scholarly journals Evaluation of the elastic properties of the arterial wall in young patients with arterial hypertension

2005 ◽  
Vol 11 (1) ◽  
pp. 17-20 ◽  
Author(s):  
G. I. Storozhakov ◽  
G. S. Vereshchagina ◽  
Yu. B. Chervyakova ◽  
N. M. Fedotova
Keyword(s):  
Arterial Hypertension ◽  
Elastic Properties ◽  
Peripheral Resistance ◽  
Young Patients ◽  
Vascular Wall ◽  
Control Group ◽  
Young Males ◽  
Ultrasound Study ◽  
Elasticity Module ◽  
Technical Simplicity

To study early impairments in the elastic properties of the vascular wall in arterial hypertension (AH), 32 hypertensive patients of young age (18,9±2,6 years) were examined, a control group comprised 35 healthy young males of the same age Doppler ultrasound study (DUSS) of the common carotid (CC), brachial, and radial arteries was performed and CC wall elasticity modules, aortic compliance, and pulse wave velocity (PWV) were estimated Analyzing the results of DUSS in patients with AH revealed no significant differences in velocity parameters and in the values of peripheral resistance The estimation of the elasticity module at rest and during functional tests demonstrated a less increment in this parameter in patients with AH during exercise than in the control group Elasticity module changes were heteiodirectional during nitroglycerine tests The estimation of PWV revealed a significant increase in this parameter, which was indicative of early impairments in the elastic properties of the vascular wall The high informative \ alue and technical simplicity permit the use of PWV as a screening of vascular wall lesion in patients with AH

Character of β-lymphocytes differentiation in women with hypertensive disorders during pregnancy

2021 ◽  
Vol 66 (8) ◽  
pp. 489-495
Author(s):  
I. A. Panova ◽  
A. V. Kudryashova ◽  
A. S. Panashchatenko ◽  
E. A. Rokotyanskaya ◽  
A. I. Malyshkina ◽  
...  
Keyword(s):  
B Cells ◽  
General Population ◽  
Arterial Hypertension ◽  
B Lymphocytes ◽  
Elastic Properties ◽  
Vascular Wall ◽  
Relative Content ◽  
Control Group ◽  
Hypertensive Disorders ◽  
B1 Cells

The aim of the work was to identify the features of B-lymphocyte differentiation in women with hypertensive disorders of various origins, to establish their relationship with indicators of the elastic properties of the vascular wall, and to develop additional diagnostic criteria for the severity of preeclampsia. We examined 193 women at 24-40 weeks of gestation. Of these, 39 women with chronic arterial hypertension, 35 women with preeclampsia that developed against the background of chronic arterial hypertension, 55 with preeclampsia. The control group consisted of 64 women without hypertensive disorders. To assess the elastic properties of the vascular wall, a sphygmographic attachment of the “Poly-Spectrum-8” hardware-software complex (“Neurosoft” Ivanovo) was used. The relative content of B-lymphocytes (CD19 + and CD20 +), regulatory B-cells (CD20 + IL-10 +), switched (CD19 + CD27 + IgD-) and non-switched (CD19 + CD27 + IgD +) memory cells, plasma cells (CD19 + CD20-CD38 +) in the general population of B-lymphocytes was assessed by flow cytometry on a FACSCantoII flow cytometer using the FACS Diva program. Statistical analysis was carried out using the programs “Statistica for Windows 6.0”, “Microsoft Excel 2010” and “MedCals”. All subjects with hypertensive disorders showed an increase in the stiffness of the arteries of the muscular and elastic types, the most pronounced in the groups of patients with PE, the maximum in women with CAH and associated PE. An increased level of B1-lymphocytes in the peripheral blood is also noted in all hypertensive disorders. There were revealed positive correlations of high strength between: the level of CD20 + cells and the velocity of pulse wave propagation through the arteries of the muscular type (PWVm) in all groups with hypertensive disorders; the content of B1 cells and PWVM in moderate preeclampsia; level emory B-cells and PWV in elastic-type arteries in women with CAH and associated PE. The ROC analysis of the relative content of B1 cells in the general population of B lymphocytes and the content of IL-10-producing cells in the population of CD20 + lymphocytes (Breg) in women with moderate and severe PE revealed criteria for the differential diagnosis of preeclampsia of varying severity. The presence of hypertensive disorders of various origins is accompanied by a decrease in the elasticity of the arterial vascular wall, which is most pronounced in patients with CAH and associated PE. These changes are largely correlated with the level of B cells. As additional criteria for determining the severity of PE, the relative content of B1 cells and IL-10-producing cells in the population of Breg CD20 + lymphocytes can be used.

