scholarly journals Once again about the prophetic mission of the Russian writer (based on material of Y.V. Bondarev’s novel “The Shore”)

Neophilology ◽  
2021 ◽  
pp. 661-669
Author(s):  
Liudmila E. Khvorova
Keyword(s):  
The Novel ◽  
Front Line ◽  
Cultural Foundations ◽  
Great Patriotic War ◽  
Russian Literary ◽  
The Common ◽  
German City ◽  
Prophetic Mission ◽  
Literary Classics ◽  
Further Development

We conduct continuous poetical and philosophical research on the work of Y.V. Bondarev (1924–2020), the greatest Russian Soviet prose writer and a participant in the Great Patriotic War. Based on the study of the novel “The Shore” (1975) and the writer’s journalistic statements of the mid-1970s of the 20th century, within the framework of cultural-axiological paradigm, we attempt to comprehend one of the central dialogues between representatives of the creative intellectuals of Russia and West. The conversation between Russian Soviet writer Nikitin, a former front-line soldier who visited the German city of Hamburg 26 years after the war, and the German journalist and publisher Dietzman is read as a kind of philosophical quintessence of both this novel and, possibly, the writer’s work as a whole. The conflict between Russia and West is seen by Y.V. Bondarev in the most complex metaphysical paradigm of the struggle of largely opposite cultural foundations, despite the common Christian basis. We state the complexity, multidimensionality, polyphonism of the Bondarev type of artistic expression, its ascent to the traditions of Russian literary classics and, above all, in this case to the work of F.M. Dostoevsky. We note the key, culminating significance of this dialogue-reflection undertaken in the chapter of the second chapter of the third part “Nostalgia” by Dietzman and Nikitin, which has some obvious similarities with the author both for the further development of latter’s character in the poetical and philosophical space of novel, and for its artistic “completion” in work finale. We comprehend the relevance of Bondarev’s metaphysical constants in the first quarter of the 21st century, prophetically written out about half a century ago.

scholarly journals Quantitative Mass Spectrometry-Based Proteomics: An Overview

2021 ◽  
pp. 85-116
Author(s):  
Svitlana Rozanova ◽  
Katalin Barkovits ◽  
Miroslav Nikolov ◽  
Carla Schmidt ◽  
Henning Urlaub ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Front Line ◽  
Quantitative Mass Spectrometry ◽  
Qualitative Level ◽  
The Common ◽  
Challenging Question ◽  
Further Development ◽  
Proteins And Peptides

AbstractIn recent decades, mass spectrometry has moved more than ever before into the front line of protein-centered research. After being established at the qualitative level, the more challenging question of quantification of proteins and peptides using mass spectrometry has become a focus for further development. In this chapter, we discuss and review actual strategies and problems of the methods for the quantitative analysis of peptides, proteins, and finally proteomes by mass spectrometry. The common themes, the differences, and the potential pitfalls of the main approaches are presented in order to provide a survey of the emerging field of quantitative, mass spectrometry-based proteomics.

Traditions of Russian literary classics in fiction by participants in the Battle of Stalingrad

2020 ◽  
pp. 13-32
Author(s):  
S. V. Perevalova
Keyword(s):  
National Culture ◽  
Lyric Poetry ◽  
Narrative Approach ◽  
Front Line ◽  
Crimean War ◽  
Russian Army ◽  
Russian Literary ◽  
Literary Classics

The article states that the heroic-patriotic traditions of Russian classics (M. Lermontov, L. Tolstoy, A. Blok) live on in the works by participants in the Battle of Stalingrad: the founder of the ‘lieutenant prose’ Viktor Nekrasov and poets Mikhail Kulchitsky and Aleksandr Korenev. M. Lermontov’s ‘Borodino’ sounds with a new vigour in the lyric poetry by the fighters at Stalingrad. Works dedicated to the Battle of Stalingrad follow and modernize the traditions of Russian realism exemplified by the first-hand accounts of L. Tolstoy, an officer during the Siege of Sevastopol. Military and engineering learnings of the Russian army garnered during the Crimean War were adopted by the characters of Front-Line Stalingrad [V okopakh Stalingrada] by V. Nekrasov, who received an architect’s degree in pre-war Kyiv and was in command of a sapper battalion on the Stalingrad front. This officer writer also follows the narrative approach of the 19th-c. classic, so that the ferocity of the battle does not obscure the ‘dialectics of the soul’ of his fellow soldiers, whom he portrays as part and parcel of the centuries-long national culture.

