scholarly journals ABNORMALITY IN LEARNING ON THE MODEL OF PARKINSON-LIKE SYNDROME: THE CORRECTABILITY BY THYMUS PEPTIDES

2018 ◽  
Vol 24 (6) ◽  
pp. 310-315
Author(s):  
A. G Korolev ◽  
A. V Novoseletskaya ◽  
N. M Kiseleva
Keyword(s):  
Parkinson’S Disease ◽  
Immune System ◽  
Wistar Rats ◽  
Peptide Drugs ◽  
Immune Systems ◽  
Avoidance Test ◽  
Early Stages ◽  
Memory Footprint ◽  
Male Wistar Rats ◽  
Bidirectional Interactions

In recent times the question of the bidirectional interactions of the neuroendocrine and immune systems is studied quite actively, its mechanisms offer the opportunity to allow for optimization the therapy of several diseases, including Parkinson’s disease. The purpose of this work is to study the influence of peptide drugs derived from the body’s immune system, the thymus, for the avoidance test conditioning, both in health and in the model of Parkinson-like syndrome. The work was performed on 80 male Wistar rats weighing 300-350 g. The injection of thymosin fraction 5 and thymalin to animals corrects clinical traits and behavioral dysfunctions caused by the singular injection of the neurotoxin. It also facilitates conditioned active evasion response in rats, which is especially noticeable at the early stages of memory footprint formation.

The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats

Toxicology ◽  
2018 ◽  
Vol 402-403 ◽  
pp. 1-8 ◽  
Author(s):  
Żaneta Broniowska ◽  
Joanna Ślusarczyk ◽  
Beata Starek-Świechowicz ◽  
Ewa Trojan ◽  
Bartosz Pomierny ◽  
...  
Keyword(s):  
Immune System ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
System Activity ◽  
Pituitary Thyroid Axis ◽  
Male Wistar Rats ◽  
Thyroid Axis

Evaluation of Neuroendocrine and Immunological Parameters in Animals Following Chronic Combined Exposure to Xenobiotics

2021 ◽  
pp. 47-51
Author(s):  
AI Smolyagin ◽  
IV Mikhaylova ◽  
EV Ermolina ◽  
AA Stadnikov ◽  
VM Boev
Keyword(s):  
Bone Marrow ◽  
Wistar Rats ◽  
The Body ◽  
Combined Exposure ◽  
Immune Systems ◽  
Cell Counts ◽  
Apoptotic Protein ◽  
Occupational Setting ◽  
Male Wistar Rats ◽  
Ifn Γ

Background: A high prevalence of chromium and benzene compounds in the environment associated with motor vehicle and industrial operations arouses interest in the study of these xenobiotics in a long-term experiment. The objective of this work was to analyze effects of a chronic combined exposure to chromium and benzene on the hypothalamic-pituitary-adrenocortical (HPA) and immune systems of male Wistar rats. Materials and methods: Eighty male Wistar rats were administered potassium dichromate and benzene with drinking water in doses equaling one maximum permissible concentration (MPC) during 135 days. The hypothalamus, pituitary gland, adrenal glands, thymus, and spleen were then studied using morphometric, histological, and electron microscopy methods. The streptavidin-biotin peroxidase method was used to determine the expression of pro-apoptotic protein p53 and anti-apoptotic protein bcl2. We also measured the body, thymus and spleen weights of animals, nucleated cell counts in the thymus, spleen, and bone marrow and evaluated the cellular composition of the spleen and bone marrow as well as spontaneous and concanavalin A-induced secretion of interferon gamma (IFN-γ), IL-4, IL-6, and IL-10 cytokines by splenocytes. Results: We established an adverse effect of the exposure on the HPA function expressed in the activation of its secretory activity, blocking the release of hypothalamic neuropeptides at the level of the neurohypophysis and leading to ultrastructural damage to the neurosecretory cells of the hypothalamus, pituitary adenocytes and adrenal cortical cells, as well as in an increase in the programmed death of thymocytes. We also observed a decrease in the thymus weight and thymocyte counts and a complex of structural and functional changes indicating the status of its accidental involution in the exposed rats. The revealed decrease in the splenocyte count in the experimental group was accompanied by an increase in the size of the white spleen pulp. An increase in the induced production of the main immunoregulatory cytokines IFN-γ and IL-4 by splenocytes was found. Conclusion: Our findings can be used to analyze impairments of the HPA and immune systems in workers with a chronic combined exposure to benzene and chromium compounds in the occupational setting.

