scholarly journals In-vivo Evaluation of Anti-Coccidial Efficacy of Aqueous Extract of Allium sativum and Carica papaya in Experimentally Infected Broiler Chicks

2018 ◽  
Vol 16 (5) ◽  
Author(s):  
Udo EJ
Keyword(s):  
Aqueous Extract ◽  
Allium Sativum ◽  
Carica Papaya ◽  
Broiler Chicks ◽  
In Vivo Evaluation

Cerebral effect of optimized Allium sativum oil-loaded chitosan nanorods: GC-MS analysis and in vitro/in vivo evaluation

2020 ◽  
Vol 11 (6) ◽  
pp. 5357-5376
Author(s):  
Rabab Kamel ◽  
Abeer Salama ◽  
Nermine M. Shaffie ◽  
Nesma M. Salah
Keyword(s):  
Factorial Design ◽  
Allium Sativum ◽  
Biological Effects ◽  
In Vivo Evaluation ◽  
Promising Strategy ◽  
Ms Analysis

Two-level orthogonal factorial design was used to optimize GO-loaded chitosan nanorods. This study proves that the nanoencapsulation of GO is a promising strategy which overcomes its limitations and improves its biological effects.

scholarly journals In Vivo Evaluation of Jatropha curcas L (Euphorbiaceae) Leaves Acute and Subacute Toxicity in Mice

2018 ◽  
Vol 10 (2) ◽  
pp. 187-193 ◽  
Author(s):  
S. Sawadogo ◽  
S. D. Sanou ◽  
A. P. Dabiré ◽  
G. R. Belemtougri ◽  
L. Sawadogo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Jatropha Curcas ◽  
Histological Study ◽  
Significant Rise ◽  
Toxicity Study ◽  
High Dose ◽  
In Vivo Evaluation ◽  
Subacute Toxicity ◽  
Hematological Analysis

Jatropha curcas is a medicinal plant whose dead leaves are particularly used in arterial hypertension and diabetes treatment. The purpose of this study is to conduct an acute and subacute toxicity study of Jatropha curcas leaves aqueous extract (JCLAE) using OECD method. For acute toxicity, dose limits of 2000 and 5000 mg/kg were used. In subacute toxicity study 4 batches were constituted including a control batch that received distilled water for 28 days and the other 3 batches, JCLAE doses of respectively 200, 400, 800 mg/kg for the same duration. The LD50 was determined and the hematological, biochemical and histological parameters were analyzed in mice. The LD50 is greater than 5000 mg/kg. HDL-C is the only biochemical parameter that has experienced significant rise variation. Hematological analysis showed a decrease in mean platelet volume and Platelets number. The histological study revealed cases of hepatic cellular apoptosis and kidneys tubular necrosis among animals treated with highest dose. JCLAE is less toxic than Jatropha curcas leaves aqueous extract and high-dose JCLAE also has a moderate toxic effect on thrombocyte line and a protective effect on cardiovascular system.

scholarly journals Evaluation of Aqueous Extract of Alphonsea sclerocarpa for in vivo and in vitro Antidiabetic Potentials in Wistar Rats

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ravi Shankar N ◽  
Ram Kishore ◽  
Puranik SB
Keyword(s):  
Blood Glucose ◽  
Glucose Uptake ◽  
Aqueous Extract ◽  
Insulin Level ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Oral Glucose ◽  
In Vivo Evaluation

The purpose of current investigation was to investigate in vivo and in vitro anti-diabetic potentials of aqueous extract of Alphonsea sclerocarpa leaves against alloxan induced diabetes in albino rats. Two in vivo and one in vitro methods were performed for the evaluation of aqueous extract for antidiabetic activity. For in-vivo evaluation, diabetes was induced in albino rats by administering a single dose of alloxan. The study was designed to test the acute effect of aqueous extract of Alphonsea sclerocarpa (AEAS) to reduce blood glucose in OGTT. The chronic study of 21 days was performed against diabetic rats and blood glucose was determined at 1st , 7 th, 14th and 21st day. In chronic in vivo study, serum parameters insulin, urea, creatinine, total cholesterol, triglycerides, ALT and AST were also estimated at 21st day to determine the effects of aqueous and aqueous extracts on complications of diabetes mellitus. Glucose uptake by hemidiaphragm assay was performed to test the ability of extract to utilize glucose. In Oral Glucose Tolerance Test, standard glibenclamide and aqueous extract (200mg/kg and 400mg/kg) treated animals have shown significant reduction in blood glucose at 90 mins but at 120 mins. In chronic model the aqueous extract effectively reduced blood glucose levels (P<0.001) at 14th and 21st day of study in therapeutic groups and effect was comparable to that of standard. The extract could also significantly (P<0.001) reduce concentrations of SGOT, triglycerides, cholesterol and urea in serum and significantly (P<0.001) increased the insulin level in blood which proves beneficial effects of the extract in diabetes. The change in concentrations of SGPT and urea were less significant (P>0.01). The presence of extract in glucose uptake assay could significantly increase utilization of the glucose by rat hemidiaphragm. The aqueous extract of Alphonsea sclerocarpa possess significant antidiabetic properties against alloxan induced diabetic animals.