Patients with arterial hypertension and abdominal obesity: Biochemical predictors of a violation of the elastic properties of the vascular wall

2019 ◽  
Vol 493 ◽  
pp. S300-S301
Author(s):  
K. Avdeeva ◽  
T. Petelina ◽  
L. Gapon ◽  
N. Musikhina ◽  
L. Zyrianova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Elastic Properties ◽  
Abdominal Obesity ◽  
Vascular Wall

scholarly journals BENEFITS OF VOLUMETRIC COMPRESSION OSCILLOMETRY FOR THE ASSESSMENT OF HEMODYNAMIC PARAMETERS IN PATIENTS WITH ARTERIAL HYPERTENSION

2013 ◽  
Vol 12 (2) ◽  
pp. 10-17
Author(s):  
L. V. Shpak ◽  
E. S. Galoshina
Keyword(s):  
Arterial Hypertension ◽  
Vascular Wall ◽  
Healthy People ◽  
Control Group ◽  
Hemodynamic Parameters ◽  
Simultaneous Reduction ◽  
Non Invasive ◽  
Wide Range ◽  
The Status ◽  
Stage 1

Aim. To compare the parameters of central and peripheral hemodynamics in healthy people and patients with Stage 1–3 arterial hypertension (AH).Material and methods. In total, 105 individuals were examined. The control group (CG) included 50 healthy people (25 women and 25 men; mean age 27,8±0,8 years) with optimal and normal levels of blood pressure (BP) (mean levels 118,5±1,6/71,82±1,2 mm Hg). The main group (MG) included 55 patients (41 women and 14 men; mean age 62,9±1,6 years) with systolo-diastolic AH: Stage 1 in 25 (mean BP levels 146,1±0,9/84,9±1,6 mm Hg), Stage 2 in 20 (164,4±1,8/95±2,1 mm Hg), and Stage 3 in 10 (189,6±10,6/92,6±6,3 mm Hg). The method of volumetric compression oscillometry (VCO) was used to assess a wide range of myocardial and hemodynamic parameters.Results. In AH patients, all AH phenotypes, vascular and cardiac parameters were increasing, with a simultaneous reduction in vascular wall distensibility, in parallel with the AH progression from Stage 1 to Stage 3. This indicated an increase in myocardial contractility, tone strain of arterial wall, and peripheral vascular resistance. From Stage 1 to Stage 3, the prevalence of hyper- and eukinetic cardiac hemodynamic types was decreasing, while the prevalence of mixed and hypokinetic types was increasing. The mixed hemodynamic type (a combination of hyper-, eu-, and particularly hypokinetic type characteristics) was considered as an incompletely developed disadaptive hypokinetic type.Conclusion. The VCO method is an effective, non-invasive way to simultaneously assess the status of multiple hemodynamic parameters in both healthy people and AH patients. A specific benefit of this method is the registration of lateral BP levels and identification of mixed (additional) hemodynamic type. 

scholarly journals The influence of autonomic nervous system and elastic properties of the aortic wall on arterial hypertension progression in patients after surgical correction of coarctation of the aorta

2016 ◽  
Vol 20 (2) ◽  
pp. 74
Author(s):  
Yu. S. Sinelnikov ◽  
E. N. Gasanov ◽  
E. N. Orekhova
Keyword(s):  
Arterial Hypertension ◽  
Elastic Properties ◽  
Aortic Wall ◽  
Surgical Repair ◽  
Coarctation Of The Aorta ◽  
Surgical Correction ◽  
Control Group ◽  
Healthy Children ◽  
Group I ◽  
Group Ii

