  
Rakina Bhansakarya ◽  
Sajjan Kumar Sharma
Keyword(s):  
Sampling Technique ◽  
Secondary Level ◽  
Tertiary Hospital ◽  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Spontaneous Vaginal Delivery ◽  
Significant Difference ◽  
The Difference

Introduction: To evaluate the maternal and perinatal outcome in booked and unbooked cases. Objectives: To assess the maternal and fetal outcomes in unbooked and booked patients. Methodology: This was a cross-sectional comparative study conducted in the Department of Obstetrics and Gynecology from Augustti2019 to January 2020. Using a convenient sampling technique, 204 samples were taken and cross-sectional study was done. Results: There were total 204 cases in this study;102were booked and 102 were unbooked. In this study, 85(83%) of booked cases were educated up to secondary level as compared toti65 (64%) of unbooked cases. There was no significant difference in Apgar score in 1 and 5 minute between booked and unbooked cases. More babies in the unbooked group were transferred to NICU as compared to the booked group and the difference was significant (9.8%vs 1.9%). Greater proportion of booked cases had spontaneous vaginal delivery (81.3% vs 59.8%) and complications like preterm delivery, anemia, preeclampsia/ eclampsia, complicated labor and puerperal sepsis was also less in the booked group. Conclusions: The study showed that unbooked mothers and their newborns had higher chance of having complications.

scholarly journals Prevalence of anxiety disorder among workers with cancer in Amman, Jordan

2020 ◽  
Author(s):  
Abdel Rahman Aref Ali Abu Shreea ◽  
Lee Khuan ◽  
Sharifah Norkhadijah Syed Ismail ◽  
Nasrudin Subhi ◽  
Sobuh (Moh’d Sobhi) Ahmad Abu-Shanab ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Marital Status ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Sample Population ◽  
Cross Sectional ◽  
Long Term Conditions ◽  
Cancer Data ◽  
Patients With Cancer ◽  
Significant Difference

AbstractIntroductionCancer is now being recognised as a long term conditions due to advances in treatments that increase the survival rate of patients with cancer to as long as 10 years from the time of the disease. Anxiety is among the commonly discovered psychiatric illness in patients with cancer and is often neglected. Approximately 10% of patients with cancer are affected with anxiety worldwide. Hence, this study was aimed to determine the prevalence of anxiety disorder and its associated factors among workers with cancer in Jordanian population.MethodsA cross-sectional study was conducted at the King Husain Cancer Centre (KHCC) in Amman, Jordan. Proportional sampling technique was used to obtain the sample population of 355 workers with cancer. Data were collected through self-administered Generalized Anxiety Disorder (GAD-7) questionnaire and analyses were carried out using SPSS version 25.ResultsResponse rate of 100% were obtained from the participants. Prevalence of anxiety disorder among workers with cancer was recorded at 20.8% with male (23.1%) having the higher prevalence rate than female (17.3%) workers with cancers. A significant difference in anxiety between marital status (p=0.025), types of cancer (p=0.001), treatment types (p=0.024) were observed. A multiple regression was run to predict anxiety disorder from marital status, type of cancer and treatment types. These variables statistically significantly predicted anxiety disorder [F(3, 351) = 8.117, p < .001, R2 = 0.225].ConclusionThere is high prevalent of anxiety disorder among workers with cancer in Jordan. Predictors of anxiety among workers with cancer were also identified in this report.

scholarly journals Knowledge, Attitudes and Practice of Dental Implants among Dental Interns in Saudi Arabia – A Cross-Sectional Study

2020 ◽  
Vol 14 (1) ◽  
pp. 440-449
Author(s):  
Khaled Alzahrani ◽  
Abdulrahman Mohammed Alnafisah ◽  
Khalid Gohormallah Alzahrani ◽  
Khalid Ghalib Alharbi
Keyword(s):  
Saudi Arabia ◽  
Dental Implants ◽  
Clinical Skills ◽  
Sampling Technique ◽  
Practical Experience ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Significant Difference ◽  
Males And Females

