scholarly journals Municipal Residence Level of Long-Term PM10 Exposure Associated with Obesity among Young Adults in Seoul, Korea

2020 ◽  
Author(s):  
Jayeun Kim ◽  
Kyuhyun Yoon
Keyword(s):  
Young Adults ◽  
Specific Effect ◽  
Life Time ◽  
Total Study Population ◽  
Logistic Regression Models ◽  
Specific Effects ◽  
Study Population ◽  
Socio Demographic Factors ◽  
Pm10 Exposure

Background: The associations between long-term exposure to particulate matters (PM) in residential ambiance and obesity are comparatively less elucidated among young adults. Methods: Using 2017 Community Health Survey data with aged 19−29 participants in 25 communities, Seoul, the relationship between obesity and long−term PM10 levels of living district was examined. We defined obesity as overweight (25≤BMI<30) or obese (30≤BMI) using Body Mass Index (BMI) from self-reported anthropometric information. Analysis was conducted sampling weighted logistic regression models by fitting municipal PM10 levels according to individual residence periods with 10 years and more residing in a current municipality. Socio-demographic factors were adjusted over all models and age−specific effect was explored among aged 19–24 and 25–29. Results: Total study population are 3,655 [men 1,680 (46.0%) and aged 19–24 1,933 (52.9%)] individuals. Among the communities with greater level of PM10; 2001–2005, associations with obesity were increased for overall with residence period; 10 years ≤ [Odds ratio, OR 1.071, 95% Confidence interval (CI) 0.969–1.185], 15 years ≤ [OR 1.118, 95% CI 1.004–1.245], and 20 years ≤ [OR 1.156, 95% CI 1.032–1.294]. However, decreased associations were detected for PM10; 2006–2010, and age–specific effects were modified according to the residence period. Conclusions: Although currently PM10 levels are decreasing, higher levels of PM10 exposure at the residential area during the earlier life-time may contribute in increasing obesity among young adults.

scholarly journals Municipal Residence Level of Long-Term PM10 Exposure Associated with Obesity among Young Adults in Seoul, Korea

2020 ◽  
Vol 17 (19) ◽  
pp. 6981
Author(s):  
Jayeun Kim ◽  
Kyuhyun Yoon
Keyword(s):  
Young Adults ◽  
Odds Ratio ◽  
Residential Area ◽  
Individual Characteristics ◽  
Long Term Effects ◽  
Specific Effects ◽  
Study Population ◽  
The Relationship ◽  
Pm10 Exposure

Background: long-term effects of ambient pollutants used to be defined in cohort studies using biomarkers. Health effects on young adults from long-term exposure to particulate matters (PM) in residential ambiance have received less attention. Methods: using the data of population-representative aged 19–29 in Seoul, the relationship between obesity and PM10 levels of the living district was examined. We defined obesity as Body Mass Index (BMI) 25 kg/m2 and more. Survey logistic regression was conducted according to individual residence periods in the current municipality. Individual characteristics were adjusted overall and were age-specific; aged 19–24 and 25–29. Results: study population was 3655 (1680 (46%) men and 1933 aged 19–24 (52.9%)) individuals. Relationship between length of residence in municipalities with a greater level of PM10 from 2001–2005 and obesity was increased over the residing period; 10 years ≤ (odds ratio (OR) 1.071, 95% confidence interval (CI) 0.969–1.185), 15 years ≤ (1.120, 1.006–1.247), and 20 years ≤ (1.158, 1.034–1.297) in aged 19–29. Age-specific effects showed slight differences. Conclusions: Although PM10 levels are currently decreasing, higher levels of PM10 exposure in the residential area during the earlier lifetime may contribute to obesity increase among young adults.

scholarly journals Evaluation of Adolescents’ and Young Adults’ Attitudes Toward Participation in Cancer Clinical Trials

2020 ◽  
Vol 16 (3) ◽  
pp. e280-e289
Author(s):  
Jeremy Lewin ◽  
Jennifer A. H. Bell ◽  
Kate Wang ◽  
Victoria Forcina ◽  
Seline Tam ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Young Adults ◽  
Logistic Regression ◽  
Adolescents And Young Adults ◽  
Cancer Clinical Trials ◽  
Patient Centered ◽  
Logistic Regression Models ◽  
Age Related ◽  
Tumor Types

