scholarly journals Infection-Genomics of COVID-19: Are Some Communities Resistant?

2020 ◽  
Author(s):  
R. Manjunatha Kini ◽  
Swati Kundu
Keyword(s):  
Alternate Splicing ◽  
Specific Expression ◽  
Lower Affinity ◽  
Severity Of Disease ◽  
The Us ◽  
The World ◽  
Detailed Evaluation ◽  
Important Field ◽  
Novel Coronavirus ◽  
Susceptible Populations

The 2019-Novel Coronavirus has currently gripped the world in terror, affecting 210 countries and territories as of April 29, 2020. Originating from Wuhan, Hubei province, China, the virus has spread so rapidly throughout the world and has already claimed 218,000 lives and is currently afflicting 3.14 million people. The US has over 1.03 million confirmed cases of COVID-19, followed by Spain, Italy, France, UK, Germany, Turkey, Russia, Iran, and China. On careful inspection of the COVID-19 statistics, a peculiar unsettling trend becomes apparent. Western European countries and the US appear to have difficulties in overcoming the catastrophe. In contrast, countries in East Asia, Middle East and mid-Europe have sorted out the situation. Here, we will highlight this trend and propose the importance of infection-genomics (sankramikogenomics), in understanding the susceptibility to COVID-19 and the severity of disease progress. More detailed evaluation may also identify more susceptible populations. Such differences are due to variations in structure or tissue-specific expression (alternate splicing and accessibility) of the target receptors. So, we will highlight mere 12-fold lower affinity is insufficient to ignore CD147, as interactions occur between tens of spike proteins and equal number of cell surface ACE2 and/or CD147. Similar to pharmacogenomics to drug development and precision medicine, Sankramikogenomics will become an important field in other infectious diseases and pathogenicity.

scholarly journals Infection-Genomics of COVID-19: Are Some Communities Resistant?

2020 ◽  
Author(s):  
R. Manjunatha Kini
Keyword(s):  
Hubei Province ◽  
Severity Of Disease ◽  
Disease Progress ◽  
Careful Inspection ◽  
The Us ◽  
The World ◽  
Novel Coronavirus

The 2019-Novel Coronavirus has currently gripped the world in terror, affecting 210 countries and territories as of April 17, 2020. Originating from Wuhan, Hubei province, China, the virus has spread so rapidly throughout the world and has already claimed 144,700 lives and is currently afflicting 2.17 million people. The US has over 677,000 confirmed cases of COVID-19, followed by Spain, Italy, France, Germany, UK and China. On careful inspection of the COVID-19 statistics, a peculiar unsettling trend becomes apparent. Here, I will highlight this trend and propose the importance of infection-genomics (sankramikogenomics), in understanding the susceptibility to COVID-19 and the severity of disease progress.

Gearing Up for a New “Pandemic” on the Eyes

2020 ◽  
Author(s):  
Sarah Wang ◽  
Keyword(s):  
Video Games ◽  
Social Networking ◽  
Electronic Devices ◽  
Health Problems ◽  
The Novel ◽  
The Past ◽  
The Us ◽  
The World ◽  
Novel Coronavirus ◽  
The Uk

As the novel coronavirus continues ravaging communities worldwide, children and adults are spending more time than ever before on their electronic devices. Social networking websites, streaming platforms, and video games accumulate hours of usage. Students and employees are turning to remote learning and working. Even before the COVID-19 pandemic, teleworking was already on the rise. In the US, the population of employees working remotely increased from 19.6% in 2003 to 24.1% in 2015, and in Sweden, the prevalence of working from home jumped from 5.9% in 1999 to 19.7% in 2012 (Feldstead & Henseke, 2017). Research conducted by the Trades Union Congress (TUC) reported that the teleworking rate in the UK increased by at least 20% over the past decade. There are currently no official reports on the increase of remote working in 2020. However, given the current pandemic situation along with the rapid advancement of technology each day, the numbers are expected to be at an all-time high. This may introduce the world to a new set of health problems: the Digital Eye Strain syndrome.

scholarly journals Pregnancy and COVID-19, a brief review

2020 ◽  
Vol 5 ◽  
Author(s):  
Olga Vasylyeva
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
World Health ◽  
Virus Spread ◽  
Resource Center ◽  
The Us ◽  
The World ◽  
Total Death ◽  
Novel Coronavirus ◽  
Health Organization

