scholarly journals ASSESSMENT OF THE CARCINOGENIC RISK FOR THE POPULATION OF ULAN-UDE

2019 ◽  
Vol 98 (1) ◽  
pp. 90-93 ◽  
Author(s):  
N. V. Efimova ◽  
S. S. Khankharev ◽  
Vladimir R. Motorov ◽  
E. V. Madeeva

Introduction. Oncological pathology has a high medical and social significance, so it is important to study the conditions of its formation. The aim of the study was to evaluate the cumulative carcinogenic risk for the population of the administrative center of the Republic of Buryatia (Ulan-Ude). Material and methods. The identification of the carcinogenic hazard caused by the entry of chemical ingredients into the ambient air was carried out in 2005-2015. The exposure assessment is based on long-term average annual concentrations of carcinogens in the air, drinking water, food. Indices of comparative carcinogenic hazard (HCR) and individual carcinogenic risk (ICR) are calculated. Results. The huge engineering enterprises are sources of several substances with carcinogenic effects (formaldehyde, chrome VI, cadmium, niсkel, epichlorohydrin, etc.).The individual carcinogenic risk for residents of Ulan-Ude is included in the range unacceptable for the general population. The main pathway for chemical agents to enter the body is inhalation (79%). The greatest contribution to the total individual carcinogenic risk on admission from the air was made by formaldehyde, chromium VI and Benz(a)pyrene. Priority carcinogens coming from drinking water and food are arsenic, cadmium, lead. Conclusion. Results of the assessment of individual carcinogenic risk in Ulan-Ude indicate an unacceptable level of the impact on the population. The assessment has a number of uncertainties, which determines the need to further improve the monitoring system for carcinogenic hazards.

2021 ◽  
Vol 100 (3) ◽  
pp. 188-195
Author(s):  
Valery N. Rakitskii ◽  
Yuriy I. Stepkin ◽  
Oleg V. Klepikov ◽  
Semyon A. Kurolap

Introduction. The high level of environmental pollution in industrial cities, including carcinogens, causes an unacceptable risk to public health. In this regard, a quantitative risk assessment is required to develop preventive measures to reduce it. The aim of the study was to assess the carcinogenic risk to the health of the population of an industrialized city, caused by the probable presence of carcinogens in the ambient air, drinking water of the centralized water supply system, and the soil of the residential area. Material and research methods. The laboratory control of the content of carcinogens in environmental objects of the city of Voronezh for 2017-2020 was used as the reference data. The carcinogenic risk was assessed under the provisions of Guideline R. 2.1.10.1920-04 “Guidelines for assessing the risk to public health when exposed to chemicals that pollute the environment.” Results. Taking into account the regional peculiarities of the composition of pollutant emissions into the atmospheric air, 1,3-butadiene (source - production of synthetic rubber) should be classified as priority carcinogens requiring systematic monitoring and measures to reduce emissions and, accordingly, concentrations in the surface layer of atmospheric air and chromium6+ compounds (the main source is an aircraft plant), which contribute 69.9-75.7% and 21.7-26.9%, respectively, to the total values of the individual carcinogenic risk, which exceeds the maximum permissible level (1 • 10-4). The carcinogenic risk from exposure to drinking water pollutants (halogenated organic substances) and soil (under the scenario of accidental ingestion by preschool children) is below the maximum permissible risk (1 • 10-4). Conclusion. It is necessary to pay attention to increasing the sensitivity of the applied laboratory control methods, expanding the list of controlled carcinogenic pollutants, improving the monitoring system of carcinogens, and implementing measures to reduce the carcinogenic risk associated with atmospheric air pollution.


