scholarly journals The Importance of Immunohistochemical Staining with DNAJB9 for the Diagnosis of Fibrillar Glomerulonephritis

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
David Campos Wanderley ◽  
Stanley de Almeida Araújo
Keyword(s):  
Renal Failure ◽  
Immunohistochemical Staining ◽  
Clinical Presentation ◽  
Morphological Characteristics ◽  
Diagnostic Challenge ◽  
Fibrillary Glomerulonephritis ◽  
Immunohistochemical Technique ◽  
Renal Biopsies ◽  
Definition Of ◽  
Diagnosis Of Diseases

Fibrillary Glomerulonephritis (FGN) is a rare glomerulopathy, corresponding to less than 1% of all renal biopsies performed. The pathogenesis mechanisms of FGN are still not completely understood and most cases are considered idiopathic. The clinical presentation is characterized by proteinuria, hematuria, arterial hypertension and renal failure. The evaluation of FGN is a diagnostic challenge in the practice of the pathologist, because there are no morphological characteristics with highly specific or pathognomonic lesion. The use of a sensitive and specific biomarker can make an important contribution to renal pathology and the differential diagnosis of diseases with fibrillar deposits. In this contexto, DNAJB9 can be investigated by immunohistochemical technique and is useful for the diagnostic definition of FGN.

scholarly journals Tuberculosis in Otorhinolaryngology: Clinical Presentation and Diagnostic Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rajiv C. Michael ◽  
Joy S. Michael
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Clinical Presentation ◽  
Extrapulmonary Tuberculosis ◽  
Common Type ◽  
The Body ◽  
Diagnostic Challenge ◽  
Cervical Adenitis ◽  
Important Form

Tuberculosis affects all tissues of the body, although some more commonly than the others. Pulmonary tuberculosis is the most common type of tuberculosis accounting for approximately 80% of the tuberculosis cases. Tuberculosis of the otorhinolaryngeal region is one of the rarer forms of extrapulmonary tuberculosis but still poses a significant clinical and diagnostic challenge. Over three years, only five out of 121 patients suspected to have tuberculosis of the otorhinolaryngeal region (cervical adenitis excluded) hadMycobacterium tuberculosisculture-proven disease. Additional 7 had histology-proven tuberculosis. Only one patient had concomitant sputum-positive pulmonary tuberculosis. We look at the various clinical and laboratory aspects of tuberculosis of the otorhinolaryngeal region that would help to diagnose this uncommon but important form of extrapulmonary tuberculosis.

Neomisticius platypi n. sp. and N. variabilis n. sp. (Tylenchomorpha: Anguinidae) from dead oak trees in Japan

Nematology ◽  
2021 ◽  
pp. 1-21
Author(s):  
Natsumi Kanzaki ◽  
Hayato Masuya ◽  
Keiko Hamaguchi
Keyword(s):  
New Species ◽  
Vas Deferens ◽  
Morphological Characteristics ◽  
Platypus Quercivorus ◽  
Oak Trees ◽  
Two New Species ◽  
Previous Definition ◽  
Rectal Glands ◽  
Stylet Length ◽  
Definition Of

Summary Two new Neomisticius species, typologically and phylogenetically close to each other, are described and illustrated from dead Quercus trees and an ambrosia beetle, Platypus quercivorus. The two species share some stylet morphological characteristics, namely, they both possess a long conus occupying more than half of the total stylet length, a long crustaformeria composed of more than 160 cells (eight rows of more than 20 cells each), and a short and broad female tail with a digitate tip. They are distinguished from each other by N. variabilis n. sp. having a wide, spindle-shaped male bursa with a blunt terminus and N. platypi n. sp. having an oval bursa with a rounded terminus. In addition, the males and females of both species have three large rectal glands and the posterior end of the male testis (distal end of the vas deferens) bears three cells that seemingly function as a valve between the vas deferens and the cloacal tube. These characteristics have not been reported in other tylenchids. Currently, the genus contains only three species: the two new species and N. rhizomorphoides, which has a normal stylet with a short conus, a short crustaformeria, and lacks rectal glands and valve cells in the vas deferens. Therefore, the two new species are readily distinguished from N. rhizomorphoides and, based on the previous definition, may even represent a new genus. However, considering their phylogenetic closeness and biological similarities (e.g., association with ambrosia beetles), the generic definition of Neomisticius was emended to include these new species.

