scholarly journals Common pathogenesis of chronic tonsillitis and acute appendicitis

2020 ◽  
Vol 19 (3) ◽  
pp. 8-15
Author(s):  
V. V. Dvoryanchikov ◽  
◽  
V. G. Mironov ◽  
S. S. Pavlova ◽  
V. I. Podsvirov ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Streptococcus Pyogenes ◽  
Bacterial Flora ◽  
Clinical Analysis ◽  
Chronic Tonsillitis ◽  
Structural Components ◽  
Acute Tonsillitis ◽  
Palatine Tonsils ◽  
History Of ◽  
Common Pathogenesis

For many decades, the problem of chronic tonsillitis still does not lose its relevance. However, some aspects of the etiology and pathogenesis of chronic tonsillitis remain unexplored. This article presents the results of a study of the bacterial flora and structural components of the tissues of the palatine tonsils in chronic decompensated tonsillitis and appendix in patients with acute tonsillitis, as well as a comparison of some indicators of the general clinical analysis of peripheral blood in patients with these types of pathology. Chronic tonsillitis occurred in the history of patients with acute appendicitis in 78% of cases, which is ten times the frequency of its detection in the urban population. In all patients with acute appendicitis, palatine tonsil hypertrophy was detected, mainly of the III degree, as well as the presence of liquid or thick caseous pus in the gaps. In chronic decompensated tonsillitis, an increase in the seeding of the palatine tonsils of Streptococcus pyogenes occurs, and in acute appendicitis, Staphylococcus aureus and Streptococcus pyogenes appear on the background of Escherichia coli. Unidirectional changes in the areas of structural components of palatine tonsils in patients with chronic decompensated tonsillitis and appendix in patients with acute appendicitis were revealed. Based on the data obtained, we can assume the similarities and interconnections of the pathogenesis of chronic decompensated tonsillitis and acute appendicitis.

Immuno-morphological correlation of tonsillar pathology and acute appendicitis in children

2021 ◽  
Vol 19 (2) ◽  
pp. 37-42
Author(s):  
T. A. Mashkova ◽  
◽  
M. S. Sorokina ◽  
A. B. Mal’tsev ◽  
◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Humoral Immunity ◽  
Inflammatory Diseases ◽  
Morphological Changes ◽  
Abdominal Cavity ◽  
Chronic Tonsillitis ◽  
Palatine Tonsils ◽  
Abdominal Organs ◽  
Gender Characteristics ◽  
And Gender

The palatine tonsils and the appendix are components of mucosa-associated lymphoid tissue (MALT), namely the peripheral part of the immune system, which provides a protective barrier of mucous membranes against foreign antigens. Topographic and anatomical unity of the lymphoid apparatus of the pharynx and abdominal organs determine their direct lymphatic connection. Despite the progress achieved in the study of the etiology and pathogenesis of chronic tonsillitis and the pathology of the appendix, surgical treatment of these diseases remains the main one. The question of the influence of tonsillectomy and appendectomy on the state of humoral immunity remains controversial. The mechanisms of interaction of various links of humoral immunity in the formation of conjugated diseases of the lymphoid apparatus of the pharynx and abdominal cavity, namely, the palatine tonsils and the appendix, as well as statistical, clinical, immunological and morphological indicators concerning 940 patients with acute appendicitis at the age from 3 to 18 years old, who were undergoing treatment at the Kruglaya Multidisciplinary Center for the period from 2015 to 2018. The analysis of the statistical, seasonal, age and gender characteristics of the prevalence of acute appendicitis (AA), suggesting a connection with infectious and inflammatory diseases of the pharynx. Clinical cases showing the combination of tonsillar pathology and AA are presented. Based on the data obtained, similar immune-morphological changes in the palatine tonsils and the appendix were revealed during their inflammation, and the possible immune mechanisms of the pathogenesis of AA in tonsillar pathology were substantiated. Keywords: acute and chronic tonsillitis, complications, appendicitis.

scholarly journals Acute appendicitis as an unusual cause of invasive ductal breast carcinoma metastasis

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Vincent De Pauw ◽  
Julie Navez ◽  
Stephane Holbrechts ◽  
Jean Lemaitre
Keyword(s):  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Acute Appendicitis ◽  
Ductal Carcinoma ◽  
Hormonal Treatment ◽  
Locoregional Therapy ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
History Of ◽  
Anticancer Treatment

