Demographic Profile, Clinical and Analysis of Osteoarthritis Patients in Surabaya

Introduction: Osteoarthritis is a degenerative joint disease which affects joint cartilage. As many as 80% patients movement are limited and 25% of them can not even perform daily activities. Osteoarthritis is one of the ten most disabling diseases in developed countries. Due to its chronic and progressive nature, socio-economic impacts in many developed and developing countries are enormous. The purpose of this study is to determine the profile of patients with osteoarthritis in the Orthopedic Department of RSUD Dr. Soetomo Surabaya (Dr. Soetomo General Hospital)Method: This is descriptive observasional research. Questionnaires data were obtained from all patients in the Department of Trauma and Orthopedic of RSUD Dr. Soetomo Surabaya during September 1, 2016 until October 31, 2016. Thirty five subjects with osteoarthritis were analyzed for the study. The variables observed in the patient profile include sex, age, body mass index, type of osteoarthritis, Kellgren-Lawrence scoring system, and knee osteoarthritis severity index.Result: The result shows that 43% of the samples were aged 60-69 years, 83% of the samples were female, 37% of the samples had an I BMI obesity, 60% of samples had bilateral osteoarthritis, and 77% of samples from primary osteoarthritis. A total of 15 of 53 knee samples had class III, and 15 of 53 knee samples also had class I, and as many as 21 of the 35 samples had a "very severe" clinical gradation. These results may be due to patients who have low grade gradation clinics and have received medical attention at the level I health facility or II.Conclusion: From the results of this study, it can be concluded that age, sex, BMI, Kellgren-Lawrence assessment system, index severity of patients Lequesne osteoarthritis in RSUD Dr. Soetomo Surabaya is in conformity with research that has been done in many places and theories that exist.Keywords: Knee osteoarthritis, age, gender, Kellgren-Lawrnce scoring system, knee osteoarthritis severity index

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DISTRIBUTION OF KNEE OSTEOARTHRITIS CASES IN PERTAMINA BINTANG AMIN HOSPITAL, BANDAR LAMPUNG

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120s00058 ◽

2020 ◽

Vol 8 (5_suppl5) ◽

pp. 2325967120S0005

Author(s):

Imam Suleman ◽

Aswedi Putra

Keyword(s):

Knee Osteoarthritis ◽

Secondary Data ◽

Joint Disease ◽

Medical Attention ◽

Low Grade ◽

Sex Distribution ◽

Cross Sectional ◽

Aged People ◽

Result Show ◽

Level I

Osteoarthritis is a degenarative joint disease which affects joint cartilage. Almost 80% patients movement are limited and 25 % of them can not evev perform daily activities. Due to its chronic and progressive nature, socio-economic impacts in many developed and developing countries are enormous. This study aimed to determine the distribution of patient with knee osteoarthritis in Pertamina Bintang Amin Hospital Bandar Lampung. Methods: This study is a decriptive cross sectional approach with secondary data taken from medical record. Thirty eight cases were evaluated in this study from January 2019 – Mei 2019. The variables observed include age, sex, body mass index (BMI) and occupations. Results: The result show that 36,8 % of the samples were aged 50-59 years,78,9 % of the samples were female, 71,1 % of the samples had BMI obesity, 60,5 % and 43,2 % were work as housewife. A total of 23 of 38 knee samples had grade III, and 3 of 38 knee samples alsohad grade I, and as many as 7 of the 38 knee samples had a” very severe” clinical gradation. These result may be due to patients who have low grade gradation clinics and have received medical attention at the level I health facility or II. Conclusion: Form the result of this study, it can be concluded that age, sex, BMI, occupations and Kellgren-Lawrence scoring system at Pertamina Bintang Amin Bandar Lampung is in comformity with research that has been done in many places and theories that exist. Reference: Apley, Ag., & Louis Solomon, (2017). Osteoarthritis. In David Warwick (ED). System of Orthopaedics and Trauma (10th Ed., pp. 91-105). London, UK: CRC Press. Fransen M.Bridgett L. March L.Hoy D. Penserga E. Brooks P.The Epidemiolgy os Osteoarthritis in Asia. International Journal of Rheumatic Diseases 2011;14;113-212. Zhang Fu – Quang,Wu Ming – Xia, Liu Xian – Xiang, Gender and Sex distribution of middle and old aged people with osteoarthritis in Fuzhou, Vol II, May 2009. American of Orthopaedic Surgeon, Relatioship of Osteoarthritis and Biochemical Reactions, Journal of Bone and Joint Surgery, 2004 volume II.