COVID-19 is a novel coronavirus capable of causing a severe acute respiratory syndrome. First identified in December 2019 in Wuhan, China, the virus spread around the world and is characterized as a pandemic by the World Health Organization. According to Johns Hopkins Coronavirus Resource Center, presently total confirmed cases mounted 156,400 with total death of 5,833 around the world, among them 2,952 cases in the US and 57 deaths.  This article summarizes what is presently known about COVID-19 infection in pregnant women, and review unique risk factors for severity of viral illnesses among pregnant women.

scholarly journals Spies and the Virus: The COVID-19 Pandemic and Intelligence Communication in the United States

2020 ◽  
Vol 5 ◽  
Author(s):  
Ana Maria Lankford ◽  
Derrick Storzieri ◽  
Joseph Fitsanakis
Keyword(s):  
United States ◽  
Strategic Communication ◽  
The United States ◽  
Policy Advice ◽  
Decision Makers ◽  
Intelligence Community ◽  
White House ◽  
The Us ◽  
The World ◽  
Novel Coronavirus

This paper introduces a crucial parameter to the novel coronavirus response in the United States, by shedding light on the early-warning role of intelligence agencies. It argues that the intelligence components of the federal government's Biological Defense Program offered actionable forewarning about an impending pandemic in the years leading to the COVID-19 outbreak. Yet, almost from the opening stages of the pandemic, senior US government officials, including President Donald Trump, have repeatedly claimed that the virus “came out of nowhere” and that “nobody saw it coming.” We show that these assertions contradict more than 15 years of pandemic preparedness warnings by intelligence professionals, and disregard the existence of intelligence-led federal pandemic response strategies of every US administration in our time. However, rather than simply placing blame on the White House for discounting these warnings, we advance a conceptual analysis of what many in the US Intelligence Community view as a critical breakdown in strategic communication between intelligence professionals and key government decision-makers. This study agrees with those who suggest that the White House disregarded its own pandemic experts. However, it also posits that the means of strategic communication employed by intelligence experts to alert the White House to the threat were unproductive. These alerts were communicated largely through the President's Daily Brief, an archaic, and ineffectual method of communication that is not designed to facilitate the kind of laser-focused, unequivocal exchange of information needed when potentially catastrophic threats confront the world. This study suggests that the Intelligence Community must implement more direct, immediate and conclusive methods of communicating intelligence to decision-makers, and should seriously consider creating a new line of products that addresses existential challenges to national security. Lastly, we contend it is time to re-evaluate existing rules that prevent intelligence analysts from offering advice on policy. Although we agree that intelligence professionals should refrain from providing policy advice on routine matters, we question the value of preventing these highly knowledgeable experts from communicating strategic policy advice to decision-makers when it comes to threats of a catastrophic nature, which may prove potentially existential for the US, its allies, and the world.

scholarly journals Forecasting COVID-19 Transmission in India Using Deep Learning Models

2020 ◽  
Vol 10 (2) ◽  
pp. 2044-2055
Keyword(s):  
Transmission Rate ◽  
World Health ◽  
Similar Data ◽  
Slowing Down ◽  
Short Period ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Susceptible Populations ◽  
Near Future

In the past 6 months, the world has come to a standstill due to an escalation in the number of cases of COVID-19. COVID-19 is an infectious disease that was formerly called as 2019-nCoV or the novel Coronavirus 2019. COVID-19 first originated in Wuhan, China, in late December 2019, and subsequently, the World Health Organization declared it as a pandemic on 11th March, 2020. Lack of preparedness for the COVID-19 pandemic has put colossal stress on the healthcare systems of the world’s largest economies. In a short period, the disease has spread to an unexpected number of people due to its high transmission rate and doesn’t show a sign of slowing down in the near future. Estimating the rising number of cases via predictive modeling can help gauge the quantity of various medical amenities required for the treatment of patients as well as protective apparatus for essential workers and susceptible populations. In this paper, we have performed time series forecasting on the publicly available COVID-19 datasets of India using RNNs with LSTM and GRU. Additionally, we also employ the final models for analyzing similar data from different countries.

Searching for new Sources of growth. Are the Developing Countries Catching up with the Developed ones?