PURPOSE: Participation in cancer clinical trials (CCTs) for adolescents and young adults (AYAs) remains the lowest of any patient group with cancer. Little is known about the personal barriers to AYA accrual. The aim of this study was to explore AYA attitudes that influence CCT participation. METHODS: A mixed-methods approach was used. AYAs and non-AYAs (≥ 40 years) completed the Cancer Treatment subscale of the Attitudes Toward Cancer Trials Scales and 9 supplementary questions formed from interview analysis. Differences between AYA and non-AYA cohorts were analyzed using the Mann-Whitney U test, and logistic regression models were constructed to evaluate the effect of demographics on perceptions of CCTs. RESULTS: Surveys were distributed to 61 AYAs (median age, 29 years; range, 17-39 years) and 74 non-AYAs (median age, 55 years; range, 40-88 years). Compared with non-AYAs, AYAs perceived CCTs to be unsafe/more difficult (Personal Barrier/Safety domain; P = .01). There were no differences based on age in other domains. AYAs were also more concerned with CCT interference in their long-term goals ( P = .04). Multivariable ordered logistic regression identified increased personal barriers in the Personal Barrier/Safety domain for AYAs ( P = .01), in patients with English as a second language (ESL; P < .01), and in patients previously not offered a clinical trial ( P = .03). Long-term goals were identified as a barrier in particular tumor types ( P = .01) and in patients with ESL ( P < .01), with a trend identified in AYAs ( P = .12). CONCLUSION: Age-related differences in attitudes toward CCTs suggest that tailored approaches to CCT accrual are warranted. Patient-centered delivery of information regarding CCTs, particularly in patients with ESL and who are trial naïve, may improve accrual.

Interaction Between Retinol Intake and ISX rs5755368 Polymorphism in Colorectal Cancer Risk: A Case-control Study Among the Korean Population

2021 ◽  
Author(s):  
Anh Quynh Bui ◽  
Madhawa Gunathilake ◽  
Jeonghee Lee ◽  
Jae Hwan Oh ◽  
Hee Jin Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Regression Models ◽  
Case Control Study ◽  
Protective Role ◽  
Case Control ◽  
Total Study Population ◽  
Logistic Regression Models ◽  
Study Population ◽  
Control Study

Abstract There is limited evidence about the interaction between retinol intake and the intestine-specific homeobox (ISX) rs5755368 polymorphism in colorectal cancer (CRC) risk. We conducted a hospital-based case-control study to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. First, to identify the association between dietary retinol and CRC risk, we recruited 923 CRC patients and 1846 controls. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. For genetic analysis, genotype data were available for 1419 patients (600 cases and 819 controls) out of the total study population. ISX rs5755368 genotyping was performed using an Illumina MEGA-Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with the development of CRC (OR = 0.49; 95% CI = 0.37–0.63) after adjusting for confounders. Patients with homozygous AA genotype of the ISX rs5755368 polymorphism were less likely to have CRC risk than subjects carrying the G allele (AG+GG) (OR = 0.76; 95% CI = 0.58–0.99). Additionally, a 68% reduced risk of CRC was related to the highest retinol intake among those carrying the rs5755368 AA genotype compared to the risk of participants carrying the G allele consumed the lowest retinol intake (OR = 0.32; 95% CI = 0.20–0.53; P interaction=0.026). In conclusion, our study confirmed a protective role of retinol intake in CRC risk reduction. Moreover, this association was strengthened significantly among individuals carrying the homozygous AA genotype of the ISX rs5755368 polymorphism.

scholarly journals Stealth-vaping: a new era of illicit substance misuse? a systematic review and meta-analysis of the prevalence of electronic nicotine delivery systems for the consumption of illicit substances

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S256-S257
Author(s):  
Tim Hicks ◽  
Rebecca Arrowsmith ◽  
Susannah Keill ◽  
Eleni Papadakou
Keyword(s):  
Random Effects ◽  
Delivery Systems ◽  
Significant Heterogeneity ◽  
Random Effects Model ◽  
Total Study Population ◽  
Electronic Nicotine Delivery Systems ◽  
Nicotine Delivery ◽  
Study Population ◽  
Illicit Substances