Objective: The aim of the study is to assess knowledge, attitude and practices of dental implants among dental interns in Saudi Arabia Materials and Methods: A self-designed, close-ended questionnaire was distributed among 205 interns chosen by stratified random sampling technique. The questionnaire consisted of 28 items pertaining to demographic characteristics, knowledge and practices of dental implants. Responses were coded and entered into spreadsheet software (Microsoft Excel 16.0.) and analyzed using Statistical Package for Social Sciences (SPSS, IBM Version 22.0) and contingency tables and chi-square test (χ2). Results: The majority of the participants were males (64.4%), between 24-26 years of age (64%) and had a GPA between 4-5 (63.4%). The majority of the participants gained knowledge of dental implants through theoretical lectures (98.5%), and most of them (80%) knew, what material, an implant was made up of. Almost all participants (91.7%) knew that dental implants had surface modifications. Most (64.4%) believed that case selection is the most important criteria for the success of dental implant therapy, and this differed significantly among participants with respect to GPA (p=0.03). Many participants (60%) believed that the most important advantage of dental implants over fixed prosthesis is that reduction of adjacent tooth is not needed, and this differed significantly between males and females (p=0.026). There was a significant difference (p<0.001) between males and females when it came to confidence in independently restoring teeth using dental implants. 63% of the participants were confident to use dental implants in their future practice. Conclusion: Knowledge of dental implants among dental interns is satisfactory, but this study reveals that participants lack practical experience and would like to acquire more clinical skills. Limitations: The response rate of participants from each university was low, which made comparisons between different universities difficult because sample size from some universities was very small, which could not produce statistically accurate results.

scholarly journals Prevalence and risk factors for myopia among school children in Aba, Nigeria

2017 ◽  
Vol 76 (1) ◽  
Author(s):  
Uchenna C. Atowa ◽  
Alvin J. Munsamy ◽  
Samuel O. Wajuihian
Keyword(s):  
School Children ◽  
Refractive Error ◽  
Age Groups ◽  
Public Health Problem ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Level Of Education ◽  
Multi Stage ◽  
Significant Difference

Aim: To study the prevalence of myopia among school children in Aba, Nigeria.Methods: This cross-sectional study was conducted in public and private (primary and secondary) schools. A multi-stage random sampling technique was used for selecting participants aged between 8 and 15 years from 12 schools in Aba, Nigeria. Data were analysed for 1197 children who underwent a comprehensive eye examination. The children were divided according to the following criteria: age groups (group 1 [8–11 years] or group 2 [12–15 years]), gender (male or female), level of education (primary or secondary) and type of school (public or private). Myopia was defined as spherical equivalent refraction (SER) ≤ -0.50 D in the poorer eye.Results: The prevalence of myopia was estimated to be 2.7%. Of the 96 children with refractive error, 78.1% were uncorrected. In using logistic regression analysis, risk of developing myopia was associated with older age groups (odds ratio [OR]: 1.20; 95% confidence interval [CI], 0.16–9.11; p < 0.010) and higher level of education (OR: 1.73; 95% CI, 1.05–2.86; p < 0.030). There was no significant difference in myopia prevalence between male and female children (p = 0.89).Conclusion: Although the prevalence of myopia and overall prevalence of refractive error in school children in Aba were low, the high prevalence of uncorrected refractive error is a significant public health problem. An effective and sustainable children’s vision screening programme is needed to prevent visual impairment and blindness.

scholarly journals DIASTASIS RECTI AMONG PREGNANT AND POSTPARTUM WOMEN IN KANO, NIGERIA: A CROSS-SECTIONAL STUDY

2017 ◽  
Vol 6 (1) ◽  
pp. 15-20
Author(s):  
Fatima Bichi ◽  
Dr. Shumaila Hanif
Keyword(s):  
Post Partum ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Postpartum Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Common Location ◽  
Diastasis Recti ◽  
Significant Difference ◽  
The Difference

Diastasis Recti (DR) is a common muscular condition often present during and after pregnancy. This cross-sectional correlational study investigated the prevalence of DR among pregnant and postpartum women. A total of 250 pregnant and postpartum women were recruited using convenience sampling technique from obstetrics and gynaecology department, Aminu Kano Teaching Hospital, Kano, Nigeria. Age, body mass, height, BMI, parity, trimester, duration of DR postpartum, location of DR and DR status was recorded for each participant. Presence of DR was confirmed using the finger width method. Descriptive statistics of mean, SD, percentage were used to describe the data and determine the prevalence. Inferential statistics of Pearson’s and Spearman’s correlation were used to analyse the relationship between prevalence of DR and age, parity and duration of DR postpartum. Chi square was computed to determine the difference in prevalence of DR across trimesters. The result of this study indicated high prevalence of DR in post-partum and pregnant women (84% and 64.7% respectively); the most common location of DR was at the umbilicus in both pregnant and postpartum women. Prevalence of DR was high among the multigravida; and a significant relationship was found between prevalence of DR and age and parity of participants. There was a significant difference in prevalence of DR across the trimesters. It can be concluded that prevalence of DR among pregnant and postpartum women is high; age and parity are determinants of DR prevalence. Evaluation of DR should be considered as routine assessment in both pregnant and postpartum women.

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