scholarly journals The Rule of Two: A Star Wars Edict or a Method of Reproducibility and Quality?

2018 ◽  
Author(s):  
Steven Forrester
Keyword(s):  
Shared Knowledge ◽  
Top Down ◽  
Manuscript Review ◽  
New Approach ◽  
Star Wars ◽  
The Individual ◽  
Biomedical Investigation ◽  
Scientific Workforce ◽  
Collective Thinking

In recent years, biomedical research has faced increased scrutiny over issues related to reproducibility and quality in scientific findings(1-3). In response to this scrutiny, funding institutions and journals have implemented top-down policies for grant and manuscript review. While a positive step forward, the long-term merit of these policies is questionable given their emphasis on completing a check-list of items instead of a fundamental re-assessment of how scientific investigation is conducted. Moreover, the top-down style of management used to institute these policies can be argued as being ineffective in engaging the scientific workforce to act upon these issues. To meet current and future biomedical needs, new investigative methods that emphasize collective-thinking, teamwork, shared knowledge and cultivate change from the bottom-up are warranted. Here, a perspective on a new approach to biomedical investigation within the individual laboratory that emphasizes collaboration and quality is discussed.

Dealing with Multiple Models in System Dynamics

2014 ◽  
Vol 3 (4) ◽  
pp. 17-35 ◽  
Author(s):  
Willem L. Auping ◽  
Erik Pruyt ◽  
Jan H. Kwakkel
Keyword(s):  
System Dynamics ◽  
Simulation Models ◽  
Dynamics Simulation ◽  
Multiple Models ◽  
Top Down ◽  
Bottom Up ◽  
New Approach ◽  
Behavioural Patterns ◽  
Copper Availability

This paper introduces an approach to compare simulation runs from multiple System Dynamics simulation models. Three dynamic hypotheses regarding the uncertain evolutions of long-term copper availability are introduced and used to illustrate the new approach. They correspond to three different perspectives on the copper system (global top-down, global bottom-up, and regional top-down). Although each of these models allows to generate a wealth of behavioural patterns, the focus in this paper is on the differences in trajectories caused by different models for identical values of shared parameters and identical settings of other assumptions, not on differences in behavioural patterns caused by each of the models. Hence, differences in trajectories between the three models are identified, quantified, and classified based on a quantified measure of difference. For these models, small differences between the trajectories are only found in stable runs, while the alternative perspectives are largely responsible for medium to large differences. Hence, it is concluded that multiple dynamic hypotheses may have to be modelled when dealing with uncertain issues.

scholarly journals Monitoring the State of Charge of the Positive Electrolyte in a Vanadium Redox-Flow Battery with a Novel Amperometric Sensor

Batteries ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 5 ◽  
Author(s):  
Isabelle Kroner ◽  
Maik Becker ◽  
Thomas Turek
Keyword(s):  
Gas Diffusion ◽  
The State ◽  
State Of Charge ◽  
Vanadium Redox Flow Battery ◽  
Rotating Disc ◽  
New Approach ◽  
Long Term Stability ◽  
The Individual ◽  
Vanadium Redox

Vanadium redox-flow batteries are a promising energy storage technology due to their safety, long-term stability, and independent adjustability of power and capacity. However, the vanadium crossover through the membrane causes a self-discharge, which results in a capacity shift towards one half cell. This leads to a gradual decrease in its efficiency over time. Capacity balancing methods for compensation of this effect require a reliable online state of charge (SoC) monitoring. Most common methods cannot provide exact values of the individual concentration of each species in both electrolytes. In particular, the state of the positive electrolyte cannot yet be precisely determined. In this work, an amperometric SoC monitoring is proposed as a new approach. First, the suitability of the principle is investigated with a rotating disc electrode (RDE). Then, a sensor based on a gas diffusion layer (GDL) is developed and tested in the positive electrolyte. The dependencies between oxidative current and V(IV)-concentration are examined as well as those between reduction current and V(V)-concentration. Using both relationships, a reliable measurement of all relevant concentrations is possible.

The Failure of Privacy Enhancing Technologies (PETs) and the Voiding of Privacy

2002 ◽  
Vol 7 (2) ◽  
pp. 25-39 ◽  
Author(s):  
Felix Stalder
Keyword(s):  
Print Culture ◽  
Personal Privacy ◽  
Electronic Communications ◽  
New Approach ◽  
The Public ◽  
Internet Privacy ◽  
Policy Frameworks ◽  
Privacy Enhancing Technologies ◽  
The Individual

Most contemporary conceptions of privacy are based on a notion of aseparation between the individual and the environment. On the oneside of this boundary lies ‘the private’ on the other lies ‘the public’.The struggle over the protection of privacy is about defending thisboundary and the individual's ability to determine who can access theprivate under what conditions. Such a conception of privacy, far from being universal, is in facthistorically specific. Its rise (and decline) is part of a particular culturalcondition connected to the dominance of print media from the 16th to the 20th century. As electronic communications rise in importance, print culture, part of which is the notion of privacy, erodes. Reacting to this development, academics and the general public havebeen concerned with the preservation of privacy for more 35 years, precisely the period when the shift from print to electroniccommunication accelerated. During most of this time, focus of privacyadvocates was on the development of policy frameworks. Despitesuccesses, this strategy has, by and large, failed to stop the erosion ofprivacy. More recently, a new approach to privacy protection which promises torestore personal privacy has been developed in the context of the Internet: Privacy Enhancing Technologies (PETs). This article analyses some of the key PETs and concludes that they, too, fail to protect privacy in the electronic environment. This supportsthe thesis of the historical situatedness of privacy and raises troublingquestions for privacy advocacy in the long term.

