scholarly journals Solid Dispersions of Biologically Active Substances

2020 ◽  
Author(s):  
Salavat Khalikov
Keyword(s):  
Rapid Development ◽  
Solid Dispersions ◽  
Animal Health ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Cultivated Plants ◽  
Industrial Complex ◽  
Scientific Papers ◽  
Active Substances

Due to the rapid development of nanotechnologies, materials, in particular , solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

scholarly journals Solid Dispersions of Anthelmintics and Plant Protection Preparations

Solids ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 60-75
Author(s):  
Salavat S. Khalikov
Keyword(s):  
Plant Protection ◽  
Rapid Development ◽  
Solid Dispersions ◽  
Animal Health ◽  
Water Soluble ◽  
Biologically Active ◽  
Cultivated Plants ◽  
Industrial Complex ◽  
Scientific Papers ◽  
Poorly Soluble

Because of the rapid development of nanotechnologies, materials, in particular, solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

FULLERENECARBOXYLIC ACIDS AND PROSPECTS FOR THEIR USE IN THE CHEMISTRY OF DRUGS

2018 ◽  
Vol 18 (2) ◽  
pp. 19-28
Author(s):  
E V Litasova ◽  
L B Piotrovskiy
Keyword(s):  
Delivery Systems ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Carboxyl Groups ◽  
Derivatives Of ◽  
Active Substances

Among the various derivatives of fullerenes, compounds containing carboxyl groups (carboxyfullerenes) occupy a prominent place. The reason is that the introduction of carboxyl groups makes it possible to obtain water-soluble derivatives of highly lipophilic fullerenes. The review deals with matters of synthesis and structure of carboxyfullerenes, the influence of the amount and structure of the addends on the solubility of the entire compound, various aspects of the usage of these compounds as independent biologically active substances and carriers for creation of various delivery systems.

scholarly journals Study of the Properties of In Vitro Dactylorhiza maculata (L.) Soó (Family Orchidaceae) Extracts

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1330
Author(s):  
Stanislav Sukhikh ◽  
Svetlana Noskova ◽  
Svetlana Ivanova ◽  
Liubov Skrypnik ◽  
Artem Pungin ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Antimicrobial Properties ◽  
Feed Additives ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Bioactive Substances ◽  
Limit Values ◽  
Active Substances

The medicinal plant Dactylorhiza maculata (L.) Soó (family Orchidaceae) is used to treat gastritis, colic, gastrointestinal tract, and bladder diseases. This study aimed to investigate the properties and characteristics of the in vitro Dactylorhiza maculata extract. The recommended parameters for producing Dactylorhiza maculata extract were determined: temperature 60 °C, process duration 60 min, hydro module 1:10. It is recommended to carry out the extraction using an aqueous ethyl alcohol solution with a mass fraction of the parent substance of 70%. It was found that such biologically active substances as rutin, quercetin, 3,3’,4’,5,5’,7-hexahydroxyflavonone, 3,3’,4’,5,5’,7-hexahydroxyflavonone-3-O-glycoside, gallic acid, and ferulic acid were dominant in Dactylorhiza maculata. A high phosphorus content was noted (2410.8 mg/kg dry matter). The studied Dactylorhiza maculata samples contained a large number of organic acids and water-soluble vitamins. The tested extracts were safe in terms of the content of heavy metals, pesticides, aflatoxin B1, and radionuclides, as well as pathogenic and opportunistic microorganisms; the content was significantly lower than the threshold limit values. The studied complex of biologically active substances from Dactylorhiza maculata extract samples had antimicrobial properties. It was found that the antioxidant activity of the samples was 217.89 ± 10.89 mg AA/g (AA—ascorbic acid). The high content of bioactive substances and the antimicrobial and antioxidant properties of Dactylorhiza maculata extract samples determine the application potential of this plant as a substitute for growth stimulants and feed antibiotics in the production of feed additives, aiming to increase the physiological and immune status of livestock and poultry.