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The stepped hybrid plate for carpal panarthrodesis

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.3415/vcot-08-07-0057 ◽

2009 ◽

Vol 22 (05) ◽

pp. 389-397 ◽

Cited By ~ 14

Author(s):

M. C. Díaz-Bertrana ◽

F. Darnaculleta ◽

J. Franch ◽

J. L. Puchol ◽

I. Durall

Keyword(s):

Bone Tumour ◽

Degenerative Joint Disease ◽

Metacarpal Bone ◽

Joint Disease ◽

Incomplete Fusion ◽

Carpal Bone ◽

Low Grade ◽

Screw Insertion ◽

The Third ◽

Metacarpal Bones

SummaryFifty-two carpal panarthrodeses (CP) were carried out in 44 dogs (eight bilateral), in a multicentre study using a single (n = 47) or double (n = 5) stepped hybrid CP plate. Of these 44 cases, 39 were between 20–55 kg in bodyweight , 26 were males , and the carpometacarpal was the most common joint involved. Falling and other impact trauma were the most common aetiology. Pain of unknown origin, carpal luxation, chronic accessory carpal bone fracture, distal comminuted intra-articular radial fracture, bone tumour, degenerative joint disease, canine erosive idiopathic polyarthritis, avascular necrosis of the radial carpal bone and fractures of several metacarpal bones were some of the pathologies reported. Fracture of the third metacarpal bone during screw insertion was the only intrasurgical complication. Malpositioning of the plate or screws and over-tightened screws were technical errors observed in seven of the procedures. The radial carpal bone was not fixed with a screw in two cases due to bone deformity. Concurrent plate breakage and bending in the same patient operated on bilaterally was observed during the follow-up period, which represented a major complication rate of 3.8% for all procedures. Minor complications were: low grade infection, lick granuloma, digit hyperextension, screw loosening or failure, incomplete fusion of some joints and a fracture of the third metacarpal bone at the distal screw hole of the plate; which represented a rate of 44.2% on all procedures. Complete carpal healing was observed radiographically in 94.2% of all procedures. Limb function was excellent to good, and all of the owners, except for one, were satisfied with the procedure.

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Corelation Between X-Ray Grading Scale And USG Examination of Knee Joint Osteoarthritis

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120s00110 ◽

2020 ◽

Vol 8 (5_suppl5) ◽

pp. 2325967120S0011

Author(s):

Basuki Supartono ◽

Riza Amalia ◽

Ika Satya ◽

Sugeng Wiyono

Keyword(s):

Knee Osteoarthritis ◽

Cross Sectional Study ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Sectional Study ◽

Cross Sectional ◽

X Ray ◽

Kolmogorov Smirnov ◽

Grading Scale ◽

Smirnov Test

Osteoarthritis is a degenerative joint disease which is related with the damage of cartilage. Xray is one of the osteoarthritis radiological examinations but only to see the damage of bone not cartilage. One of an effective examination to visualize the damage of cartilage is Ultrasound. The objective of this study is to determine the relation between osteoarthritis grading scale with cartilage ultrasonographic in knee osteoarthritis patients. This was a Cross-sectional study on 32 knee osteoarthritis patients. Statistical analysis was performed using Kolmogorov-Smirnov Test showed there was a correlation between osteoarthritis grading scale with cartilage ultrasonographic. The conclusion in this study, there is a significant correlation between osteoarthritis grading scale with cartilage ultrasonographic in knee osteoarthritis patients.

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Curcumin as adjuvant therapy to Meloxicam in treatment of patients with knee Osteoarthritis; Evaluation of antioxidant activity

Al Mustansiriyah Journal of Pharmaceutical Sciences ◽

10.32947/ajps.20.01.0441 ◽

2020 ◽

pp. 71-81

Keyword(s):