scholarly journals Inguinal ulcerated sebaceous carcinoma: an unusual presentation

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 48-51 ◽  
Author(s):  
David Oschilewski Lucares ◽  
Fred Bernardes Filho ◽  
Hernando Vega ◽  
Bernard Kawa Kac ◽  
Maria Rita Pereira ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Clinical Presentation ◽  
Sebaceous Carcinoma ◽  
The Body ◽  
Skin Tumor ◽  
Diagnostic Challenge ◽  
Elderly Male ◽  
Genital Ulcers ◽  
Clinical Description

Sebaceous carcinoma is a rare and aggressive skin tumor. It can be located in any area of the body, the most commonly involved area being the periorbital region. It does not entail a typical clinical presentation, which explains the often late diagnosis. The aim of this report is to outline the rarity of the disease and its atypical clinical description, since to this day, inguinal ulcers with clinical manifestation have not been reported. We present and discuss a case of sebaceous carcinoma with an unusual clinical presentation, in an elderly male patient. The precise approach to genital ulcers, as shown in this case, is a diagnostic challenge that requires a great deal of effort on the part of the clinician.

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

2018 ◽  
Vol 36 (5) ◽  
pp. 369-376 ◽  
Author(s):  
Nurit Loberman-Nachum ◽  
Michael Schvimer ◽  
Camila Avivi ◽  
Iris Barshack ◽  
Avishay Lahad ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Immunohistochemical Staining ◽  
Clinical Presentation ◽  
Tissue Transglutaminase ◽  
Mucosal Damage ◽  
High Serum ◽  
Tissue Transglutaminase Antibodies ◽  
Antibody Levels ◽  
Age Range ◽  
Multiple Symptoms

Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. Methods: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011–2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits. Patients were classified as monosymptomatic or polysymptomatic. Mucosal anti-tTG deposits were classified according to the location of deposits, dominant intensity, maximal intensity, and percentage of stained area. Results: Of 252 patients with confirmed CD, complete data were available for 100: 37 males in the age range 1.3–16.7 with median 4.0 years. Monosymptomatic patients (n = 54) presented at an older age than polysymptomatic patients (1.3–15.5, median 8.1 vs. 1.3–16.7, median 6.3 years, p = 0.026). Marsh 2–3c was more prevalent in polysymptomatic patients (93 vs. 78%, p = 0.028). The intensity of mucosal anti-tTG deposits correlated with serum anti-tTG levels but not with the clinical presentation. Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.

scholarly journals Heterotaxy syndrome: This is the left, right?

2015 ◽  
Vol 19 (2) ◽  
Author(s):  
Lili Huang ◽  
Belinda J. Mitchell ◽  
Savvas Andronikou ◽  
Zarina I. Lockhat ◽  
Farhana Suleman
Keyword(s):  
Morphological Characteristics ◽  
Imaging Modalities ◽  
Right Atrial ◽  
Abdominal Organ ◽  
Heterotaxy Syndrome ◽  
Diagnostic Challenge ◽  
Complex Disorder ◽  
Left And Right ◽  
Atrial Isomerism ◽  
Heterotaxy Syndromes

Heterotaxy syndrome is a rare and complex disorder of the chest and abdominal organ arrangements, and presents a diagnostic challenge to the radiologist. This article describes the morphological characteristics of heterotaxy and situs abnormalities, in particular left and right atrial isomerism, and suggests an approach in evaluating the spectrum of abnormalities associated with heterotaxy syndromes, using appropriate imaging modalities.