AimsTo estimate the prevalence of using Electronic Nicotine Delivery Systems (ENDS) for the consumption of illicit Substances (illegal under UK Law). We hypothesised that this is an increasingly common mode of delivery.BackgroundUsing ENDS to consume nicotine is increasing in popularity worldwide with a prevalence in the UK of 6% and in the USA 4%-6%. Existing studies have reported that people are switching to vaping because it is felt to be safer than smoking.However there is also emerging evidence that this mode of consumption is increasingly being used as it is discreet and much less easy to detect, hence sometimes referred to as stealth-vaping. This appears to be driving a switch to vaping to administer substances other than nicotine, notably, but not exclusively cannabis, including concentrated forms of Tetrahydrocannabinol (THC) and synthetic cannabinoids. Anecdotally this practice is known to be occurring in psychiatric inpatient settings.This is against a backdrop of the uncertain long-term effects of vaping and the emergence of case reports of the death of otherwise healthy young persons after using ENDS to consume cannabis.MethodSearch strategy: MEDLINE , EMBASE, Cochrane Database of Systematic Reviews, Grey Literature using Medical Subject Headings (MeSH), text words relating to vaping of drugs and hand searching journals.Statistical methods: Synthesis of data was performed using inverse variance with double arcsine transformation in MetaXL. Heterogeneity was assessed with the Cochran's Q and I2.ResultFrom 970 abstracts, 61 papers were selected for full text review, 18 met the inclusion criteria. The total study population for the outcome of ENDS nicotine users who also use ENDS for the consumption of illicit substances was 9098. There was significant heterogeneity with a random effects model prevalence of 17% (95%CI 7%-32%). The total study population for the outcome of cannabis users who use ENDS to consume cannabis was 52708. There was significant heterogeneity with a random effects model prevalence of 23% (95%CI 12%-37%).ConclusionThe use of ENDS to consume illicit substances is concerning as it appears to be relatively common practice. This was most notable in studies of existing cannabis users, younger people and medical marijuana users.Given the uncertainty of long term health consequences and poor understanding of sudden death in some users, this study highlights an emerging and substantial public health concern.Currently there is a paucity of primary studies to elucidate the impact on health.

scholarly journals Higher risk of COVID-19 hospitalization for unemployed: an analysis of 1,298,416 health insured individuals in Germany

2020 ◽  
Author(s):  
Nico Dragano ◽  
Christoph J. Rupprecht ◽  
Olga Dortmann ◽  
Maria Scheider ◽  
Morten Wahrendorf
Keyword(s):  
Social Inequalities ◽  
Routine Data ◽  
Daily Basis ◽  
Logistic Regression Models ◽  
Universal Health Care System ◽  
Icd 10 ◽  
The Usa ◽  
Study Population ◽  
Short And Long Term

AbstractBackgroundPrevious research on infectious disease has revealed that infection risk as well as the severity of diseases is related to income and poverty. In this study we investigate if unemployed persons have a higher risk to become hospitalized with a COVID-19 diagnosis compared with employed persons.MethodsWe used routine data on hospitalizations in a study population of 1,298,416persons between the ages 18 and 65 who were enrolled in a German health insurance and who were active on the labour market (either employed or unemployed). Hospital diagnosis of COVID-19 (ICD-10-GM U07.1 and U07.2) were reported on a daily basis from 01.01.2020 to 04.06.2020. We studied if the rate of persons hospitalized with a COVID-19 diagnoses differed by employment situation. Logistic regression models comparing employed with short- and long-term unemployed were calculated adjusting for age and sex.ResultsIn total, we observed 1,311 persons who were hospitalized, corresponding to a rate of 100.98 cases per 100.000 in our study population. Rates varied between the groups in different employment situations with lowest rates for employed and highest for long-term unemployed. Odds ratio for a hospitalization was 1.84 (1.64 - 2.07) for long-term and 1.18 (0.75 - 1.85) for short-term unemployed compared with employed persons.ConclusionThe results are in line with earlier (mainly ecological) studies from the USA and Great Britain which found social inequalities in hospitalization risk. The fact that differences exist in Germany, a country with a universal health care system, indicates socioeconomic differences in the COVID-19 pandemic exists across countries.

