Efficacy of Whole Blood Transfusion as an Adjunct Therapy in Severe Cases of Haemolytic Anaemia in Cattle

2021 ◽  
Author(s):  
N.D. Shah ◽  
A.U. Bhikane ◽  
R.K. Jadhav ◽  
S.G. Chavhan
Keyword(s):  
Blood Transfusion ◽  
Haemolytic Anaemia ◽  
Whole Blood ◽  
Standard Treatment ◽  
Case Fatality ◽  
Rapid Improvement ◽  
Adjunct Therapy ◽  
Treatment Groups ◽  
Group A ◽  
Group B

Background: In view of common occurrence of haemoprotozoan infections leading to severe haemolytic anaemia and increased case fatality rate in cattle in study area the present investigation was planned to evaluate efficacy of whole blood transfusion as an adjunct therapy in severe cases of hemolytic anaemia in cattle. Method: Sixteen cattle suffering from one or other haemoprotozoan infections induced haemolytic anaemia and having haemoglobin values less than 5 gm/dl were randomly divided in to two treatment groups. Group A (n=8) cattle were treated with standard treatment of haemoprotozoan infection without blood transfusion while group B (n=8) cattle were treated with whole blood transfusion in addition to standard treatment for haemoprotozoan infections. Result: Clinical and haematological parameters revealed rapid improvement in group B cattle as compared to group A cattle. The survival rate was significantly higher in group B cattle (100%) as compared to group A cattle (62.5%). The haemoglobin and haematocrit values were also found significantly higher in group B as compared to group A at 12 hours as well as on 21st day post treatment. Thus, it is concluded that, whole blood transfusion could be used as an adjunct therapy to hasten clinical recovery and to increase the survivability in cattle suffering from severe haemolytic anaemia due to haemoprotozoan infections.

scholarly journals Effectiveness of Ponseti Versus Kite Method for the Management of Club Foot- A Quasi Experimental Trial

2021 ◽  
Vol 15 (6) ◽  
pp. 1871-1873
Author(s):  
Shabana Sharif ◽  
Rehan Ramzan Khan ◽  
Saima Riaz ◽  
Sajid Rashid ◽  
Zaigham Rasool Athar ◽  
...  
Keyword(s):  
Club Foot ◽  
Rapid Improvement ◽  
Treatment Groups ◽  
Experimental Trial ◽  
Score Difference ◽  
Pirani Score ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

Objective: To determine the effectiveness of ponseti versus kite method for the management of club foot among children. Methods: A quasi experimental trial was conducted to determine the most effective conservative method for managing idiopathic club foot. This study was carried out in District Head Quarter Hospital, Layyah. A total of 46 children (60 Feet) aged less than six months of both genders were included in this study using convenience sampling technique. The study sample was divided into Group A (Ponseti) and Group B (Kite). Each treatment group comprises of 30 feet. Patients were called for weekly follow up till ten weeks consecutively. At every follow-up visit, patients were assessed to check the improvement of deformity with the help of the Pirani scoring system for the foot. Pirani score difference was measured in both treatment groups from the baseline until the last follow-up interval until the 10th Week. Pirani score difference was measured in both treatment groups from the baseline until the last follow-up interval until the 10th Week. A greater negative value signified better correction. SPSS 23 was used for data entry and analysis. Results: Children's mean age in both treatment groups (A and B) was 10.83±4.59 and 10.20±4.75 weeks. At presentation mean Pirani score in both treatment groups (A and B) was 5.85±0.67 and 5.86±0.45, respectively, while at 10th follow up it was 1.42±0.39 and 2.35±0.54 for group A and group B, respectively. Conclusion: This study demonstrates that the Ponseti technique significantly improved the management of club foot as that of the Kites method. Ponseti's method is more effective in terms of rapid improvement in the involved group. Key words: Non operative Management, Idiopathic Club foot, Kites method, Ponseti method.