In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models

2008 ◽  
Vol 118 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Rajesh Kumar Gupta ◽  
Achyut Narayan Kesari ◽  
Sandhya Diwakar ◽  
Ameetabh Tyagi ◽  
Vibha Tandon ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Annona Squamosa ◽  
In Vivo Evaluation ◽  
Anti Oxidant ◽  
Type 2 Diabetic

scholarly journals In-vitro and In-vivo Evaluation of Anti-trypanosomal Activity of Carica papaya Seed Extracts and Fractions in Albino Wister Rats

2020 ◽  
pp. 13-25
Author(s):  
H. Kinjir ◽  
M. A. Madusolumuo ◽  
S. Sarkiyayi
Keyword(s):  
Carica Papaya ◽  
Oral Toxicity ◽  
Infection Level ◽  
In Vivo Evaluation ◽  
Trypanocidal Activity ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Seed Extracts

Aims: This study presents baseline data on the In-vitro and In-vivo evaluation of anti-trypanosomal activity of Carica papaya seed extracts and fractions in Albino Wister rats. Study Design: Mention the design of the study here. Place and Duration of Study Sample: Department of Biochemistry, Modibbo Adama University of Technology, Yola, between June 2009 and July 2010. Methodology: 56 Wister rats of both sexes were randomly divided into 8 groups (I – VIII) of 7 rats each were used for this study. Four concentrations (100, 200, 400 and 800 mg/kg) of different extracts of seed carica papaya were screened for trypanocidal activity against Trypanosoma brucei In vitro and In vivo. The effect of the extracts was evaluated for trypanocidal activity in rats infected and not infected with the parasite. Administration of the extract and the drugs was orally daily for 5 consecutive days from day 7 of post infection. Level of parasitemia and body weight was taken daily for 21 days. Results: The extracts inhibited parasite motility and totally eliminated the organisms at the concentrations used In vitro. The extract also showed promising in vivo trypanocidal activity. The observed In vitro and In vivo trypanocidal activities may be due to the presence of bioactive compounds present in the extracts as seen in this study. The extract also improved the observed decreases in haematological parameters of the treated rats, which may be due to their ability to decrease parasite load. The LD50 was estimated to be ≥2,000 mg/Kg (v/v) for acute oral toxicity test (because all the rats survived at the end of the 14-day observation period). This is an indication of very low toxicity, implying that the extract could be administered with some degree of safety. A significant decreased (p<0.05) were observed in weight of rats at 100 mg/kg, 200 mg/kg 400 mg/kg 800 mg/kg negative control and prophylactic at four to eight days of infections, while significantly increased (p<0.05) were observed in weight of rats for berenil control and normal control. Conclusion: The decrease in weight of rats could be as a result of loss of appetite due to severe fever and also the trypanosome.

In vivo evaluation of garlic (Allium sativum ) supplementation to rice straw-based diet on mitigation of CH4 and CO2 emissions and blood profiles using crossbreed rams

2018 ◽  
Vol 98 (14) ◽  
pp. 5197-5204
Author(s):  
Ji Yung Kim ◽  
Jalil Ghassemi Nejad ◽  
Ji Young Park ◽  
Bae Hun Lee ◽  
Masaaki Hanada ◽  
...  
Keyword(s):  
Co2 Emissions ◽  
Rice Straw ◽  
Allium Sativum ◽  
In Vivo Evaluation ◽  
Blood Profiles

scholarly journals Cumulative Effect of the Aqueous and Ethanolic Extracts of Annona Reticulate and Allium Sativumon Brine Shrimp Lethality Assay

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 36
Author(s):  
Sandeep Waghulde ◽  
Ashwini Bhoir ◽  
Jyoti Gholap ◽  
Varsha Patil ◽  
Mohan K. Kale ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Brine Shrimp ◽  
Allium Sativum ◽  
Cumulative Effect ◽  
Leaf Extracts ◽  
Brine Shrimp Lethality ◽  
Brine Shrimp Lethality Assay ◽  
Ethanolic Extracts ◽  
Annona Reticulata

The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts Annona reticulate Linn. and Allium sativumand correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 24 h the surviving brine shrimp larvae were counted and LC50 was assessed. Results showed that the presence of alkaloids, tannins, and flavonoids could be accounted for its cytotoxic properties. In the other hand, studies have shown that the leaf extracts of Alcoholic and aqueous extract of Annona reticulata and bulbs of Allium sativum extracts exhibited cumulative activity when they were combined and compared. Thus, the results on the leaf extracts of Alcoholic and aqueous extract of Annona reticulata and bulbs of Allium sativum exhibited increase in activity support its use in traditional medicine.

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