scholarly journals Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats

2018 ◽  
Vol 43 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Limeng Wang ◽  
Zhihua Yang ◽  
Long Xu ◽  
Xiujie Pan ◽  
Xingyu Liu ◽  
...  
Keyword(s):  
Immune System ◽  
Wistar Rats ◽  
Acute Exposure ◽  
Male Wistar Rats

The beneficial effect of vanillin on 6-hydroxydopamine rat model of Parkinson’s disease

2020 ◽  
Vol 38 (5) ◽  
pp. 369-373
Author(s):  
Rasha Abuthawabeh ◽  
Amjad N. Abuirmeileh ◽  
Karem H. Alzoubi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beneficial Effect ◽  
Wistar Rats ◽  
Neurodegenerative Disorder ◽  
Striatal Dopamine ◽  
Intracerebral Injection ◽  
Protective Properties ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is related to neuroinflammation. Vanillin, which possesses both antioxidant, and anti-inflammatory properties, can be a candidate for neuroprotection in PD. Objective: This study was aimed to investigate the effects of vanillin on the 6-hydroxydopamine (6-OHDA) rodent model of PD. Methods: Male Wistar rats were administrated intraperitoneal (i.p) or oral vanillin at a dose of 20 mg/kg/day for 7 days that was started at three days before or seven days after intracerebral injection of 6-OHDA. The 6-OHDA-induced lesions were assessed behaviorally using the apomorphine rotation test, neurochemically via measuring striatal dopamine concentrations, and through immunohistochemistry. Results: Both oral and IP vanillin at three days before or seven days after 6-OHDA lesioning exhbited significantly lower tight contralateral rotations upon apomorphine challenge, and higher striatal dopamine concentrations. Conclusions: Vanillin seems to offer protective properties against 6-OHDA lesion via preserving striatal dopamine levels.

scholarly journals Oxidative stress and antioxidant status in rotenone induced rat models of Parkinson’s disease

2020 ◽  
Vol 11 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Suchitra Kavuri ◽  
Senthilkumar Sivanesan ◽  
Vijayaraghavan Rajagopalan
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Wistar Rats ◽  
Scientific Evidence ◽  
Antioxidant Properties ◽  
Treatment Modalities ◽  
Study Results ◽  
Male Wistar Rats ◽  
Antioxidant Markers

Parkinson disease (PD) is involved in the damage of neurons of the brain that secretes dopamine. Understanding the mechanisms involved in Parkinson's disease helps to develop effective management methods. Hence, the present work aimed to unravel to observe the variations, if any, in the parameters of oxidative stress and antioxidant markers between oral and ip rotenone-induced rat model of Parkinson’s disease. Male Wistar rats weighing between 250-300g were housed in solid bottomed polypropylene cages under strict veterinary supervision and maintained in rooms with 12hrs light / dark cycle. The randomly selected male Wistar rats were equally divided into four groups, with six rats in each group. The study results provide scientific evidence for marked changes in both the oxidative and anti-oxidant parameters, followed by the ip and po rotenone administration. It is the need of the time to consider the neuroprotective and antioxidant properties while developing the newer treatment modalities for the management of PD.

scholarly journals Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Napatr Sriraksa ◽  
Jintanaporn Wattanathorn ◽  
Supaporn Muchimapura ◽  
Somsak Tiamkao ◽  
Kamoltip Brown ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spatial Memory ◽  
Rat Model ◽  
Wistar Rats ◽  
Once Daily ◽  
Enhancing Effect ◽  
Neuron Density ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine

Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200–250 g, were orally given quercetin at doses of 100, 200, 300 mg/kg BW once daily for a period of 14 days before and 14 days after the unilateral lesion of right substantia nigra induced by 6-hydroxydopamine (6-OHDA). Their spatial memory was assessed at 7 and 14 days of treatment and neuron density was determined, malondialdehyde (MDA) level, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were evaluated at the end of the experiment. In addition, the activity of acetylcholinesterase (AChE) was also measured. It was found that all doses of quercetin enhanced spatial memory. Therefore, it is suggested that the cognitive-enhancing effect of quercetin occurs partly because of decreased oxidative damage resulting in increased neuron density.

scholarly journals Behavioral Evaluation of rotenone model of Parkinson’s disease in male Wistar rats

2020 ◽  
Vol 24 (2) ◽  
pp. 8-14
Author(s):  
dina hegab ◽  
Omyma Ahmed ◽  
Motamed Mahmoud ◽  
Amany Abdelhamid
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals BEHAVIORAL STUDIES OF WISTAR RATS IN ROTENONE INDUCED MODEL OF PARKINSON’S DISEASE