<p><strong>Aim:</strong> To assess sensitivity of the baroreceptors and elastic properties of the aortic wall in patients who underwent surgical correction of coarctation of the aorta.<br /><strong>Methods:</strong> In this prospective cohort study focus was placed on the evaluation of baroreceptors function and elastic properties of the aorta in 26 young patients who underwent surgical repair of coarctation of the aorta by using end-to-end extended anastomosis (Group I). The evaluation data obtained was then compared with that of the control group consisting of 26 healthy children without any congenital heart defects (Group II).<br /><strong>Results:</strong> Follow-up period was 25 (21;30) months. The spontaneous sensitivity of baroreceptors varied between the groups and was significantly higher in Group I 11.6 (10.5;12.6) versus 8.8 (8.1;9.9) in Group II, p=0.01. The velocity of pulsatile blood flow was higher in Group I 7.7 (5.8;9) (m/s) -1 versus 5.9 (4.8;7.1) (m/s) -1 in Group II, with a statistically significant difference between them (p = 0.003). The elastic properties of the aortic wall in Group I also considerably differed from those in the control group.<br /><strong>Conclusion:</strong> A high baroreceptors sensitivity and aortic wall stiffness in patients after surgical repair of coarctation of the aorta are direct predictors of arterial hypertension progression. However, it is important to assess the influence of the stroke volume on the rate of arterial hypertension incidence in patients who underwent surgical repair of coarctation of the aorta.</p>

scholarly journals THE MECHANISM OF ENDOTHELIAL DYSFUNCTION FORMATION IN YOUNG PATIENTS WITH SPONDYLOGENIC VERTEBROBASILAR INSUFFICIENCY

2016 ◽  
pp. 28-32
Author(s):  
N. A. Nekrasova ◽  
E. L. Tovazhnyanskaya ◽  
N. V. Galinovskaya ◽  
A. N. Tsukanov
Keyword(s):  
Shear Stress ◽  
Endothelial Dysfunction ◽  
Vertebral Column ◽  
Young Patients ◽  
Duplex Ultrasound ◽  
Vascular Wall ◽  
Control Group ◽  
Vertebrobasilar Insufficiency ◽  
Endothelin 1 ◽  
Vertebrobasilar System

Objective: to determine the type of changes of shear stress in vessels of the vertebrobasilar system in patients of young age with spondylogenic vertebrobasilar insufficiency (SVI). Material and methods. We examined 131 patients (70 women and 61 men) aged 18-40 (average age was 29.8 ± 3.8) with manifestations of spondylogenic vertebrobasilar insufficiency associated with muscular reflex, neurovascular and radicular syndromes of osteochondrosis of the cervical part of the vertebral column. 25 healthy donors made the control group. All the patients underwent radiological examination of the cervical part of the vertebral column with functional probes, doppler and duplex ultrasound of vessels of the neck and arteries of the head with functional probes; we performed the detection of endothelin-1, nitric oxide (NO) of blood serum. The changes of the shear stress in vessels of the vertebrobasilar system were assessed analyzing the Stuart index (ISD), systolic and diastolic parameter. Results. It has been found that development of spondylogenic vertebrobasilar insufficiency is accompanied by signs of endothelial dysfunction (ED), which is characterized by increased concentration of endothelin-1 related to the reduction of active metabolite of nitrogen oxide - S-NO. One of the mechanisms of ED in this cohort of patients is changes of the shear stress. Conclusion. In order to predict the development of ED in patients with spondylogenic vertebrobasilar insufficiency, it is recommended to pay particular attention to the state of the vascular wall.

scholarly journals Prevalence of risk factors for arterial hypertension among draft age youth

2021 ◽  
Vol 18 (2) ◽  
pp. 88-93
Author(s):  
Basana V. Uvarovskaia ◽  
Mariia V. Mel’nik ◽  
Svetlana A. Kniazeva
Keyword(s):  
Risk Factors ◽  
Arterial Hypertension ◽  
Quantitative Description ◽  
Young Patients ◽  
Adult Life ◽  
Circulatory System ◽  
Control Group ◽  
Study Group ◽  
Working Age ◽  
Individual Program

