Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer

2020 ◽  
Author(s):  
Ashley Tinsley
Keyword(s):  
Large Scale ◽  
Current Knowledge ◽  
Treatment Plan ◽  
The Body ◽  
Future Research ◽  
Survival Times ◽  
Cell Structures ◽  
Hemorrhagic Events ◽  
Client Communication ◽  
Future Direction

Canine Hemangiosarcoma (HSA) is a devastating cancer affecting blood vessels in numerous sites within the body that is primarily seen in middle to older aged dogs. It is marked by its rapid aggressive metastatic pathology that often results in a lack of apparent symptoms in early stages. In most cases, disease becomes apparent due to hemorrhagic events following the rupture of the malignant vascular cell structures that can capture and pool blood cells, resulting in necrosis of the affected tissues. The poor survival times in affected patients cause a hindrance to the ability to carry out large scale studies, leaving numerous knowledge gaps to be filled in future research. The pathologic similarities between this and human angiosarcoma (HA) provides the potential for translatable research to be carried out that would improve outcomes across species. Here, current knowledge is outlined in order to improve understanding HSA holistically and suggest future direction. Emphasis is placed on the potential to improve veterinary practices in ways that will improve the ability to quickly and accurately diagnose patients in order to establish better client communication and provide clarity in collaborating to create the best informed treatment plan possible.

Business model innovation: past research, current debates, and future directions

2017 ◽  
Vol 10 (3) ◽  
pp. 342-359 ◽  
Author(s):  
Mokter Hossain
Keyword(s):  
Literature Review ◽  
Business Model ◽  
Systematic Literature Review ◽  
Current Knowledge ◽  
Past Research ◽  
Business Model Innovation ◽  
The Body ◽  
Future Research ◽  
Content Type ◽  
Body Of Knowledge

Purpose The purpose of this paper is to provide state-of-the-art knowledge about business model innovation (BMI) and suggest avenues for future research. Design/methodology/approach A systematic literature review approach was adopted with thematic analysis being conducted on 92 articles. Findings The body of knowledge for this concept is in its infancy and is highly fragmented. This study therefore attempts to consolidate this fragmented knowledge. It reveals dominant themes, establishes coherence, and identifies conflicting arguments in the current literature. It also points out gaps in the research and highlights new directions for research. Research limitations/implications This study analyzed articles that were found based on a systematic literature review approach. Practical implications This study identifies some fundamental issues that managers need to understand regarding BMI. Originality/value The main value of this study lies in its synthesis of the current knowledge of BMI.

scholarly journals Iron Regulation in Athletes: Exploring the Menstrual Cycle and Effects of Different Exercise Modalities on Hepcidin Production

2014 ◽  
Vol 24 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Marc Sim ◽  
Brian Dawson ◽  
Grant Landers ◽  
Debbie Trinder ◽  
Peter Peeling
Keyword(s):  
Oral Contraceptive ◽  
Inflammatory Cytokine ◽  
Iron Absorption ◽  
Current Knowledge ◽  
Oral Contraceptive Pill ◽  
Well Being ◽  
The Body ◽  
Iron Regulation ◽  
Future Research ◽  
Exercise Induced

The trace element iron plays a number of crucial physiological roles within the body. Despite its importance, iron deficiency remains a common problem among athletes. As an individual’s iron stores become depleted, it can affect their well-being and athletic capacity. Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6. As such, when hepcidin levels are elevated, iron absorption and recycling may be compromised. To date, however, most studies have explored the acute postexercise hepcidin response, with limited research seeking to minimize/attenuate these increases. This review summarizes the current knowledge regarding the postexercise hepcidin response under a variety of exercise scenarios and highlights potential areas for future research—such as: a) the use of hormones though the female oral contraceptive pill to manipulate the postexercise hepcidin response, b) comparing the use of different exercise modes (e.g., cycling vs. running) on hepcidin regulation.

The Body of Laozi and the Course of a Taoist Journey through the Heavens

2008 ◽  
Vol 4 (2) ◽  
pp. 515-547
Author(s):  
Patrice Fava ◽  
Vivienne Lo
Keyword(s):  
Large Scale ◽  
The Body ◽  
Future Research ◽  
Liturgical Texts ◽  
Intimate Knowledge ◽  
The Rich

AbstractAt the border of Hunan and Jiangxi, where Taoist rituals and the Nuo tradition of masked theatre have undergone a large scale revival in recent decades, a Taoist master of the Orthodox Zhengyi sect, Master Yi Songyao , has preserved a number of rare ancient paintings and manuscripts that have been transmitted to him as the liturgical texts of his lineage; these include a map of the body of Laozi and a chart of the course of a Taoist journey through the Heavens. The following brief introduction to these two documents serves mainly as an example of how an intimate knowledge of Taoist ritual can provide a key to the performative nature of the charts and indicates the rich scope for future research.