Oxidative Stress ◽

Serum Level ◽

Knee Osteoarthritis ◽

Physical Function ◽

Oxford Knee Score ◽

Degenerative Joint Disease ◽

The Body ◽

Joint Disease ◽

Controlled Study ◽

Antioxidant Parameters

Osteoarthritis (OA) is a chronic degenerative joint disease that doubled in prevalence since the mid of 20th century most commonly due to obesity and aging. Osteoarthritis can affect any joint in the body. The pathogenesis of OA is multifactorial influenced by range of biochemical and mechanical factors. Oxidative stress is described to play an important role in many diseases including OA. Accumulating evidences suggested the beneficial effect of anti-oxidants for reducing OA severity. Curcumin is a well-known antioxidant agent that acts by different mechanisms in modulating oxidative stress status. This study was designed to evaluate the antioxidant effect of curcumin as adjuvent therapy to a non-steroidal anti-inflammatory drug, meloxicam, in the management of knee osteoarthritis. This prospective open-labelled randomized controlled study was carried out on forty-two eligible patients who were allocated in two groups, serum superoxide dismutase 3 (SOD3) and glutathione reductase (GR) were measured at baseline and after 3 months of the study. Pain and physical function assessment were evaluated by oxford knee score (OKS). Results illustrated highly significant improvement in pain and physical function scores when curcumin used as adjuvant to meloxicam, also curcumin supplementation resulted in significant increase in SOD3 serum level and only a modest decrease in GR serum level when compared to meloxicam alone. In conclusion, this study demonstrated benefit of curcumin when used in combination with meloxicam over using meloxicam alone in modulating antioxidant parameters in blood, in addition to significantly improving pain and physical function after 3 months of treatment.

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EFFECTIVENESS OF KNEE BRACES IN THE TREATMENT OF KNEE OSTEOARTHRITIS : AN EVIDENCE BASED CASE REPORT

10.31219/osf.io/ctz3y ◽

2021 ◽

Author(s):

Muhammad Sobri Maulana

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Knee Osteoarthritis ◽

Clinical Symptoms ◽

Physical Symptoms ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Serious Adverse Events ◽

Knee Braces

Introduction: Osteoasthritis is a degenerative joint disease characterized by boney inflammation. Thetreatment goals are to reduce physical symptoms and to improve quality of life through exercises,biomechanical interventions, and pharmacological management.Objectives: To find out the effectiveness of knee braces compared to no treatment or otherconservative treatment for improving the quality of life in patients with knee osteoarthritis.Methods: Literatures were taken from OVIDMedline®, EBMreviews®, and Cochrane®. Threesystematic reviews were selected and critically appraised using standard criteria for interventionresearch.Results: Two systematic reviews had acceptable validity, while another systematic review neededfurther improvement for the methodological quality. High heterogeneity was shown from all reviews.Knee braces is considered as applicable based on the appraisal. One systematic review did notrecommend the use of knee braces for patients without any specific conditions.Discussion: All results stated that knee braces could improve clinical symptoms and quality of lifewithout any serious adverse events. The superiority of knee braces compared to other conservativetreatment and/or no treatment still remained as a question due to inconclusive evidences. Differenttypes of knee braces showed different effectiveness to different types of osteoarthritis, which may alsocontributed to high heterogeneity.Conclusion: 1) In patients with knee osteoarthritis, the use of knee braces can improve thequality of life. 2) It is inconclusive whether knee braces are more effective to improve thequality of life of patients with knee osteoarthritis compared to other conservative treatment.

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Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

Disease Markers ◽

10.1155/2015/684794 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 13

Author(s):

Qingmeng Zhang ◽

Heng Li ◽

Zhendong Zhang ◽

Fan Yang ◽

Jiying Chen

Keyword(s):

Knee Osteoarthritis ◽

Metabolic Profile ◽

Elderly Population ◽

The Elderly ◽

Ultra Performance Liquid Chromatography ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Healthy Controls ◽

Knee Oa ◽

Potential Biomarkers

Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.

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PROFIL PENDERITA OSTEOARTRITIS LUTUT DENGAN OBESITAS DI INSTALASI REHABILITASI MEDIK BLU RSUP PROF. DR. R. D KANDOU MANADO

e-CliniC ◽

10.35790/ecl.2.3.2014.6038 ◽

2014 ◽

Vol 2 (3) ◽

Author(s):