scholarly journals VARIABILITY OF BIOCHEMICAL PARAMETERS OF AMARANTH PLANTS DURING CULTIVATION TO OBTAIN THE NATURAL FOOD COLORANT WITH A HIGH CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES

2018 ◽  
pp. 69-72
Author(s):  
M. S. Gins ◽  
V. K. Gins ◽  
A. A. Baikov ◽  
M. M. Tareeva ◽  
S. Yu. Platonova ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Biochemical Parameters ◽  
Relative Concentration ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Reduced Form ◽  
Natural Food ◽  
Dry Matter Content ◽  
Active Substances

Amaranth leaves can be used in salads, soups, sauces enriching them with biologically active substances (in particular, ascorbic acid and phenolic compounds), as well as giving them an original taste and color. Plants were grown on the experimental field of VNIISSOK in the Moscow region. The experiment was laid on sod-podzolic soil. For the period of 2013-2016 years, biochemical parameters were investigated: total content of water-soluble antioxidants, ascorbic acid content, dry matter content, amarantine content in three amaranth varieties (Valentina, Don Pedro and Fakel) and two green leaf varieties (Pamyati Kovasa and Eku 17020) of FSBSI FSVC (formerly VNIISSOK) and INIAP selection and a correlation analysis was performed, which showed a relationship between the relative concentration of amarantine in the leaves and other biochemical parameters at different stages of plant development. The maximum accumulators of antioxidants according to the TAC parameter were the Valentina and Don Pedro varieties - up to 2.9 mg gallic acid equivalents/g. The situation was similar in terms of the content of the reduced form of ascorbic acid. So also the Valentina and Don Pedro varieties were leading with values of about 140 mg%. A positive correlation between the content of ascorbic acid and the sum of hydrophilic antioxidants was confirmed. Pamyati Kovasa and Eku 17020 varieties can be recommended as a source of green mass of leaves with a high content of ascorbic acid, red colored varieties Don Pedro, Valentina, Fakel – for obtaining red dye enriched with antioxidants.

Improving the fattening and meat traits of broiler chickens

2021 ◽  
pp. 38-51
Author(s):  
G. N. Vyayzenen ◽  
S. V. Razaev ◽  
A. G. Vyayzenen ◽  
N. S. Prodanov ◽  
A. E. Barashkov ◽  
...  
Keyword(s):  
Amino Acids ◽  
Laser Beam ◽  
Broiler Chickens ◽  
The Body ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Poultry Meat ◽  
Control Group ◽  
Active Substances

In order to save the cost of expensive compound feed, a number of biologically active substances (vitamins and amino acids) and improve the digestibility of nutrients for the first time in poultry meat using laser technology there is a real possibility of “transferring” the studied amino acids (methionine, glycine) and all water-soluble vitamins using a laser beam through the skin in the breast area of broiler chickens. The research has been carried out in Belgrankorm-Veliky Novgorod LLC in the Krestetsky district in the Novgorod region with a large-cage housing method of broiler chickens of the cross Hubbard. The duration of broilers rearing was 39 days, 4 recipes of compound feed based on wheat grain, corn, soybeen meal with the inclusion of fish flour, sunflower oil, corn gluten, sunflower meal, meat and bone meal and mineral additives (monocalcium phosphate, lime flour) have been used. For better assimilation of nutrients and biologically active substances by the body amino acids (methionine, glycine) and water-soluble vitamins Undevit, both individually and in combination with them in a ratio of 1:1 (by weight), in the form of powders passed through an infra-red laser beam in a spatial modulator, which were attached to two emitters (simultaneously) of the “Uzor-2K-Super” laser in the chest area have been used. Broilers of the experimental groups ate feed more often and faster than the herdmates of the control group. Air ozonation in the poultry house and broilers has been carried out in a mobile way using the Rios ozonator of the Decont series (mode 3, with a capacity of 20 g/m3 ). Innovative methods of influencing on the body caused the increase in the intensity of metabolic processes, growth and development, fattening and meat traits, and feed conversion in broilers.