Abstract Acute appendicitis is one of the most common causes of abdominal pain at the emergency room. In rare cases, it can be caused by malignancy, even metastatic lesions from extra-abdominal neoplasia. Herein, we report a case of a 64-year-old female with a history of invasive ductal carcinoma of the breast treated by chemotherapy, surgery, radiotherapy and hormonotherapy, relapsing several years later as a bone and a pleura metastasis successfully cured by locoregional therapy and hormonal treatment. She presented with acute abdominal pain without signs of peritonitis. Abdominal computed tomodensitometry showed sign of appendicitis. Therefore, laparoscopic exploration and appendicectomy was performed. During surgery, multiple peritoneal nodules were found and harvested. Pathology showed metastatic nodules of invasive ductal breast carcinoma, including in the appendicular wall, concluding to peritoneal carcinomatosis. The postoperative course was uneventful, but the patient died 1 year later after refusing anticancer treatment.

scholarly journals Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183214 ◽  
Author(s):  
Katharina Geißler ◽  
Robby Markwart ◽  
Robert Pascal Requardt ◽  
Cynthia Weigel ◽  
Katja Schubert ◽  
...  
Keyword(s):  
T Cells ◽  
Functional Characterization ◽  
Chronic Tonsillitis ◽  
Palatine Tonsils

Acute appendicitis, an unusual presentation of Streptococcus pyogenes infection

2009 ◽  
Vol 27 (2) ◽  
pp. 254.e1-254.e2 ◽  
Author(s):  
Florence Dumas ◽  
Gerald Kierzek ◽  
Sophie Coignard ◽  
Anne Bouvet ◽  
Jean-Louis Pourriat
Keyword(s):  
Acute Appendicitis ◽  
Streptococcus Pyogenes ◽  
Unusual Presentation

Detection of Viruses: insides of antibody-antigen interactions and Multifunctional Lab-On-particle for SARS CoV-2 detection

Coronaviruses ◽  
2021 ◽  
Vol 02 ◽  
Author(s):  
Martin Amé ◽  
Esraa Samy Abu Serea ◽  
Ahmed Esmail Shalan ◽  
A. Guillermo Bracamonte
Keyword(s):  
Fast Response ◽  
Clinical Analysis ◽  
New Drugs ◽  
Detection Systems ◽  
Current State ◽  
History Of ◽  
Non Covalent Interactions ◽  
Genomic Factor ◽  
New Treatments ◽  
Covalent Interactions

: The design of new Drugs, Molecules, Nano-, and Microstructures for targeted applications along the pass of the time within the history of Chemistry and Clinical Analysis showed to be of high impact on Life Sciences. In this context, and mainly for the actual Corona Virus Pandemic status, it should be highlighted the importance of a fast response. Thus, the developments of differents approaches looking for improved and higher sensitive solutions in the Biodetection field accompanied with new treatments of SARS CoV-2 are required. In this way, in this short communication based on the latest Research publications it was afforded and discussed the following topics: i) the importance of non-covalent interactions from antibody-antigen recognition events, ii) the genomic factor, and iii) the use of non-covalent interactions in different Optical detection systems and Lab-On particles. Moreover, it was afforded the theme related with the importance of new treatments in progress, such development of new vaccines; and current state of the pandemic situation. So, it was discussed and stimulated the improvement of innovative Multifunctional Nanophotonic approaches intended for SARS CoV-2 detection accompanied with potential targeted treatments.

Immune-response against Streptococcus pyogenes in the development of abdominal aortic aneurysm – A population-based case-control study

VASA ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Wanhainen ◽  
Rasmussen ◽  
Björck ◽  
Björck
Keyword(s):  
Immune Response ◽  
Abdominal Aortic Aneurysm ◽  
Streptococcus Pyogenes ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Abdominal Aortic ◽  
History Of ◽  
Antibody Levels ◽  
Control Study

Background: In a population-based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, SclB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical). Results: Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with controls (0.25 vs 0.17, p = 0.021). A similar trend was observed in current GRAB antibody levels (0.23 vs 0.17, p = 0.072). GRAB-antibody levels at age 60 years retained the association with AAA in a logistic regression model after adjustment for a history of atherosclerosis (OR 20.2, p = 0.022), current smoking (OR 21.4, p = 0.025) and family history of AAA (OR 12.9, p = 0.053). Current and historical antibody levels against SclA and SclB in AAA patients were similar to those in controls. Conclusions: The results indicate that the immune response against S. pyogenes protein GRAB may be involved in the pathogenesis of AAA.

scholarly journals Association of Androgenetic Alopecia with Benign Prostatic Hyperplasia: A Case Control Study