Survival of classic swine fever virus in hams made from the meat of pigs vaccinated with the PAV-250 strain and unvaccinated pigs

2019 ◽  
Vol 10 (3) ◽  
pp. 536-551
Author(s):  
Heidi Amezcua Hempel ◽  
María Salud Rubio Lozano ◽  
Eliseo Manuel Hernández Baumgarten ◽  
Pablo Correa Girón † ◽  
Oscar Torres Ángeles ◽  
...  
Keyword(s):  
Reference Strain ◽  
Clinical Signs ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Direct Immunofluorescence ◽  
Biometric Analysis ◽  
Treatment Groups ◽  
Group A ◽  
Group B ◽  
Group D

The study was to determine the presence of Classical Swine Fever virus (CSFv), in the meat of vaccinated pigs with the PAV-250 strain and then challenged using the same strain. Five treatment groups were established (each with four pigs). Group A: Pigs thatwere fed with processed hams from negative animals; Group B: Pigs that were fed with processed hams from commercial pigs inoculated with the ALD (reference strain) (titre of 104.0/ml); Group C: Pigs fed with processed hams from pigs infected with the virulent ALD strain (titre of 102.5/ml); Group D: Pigs fed with processed hams from pigs vaccinated with the PAV-250 strain and challenged with the ALD strain (titre of 101.1/ml); and Group E: Pigs fed with processed hams from pigs vaccinated with two doses of the PAV-250 strain and challenged with the ALD strain (negative). Blood samples were taken at d 1, 5, 10, 15 and 20 for biometric analysis. Groups B, C and D manifested clinical signs of CSFv: 40 °C temperature, anorexia, paralysis, vomiting, diarrhea, tremor, hirsute hair and cyanosis. Pigs were slaughtered and necropsies performed to identify lesions in tissues. Results of direct immunofluorescence testing of tissues were positive and the virus was recovered. Under these study conditions, it was found that CSFv resisted the cooking method at 68 °C for 40 min in hams from unvaccinated pigs, and that the virus was able to transmit the disease to healthy unvaccinated pigs, whereas the hams from the vaccinated animals did not transmit the virus.

High-Dose Cyclophosphamide and Dexamethasone in Paraquat Poisoning: A Prospective Study

1992 ◽  
Vol 11 (2) ◽  
pp. 129-134 ◽  
Author(s):  
J.H. Perriëns ◽  
S. Benimadho ◽  
I. Lie Kiauw ◽  
J. Wisse ◽  
H. Chee
Keyword(s):  
Prospective Study ◽  
Standard Treatment ◽  
Case Fatality ◽  
Fluid Replacement ◽  
High Dose ◽  
Serum Concentrations ◽  
Treatment Groups ◽  
Paraquat Poisoning ◽  
A Prospective Study ◽  
Urine Testing

Between March 1986 and March 1988, 47 consecutive patients, whose paraquat intoxication was confirmed by urine testing, were enrolled in a prospective study on the treatment of paraquat poisoning. Fourteen received a standard treatment regimen consisting of fluid replacement and oral absorbents, and 33 received high-dose cyclophosphamide and dexamethasone, in addition to standard therapy. The case fatality rate in both treatment groups (63 and 61%) was similar. In addition, all 26 patients whose paraquat serum concentrations were measured and who had a probability of survival of less than 65% according the survival curve of Hart et al. died, regardless of therapy. These included four in the cyclophosphamide/dexamethasone group and two in the standard treatment group who had prior survival probabilities between 50 and 65%. This indicated that the cut-off curve relating mortality and paraquat serum concentrations was similar in both treatment groups. High-dose cyclophosphamide/dexamethasone treatment is unlikely to improve the prognosis of paraquat poisoning.

scholarly journals Effect of certain haematinics on body weight and haemato-biochemical changes in laboratory mice

1970 ◽  
pp. 103-105
Author(s):  
M Jahan ◽  
N Ahmad ◽  
M Myenuddin
Keyword(s):  
Body Weight ◽  
Vitamin B12 ◽  
Biochemical Changes ◽  
The Body ◽  
Treatment Groups ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
Physiology Laboratory ◽  
Hb Concentration