scholarly journals Microalgae - an alternative source of biologically active substances for the agro-industrial complex of Russia

2019 ◽  
pp. 21-24
Author(s):  
S.Sh. Shinkarev ◽  
A.Ya. Samuylenko ◽  
L.A. Neminushchaya ◽  
T.A. Skotnikova ◽  
V.I. Yeremets ◽  
...  
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Industrial Complex ◽  
Alternative Source ◽  
Active Substances

FEATURES OF ALKALOID ACCUMULATION IN MEDICINAL PLANTS DUE TO GROWING CONDITIONS AND AGE CHARACTERISTICS

2020 ◽  
pp. 88-96
Author(s):  
Sangadzhieva L.Ch. ◽  
Bambaeva E.N. ◽  
Davaeva Ts.D. ◽  
Sangadzhieva O.S. ◽  
Tsombueva B.V.
Keyword(s):  
Medicinal Plants ◽  
Raw Materials ◽  
Biochemical Properties ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Anthropogenic Pressure ◽  
Tannin Content ◽  
Growing Conditions ◽  
Active Substances

Nowadays biologically active substances in medicinal plants of Kalmykia are poorly studied. Thus biochemical properties of medicinal plants of the arid territories of the North-Western Caspian region have been studied for the first time. Study of intraspecific variability allowed to determine the influence of growing conditions on the accumulation of biologically active substances and microelements in medicinal plants, that grow in Kalmykia. In this regard, as the alkaloid, flavonoid and tannin content has been shown, approaches of application of known medicinal plants and searching for new raw materials should be reconsidered. This work is a part of comprehensive resource investigation focused on the research in the aim to find rational application of plant growing in Caspian and Volga regions. On the natural forage lands of Kalmykia, alkaloid-bearing plants can be found; they are poisonous to animals, and their number and abundance are directly dependent on anthropogenic pressure. Anabasis, harmalа and ephedra, that grow on the Caspian lowland, contain all groups of studied substances: alkaloids, flavonoids, tannins and extractives. The conducted research shows that alkaloid plants might be used as medicinal plant raw materials. In Anabasis, the total alkaloid content reaches 1.26% in summer and 1.44% in autumn. Percentage of peganin in Harmala grass, stem and root, is about 4.04%, 0.31% and 0.21% respectively while the total amount of alkaloids in harmala exceeds 5.0%. Tannin content is quite high in Anabasis and harmala, as the presence of tannins is a characteristic feature of ephemera. The composition of plant extractives includes all water-soluble biologically active substances: carbohydrates, vitamins, flavonoids, etc., content of the chemicals is high in both Anabasis and harmal. Accumulation occurs even regardless of the season, place of growth in the whole plant.

scholarly journals Analysis of the bioavailability of tea species

2021 ◽  
Vol 291 ◽  
pp. 02005
Author(s):  
Pavel Maslennikov ◽  
Mikhail Zorin ◽  
Anna Seregina
Keyword(s):  
Ascorbic Acid ◽  
Green Tea ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Biological Availability ◽  
Total Water ◽  
Low Level ◽  
Initial Content ◽  
Active Substances

In samples of different tea brands the content of biologically active substances (total water-soluble antioxidants content, ascorbic acid, rutin, polyphenols, anthocyanins) was determined. The water-soluble antioxidant biological availability of the studied tea samples was evaluated. Green Tea with Lemon and Ceylon Baikhovi Black Spiced Tea is characterized by similar levels of antioxidant bioavailability. After the consumption of both beverages, there was a definite increase in the content of antioxidants in saliva of individuals with an initially low content of antioxidants. Amaranth Phytotea antioxidants were characterized by low level of bioavailability. The consumption of this beverage did not change the level of antioxidants in saliva, regardless of their initial content.

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