I. Visions of epithelial research

2003 ◽  
Vol 284 (4) ◽  
pp. G547-G550 ◽  
Author(s):  
Marshall H. Montrose
Keyword(s):  
Epithelial Cells ◽  
Laser Capture Microdissection ◽  
Current Knowledge ◽  
The Body ◽  
Transepithelial Transport ◽  
Future Research ◽  
New Methodologies ◽  
Functionally Diverse ◽  
Microarray Analyses ◽  
Laser Capture

Epithelial cells are gatekeepers that sit at the interface between two compartments. By controlling the flow of molecules and information between two compartments, epithelial cells provide unique benefit to the body. This article provides a brief appraisal of our current knowledge about the functions of gastrointestinal epithelial cells as a functionally diverse set of cells mediating transepithelial transport and as a continually renewing layer of cells. The convergence of new methodologies in laser capture microdissection, microarray analyses, microscopic analyses, and generation of mutant animals provides an exciting template for future research.

Genetic contributions to anxiety disorders: where we are and where we are heading

2021 ◽  
pp. 1-16
Author(s):  
Helga Ask ◽  
Rosa Cheesman ◽  
Eshim S. Jami ◽  
Daniel F. Levey ◽  
Kirstin L. Purves ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Psychiatric Disorders ◽  
Large Scale ◽  
Current Knowledge ◽  
Association Studies ◽  
Twin Studies ◽  
Future Research ◽  
Specific Gene ◽  
Genome Wide Association Studies ◽  
Genome Wide

Abstract Anxiety disorders are among the most common psychiatric disorders worldwide. They often onset early in life, with symptoms and consequences that can persist for decades. This makes anxiety disorders some of the most debilitating and costly disorders of our time. Although much is known about the synaptic and circuit mechanisms of fear and anxiety, research on the underlying genetics has lagged behind that of other psychiatric disorders. However, alongside the formation of the Psychiatric Genomic Consortium Anxiety workgroup, progress is rapidly advancing, offering opportunities for future research. Here we review current knowledge about the genetics of anxiety across the lifespan from genetically informative designs (i.e. twin studies and molecular genetics). We include studies of specific anxiety disorders (e.g. panic disorder, generalised anxiety disorder) as well as those using dimensional measures of trait anxiety. We particularly address findings from large-scale genome-wide association studies and show how such discoveries may provide opportunities for translation into improved or new therapeutics for affected individuals. Finally, we describe how discoveries in anxiety genetics open the door to numerous new research possibilities, such as the investigation of specific gene–environment interactions and the disentangling of causal associations with related traits and disorders. We discuss how the field of anxiety genetics is expected to move forward. In addition to the obvious need for larger sample sizes in genome-wide studies, we highlight the need for studies among young people, focusing on specific underlying dimensional traits or components of anxiety.

scholarly journals Analyzing Healthcare Facility Resilience: Scientometric Review and Knowledge Map

2021 ◽  
Vol 9 ◽  
Author(s):  
Lingzhi Li ◽  
Shuni Liao ◽  
Jingfeng Yuan ◽  
Endong Wang ◽  
Jianjun She
Keyword(s):  
Current Knowledge ◽  
Research Work ◽  
Healthcare Facility ◽  
The Body ◽  
Risk Society ◽  
Future Research ◽  
Knowledge Map ◽  
Knowledge Gaps ◽  
Healthcare Facilities ◽  
Knowledge Domains

In contemporary “high-risk” society, unexpected disasters (epidemics and extreme weather) and chronic pressures (aging problems) put tremendous pressure on healthcare facilities. Enhancing the healthcare facilities' resilience ability to resist, absorb, and respond to disaster disruptions is urgent. This study presents a scientometric review for healthcare facility resilience research. A total of 374 relevant articles published between 2000 and 2020, collected from Web of Science (WoS) core collection database, Scopus database and MEDLINE database were reviewed and analyzed. The results indicated that research on resilience in healthcare facilities went through three development periods, and the research involved countries or institutions that are relatively scattered. The studies have been focused on the subject categories of engineering, public, environmental, and occupational health. The keywords of “resilience,” “hospital,” “disaster,” “healthcare,” and “healthcare facility” had the most frequency. Furthermore, based on the literature co-citation networks and content analysis, the detected seven co-citation clusters were grouped into four knowledge domains: climate change impact, strengthening resilience in response to war and epidemic, resilience assessment of healthcare facility, and the applications of information system. Moreover, the timeline view of literature reflected the evolution of each domain. Finally, a knowledge map for resilience of healthcare facilities was put forward, in which critical research contents, current knowledge gaps, and future research work were discussed. This contribution will promote researchers and practitioners to detect the hot topics, fill the knowledge gaps, and extend the body of research on resilience of healthcare facilities.

scholarly journals Restored freshwater flow and estuarine benthic communities in the northern Gulf of Mexico: research trends and future needs

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8587
Author(s):  
Jillian C. Tupitza ◽  
Cassandra N. Glaspie
Keyword(s):  
Mississippi River ◽  
Large Scale ◽  
Aquatic Vegetation ◽  
Nutrient Loading ◽  
Benthic Communities ◽  
Geographic Region ◽  
Community Response ◽  
The Body ◽  
Future Research ◽  
Freshwater Flow