Reduction of major amputations in the diabetic ischaemic foot: A strategy to "take control" with conservative care as well as revascularisation

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 6-14 ◽  
Author(s):  
Edmonds ◽  
Foster
Keyword(s):  
Natural History ◽  
Treatment Plan ◽  
Staging System ◽  
Vascular Control ◽  
New Approach ◽  
Conservative Care ◽  
Arterial Bypass ◽  
Therapeutic Footwear ◽  
Frequent Problem

The diabetic ischaemic foot has become an increasingly frequent problem over the last decade. However, we report a new approach consisting of a basic classification, a simple staging system of the natural history and a treatment plan for each stage, within a multi-disciplinary framework. This approach of "taking control" consists of two parts: 1. long-term conservative care including debridement of ulcers (to obtain wound control), eradication of sepsis (micribiological control), and provision of therapeutic footwear (mechanical control), and 2. revascularisation by angioplasty and arterial bypass (vascular control). This approach has led to a 50% reduction in the rate of major amputations in patients attending with ischaemic ulceration and absent foot pulses from 1989 to 1999 (from 4.6% to 2.3% per year). Patients who underwent angioplasty increased from 6% to 13%. Arterial bypass similarly increased from 3% to 7% of cases. However, even with an increased rate of revascularisation, 80% of patients responded to conservative care alone. This,we conclude, is an essential part of the management of all patients with ischaemic feet.

A New Approach for SRAM Soft Defect Root Cause Identification

2007 ◽  
Author(s):  
Peter Egger ◽  
Stefan Müller ◽  
Martin Stiftinger
Keyword(s):  
Integrated Circuits ◽  
Top Down ◽  
Feature Size ◽  
Design Rules ◽  
New Approach ◽  
Root Cause ◽  
Wafer Fab ◽  
Sram Cell ◽  
Tcad Simulation ◽  
Root Cause Identification

Abstract With shrinking feature size of integrated circuits traditional FA techniques like SEM inspection of top down delayered devices or cross sectioning often cannot determine the physical root cause. Inside SRAM blocks the aggressive design rules of transistor parameters can cause a local mismatch and therefore a soft fail of a single SRAM cell. This paper will present a new approach to identify a physical root cause with the help of nano probing and TCAD simulation to allow the wafer fab to implement countermeasures.

Attention To Music In The Years Of Independence: A New Approach To Scientific Research

2020 ◽  
Vol 2 (09) ◽  
pp. 395-398
Author(s):  
Sultanov A. ◽  
Tajiboev E.
Keyword(s):  
Music Education ◽  
Education System ◽  
Scientific Research ◽  
Educational Technologies ◽  
New Approach ◽  
Modern Methods

This article reveals the attention paid to music education in Uzbekistan, the new approach implemented in the education system, the development of pedagogical educational technologies and modern methods based on long-term independence.

CHANGES IN BLOOD PROTEOME OF COSMONAUTS WITH MICRO- AND MACROVASCULAR INJURIES DUE TO G-LOADS AT THE FINAL STAGE OF LONG-DURATION SPACE MISSIONS

2020 ◽  
Vol 54 (5) ◽  
pp. 5-14
Author(s):  
L.Kh. Pastushkova ◽  
◽  
K.S. Kireev ◽  
I.M. Larina ◽  
◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Soft Tissues ◽  
Blood Rheology ◽  
Landing Site ◽  
Space Missions ◽  
Vascular Injuries ◽  
New Approach ◽  
Long Duration ◽  
Integrated Response

The integrated response of the human proteome to re-entry g-loads following long-term space missions was studied in 13 male cosmonauts at the age of 44 ± 6 years. Examination at the landing site discovered local petechial hemorrhages into soft tissues of the back and lower legs. The paper presents a new approach to evaluation of petechia and soft tissue hemorrhages in cosmonauts on return to Earth. Proteomic analysis was performed with the use of LC-MS. Bioinformation analysis was made using Perseus, PubMed, Uniprot and ANDSystem software. Nine out of 19 significantly different (p < 0.05) proteins were related to vascular injuries directly. We described proteins with a primarily protecting effect against endothelial cells apoptosis and augmentation of vascular permeability, proteins that are responsible for blood rheology and proteins antagonistic to the main triggers of ischeamia-reperfusion injuries of the lungs, liver and other parenchymal organs.

In silico modeling of cellular probabilistic nanoparticle radiosensitization in head and neck cancers

Nanomedicine ◽  
2020 ◽  
Vol 15 (29) ◽  
pp. 2837-2850
Author(s):  
Myxuan Huynh ◽  
Ivan Kempson ◽  
Eva Bezak ◽  
Wendy Phillips
Keyword(s):  
Head And Neck ◽  
Patient Outcomes ◽  
Head And Neck Cancers ◽  
New Approach ◽  
Treatment Regimens ◽  
Therapeutic Benefits ◽  
In Silico Modeling ◽  
The Individual ◽  
Dose Deposition ◽  
Therapy Treatment

Background: The use of gold nanoparticles (AuNPs) as radiosensitizers may offer a new approach in the treatment of head and neck cancers; minimizing treatment-associated toxicities and improving patient outcomes. AuNPs promote localized dose deposition; permitting improved local control and/or dose reduction. Aim: This work aimed to address the theoretical optimization of radiation doses, fractionation and nanoparticle injection schedules to maximize therapeutic benefits. Materials & methods: Probabilistic nanoparticle sensitization factors were incorporated into the individual cell-based HYP-RT computer model of tumor growth and radiotherapy. Results: Total dose outcomes across all radiation therapy treatment regimens were found to be significantly reduced with the presence of AuNPs, with bi-weekly injections showing the most decrease. Conclusion: Outcomes suggest the need for regular AuNP administration to permit effective radiosensitization.

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