A total of 24, six weeks old mice were used to study the body weight and haemato-biochemical changes following administering of different haematinics (CuSO4, FeSO4 and Vitamin B12). The experiment was performed in Physiology laboratory, Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, from February to March 2006. They were randomly assigned to one of four equal groups (n = 6). In addition to normal rat pellets Group A was supplemented with CuSO4 @ 0.6mg/mice/day orally, Group B with FeSO4 @ 1.2mg/mice/day orally, and Group C with Vitamin B12 (Cytamin®, Glaxo) @ 0.004mg/mice intramuscularly at every 7 days. Group D was considered as control and was also supplemented with rat pellets. Increased body weight was observed in all haematinic treated mice but group B had a significant (p < 0.05) higher weight gain compared to the control. TEC and PCV increased significantly (p < 0.05) in all the treatment groups compared to the control. Statistically insignificant (p > 0.05) increase in TLC was also recorded in all the treated groups. Hb concentration increased for all the treatment groups. The ESR values of the experimental mice were negligible in first hour. The serum transaminases (SGPT and SGOT) increased in all treated groups but the difference in group A was significant (p < 0.05) compared to the control. Blood urea was recorded significantly (P < 0.01) higher for group A and lower for group C compared to the control. This study can be helpful to study the effect of particular haematinic on animal especially on simple stomach animal and human being as mice is used as human and animal model. Key words: Haematinics, haemato-biochemical parameters, mice DOI = 10.3329/bjvm.v5i1.1325 Bangl. J. Vet. Med. (2007). 5 (1 & 2): 103-105

Telemedicine in the blood transfusion laboratory – remote interpretation of pre-transfusion tests

2007 ◽  
Vol 13 (7) ◽  
pp. 357-362 ◽  
Author(s):  
Marko Meža ◽  
Marko Breskvar ◽  
Andrej Košir ◽  
Irena Bricl ◽  
Jurij Tasič ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Expert Opinion ◽  
Reference Laboratory ◽  
Local Hospital ◽  
Telemedicine System ◽  
Visual Method ◽  
Routine Work ◽  
Group A ◽  
Group B ◽  
Remote Inspection

We have developed a telemedicine system for blood transfusion work, to supply the local hospital laboratory with an expert opinion from the central reference laboratory. The telemedicine system allows remote inspection and interpretation of pre-transfusion tests, which are performed by ID-cards (micro-tube gel technology). The system was installed at three blood transfusion laboratories in Slovenia, approximately 70 km apart. Validation of the telemedicine system was performed using 99 clinical cases selected randomly from routine work. Two groups of immunohaematology specialists participated. Group A ( n = 8) performed the read-out of the pre-transfusion tests on ID-cards by using the telemedicine system. Group B ( n = 2) then read the ID-cards independently using the standard visual method. All 98 final interpretations which were recorded using the telemedicine system were correct. We recorded 591 micro-tube read-outs of agglutination strength using the telemedicine system, of which 582 were correct. For comparison, we recorded 591 micro-tube read-outs using the standard visual method, of which 582 were correct. The validation proved that the telemedicine system was suitable for operational use.

Acute normovolemic hemodilution in total knee arthroplasty, a prospective study

2016 ◽  
Author(s):  
Jin Kyu Lee ◽  
Mi Ae Cheong ◽  
Choong Hyeok Choi
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Transfusion ◽  
Knee Arthroplasty ◽  
Allogeneic Blood ◽  
Acute Normovolemic Hemodilution ◽  
Allogeneic Transfusion ◽  
Group A ◽  
Total Knee ◽  
Normovolemic Hemodilution ◽  
Group B

Abstract Objective: In this prospective, randomized, controlled trial we sought to evaluate the effectiveness of acute normovolemic hemodilution (ANH) in terms of decreasing the need for allogeneic transfusion after conventional unilateral total knee arthroplasty (TKA). Summary of Background Data: TKA is often performed with an occlusive tourniquet, and thus, it could be considered ideally suited for ANH, because the chief benefit of ANH is red blood cell loss reduction and the shedding of whole blood perioperatively at lower hematocrit levels. Methods: Between January 2012 and May 2012, 40 consecutive patients scheduled to undergo elective, primary, cemented, unilateral TKA for knee osteoarthritis were enrolled. Patients were randomized to either a study (ANH) group (n=20) (Group A) or a control group (n=20) (Group B). Unit of allogeneic blood transfused was considered the primary outcomes. Results : In the ANH group, less allogeneic blood transfusion (6 units in Group A vs 15 units in Group B) was required after operation. Six patients, who required a transfusion in Group A received 1 unit of allogeneic blood. In contrast, 6 of 9 patients, who required transfusion in Group B, received at least 2 units of allogeneic blood (p&lt;0.05). There was no complication related to the methods of the protocol. Conclusions: ANH is likely to reduce postoperative allogeneic transfusion requirement in patients undergoing unilateral TKA. However, adjunctive strategies are required to further reduce allogeneic blood transfusion requirements.