2019 ◽  
Vol 98 (9) ◽  
pp. 997-1003 ◽  
Author(s):  
Lidia G. Konshina

Introduction. In recent years, the risk assessment methodology has become the leading tool for assessing the health of various groups of the population, allowing identifying priority negative environmental factors. Material and methods. There were explored 212 wells, including 150 in collective gardens and 62 in cottage settlements. The priority oral route of chemical intake into the body was studied. Results. Nitrates and arsenic compounds create the main non-carcinogenic risk in the sources of non-centralized water supply in the territory of the Municipal Settlement of the city of ekaterinburg. When using water from wells in cottage settlements levels of non-carcinogenic risks are significantly lower than non-carcinogenic risks in horticultural partnerships. Acceptable level of non-carcinogenic risk for children under 6 years are related with 17.4% of water sources in collective gardens and 25% of wells in cottage settlements; for adults - 60.8% and 93.8% respectively. The detected nitrate concentrations in individual wells of horticultural associations can create a high non-carcinogenic risk. The total individual lifetime carcinogenic risk, both in the water of collective gardens and in the water wells of cottage settlements ranges from 10-5 to 10-4 and, therefore, is at a low level, the greatest contribution is made by arsenic compounds. Discussion. In contrast to the earlier traditional assessment of drinking water quality, when the main substances for which the discrepancy was found to hygienic standards were manganese, nitrates, iron and silicon, in the assessment of water danger using the methodology of risk assessment, nitrates and arsenic come to the first place, with a much smaller role of manganese. The calculation of carcinogenic risks using age correction factors (ADAF) has increased the risk values calculated by the traditional method by almost 2 times. Summary Levels of non-carcinogenic risks when using water from wells in cottage settlements are significantly lower than non-carcinogenic risks in horticultural partnerships.


2019 ◽  
Vol 98 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Pavel F. Kiku ◽  
L. V. Kislitsyna ◽  
V. D. Bogdanova ◽  
K. M. Sabirova

Ntroduction. The assessment of water quality and safety of centralized water supply systems in the Primorsky Krai was carried out in order to assess hygiene levels of public health risks associated with drinking water from the distribution network. Material and methods. The data of laboratory studies on sanitary and chemical parameters in drinking water of the distribution network of the Primorsky region were used. Hygienic assessment of drinking water was carried out according to regulatory requirements, the effect of summation of biological effect was calculated. The work used methodological recommendations for calculating the index of chemical water pollution and the utility coefficient, as well as a guide for assessing the health risks of the population when exposed to chemicals of a non-carcinogenic and carcinogenic nature. Non-carcinogenic and carcinogenic risks were calculated for all potable water of centralized water supply based on the average daily intake dose and the reference dose of chemicals supplied with drinking water. The risk profile for carcinogenic and non-carcinogenic effects was achieved by comparing exposure levels with reference concentrations (safe) for human health. The risk profile for the combined effects of chemical compounds is based on the calculation of the hazard index (HI). A study on carcinogenic risk was carried out for substances that are identified as carcinogens according to the classification of an international agency for the study of cancer. For the analysis and statistical processing of information, the program "MS Excel" was used. Results. An assessment of the sanitary and epidemiological safety of centralized systems of domestic and drinking water supply in the region showed that the highest contribution to poor health is made by the content of arsenic, nitrates, iron, silicon, and petroleum products in drinking water. According to the values of hazard indices, the skin and mucous membranes, the central nervous system, the immune system, the endocrine system, the circulatory and digestive organs are exposed to adverse effects from chemicals in drinking water. The individual carcinogenic risk ranges from negligibly small to the upper limit of acceptable carcinogenic risk. Assessment of the potable water value indicator revealed a deficit situation in calcium, sodium, fluorine and general mineralization of water. The risk assessment for arsenic, tetrachlorethylene, and chloroform, which have carcinogenic properties and are the most important pollutants of drinking water, has shown that the individual risk levels for these substances are within the first and second ranges, which corresponds to the allowable and maximum allowable risk. Discussion. Arsenic concentration in adults was found to be not detected with risks greater than one, while for children, the non-carcinogenic risk from arsenic exceeded the level of safe exposure (HQ> 1), because children are more susceptible to toxic substances due to their relatively large volume of respiration and the rate of gastrointestinal absorption (due to greater permeability of the intestinal epithelium), and also due to the immature system of detoxification enzymes and a relatively lower rate of excretion of toxic chemicals. According to the level of non-carcinogenic risk for children, nitrates follow arsenic. Nitrates have a hypoxic effect, increasing the concentration of the irreversible form of hemoglobin - methemoglobin. The toxicity of nitrates is related to their transformation into the human body into nitrosamines. As a result, the child's organism responds more sharply than in adults to the presence of chemicals in the water. The general mineralization of drinking water is one of the integral index of the quality of drinking water. Calcium and magnesium deficiency can be an independent risk factor for the development of various diseases and manifest pathologies of the cardiovascular system: coronary heart disease, hypertensive disease, myocardial infarction, etc. The tap water is known to be is not overloaded with carbonates, since they can lead to spoilage of water pipes. Therefore, to enrich the water with calcium and magnesium, the technology of creating bottled water uses mineral additives, which means that such water can become an additional source of minerals. Conclusion. Sanitary and hygienic assessment of centralized systems of domestic and drinking water supply in the Primorsky Territory has shown that the quality of drinking water depends on the concentration of arsenic, nitrates, iron, silicon and petroleum products. It should be noted that with the daily use of water from the distribution network throughout life, the likelihood of developing harmful effects on the health of adults and children is insignificant.