Restoring river connectivity to rebuild and sustain land is a promising restoration strategy in coastal areas experiencing rapid land loss, such as the Mississippi river delta. Results of these large-scale hydrologic changes are preliminary, and there exists limited empirical evidence regarding how benthic communities will respond, specifically in Barataria Bay and Breton Sound in southeast Louisiana. In this review, the body of existing research in this geographic region pertaining to the drivers of benthic community response that are related to restored freshwater flow and sediment deposition is examined. Overall trends include (1) potential displacement of some species down-estuary due to reduced salinities; (2) temporary lower diversity in areas closest to the inflow; (3) increased benthic production along the marsh edge, and in tidal bayous, as a result of nutrient loading; (4) more habitat coverage in the form of submerged aquatic vegetation; and (5) reduced predation pressure from large and/or salinity-restricted predators. These trends highlight opportunities for future research that should be conducted before large-scale hydrologic changes take place.

scholarly journals Employee engagement and performance: a systematic literature review

2018 ◽  
Vol 54 (3) ◽  
pp. 227-244 ◽  
Author(s):  
Błażej Motyka
Keyword(s):  
Employee Engagement ◽  
Work Engagement ◽  
Work Performance ◽  
Current Knowledge ◽  
The Body ◽  
Future Research ◽  
Significant Relation ◽  
Economic Problems ◽  
And Performance ◽  
Academic Implications

AbstractScholars and practitioners indicate that low level of employee engagement at work is currently one of the most alarming global economic problems. The potential consequence of this phenomenon is declining work performance. Therefore, it becomes important to understand the concept of work engagement, its meaning for employees, and implications for employers. The article is a systematic review of the body of literature, presenting the results of research on the association between employee engagement and various performance categories. The paper’s objective is to summarize prior studies based on their ordering and categorization, identify gaps in the current knowledge, and propose an agenda for future research. The article presents these findings in a synthetic manner, offering practical and academic implications arising therefrom. Results of the review indicate that, in the case of most peer-reviewed publications, a statistically significant relation between employee engagement and numerous categories and subcategories of performance was confirmed.

Cryptic species in plant-parasitic nematodes

Nematology ◽  
2014 ◽  
Vol 16 (10) ◽  
pp. 1105-1118 ◽  
Author(s):  
Juan E. Palomares-Rius ◽  
Carolina Cantalapiedra-Navarrete ◽  
Pablo Castillo
Keyword(s):  
Cryptic Species ◽  
Large Scale ◽  
Current Knowledge ◽  
Species Conservation ◽  
Future Research ◽  
Parasitic Nematodes ◽  
Plant Parasitic Nematodes ◽  
The Many ◽  
Diverse Groups ◽  
Plant Parasitic

This paper summarises the current knowledge concerning cryptic species of plant-parasitic nematode and briefly reviews the different methods available for their detection and characterisation. Cryptic species represent an important component of biodiversity, such speciation being common among plant-parasitic nematodes and occurring in diverse groups with different life history traits, including the spiral, virus vector, root-lesion and false root-knot nematodes. Cryptic species are important for a number of reasons, including food security, quarantine, non-chemical management technologies and species conservation, and should not be ignored. The magnitude of the phenomenon is largely unknown, but the available data on plant-parasitic nematodes demonstrate that reliance on morphology alone for species delimitation seriously underestimates the total number of taxa. Future research should focus on appropriately designed case studies using combined approaches, including large-scale, whole sample analyses by next-generation sequencing or proteomics in order to be able to answer the many questions that still remain.

scholarly journals Histone 4 Lysine 20 Methylation: A Case for Neurodevelopmental Disease

Biology ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 11 ◽  
Author(s):  
Rochelle Wickramasekara ◽  
Holly Stessman
Keyword(s):  
Large Scale ◽  
Developmental Process ◽  
Current Knowledge ◽  
Fine Tuning ◽  
Future Research ◽  
Sequencing Data ◽  
Neurodevelopmental Disease ◽  
Kleefstra Syndrome ◽  
Sequencing Studies ◽  
Methyltransferase Gene

Neurogenesis is an elegantly coordinated developmental process that must maintain a careful balance of proliferation and differentiation programs to be compatible with life. Due to the fine-tuning required for these processes, epigenetic mechanisms (e.g., DNA methylation and histone modifications) are employed, in addition to changes in mRNA transcription, to regulate gene expression. The purpose of this review is to highlight what we currently know about histone 4 lysine 20 (H4K20) methylation and its role in the developing brain. Utilizing publicly-available RNA-Sequencing data and published literature, we highlight the versatility of H4K20 methyl modifications in mediating diverse cellular events from gene silencing/chromatin compaction to DNA double-stranded break repair. From large-scale human DNA sequencing studies, we further propose that the lysine methyltransferase gene, KMT5B (OMIM: 610881), may fit into a category of epigenetic modifier genes that are critical for typical neurodevelopment, such as EHMT1 and ARID1B, which are associated with Kleefstra syndrome (OMIM: 610253) and Coffin-Siris syndrome (OMIM: 135900), respectively. Based on our current knowledge of the H4K20 methyl modification, we discuss emerging themes and interesting questions on how this histone modification, and particularly KMT5B expression, might impact neurodevelopment along with current challenges and potential avenues for future research.

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