Bisphosphonates and Osteonecrosis of the Jaw: Advantages of a New Schedule.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3590-3590
Author(s):  
Patrizia Zappasodi ◽  
Alessandro Corso ◽  
Marzia Varettoni ◽  
Catherine Klersy ◽  
Gianmatteo Pica ◽  
...  
Keyword(s):  
Median Time ◽  
Standard Treatment ◽  
Performance Status ◽  
Pathologic Fracture ◽  
Disease Status ◽  
Osteonecrosis Of The Jaw ◽  
Standard Group ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background: Bisphosphonates (Bi) have been proven to be effective in preventing or delaying skeletal complications in multiple myeloma (MM) with a significant improvement of the quality of life. The 2002 ASCO guidelines indicate that once initiated intravenous Bi should be continued until an evident substantial decline of performance status. Recently, osteonecrosis of the jaw (ONJ) has been reported as complication of intravenous Bi treatment, with an incidence ranging between 6 and 13% and a greater occurrence in patients (pts) receiving zoledronic acid (Zol) than in those treated with pamidronate (Pam). Aim. In this retrospective study we evaluated the incidence of ONJ and of skeletal related events (SRE) in a cohort of MM pts divided in two groups according to the schedule of administration of Bi; group A: monthly administrations until tolerated (standard), group B: monthly administrations during the first year and then every 3 months (reduced). Methods: One hundred and six MM pts (M: 63, F: 43) were included in this study: 51 pts received a standard treatment (group A) and 55 a reduced schedule (group B). Pam 90 mg i.v. was administered as a three hour infusion and Zol 4 mg i.v. as a 15 minutes infusion. SRE was defined as: pathologic fracture, radiation to bone, spinal cord compression with vertebral fracture, hypercalcemia. Results: No difference was found between the two groups concerning pts characteristics at the onset: age, sex, extension of bone disease, status of the disease (progressive or responsive). Twenty pts received only Pam, 42 only Zol and 44 pts Pam followed by Zol. The distribution of the different type of Bi was not different in the two groups. ONJ occurred in 7 pts (6.6%) with a significant difference between the two groups: 6 pts in standard schedule (11.7%) and 1 in the reduced (1.8%), p=0.01, after a median time of 22.8 months in group A, and 37.8 months in the case of group B. Four of out 7 ONJ occurred during the second year of treatment (12–24 months): that period resulted significantly related (p=0.000) to the occurrence of ONJ with respect to the others (24–38 months, 40–100 months). All ONJ occurred in pts treated with Zol alone (5 pts) or with Zol after Pam (2 pts), whereas no cases were observed in Pam alone pts (p= 0.005). The median number of infusions was 20 with comparable results in the two groups (20 in group A, 19 in group B). SRE was observed in 38 pts (35.8%): 16 pts in group A and 22 pts in group B without statistical difference (p=0.6), after a median time of 9.8 months. Conclusions: These results suggest that the reduced schedule of Bi is associated with a significant lower incidence of ONJ and, although the sample size is limited, the appearance of ONJ seems delayed with respect to the standard treatment. Moreover, the incidence of SRE is similar in the two groups. In conclusion, the reduced schedule, could be applied in order to combine the antiresorptive efficacy of Bi with a higher safety and a better compliance.

How growth parameters of sexed native Aseel chickens affected when fed with selenium supplemented diets during three growth phases

2017 ◽  
Author(s):  
Waseem Muhammad Zia ◽  
Anjum Khalique ◽  
Saima Naveed ◽  
Jibran Hussain
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth Parameters ◽  
Body Weight Gain ◽  
Control Diet ◽  
Growth Phases ◽  
Feed Conversion ◽  
Treatment Groups ◽  
Group A ◽  
Group B

In total, 240 three-weeks-old sexed birds (191.06±6.01g), 120 + 120 from Lakha, Mushki, Peshaweri and Mianwali varieties of local Aseel were used to determine the influence of selenium forms on growth during three growth phases. Birds were divided into four equal groups, 60 birds/variety (30 + 30 ), further subdivided into A, B and C treatment groups, 10 bids/treatment. Each group was allocated starter, grower and finisher diets. Group A was offered the diet supplemented with 0.3 ppm Se-enriched yeast and the diet of group B included 0.3 ppm sodium selenite, while group C was fed with un-supplemented control diet. Birds were maintained individually for 18 weeks. Feed intake was decreased, while, body weight gain, feed conversion ratio (FCR) and body weight gain were improved in males and females of Lakha, while best results detected in males during all growth phases in Se-enriched yeast fed groups. In conclusion, Se-enriched yeast had the positive effect in improving growth parameters of native Aseel.