scholarly journals The Libraries’ contributing to the Victory in the Great Patriotic War

2020 ◽  
pp. 111-120
Author(s):  
E. A. Pleshkevich
Keyword(s):  
Information Support ◽  
Development Projects ◽  
Front Line ◽  
Scientific Discussion ◽  
Great Patriotic War ◽  
Red Army ◽  
History Of ◽  
Library Support ◽  
Learning Guide ◽  
Further Development

Review of the book: Mazuritsky A. M. Libraries in the years of Great Patriotic War: A learning guide. – Orel, 2020. – 139 p.The reviewed textbook introduces to the history of Russian librarianship during the Great Patriotic War. The structure of the manual is overviewed. The didactic analysis demonstrates the presentation logic which facilitates learning and is of great ethical educative value. In terms of scientific discussion, recommendations are given for further development of this subject scope to cover the following issues: 1) library support facilities for high morale and combative mood of the Red Army (the front-line and navy libraries); 2) library support of healing and bibliotherapy (hospital libraries); 3) library and information support of promising research and development projects (scientific and technical libraries of plants and factories); 4) libraries in the system of cultural, educational, moral and psychological support for the residents of blockaded Leningrad; 5) library support of high morale of the population and its faith in the victory over the enemy. The significance and relevance of the learning guide is emphasized. The reviewer recommends to prepare a textbook on the history of library construction during the Great Patriotic War.

scholarly journals INTERCONTEXTUAL READING OF ROBERT MUSIL’S “MAN WITHOUT QUALITIES”

2021 ◽  
Vol 6 (1) ◽  
pp. 18-34
Author(s):  
Alexander W. Belobratov
Keyword(s):  
Cultural Awareness ◽  
The Novel ◽  
Individual Concepts ◽  
Contextual Framework ◽  
Russian Literary ◽  
Micro Level ◽  
Foreign Text ◽  
The One ◽  
Literary Classics ◽  
The 19Th Century

The analysis of the active reception process, the interaction of “its own” and “alien” seems very fruitful in the study of the epoch-making Robert Musil’s novel “Man without qualities” (1930–1942). The analytical evaluation of the Austrian author’s contact with the “alienness” (in this case, with Russian literary classics) in the form of the discovery of “his own essence” is carried out at the micro-level of individual concepts, expressions, descriptions of characters, and explicit or implicit quotations. The intertextual level of reading the novel expands at the expense of the intercontextual level. Thus, the literary text is read from the foreign (Russian) reader’s cultural referential framework. This means an attempt to recognize the reader’s “own essence” in the “alienness” text, to reinterpret a foreign text, when, on the one hand, the “own essence”, i.e. in this case the work of the 19th century Russian novelists, is subjected to scrutiny in relation to its reception of the Austrian writer as “alien”. On the other hand, Musil’s novel is read through the lens of Russian cultural awareness, and included in the contextual framework of Russian reception, formed by Goncharov’s, Dostoevsky’s, and Leo Tolstoy’s works.

CULTURE OF THE RUSSIAN WORLD - A SPIRITUAL SLOGAN FACTOR OF VICTORY IN THE GREAT PATRIOTIC WAR

2020 ◽  
Vol 10 (2) ◽  
pp. 169-173
Author(s):  
VLADIMIR KSENOFONTOV ◽  
Keyword(s):  
Emotional Expression ◽  
Front Line ◽  
Soviet People ◽  
The People ◽  
Great Patriotic War ◽  
Red Army ◽  
Art Activities ◽  
Artistic Images ◽  
Great Victory

The article reveals the essence and specificity of culture as an important component of the spiritual factor of victory. Special attention is paid to the characteristics of fiction. The article substantiates the moral and aesthetic impact on the consciousness of defenders of the Motherland, such works of art as“They fought for the Motherland”,“Leningrad poem”,“Russian character”,“Invasion”, etc. The article describes the significant role of theatrical art, which reveals the moral values of the people and Soviet soldiers. This is reflected in such plays as: “the Front”; “the Guy from our city”; “Once upon a time”, etc. The article substantiates the important role of the spiritual influence of cinema on Soviet people. This influence was realized through artistic images of selfless service to the Motherland, loyalty to military duty. Among these films: “Two fighters”, “Wait for me”, “Front-line friends”. During the war, as the article emphasizes, an important component of the spiritual factor of victory was the musical art. Activities in this area of culture famous musicians:B. Astafiev, S. Prokofiev, D. Shostakovich, A. Alexandrov, V. Soloviev-Sedoy, and others, was implemented in operas, symphonies, cantatas and songs, which by their nature emotional expression differed Patriotic and epic strength. The purpose of the research : to reveal the axiological components, culture of the Russian world, as important components, spiritual factor during the great Patriotic war. Conclusions : the culture of the Russian world at various stages of the great Patriotic War, through a variety of means and forms, actively mobilized all Soviet people to defend the Motherland and defeat Nazi Germany. The spiritual culture of our country and its types, in the course of functioning, during the war, clearly and expressively revealed the idea of patriotism, courage, bravery and heroism, and encouraged the Soviet people, the soldiers of the red Army, to achieve a great Victory.