scholarly journals Recent advancements in management of gastrointestinal tuberculosis

2018 ◽  
Vol 5 (9) ◽  
pp. 3730
Author(s):  
Basim F. Khan ◽  
Ahmed M. Basha ◽  
Bandar R. Bakhurji ◽  
Bader J. Aldossari ◽  
Abdulaziz S. Alsumaihi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Good Accuracy ◽  
Clinical Presentation ◽  
Intestinal Tuberculosis ◽  
Scoring Systems ◽  
Abdominal Tuberculosis ◽  
Diagnostic Challenge ◽  
Important Concern ◽  
Diagnostic Modalities

Abdominal tuberculosis and its protean manifestations still create a worldwide diagnostic challenge for clinicians and remain an important concern in the developing world. Crohn’s disease, which is being increasingly recognized in countries where intestinal tuberculosis is prevalent, needs to be differentiated as the two diseases resemble each other in their clinical presentation, and in their radiological, endoscopic, and histological findings. New diagnostic modalities and scoring systems have facilitated the differentiation of Crohn’s disease from intestinal tuberculosis with good accuracy. Randomized trials have shown 6 months of therapy to be equivalent to longer durations of treatment for patients with abdominal tuberculosis. 

scholarly journals The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations

2017 ◽  
Vol 29 (2) ◽  
pp. 680-693 ◽  
Author(s):  
Volker Nickeleit ◽  
Harsharan K. Singh ◽  
Parmjeet Randhawa ◽  
Cinthia B. Drachenberg ◽  
Ramneesh Bhatnagar ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Working Group ◽  
Classification Scheme ◽  
Clinical Presentation ◽  
Interstitial Fibrosis ◽  
The United States ◽  
Systematic Analysis ◽  
Definition Of ◽  
Morphologic Classification

Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence of approximately 5%. A generally accepted morphologic classification of definitive PVN that groups histologic changes, reflects clinical presentation, and facilitates comparative outcome analyses is lacking. Here, we report a morphologic classification scheme for definitive PVN from the Banff Working Group on Polyomavirus Nephropathy, comprising nine transplant centers in the United States and Europe. This study represents the largest systematic analysis of definitive PVN undertaken thus far. In a retrospective fashion, clinical data were collected from 192 patients and correlated with morphologic findings from index biopsies at the time of initial PVN diagnosis. Histologic features were centrally scored according to Banff guidelines, including additional semiquantitative histologic assessment of intrarenal polyomavirus replication/load levels. In-depth statistical analyses, including mixed effects repeated measures models and logistic regression, revealed two independent histologic variables to be most significantly associated with clinical presentation: intrarenal polyomavirus load levels and Banff interstitial fibrosis ci scores. These two statistically determined histologic variables formed the basis for the definition of three PVN classes that correlated strongest with three clinical parameters: presentation at time of index biopsy, serum creatinine levels/renal function over 24 months of follow-up, and graft failure. The PVN classes 1–3 as described here can easily be recognized in routine renal biopsy specimens. We recommend using this morphologic PVN classification scheme for diagnostic communication, especially at the time of index diagnosis, and in scientific studies to improve comparative data analysis.

Geostatistical approach for multi-scale seismic liquefaction risk assessment

2021 ◽  
Author(s):  
Rose Line Spacagna ◽  
Massimo Cesarano ◽  
Stefania Fabozzi ◽  
Edoardo Peronace ◽  
Attilio Porchia ◽  
...  
Keyword(s):  
Regional Scale ◽  
Morphological Characteristics ◽  
Predisposing Factors ◽  
Data Availability ◽  
Hazard Maps ◽  
Multi Scale ◽  
Seismic Liquefaction ◽  
Research Activities ◽  
Geostatistical Approach ◽  
Definition Of