2021 ◽  
Vol 27 (2) ◽  
pp. 315-337
Author(s):  
Dina Lončarić ◽  
Marina Perišić Prodan ◽  
Jasmina Dlačić

Purpose – Today's tourists are increasingly looking for an active, healthy and meaningful way to spend their time at a destination. The purpose of this study, therefore, is to determine the key dimensions of memorable tourism experiences (MTEs) that influence tourists' satisfaction with the vacation experience motivated by the beauty of nature and landscape, as well as the impact of satisfaction with vacation experience on behavioural intentions. Design – Using a structured questionnaire on pencil and paper, data were collected from a sample of 334 travellers who were citizens of the Republic of Croatia and whose primary motive for travel was to visit a natural attraction. Methodology/approach – The questionnaire adopted previously validated scales and was used to explore MTEs, satisfaction with the vacation experience and behavioural intentions. The hypotheses were empirically tested using partial least square structural equation modelling. Findings – The results show that not all MTE dimensions influence satisfaction with the vacation experience among tourists whose primary travel motive was the beauty of nature and landscape. Hedonism, refreshment, and involvement as MTE dimensions had a statistically significant influence on satisfaction with the vacation experience. In addition, satisfaction with the vacation experience had a statistically significant influence on several behavioural intentions, with the strongest influence on intention to recommend. Originality of the research – Tourists in nature-based destinations were found to exhibit specific behaviours, as not all MTE dimensions contribute equally to satisfaction with the vacation experience. This study extends the body of knowledge on tourism experience theory by empirically testing its premises on tourists motivated by the beauty of nature and landscape.


2020 ◽  
pp. 1-15
Author(s):  
Anna Bishop ◽  
Erica A. Cartmill

Abstract Classic Maya (a.d. 250–900) art is filled with expressive figures in a variety of highly stylized poses and postures. These poses are so specific that they appear to be intentionally communicative, yet their meanings remain elusive. A few studies have scratched the surface of this issue, suggesting that a correlation exists between body language and social roles in Maya art. The present study examines whether one type of body language (hand gestures) in Classic Maya art represents and reflects elements of social structure. This analysis uses a coding approach derived from studies of hand gesture in conversation to apply an interactional approach to a static medium, thereby broadening the methods used to analyze gesture in ancient art. Statistics are used to evaluate patterns of gesture use in palace scenes across 289 figures on 94 different vases, with results indicating that the form and angling of gestures are related to social hierarchy. Furthermore, this study considers not just the individual status of each figure, but the interaction between figures. The results not only shed light on how gesture was depicted in Maya art, but also demonstrate how figural representation reflects social structure.


2005 ◽  
Vol 48 (3) ◽  
pp. 743-768 ◽  
Author(s):  
MARTIN SIMPSON

This article examines the ‘republicanization’ of the Aveyron under the Third Republic, exploring issues of the practice and meaning of politics in this rural département. I look at the impact of the Republic's efforts to secularize education and ask on what grounds a département that emphatically rejected the secular/anti-clerical programme of the Republic could nonetheless eventually vote republican. This opens up questions of peasant understandings of politics. In particular I refer to the work of P. M. Jones who has written on this area, attributing republican success to the material benefits offered by the ‘milch-cow state’ and forceful administrative intervention. I argue that whilst the action of the Republic was significant, the success of the republicans rested on more than their ability to deliver local services. Republican politics in the Aveyron succeeded in redefining republicanism, arriving at an alternative conception of the Republic that was acceptable to the strongly Catholic and politicized electorate. We need to move away from any ideas of a single opportunist republicanism to realize that there were multiple conceptions of the Republic and a range of local republicanisms forged in relation to the circumstances of the individual French peripheries.


2019 ◽  
Vol 95 (6) ◽  
pp. 533-538 ◽  
Author(s):  
A. V. Skalny ◽  
Elena S. Berezkina ◽  
V. A. Demidov ◽  
A. R. Grabeklis ◽  
M. G. Skalnaya

The study of elemental status was carried out as a result of a multielement analysis of hair by ICP-MS within the framework of the Federal Program "National System of chemical and biological security of the Russian Federation, 2009-2014". This parameter is an index of the impact of the environment on the body. A total of 1,138 adult residents of the Republic of Bashkortostan (624 women and 514 men aged of25-50 years) were examined. The features of the element status of the adult population of the Republic were shown. The obtained data can be used as reference values of chemical elements in the hair of the adult population of the Republic of Bashkortostan.


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