scholarly journals Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold

2021 ◽  
Vol 14 (3) ◽  
pp. 265
Author(s):  
Ana Dolšak ◽  
Tomaž Bratkovič ◽  
Larisa Mlinarič ◽  
Eva Ogorevc ◽  
Urban Švajger ◽  
...  
Keyword(s):  
Systematic Investigation ◽  
The Novel ◽  
Indoleamine 2,3 Dioxygenase ◽  
Tryptophan Dioxygenase ◽  
Promising Target ◽  
Synthetic Procedure ◽  
Ic50 Values ◽  
Novel Scaffold ◽  
Further Development ◽  
Micromolar Range

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. A focused library was prepared using a 6- or 7-step synthetic procedure to allow a systematic investigation of the structure-activity relationships of the described scaffold. Chemistry-driven modifications lead us to the discovery of our best-in-class inhibitors possessing p-trifluoromethyl (23), p-cyclohexyl (32), or p-methoxycarbonyl (20, 39) substituted aniline moieties with IC50 values in the low micromolar range. In addition to hIDO1, compounds were tested for their inhibition of indoleamine 2,3-dioxygenase 2 and tryptophan dioxygenase, and found to be selective for hIDO1. Our results thus demonstrate a successful study on IDO1-selective isoxazolo[5,4-d]pyrimidin-4(5H)-one inhibitors, defining promising chemical probes with a novel scaffold for further development of potent small-molecule immunomodulators.

scholarly journals Development of Resistance to Hymexazol Among Pythium Species in Cucumber Greenhouses in Oman

Plant Disease ◽  
2018 ◽  
Vol 102 (1) ◽  
pp. 202-208 ◽  
Author(s):  
Zainab M. Al-Balushi ◽  
Hesham Agrama ◽  
Issa H. Al-Mahmooli ◽  
Sajeewa S. N. Maharachchikumbura ◽  
Abdullah M. Al-Sadi
Keyword(s):  
Ribosomal Rna ◽  
Management Strategies ◽  
Soil Samples ◽  
Integrated Disease Management ◽  
Pythium Species ◽  
Internal Transcribed Spacer Region ◽  
Development Of Resistance ◽  
The Common ◽  
Cucumber Roots ◽  
Further Development

A study was conducted to characterize the common Pythium spp. in greenhouses in Oman and their level of resistance to hymexazol, a widely used fungicide in the country. Pythium isolates were obtained from soil samples, cocopeat bags, and cucumber roots collected from seven regions in the country. Identification of 80 Pythium isolates to the species level using sequences of the internal transcribed spacer region of the ribosomal RNA showed that they belong to four species: Pythium aphanidermatum (77 isolates), P. spinosum (1 isolate), P. myriotylum (1 isolate), and P. catenulatum (1 isolate). Investigating the aggressiveness of three Pythium spp. on cucumber showed that P. aphanidermatum, P. myriotylum, and P. spinosum are pathogenic. Phylogenetic analysis of P. aphanidermatum isolates showed that most of the isolates obtained from cocopeat clustered separately from isolates obtained from soil and roots. This may indicate a difference in the origin of the cocopeat isolates. Evaluating the resistance of 27 P. aphanidermatum isolates to hymexazol showed that most isolates were sensitive (0.9 to 31.2 mg liter−1) whereas one isolate was resistant (142.9 mg liter−1). This study is the first to report P. myriotylum and P. catenulatum in Oman. It is also the first to report the development of resistance to hymexazol among P. aphanidermatum populations from greenhouses. Growers should use integrated disease management strategies to avoid further development of resistance to hymexazol.