2017 ◽  
Vol 9 (10) ◽  
pp. 159
Author(s):  
Srimathi Priyanga K. ◽  
Vijayalakshmi K. ◽  
Selvaraj R.
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Treated Group ◽  
Behavioral Activity ◽  
Behavioral Abnormalities ◽  
Group I ◽  
Male Wistar Rats

Objective: The objective of the study was to determine the behavioral activities of Wistar rats induced with rotenone. Methods: Thirty-six male Wistar rats were taken for the study and divided into six groups of six rats each. Group-I is the vehicle-treated, Group–II animals were induced with rotenone (3 mg/kg/bwt) by i. p. Group-III were co-treated with rotenone and L-DOPA (10 mg/kg/bwt) orally, Group-IV were co-treated with rotenone and quercetin (25 mg/kg/bwt) orally, Group-V were co-treated with rotenone and hesperidin (50 mg/kg/bwt) orally, Group-VI were treated with rotenone, quercetin and hesperidin in the same dosage regime for 60 d. The behavioural tests, such as open field test, ladder climbing test and hanging wire test were performed. The biochemical parameters such as urea, creatinine and activities of ALT and AST were also analysed.Results: All data are expressed as the mean±SD. Disability was noted in the behaviour of rats induced with Parkinson’s disease (PD). The deficits in behavioral activity were significantly changed when compared with an induced group (p<0.001) and biochemical parameters due to rotenone were significantly (p<0.001) restored by co-treatment with quercetin and hesperidin.Conclusion: In our in vivo study, we have demonstrated the combination of quercetin and hesperidin to serve as neuroprotective compounds by improving the behavioral abnormalities and restoring the biochemical parameters. Hence, these powerful antioxidants may protect brain cells.

scholarly journals Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rosalía Hernández-Cervantes ◽  
Armando Pérez-Torres ◽  
Óscar Prospéro-García ◽  
Jorge Morales Montor
Keyword(s):  
Immune System ◽  
Wistar Rats ◽  
Trichinella Spiralis ◽  
Intestinal Parasites ◽  
Control Group ◽  
Prenatally Exposed ◽  
Mucus Production ◽  
Gestational Exposure ◽  
Male Wistar Rats ◽  
Marijuana Consumption

AbstractThe consequences of marijuana consumption during pregnancy and its effects on the function of the immune system have been little studied. Marijuana is one of the most consumed recreational drugs among pregnant women, and it is known that gestational exposure to marijuana can have serious effects on the offspring after birth. In this study, we challenged the immune system of Wistar rats by infecting them with the parasitic nematode Trichinella spiralis. A treatment group of these animals was prenatally exposed to the cannabinoid WIN 55,212-2; a control group was not exposed. At 5 days of infection, the treated animals were less effective in eliminating intestinal parasites; moreover, this effect was correlated with a deficiency in mucus production, lower recruitment of eosinophils in the duodenum, and a reduced percentage of Tγδ and NK cells. In conclusion, the gestational administration of the synthetic cannabinoid WIN 55,212-2 induces lasting changes to the function of the immune system against infection with T. spiralis in male Wistar rats, making them more susceptible to infection.

scholarly journals Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats

2003 ◽  
Vol 60 (6) ◽  
pp. 657-661 ◽  
Author(s):  
Maja Jurhar-Pavlova ◽  
Aleksandar Petlichkovski ◽  
Dejan Trajkov ◽  
Olivija Efinska-Mladenovska ◽  
Todor Arsov ◽  
...  
Keyword(s):  
Immune System ◽  
Ambient Temperature ◽  
Immunoglobulin G ◽  
Wistar Rats ◽  
Control Group ◽  
Immunoglobulin G Subclasses ◽  
Male Wistar Rats ◽  
Regulation Mechanisms ◽  
Experimental Group ◽  
Igg1 Level

The aim of our research was to examine changes in the immune system of the rats influenced by the elevated ambient temperature. Male Wistar rats were divided, into 2 groups and housed at 20 ? 2?C (n=64, control group) and 35 ? 1?C (n=74, experimental group), during precise timing of 1, 4, 7, 14, 21, and 30 days. All the animals were given food and water ad libitum, and were lighted during 12 hours per day. We have measured IgG, IgG1, IgG2a, IgG2b and IgG2c. The obtained results showed significant elevation in the level of IgG after 4 and 7 days (+32%), IgG2a after 7th (+88%), 14th and 21nd day (+110%), IgG2b after 14 days (+60%) at 35 ? 1?C compared with the control group at 20 ? 2?C. IgG1 level was not affected and IgG2c showed significant decrease after 21st day at 35 ? 1?C. In conclusion, during the elevated ambient temperature the immune system is activated as one of the regulation mechanisms in homeostasis and survival of the population.

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