Isolation of Industrial Important Bioactive Compounds From Microalgae: A Review

Microalgae are known as a rich source of bioactive compounds which exhibit different biological activities. Increased demand for sustainable biomass for production of important bioactive components with various potential especially therapeutic applications has resulted in noticeable interest in algae. Utilization of microalgae in multiple scopes has been growing in various industries ranging from harnessing renewable energy to exploitation of high-value products. The focuses of this review are on the isolation of bioactive compounds from microalgae regarding different metabolites which are currently used and new possible applications of the compounds in industries and future prospects. Moreover, this work discusses the advantage, potential new beneficial strains, applications, limitations, research gaps and future prospect of microalgae in industry.

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Isolation of Industrial Important Bioactive Compounds from Microalgae

Molecules ◽

10.3390/molecules26040943 ◽

2021 ◽

Vol 26 (4) ◽

pp. 943

Author(s):

Vimala Balasubramaniam ◽

Rathi Devi-Nair Gunasegavan ◽

Suraiami Mustar ◽

June Chelyn Lee ◽

Mohd Fairulnizal Mohd Noh

Keyword(s):

Renewable Energy ◽

Bioactive Compounds ◽

Potential Application ◽

Future Prospect ◽

Biological Activities ◽

Value Added ◽

Rich Source ◽

Bioactive Components ◽

Research Gaps ◽

Food Industries

Microalgae are known as a rich source of bioactive compounds which exhibit different biological activities. Increased demand for sustainable biomass for production of important bioactive components with various potential especially therapeutic applications has resulted in noticeable interest in algae. Utilisation of microalgae in multiple scopes has been growing in various industries ranging from harnessing renewable energy to exploitation of high-value products. The focuses of this review are on production and the use of value-added components obtained from microalgae with current and potential application in the pharmaceutical, nutraceutical, cosmeceutical, energy and agri-food industries, as well as for bioremediation. Moreover, this work discusses the advantage, potential new beneficial strains, applications, limitations, research gaps and future prospect of microalgae in industry.

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Natural Product Repertoire of the Genus Amphimedon

Marine Drugs ◽

10.3390/md17010019 ◽

2018 ◽

Vol 17 (1) ◽

pp. 19 ◽

Cited By ~ 5

Author(s):

Nourhan Shady ◽

Mostafa Fouad ◽

Mohamed Salah Kamel ◽

Tanja Schirmeister ◽

Usama Abdelmohsen

Keyword(s):

Secondary Metabolites ◽

Natural Product ◽

Bioactive Compounds ◽

Biological Activities ◽

Marine Sponges ◽

Rich Source ◽

Undescribed Species ◽

Pharmacological Activities ◽

Wide Range ◽

Complete Survey

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.

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Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities

Pharmaceutics ◽

10.3390/pharmaceutics12100933 ◽

2020 ◽

Vol 12 (10) ◽

pp. 933

Author(s):

Verônica da Silva Oliveira ◽

Amanda Silva de Almeida ◽

Ingrid da Silva Albuquerque ◽

Fernanda Ílary Costa Duarte ◽

Bárbara Cristina Silva Holanda Queiroz ◽

...

Keyword(s):

Physicochemical Properties ◽

Bioactive Compounds ◽

Biological Activities ◽

Solid Dispersions ◽

Polymeric Matrices ◽

Therapeutic Applications ◽

Biological Potential ◽

New Applications

This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications.

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BIOACTIVE COMPOUNDS IN ETHANOL EXTRACT OF LENTINUS SQUARROSULUS MONT - A NIGERIAN MEDICINAL MACROFUNGUS

African Journal of Traditional Complementary and Alternative Medicines ◽

10.21010/ajtcamv15i2.6 ◽

2018 ◽

Vol 15 (2) ◽

pp. 42 ◽

Cited By ~ 6

Author(s):

Morenike Olutunmbi Adeoye-Isijola ◽

Olufunmiso Olusola Olajuyigbe ◽

Segun Gbolagade Jonathan ◽

Roger Murugas Coopoosamy

Keyword(s):