LINGUISTIC REPRESENTATION OF THE EVERYDAY LIFE CATEGORY IN THE NOVEL WRITTEN BY G. SH. YAKHINA “ZULEIKHA OPENS HER EYES” AND IN ITS TRANSLATION INTO CHINESE

2021 ◽  
Vol 7 (2) ◽  
pp. 77-95
Author(s):  
Iana E. ANDREEVA
Keyword(s):  
Everyday Life ◽  
Literary Text ◽  
The Novel ◽  
Chinese Translation ◽  
Lexical Semantic ◽  
The Everyday ◽  
Russian Literary ◽  
Linguistic Methods ◽  
Linguistic Units ◽  
Language Pair

This article examines the linguistic means of representing the category of everyday life in the novel by G. Sh. Yakhina “Zuleikha opens her eyes” and in its translation into Chinese. Recently, there has been an increasing interest in the anthropology of everyday life, a broad line of research into everyday life. Comparative study of linguistic units, which reveal the essence of everyday human existence, makes it possible to identify lacunar units that are difficult to translate fiction in the context of the Russian-Chinese language pair. The scientific novelty of the research is determined by the involvement in the analysis of linguistic methods of conveying the category of everyday life in the aspect of translating a Russian literary text into Chinese. The work used the methods of comparative, component, contextual analysis, the method of linguoculturological commenting. As a result of the study, the lexical-semantic, lexical-stylistic and grammatical lacunar units were identified, which demonstrate linguocultural barriers in the process of translating a text into Chinese. A comparative analysis of the texts was carried out in order to comprehend the lexical and grammatical transformations performed in the process of translation. As a result, the main ways of compensating for the lacunae of everyday life in Russian-Chinese translation were identified: transcription, tracing, descriptive translation, lexical-semantic replacement. In addition, it was found that the study of various options for depicting everyday life in a literary text not only makes it possible to identify lacunar units of everyday life, but also reveals the artistic and philosophical intention of the work.

Re-Visioning the Past: Russian Literary Classics in Film

2011 ◽  
Vol 85 (6) ◽  
pp. 55-58
Author(s):  
Catharine Theimer Nepomnyashchy
Keyword(s):  
The Past ◽  
Russian Literary ◽  
Literary Classics

CHOLANGITIS AS A SYSTEMIC MANIFESTATION OF ACUTE BILIARY INFECTION

2020 ◽  
pp. 43-47
Author(s):  
A. O. Nekludov ◽  
M. O. Klosova ◽  
O. V. Volchenko ◽  
M. M. Goloborodko ◽  
A. Yu. Korolevska
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Water Column ◽  
Biliary Tract ◽  
Bile Ducts ◽  
Inflammatory Process ◽  
Acute Cholangitis ◽  
Biliary Infection ◽  
The Common ◽  
Further Development

The main causes of cholangitis are hypertension in the biliary ducts and infection. In order to determine the place of the infectious factor in the acute cholangitis development, a retrospective and prospective analysis of case histories of 176 patients with choledocholithiasis and manifestations of acute and chronic cholangitis was performed. Bile from the common bile duct in the patients with obstruction of the biliary tract was studied. In the patients with mechanical jaundice without and with cholangitis, the intraductal pressure in the common bile duct averaged 227.3±26.1 mm of water column, in the patients without signs of cholangitis that was 97.5±8.3 mm of water column. With mechanical jaundice without acute cholangitis, it was slightly elevated if compared to normal. This suggests that the increase in pressure in the bile ducts in acute cholangitis is not influenced by the fact of obstruction of the biliary tract, and the development of the inflammatory process in them. In the patients with cholangitis, the initial values of the number of colonizing units were much higher than in "pure" choledocholithiasis. After endoscopic papillosphincterotomy in the patients with vivid clinical cholangitis, in whom decompression was achieved, in the control study, this value decreased by 100−500 times, which was accompanied by clinical improvement. According to the results of the study, it was noted that in the patients with a manifested clinic sign of cholangitis there is a significant decrease in the number of colonizing units on the third day after endoscopic papillosphincterotomy. At the stone stuck in a papilla the choledoch turns into so−called analog of an abscess. The opening of the papilla provides a free passage of the contents of the choledochus (i.e. pus) into the duodenum, so there is an almost instant therapeutic effect. The increase in pressure in the bile ducts in acute cholangitis is influenced by the development of an inflammatory process, which indicates the manifestations of biliary infection. The presented research has a prospective character and needs further development. Key words: cholangitis, biliary infection, intraductal pressure, bile.

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