2015 ◽  
pp. 30-53
Author(s):  
V. Popov
Keyword(s):  
Developing Countries ◽  
Western Europe ◽  
Gdp Per Capita ◽  
The West ◽  
Catching Up ◽  
The Us ◽  
The World ◽  
Economic Divergence ◽  
Per Capita ◽  
Relative Standing

This paper examines the trajectory of growth in the Global South. Before the 1500s all countries were roughly at the same level of development, but from the 1500s Western countries started to grow faster than the rest of the world and PPP GDP per capita by 1950 in the US, the richest Western nation, was nearly 5 times higher than the world average and 2 times higher than in Western Europe. Since 1950 this ratio stabilized - not only Western Europe and Japan improved their relative standing in per capita income versus the US, but also East Asia, South Asia and some developing countries in other regions started to bridge the gap with the West. After nearly half of the millennium of growing economic divergence, the world seems to have entered the era of convergence. The factors behind these trends are analyzed; implications for the future and possible scenarios are considered.

Russian Policy of Agriculture Support and the Necessity of Its Modification after WTO Accession

2012 ◽  
pp. 132-149 ◽  
Author(s):  
V. Uzun
Keyword(s):  
Comparative Analysis ◽  
World Trade Organization ◽  
Agricultural Production ◽  
World Trade ◽  
The Us ◽  
The World ◽  
Wto Accession ◽  
The Eu ◽  
Agriculture Support

The article deals with the features of the Russian policy of agriculture support in comparison with the EU and the US policies. Comparative analysis is held considering the scales and levels of collective agriculture support, sources of supporting means, levels and mechanisms of support of agricultural production manufacturers, its consumers, agrarian infrastructure establishments, manufacturers and consumers of each of the principal types of agriculture production. The author makes an attempt to estimate the consequences of Russia’s accession to the World Trade Organization based on a hypothesis that this will result in unification of the manufacturers and consumers’ protection levels in Russia with the countries that have long been WTO members.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Current updates on COVID-19 - A review

2020 ◽  
Vol 10 (1) ◽  
pp. 1-8
Author(s):  
Ghotekar D S ◽  
Vishal N Kushare ◽  
Sagar V Ghotekar
Keyword(s):  
World Health Organization ◽  
Common Cold ◽  
Respiratory Diseases ◽  
Gastrointestinal Diseases ◽  
Hubei Province ◽  
World Health ◽  
The World ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

Coronaviruses are a family of viruses that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory diseases can range from the common cold to more severe diseases. A novel coronavirus outbreak was first documented in Wuhan, Hubei Province, China in December 2019. The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) a pandemic. A global coordinated effort is needed to stop the further spread of the virus. A novel coronavirus (nCoV) is a new strain that has not been identified in humans previously. Once scientists determine exactly what coronavirus it is, they give it a name (as in the case of COVID-19, the virus causing it is SARS-CoV-2).

An approach to the understanding of the clinical-etiopathological aspect of COVID-19 (SARS-CoV-2)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 862-869
Author(s):  
Meena Kumari ◽  
Monika Agrawal ◽  
Rakesh Kumar Singh ◽  
Parameswarappa S Byadgi
Keyword(s):  
World Health ◽  
Apical Surface ◽  
Therapy Assessment ◽  
Differentiated Cells ◽  
The World ◽  
Polarized Epithelia ◽  
Well Differentiated ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Epidemiological Characteristics

Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus disease COVID-19. On 11 March 2020, the World Health Organization (WHO) has declared this disease as a pandemic. The condition (COVID-19) is an infectious disorder triggered by a newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2. Most of the COVID-19 infected patients will experience mild to moderate respiratory symptoms and recover without any unique therapy. Assessment of the clinical and epidemiological characteristics of SARS-CoV-2 cases suggests the infected patients will not be contagious until the onset of severe symptoms and affects the other organs. Well-differentiated cells of apical airway epithelia communicating with ACE2 were promptly infected to SARS-CoV-2 virus. But the expression of ACE 2 in poorly differentiated epithelia facilitated SARS spike (S) protein-pseudo typed virus entry and it is replicated in polarized epithelia and especially exited via the apical surface. Limiting the transmission of COVID-19 infection & its prevention can be regarded as a hierarchy of controls. In this article, we briefly discuss the most recent advances in respect to aetiology, pathogenesis and clinical progression of the disease COVID-19.

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