scholarly journals COVID-19 among young adults in Sweden: self-reported long-term symptoms and associated factors

2021 ◽  
pp. 140349482110254
Author(s):  
Sandra Ekström ◽  
Niklas Andersson ◽  
Alexandra Lövquist ◽  
André Lauber ◽  
Antonios Georgelis ◽  
...  
Keyword(s):  
Young Adults ◽  
Chronic Conditions ◽  
Population Based ◽  
Lifestyle Factors ◽  
Swedish Population ◽  
Significant Difference ◽  
Study Population ◽  
Web Questionnaire

Aims: The main aim of the study was to describe self-reported symptoms of COVID-19 and examine if long-term symptoms are associated with lifestyle factors or common chronic diseases among Swedish young adults. A secondary aim was to compare the prevalence of smoking and snuff use before and during the COVID-19 pandemic. Methods: The study population includes 1644 participants aged 23–26 years from the Swedish population-based birth cohort BAMSE. From August to November 2020, the participants answered a web questionnaire on COVID-19 symptoms, lifestyle and health. Information on tobacco use was compared against the previous study follow-up in 2016–2019. Results: The prevalence of suspected COVID-19 symptoms was 45.3% ( n=742), and 80 of these (10.8%) reported long-term symptoms (⩾4 weeks). There was no significant difference in sociodemographic or lifestyle factors in relation to the duration of suspected COVID-19 symptoms. Rhinitis, migraine and lower self-rated health before the pandemic was more common among participants with long-term symptoms. In addition, there was a tendency for higher prevalences of asthma, chronic bronchitis and depression in this group. The prevalence of smoking decreased from 18.9% before the pandemic to 14.7% during the pandemic, while snuff use increased from 12.7% to 22.4% ( P<0.001). Conclusions: Almost half of Swedish young adults have had symptoms of suspected COVID-19 from February up to August 2020. Among these, one out of 10 have had long-term symptoms for at least 4 weeks. Long-term symptoms of suspected COVID-19 were associated with several common chronic conditions. Smoking may have decreased during the pandemic, while snuff use may have increased.

Pauperism in America: Long-term effects of childhood poverty on Caucasian young adults

2014 ◽  
Author(s):  
Benjamin Finch ◽  
Heather Lopez ◽  
Jessie Shafer ◽  
Chrysalis L. Wright
Keyword(s):  
Young Adults ◽  
Long Term Effects ◽  
Childhood Poverty

The generalized regularities of damageability and integrity in estimations of the endurance in conditions of variability of loading regimes

2019 ◽  
Vol 85 (9) ◽  
pp. 61-65
Author(s):  
N. A. Makhutov
Keyword(s):  
Life Time ◽  
Cyclic Strength ◽  
Laboratory Diagnostics ◽  
Methodological Issues ◽  
Break Points ◽  
Number Of Cycles ◽  
Cyclic Damage ◽  
Damage Summation ◽  
Temperature Factors

We consider and analyze general methodological issues regarding the strength and endurance (life-time) of the materials and structure elements under a combined effect of various force, deformation and temperature factors. The Journal "Zavodskaya laboratoriya. Diagnostika materialov" (Industrial laboratory. Diagnostics of materials) has launched systematic publications on this problematic since 2018. For many decades, domestic and foreign laboratory studies have gleaned to a traditional methodology for obtaining initial curves of the long-term and cyclic strength that related the breaking stresses with time or number of cycles. These curves, with the characteristic sections and break points, separating the areas of elastic and inelastic (plastic strain or creep strain) strain, are used in analysis of long-term and cyclic damage. Using the elementary linear law of damage summation, it is possible to calculate at a first approximation the strength and endurance under varying conditions of loading. Stepping up the requirements to the accuracy of calculations necessitates a transition from force fracture criteria (at stresses a) to deformation criteria (in elastic and inelastic deformations e). Thus, it becomes possible to construct and use a unified expression for the curve of the long-term cyclic fracture (taking into account the temporal x and cyclic N factors) and a long-term cyclic damage. With such approach it is possible to remain the linear law of damage summation though those damages are obviously nonlinear. The goal of the study is to continue and support the discussion of the most complex problems of a comprehensive assessment of the strength, resource, survivability and safety of high-risk engineering equipment within the journal pages.

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