Background. The currently observed diseases of the circulatory system getting younger, the increase in the incidence of arterial hypertension (AH) and the high mortality rate of men of working age in Russia are elements of one of the main medical and social problems. The identification of risk factors (RF) for the development of hypertension in young patients and the identification of the groups with the highest risk of cardiovascular events in their future adult life is aimed at preventing hypertension, early treatment initiation, increasing life expectancy and reducing mortality. Aim. To study the prevalence of the main modifiable RF associated with arterial hypertension among draft age youth. Materials and methods. The identification of RF, their qualitative, quantitative description, assessment and comparative analysis among men with normal and high blood pressure (BP) of varying degrees. Results. In the control group without hypertension, 37.1% of the subjects did not have any RF; 48.6% of the surveyed each had one RF; 14.3% were persons with two RFs. There were no people identified with three or more RFs. In the study group with AH, 27.0% of patients did not have any RF; 37.4% of patients had one RF; 22.6% of patients with two RFs; 9.5% of patients with three RFs and 2.6% of patients had four RFs. The occurrence of each RF in the control group without hypertension and in the study group with hypertension as a whole is presented as follows respectively: overweight/obesity 37.1 and 59.1%; smoking 34.3 and 38.3%; alcohol abuse 0 and 2.6%; physical inactivity 8.4 and 12.2%; hypercholesterolemia 2.9 and 20.9%; hypertriglyceridemia 5.7 and 16.5%; hyperglycemia 5.7 and 5.2%. Conclusion. RF is widespread in young men, regardless of BP level. More than 60% of draft age youth without hypertension have at least one RF. Among all modifiable RFs, the highest frequency of occurrence is associated with increased weight and smoking. Overweight or obesity is always found in individuals with two or more RFs. Among men with hypertension, people with obesity, low physical activity and impaired lipid metabolism are more common than among men without hypertension. Risk assessment in draft age youth presents certain difficulties. Identification and assessment of risk factors will make it possible to develop an individual program for their modification, prevention of the development of hypertension and detection of the disease in the early stages.

scholarly journals Markers of endothelial dysfunction in adolescent and young patients with hypothalamic syndrome

2020 ◽  
Vol 17 (3) ◽  
pp. 257-268
Author(s):  
Lana K. Tsertsvadze ◽  
Marina V. Avdeeva ◽  
Larisa V. Scheglova ◽  
Vladimir S. Vasilenko
Keyword(s):  
Endothelial Dysfunction ◽  
Functional State ◽  
Clinical Laboratory ◽  
Young Patients ◽  
Vascular Wall ◽  
Control Group ◽  
Functional Changes ◽  
Hypothalamic Syndrome ◽  
Wall Stiffness ◽  
Group 2

Background: Endothelial dysfunction is the first but reversible stage of atherosclerosis. A change in the functional state of the vascular endothelium, especially of a growing organism, can be the basis for the development of many diseases in adulthood. The study of the structural and functional state of peripheral vessels of adolescents with hypothalamic syndrome is extremely important for understanding of the mechanisms of formation of cardiometabolic risks.Aims: to compare the structural and functional state of the vascular wall of young men with hypothalamic syndrome and constitutionally exogenous obesity.Methods: During the study 360 males were examined (average age 21.27±2.44 years) and divided into 3 groups: group 1 -with hypothalamic syndrome (n=242); group 2 - with constitutionally exogenous obesity (n=98); control group - practically healthy individuals (n=20). Hypothalamic syndrome was verified in the presence of a symptom complex, including obesity and pink striae. Cross-group comparative analysis of results of clinical, laboratory and instrumental examination was carried out.Results: In the group of patients with hypothalamic syndrome, endothelium-dependent vasodilatation (9.44±1.26 versus 10.37±1.21%; p=0.001) and endothelium-independent vasodilatation (10.29±1.28 versus 11.29±1.14%; p=0.001) is worse than in the group of patients with constitutionally exogenous obesity, and the rate of endothelium-dependent vasodilatation is lower than the generally accepted norm. In addition, among patients with hypothalamic syndrome, the stiffness of the vascular wall is higher than among patients with constitutionally exogenous obesity (15.47±2.58 versus 13.24±3.84%; p=0.001). Statistically significant correlations were revealed between the structural and functional state of peripheral arteries and hemodynamic, hormonal, metabolic changes, and the level of C-reactive protein (p<0.05).Conclusions: The obtained data indicate a deterioration of endothelial function and an increase in vascular wall stiffness in obese patients, regardless of its etiology. The patients with hypothalamic syndrome have more pronounced structural and functional changes in the vascular wall are observed than patients with constitutionally exogenous obesity.

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