William Kusuma ◽

Engeline Angliadi ◽

L. S. Angliadi

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Medical Record ◽

Developed Countries ◽

Degenerative Joint Disease ◽

Overweight And Obesity ◽

Joint Disease ◽

Osteoarthritis Of The Knee ◽

Keywords Knee ◽

Number Of Patients

Abstract: osteoarthritis is derived from greek meaning bone, arthro meaning joint and itis meaning inflammation. Osteoarthritis is a degenerative joint disease that is chronic,progessive runing slow, often inflamed or causes only mild inflammation, and characterized by deterioration and abrasion of articular cartilage as well as by two risk factor are: risk factors that cannot be changed and modifable risk factors. Obesity is a global epidemic in developed countries and developing countries such as Indonesia, particularly in urban strip. This situation is caused by unbalanced energy intake with energy expenditure and excess energy is stored as body fat within a specified period. Objectives: this study aimed to determine the role of risk factor of obesity on the incidence of osteoarthitis of the knee in patients who visit the Rehabilitation Medical Installation BLU Prof. DR. R. D. Kandou Manado. Method: this type of research is descriptive research by taking medical record in medical rehabillitation installation at BLU RSUP Prof. DR. R. D. Kandou Manado. Result: in this study was obtained from descriptive data/medical record(MR) found the number of patients diagnosed with osteoarthritis of the knee by 74 people. Obtained as many as 31 people who have data(weight and height),3 complete lack data because just have weight and 40 people don’t have either weight or height. Research results knee OA patient who come control in the installation of medical rehabillitation only 31are listed the data Body Mass Indeks(weight and height), there are 5 people who have normal BMI, and 26 people who had a BMI of both overweight and obesity excess. Conclusion: from here we may see one of the risk factor for OA knee is obesity Keywords: Knee osteoarthritis, obesity. Abstrak: Osteoartritis (OA) berasal dari bahasa Yunani yaitu osteo yang berarti tulang, arthro yang berarti sendi dan itis yang berarti inflamasi. Osteoartritis adalah penyakit degeneratif sendi yang bersifat kronik, berjalan progresif lambat, seringkali tidak meradang atau hanya menyebabkan inflamasi ringan, dan ditandai dengan adanya deteriorasi dan abrasi rawan sendi serta oleh 2 faktor resiko yaitu: faktor resiko yang tidak dapat diubah dan faktor resiko yang dapat diubah. Obesitas merupakan epidemi global pada negara-negara maju dan negara berkembang seperti di Indonesia, terutama di daerah perkotaan. Keadaan ini diakibatkan karena pemasukan energi tidak seimbang dengan pengeluaran energi dan kelebihan energi ini disimpan dalam bentuk lemak tubuh dalam jangka waktu tertentu. Tujuan: Penelitian ini bertujuan untuk mengetahui peranan faktor resiko obesitas terhadap angka kejadian osteoartritis lutut pada penderita yang berkunjung di Instalasi Rehabilitasi Medik BLU RSUP Prof. DR. R. D. Kandou Manado. Metode: Jenis penelitian ini adalah penelitian deskriptif dengan mengambil data rekam medik di Instalasi Rehabilitasi Medik BLU RSUP Prof. DR. R. D. Kandou Manado. Hasil: Pada penelitian yang didapatkan dari data deskriptif/rekam medik (RM) didapatkan jumlah penderita yang didiagnosis dengan osteoartritis lutut sebanyak 74 orang. Didapatkan sebanyak 31 orang yang memiliki data BB dan TB, 3 data kurang lengkap yaitu hanya terdapat data BB dan 40 data yang tidak mempunyai baik BB maupun TB. Hasil penelitian menyatakan penderita OA lutut yang datang kontrol di Instalasi Rehabilitasi Medik,hanya 31 yang tercantum data IMT (BB&TB),terdapat 5 orang yang memiliki IMT normal,dan 26 orang yang memiliki IMT berlebih baik overweight maupun obesitas. Simpulan: Dari sini kita bisa melihat salah satu faktor resiko OA lutut adalah obesitas. Kata Kunci: Osteoartritis lutut, Obesitas.

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Response of osteoarthritis biomarkers after a rehabilitation program: study protocol

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20200205 ◽

2020 ◽

Vol 7 (1) ◽

pp. 35

Author(s):

Eliane Antonioli ◽

Felipe B. D. Oliveira ◽

Rosana R. Campedelli ◽

Alessandro R. Zorzi ◽

Danielli Specialli ◽

...

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

High Mobility ◽

Rehabilitation Program ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Functional Evaluation ◽

Symptomatic Knee Osteoarthritis ◽

Symptomatic Knee

Background: Knee osteoarthritis is a progressive degenerative joint disease and remains a leading cause of pain, physical impairment and decline in health-related quality of life in adults. Despite its incidence being amongst the highest in chronic diseases, effective biomarkers are not available to assist in its management. The main goal of this study is to identify mediators that serve as biomarkers and investigate if the levels of these biomarkers will be correlated to the efficacy of a rehabilitation program.Methods: This is a prospective cohort study with 65 participants. Patients with mild-to-moderate symptomatic knee osteoarthritis will be recruited. The Rehabilitation Program will consist of three session/week during eight weeks. Assessment about functional evaluation will be performed before and after treatment, using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and EuroQOL-5D (Euro quality of life - five dimension) scales, Visual Analog Scale (VAS), and physical function tests (time up and go, isometric strength testing and kinematic gait analysis). Serum levels of classical pro-inflammatory cytokines, hyaluronan and high mobility group box 1 protein (HMGB-1) will be evaluated. The primary outcome is the change in WOMAC scale from baseline to end. Statistical analyses will be used to determine correlation of physical improvement and serum biomarkers. Adverse events will be monitored throughout the study.Conclusions: This trial expect to study the correlation between the anti-inflammatory effects of rehabilitation program derived factors that may be involved in suppressing cytokine induction via suppressing HMGB-1.Trial registration: Clinicaltrials.gov - NCT02964624.