2018 ◽  
Vol 16 (1) ◽  
pp. 17-23
Author(s):  
Manoj Kumar Chaudhary ◽  
Sudha Agrawal ◽  
Chandra Shekhar Agrawal
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Family History ◽  
Early Onset ◽  
Positive Family History ◽  
Prostatic Hyperplasia ◽  
Androgenetic Alopecia ◽  
Pelvic Ultrasonography ◽  
Increased Risk ◽  
History Of ◽  
Common Pathogenesis

Introduction: Androgenetic alopecia (AGA) is associated with increased risk of several systemic diseases and some environmental factors, however, controversies exist. Since AGA and Benign Prostatic Hyperplasia (BPH) share common pathogenesis and AGA manifests some decades before BPH onset, it may serve as an early marker of BPH.Objective: This study was conducted to know AGA and its association with BPH in men ≥20 years of age.Materials and Methods: Clinically diagnosed cases of AGA (n=176) and 117 age matched healthy controls were enrolled. All cases and controls were subjected for abdomino-pelvic ultrasonography, urinary flowmetry, fasting lipid profiles, glycemic index and body mass index. International Prostate Symptom Score (IPSS) was also assessed.Results: Among 176 patients, 120 (68.18%) had Hamilton-Norwood grade III AGA and 56 (31.82%) had grade IV-VII AGA. In both groups, 140 (79.55%) cases and 93 (79.49%) controls were aged <35 years respectively. Family history of AGA was present in 108 (61.36%) cases and 2 (1.71%) controls. This observation was statistically significant with OR= 89.61 (95%CI 23.67-339.29). Three (1.7%) cases and none of the controls had prostate volume >30ml. Seventeen(9.66%) cases and 4 (3.42%) controls were graded as moderately/severely symptomatic IPSS. Statistically significant association was seen between family history and early onset of hair loss (<35 years) in a male sibling or parent.Conclusion: Although positive family history was associated with early onset of AGA, no association between AGA and BPH could be elicited in our study.

scholarly journals Socio-anamnestic and clinical analysis of pregnant women with ulcerative colitis

2021 ◽  
Vol 25 (1) ◽  
pp. 65-69
Author(s):  
I. V. Oleksiienko
Keyword(s):  
Ulcerative Colitis ◽  
Health Care ◽  
Inflammatory Bowel Disease ◽  
Pregnant Women ◽  
Bowel Disease ◽  
Clinical Analysis ◽  
Chronic Inflammatory Bowel Disease ◽  
Care Providers ◽  
History Of ◽  
Inflammatory Bowel

Annotation. At the turn of the 21st century, chronic inflammatory bowel disease (CIBD) has become a global disease with accelerating morbidity in industrialized countries with a prevalence exceeding 0.3%. These data underscore the need for research into the prevention of inflammatory bowel disease and innovations in health care systems to manage this complex and costly disease. The information from a personal anamnesis of 40 women patients with ulcerative colitis (clinical group (main). In the second group (control), 30 practically healthy pregnant women with a physiological course of gestation were included, which did not have in their history of inflammatory intestinal diseases. Statistical processing of research results was performed using the software package Statistica 6.0. The arithmetic mean (M) and the standard deviation error (± m) (p<0.05) were determined, as well as the odds ratio (OR), confidence interval (CI) at p=95%. It was found that for women with ulcerative colitis is characterized by the presence of a history of obstetric pathology, such as: spontaneous miscarriage of OR 3.33, 95% CI [1.06-10.53], p=0.04 and blood secretions of OR 3.0, 95% CI [1.00-8.98], p=0.0496; among extragenital pathology in the anamnesis: children's infectious diseases of OR 4.85, 95% CI [1.25-18.85], p=0.02, chronic bronchitis of OR 7.54, 95% CI [1,56-36, 41], p=0.01, varicose veins OR 4.33, 95% CI [1.11-16.95], p=0.035, chronic gastritis OR 6.0, 95% CI [1,23-29, 31], p=0.03, anemia of OR 15.0, 95% CI [4.53-49.68], p<0.0001, allergy history of OR 6.65, 95% CI [1.73-25.60], p=0.006; among gynecological complications – premenstrual syndrome OR 6.0, 95% CI [1.55-23.15], p=0.009, algomenorrhea OR 8.14, 95% CI [2.12-31.24], p=0.002 , salpingo-oophoritis, OR 7.54, 95% CI [1.56-36.41], p=0.01. Because CIBD during pregnancy is associated with an increased risk of adverse effects on the mother and fetus, information on socio-anamnestic and clinical analysis of pregnant women with ulcerative colitis will be useful to health care providers in making decisions about CIBD during pregnancy.

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