<p>The Seismic Microzonation studies (SMs), promoted all over the Italian territory by the Department of Civil Protection, provide fundamental knowledge of the subsoil response in seismic conditions at the urban scale. Amplification phenomena related to lithostratigraphic and morphological characteristics, instabilities and permanent deformations activated by the earthquake, are highlighted in hazard maps produced at increasing reliability levels (level 1 to 3 of SM). In particular, zones prone to liquefaction instability are firstly identified following the predisposing factors, such as geological and geotechnical characteristics and seismicity. The robustness of the definition of these areas is strongly correlated to the availability and the spatial distribution of surveys. Moreover, the typology and quality of the investigations considerably influence the method of analysis and the degree of uncertainty of the results.</p><p>This work aims to establish an updated procedure of the actual SM guidelines and integrates recent research activities at different levels of SMs, to improve the hazard maps accuracy in terms of liquefaction susceptibility. For the scope, the case of the Calabria region in the south of Italy, well known for the high level of seismicity, was studied. At a regional scale, the base-level analysis was implemented for a preliminary assessment of the Attention Zones (AZ), potentially susceptible to liquefaction. The predisposing factors were implemented at a large scale, taking advantage of geostatistical tools to quantify uncertainties and filter inconsistent data. The regional-scale analysis allowed to highlight areas prone to liquefaction and effectively addressed the subsequent level of analysis. At a local scale, the quantitative evaluation of the liquefaction potential was assessed using simplified methods, integrating data from different survey types (CPT, SPT, Down-Hole, Cross-Hole, MASW) available in SM database. The definition of Susceptibility Zones (SZ) was provided considering additional indexes, combining the results obtained from different surveys typologies and quantifying the uncertainty due to the limited data availability with geostatistical methods. The analyses at the regional and municipality scale were matched with seismic liquefaction evidence, well documented in past seismic events. This multi-scale process optimises resource allocation to reduce the level of uncertainty for subsequent levels of analysis, providing useful information for land management and emergency planning.</p>

Acute Kidney Injury

2020 ◽  
Author(s):  
Aileen Ebadat ◽  
Eric Bui ◽  
Carlos V. R. Brown
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Loss Of Function ◽  
Management Algorithm ◽  
Consensus Statements ◽  
Definition Of ◽  
Stage Renal Disease ◽  
End Stage

Acute renal failure definitions have changed dramatically over the last 5 to 10 years as a result of criteria established through the following consensus statements/organizations: RIFLE (Risk, Injury, Failure, Loss of function, End stage renal disease), AKIN (Acute Kidney Injury Network), and KDIGO (Kidney Disease: Improving Global Outcomes). In 2002, the Acute Dialysis Quality Initiative was tasked with the goal of establishing a consensus statement for acute kidney injury (AKI). The first order of business was to provide a standard definition of AKI. Up to this point, literature comparison was challenging as studies lacked uniformity in renal injury definitions. Implementing results into evidence-based clinical practice was difficult. The panel coined the term “acute kidney injury,” encompassing previous terms, such as renal failure and acute tubular necrosis. This new terminology represented a broad range of renal insults, from dehydration to those requiring renal replacement therapy (RRT). This review provides an algorithmic approach to the epidemiology, pathophysiology, diagnosis, prevention, and management of AKI. Also discussed are special circumstances, including rhabdomyolysis, contrast-induced nephropathy, and hepatorenal syndrome. Tables outline the AKIN criteria, most current KDIGO consensus guidelines for definition of AKI, differential diagnosis of AKI, agents capable of causing AKI, treatment for specific complications associated with AKI, and options for continuous RRT. Figures show the RIFLE classification scheme and KDIGO staging with prevention strategies. This review contains 1 management algorithm, 2 figures, 6 tables, and 85 references. Keywords: Kidney, renal, KDIGO, azotemia, critical, urine, oliguria, creatinine, dialysis

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