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Combined therapies with exercise, ozone and mesenchymal stem cells improve the expression of HIF1 and SOX9 in the cartilage tissue of rats with knee osteoarthritis

Physiology International ◽

10.1556/2060.2020.00024 ◽

2020 ◽

Vol 107 (2) ◽

pp. 231-242

Author(s):

Sara Asadi ◽

Parvin Farzanegi ◽

Mohammad Ali Azarbayjani

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Knee Osteoarthritis ◽

Combined Therapy ◽

Hypoxia Inducible Factor ◽

Degenerative Joint Disease ◽

Exercise Group ◽

Joint Disease ◽

Cartilage Tissue ◽

Knee Oa

AbstractPurposeKnee osteoarthritis (OA) is a common type of degenerative joint disease which decreases the quality of life. Sex-determining region Y box 9 (SOX9) and hypoxia-inducible factor-1 (HIF1) are considered as the key regulators of OA. We investigated the effect of combined therapies with mesenchymal stem cells (MSCs), ozone (O3) and exercise training on SOX9 and HIF1 expression in the cartilage of rats with knee OA.MethodsKnee OA was induced by surgical method. OA rats were divided into model, MSCs, ozone, exercise, MSCs + ozone, MSCs + exercise, ozone + exercise and MSCs + ozone + exercise groups. Rats in the MSCs group received intraarticular injection of 1 × 106 cells/kg. Rats in the ozone group received O3 at the concentration of 20 μg/mL, once weekly for 3 weeks. Rats in the exercise group were trained on rodent treadmill three times per week. 48 hours after the programs, cartilage tissues were isolated and the expression of SOX9 and HIF1 was determined using Real-Time PCR.ResultsSignificant differences were found in the expression of SOX9 and HIF1 between groups (P < 0.0001). Although combined therapies with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 in the cartilage tissue of rats with knee OA, combination of exercise with O3 was significantly more effective compared to the other combined therapies (P < 0.001).ConclusionsCombined therapy with exercise, MSCs and O3 significantly increased the expression of SOX9 and HIF1 genes in the cartilage of rats with knee OA; however, exercise + O3 was significantly more effective.

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Platelet-rich plasma intra-articular injections as an alternative treatment for knee osteoarthritis: a systematic review

Timisoara Physical Education and Rehabilitation Journal ◽

10.1515/tperj-2017-0015 ◽

2017 ◽

Vol 10 (19) ◽

pp. 46-51

Author(s):

Elena Sîrbu ◽

Șerban Gligor ◽

Corina Pantea

Keyword(s):

Knee Osteoarthritis ◽

Platelet Rich Plasma ◽

Cartilage Degeneration ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Primary Analysis ◽

Beneficial Effects ◽

Inappropriate Treatment ◽

Symptomatic Knee Osteoarthritis ◽

Symptomatic Knee

Abstract Knee osteoarthritis is a degenerative joint disease characterized by cartilage degeneration and hypertrophic lesions of the epiphyseal bone. It is a disabling condition that causes difficulties of locomotion and severe complications in case of inappropriate treatment. There is growing evidence proving the beneficial effects of using platelet-rich plasma (PRP) in the treatment of knee osteoarthritis. The aim of the present paper is to review the recent scientific literature on the treatment of knee osteoarthritis with platelet-rich plasma presenting the current opinion on this subject. Methods: We analys several studies about PRP who were identified using online databases: EBSCO, ScienceDirect, Scopus and PubMed. Results: After the primary analysis we selected a total of 23 relevant studies. The analysis focused on different PRP administration techniques and methods used in knee osteoarthritis. Conclusions: PRP is most widely used in incipient and moderate symptomatic knee osteoarthritis. Most studies show a significant decrease in pain and significant improvement in joint functionality. These results were mostly obtained after a short follow-up period (6 months-1 year) and also this treatment has a small number of side effects.

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