scholarly journals Paper patching in traumatic perforation of tympanic membrane

2018 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Vinod Shinde ◽  
Sudeep Choudhary ◽  
Mayur Ingale ◽  
Paresh Chavan
Keyword(s):  
Tympanic Membrane ◽  
Standard Treatment ◽  
Tympanic Membrane Perforation ◽  
Spontaneous Healing ◽  
Medical College ◽  
Membrane Perforation ◽  
Group A ◽  
Inflammatory Drugs ◽  
Group B ◽  
Random Groups

<p class="abstract"><strong>Background:</strong> Traumatic perforations are not new for ENT surgeons. The dictum for treatment is to keep the ear dry and leave the tympanic membrane to heal by itself. Most of the time it heals completely, but if it does not, a tympanoplasty is required.</p><p class="abstract"><strong>Methods:</strong> 144 patients of traumatic tympanic membrane perforation, who reported in the outdoor patient department of Otorhinolaryngology, at Dr. D. Y. Patil Medical college, DPU, Pune, were divided in two random groups; Group A was treated with standard treatment while Group B was treated with patching of perforation as an adjuvant to standard treatment. A simple paper, (from the envelop of gel foam) was used for this procedure. The standard taught and performed treatment for a tympanic membrane perforation is administering antibiotics, antihistaminic and anti-inflammatory drugs and keeping the ear dry; leaving the perforation for spontaneous healing.  </p><p class="abstract"><strong>Results:</strong> Group A 75% perforations had healed while in Group B 97.22% perforations healed completely.</p><p class="abstract"><strong>Conclusions:</strong> Paper patching supports the healing tympanic membrane and significantly improves the chances of spontaneous healing thus reducing the requirement of surgical intervention.</p>

scholarly journals Combining 10% propolis with carbonated hydroxyapatite to observe the RANKL expression in a rabbit’s alveolar bone

2020 ◽  
Vol 53 (4) ◽  
pp. 212
Author(s):  
Nungky Devitaningtyas ◽  
Ahmad Syaify ◽  
Dahlia Herawati
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Rankl Expression ◽  
Carbonated Hydroxyapatite ◽  
Treatment Groups ◽  
Group A ◽  
Group B ◽  
Post Hoc ◽  
Regenerative Periodontal Treatment ◽  
Open Flap Debridement

Background: Periodontitis causes an increased receptor activator level in the nuclear factor-κβ ligand (RANKL), which is one of the inflammatory mediators that plays a role in osteoclastogenesis. The open flap debridement (OFD) technique is the preferred treatment when accompanied by regenerative periodontal treatment using guided tissue regeneration (GTR) and guided bone regeneration (GBR). Carbonated hydroxyapatite is a GBR material that serves as a scaffold and has strong osteoconductive properties for bone regeneration. Propolis is natural product that can decrease osteoclastogenesis in periodontitis by decreasing the RANKL expression. Purpose: To investigate the RANKL expression after open flap debridement by applying carbonated hydroxyapatite to 10% propolis in the alveolar bone of rabbits. Methods: Nine induced-periodontitis rabbits (Oryctolagus cuniculus) were divided into three treatment groups of Group A OFD, Group B OFD followed by the application of carbonated hydroxyapatite, and Group C OFD followed by application of 10% propolis-carbonated hydroxyapatite. Each group was selected one to euthanised on the seventh, 14th and 28th day, respectively, and prepared using histology slides. The data was analysed using a two-way ANOVA followed by a post-hoc LSD test (p<0.05). Results: The RANKL expression in each group showed significant differences (p=0.00; p<0.05) on the seventh, 14th and 28th day. The post-hoc LSD test showed that the RANKL expression in the treatment group with carbonated hydroxyapatite-10% propolis had significant differences (p<0.05) in the intergroup analysis at different time points. Conclusion: Combining 10% propolis with carbonated hydroxyapatite in OFD treatment can decrease the RANKL expression in a rabbit’s alveolar bone.

Sign in / Sign up

Export Citation Format

Share Document