Ethyl Ester ◽

Bioactive Compounds ◽

Octadecadienoic Acid ◽

Biological Activities ◽

Ethyl Oleate ◽

Acid Ethyl Ester ◽

Ethyl Esters ◽

Gas Chromatography Mass Spectrometry ◽

Bioactive Components ◽

Hexadecanoic Acid

Background: The continuous search for new lead compounds of therapeutic importance has become necessary in the face of treatment failures and multidrug resistance plaguing the world. While many plants and higher fungi are sources of bioactive compounds yet to be fully harnessed, understanding the bioactive components in macrofungus could serve as a lead for investigating its biological activities and medicinal potentials. Materials and Methods: The bioactive compounds in the ethanolic extract of Lentinus Squarrosulus, an edible Nigerian macrofungus, were investigated by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Results: There were nine bioactive compounds in this edible macrofungus. Of these compounds, 9,12-Octadecanoic acid ethyl ester (37.39%; RT:39.815) was the highest in quantity, followed by Hexadecanoic acid ethyl ester (14.49%; RT:36.550). Other fatty acids, their ethyl esters and other compounds identified included 2-Butenethioic acid,3-(ethylthio)-S-(1-methylethyl) ester (4.51%; RT:15.866), n-Hexadecanoic acid (4.74%; RT:36.034), 9,12-Octadecadienoic acid (Z,Z)- (11.88%; RT:39.429), 9,17-Octadecadienal,(Z)- (5.01%; RT:39.500), ethyl oleate (5.27%; RT:39.898), 3a,6-Methano-3aH-indene,2,3,6,7 tetrahydro (4.04%; RT:48.379), and 9,12-Octadecadienoic acid (Z,Z)-,2 hydroxy-1-(hydroxymethyl) ethyl ester (12.68%; RT:48.682). Some of these compounds have antimicrobial, antioxidant, hepatoprotective, hypocholesterolemic as well as cancer preventive activities amongst others. Conclusion: This study showed the bioactive components of therapeutic potentials in L. squarrosulus while creating a platform for screening, isolating and identifying many bioactive components which may be useful in the treatment of the various ailments, disorders and diseases in the nearest future.

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Pharmacologically potentials of different substituted coumarin derivatives

10.31221/osf.io/w6hdg ◽

2019 ◽

Cited By ~ 1

Author(s):

Chem Int

Keyword(s):

Benzene Ring ◽

Bioactive Compounds ◽

Biological Activities ◽

Pharmacological Properties ◽

Coumarin Derivatives ◽

Wide Range ◽

Anti Oxidant ◽

Anti Inflammatory ◽

Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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Determination of Antioxidant Activities and Bioactive Components of Foeniculum vulgare Mill. (Samonsabar)

Myanmar Health Sciences Research Journal ◽

10.34299/mhsrj.00917 ◽

2019 ◽

Vol 30 (3) ◽

pp. 16-22

Keyword(s):

Antioxidant Activities ◽

Biological Activities ◽

Scientific Information ◽

Ethanolic Extract ◽

The Body ◽

World Health ◽

Gas Chromatography Mass Spectrometry ◽

Molecular Formula ◽

Bioactive Components ◽

Foeniculum Vulgare

World Health Organization (WHO) estimated that 80% of the population of developing countries use traditional medicines, mostly natural plant products, for their primary health care needs. In the past few decades, the medicinal value of plants has been assumed more important dimension owing largely to the discovery that extracts from plants contain not only primary metabolites but also a diverse array of secondary metabolites with antioxidant potential. Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Antioxidants are vital substances which possess ability to protect the body from damage due to free radical-induced oxidative stress. The purpose of current study was to determine the antioxidant activities and bioactive components of Foeniculum vulgare (fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml) than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in identification of compounds based on peak area, retention time, molecular formula, molecular weight, MS Fragmentions and pharmacological actions. Ten bioactive phytochemical compounds from aqueous extracts and 11 from ethanolic extract of fennel seeds were identified. These findings indicated that fennel seeds are potential to provide preventive properties against oxidative damage. These results will give scientific information for quality control of indigenous drug to herbal medicine users and local practitioners using fennel for different types of ailments

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Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽

10.3390/md19050241 ◽

2021 ◽

Vol 19 (5) ◽

pp. 241

Author(s):

Shaden A. M. Khalifa ◽

Eslam S. Shedid ◽

Essa M. Saied ◽

Amir Reza Jassbi ◽

Fatemeh H. Jamebozorgi ◽

...

Keyword(s):

Bioactive Compounds ◽

Biomedical Applications ◽

Large Scale ◽

Biological Activities ◽

Scale Production ◽

Pharmacological Activities ◽

Large Scale Production ◽

Marine Products ◽

Hiv 1 ◽

Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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Pinus Species as Prospective Reserves of Bioactive Compounds with Potential Use in Functional Food—Current State of Knowledge

Plants ◽

10.3390/plants10071306 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1306

Author(s):

Marcin Dziedziński ◽

Joanna Kobus-Cisowska ◽

Barbara Stachowiak

Keyword(s):

Human Health ◽

Bioactive Compounds ◽

Functional Food ◽

Biological Activities ◽

Food Ingredients ◽

Beneficial Effects ◽

Pine Tree ◽

Pine Trees ◽

Health Promoting ◽

Few Data

The pine (Pinus L.) is the largest and most heteromorphic plant genus of the pine family (Pinaceae Lindl.), which grows almost exclusively in the northern hemisphere. The demand for plant-based remedies, supplements and functional food is growing worldwide. Although pine-based products are widely available in many parts of the world, they are almost absent as food ingredients. The literature shows the beneficial effects of pine preparations on human health. Despite the wide geographical distribution of pine trees in the natural environment, there are very few data in the literature on the widespread use of pine in food technology. This study aims to present, characterise and evaluate the content of phytochemicals in pine trees, including shoots, bark and conifer needles, as well as to summarise the available data on their health-promoting and functional properties, and the potential of their use in food and the pharmaceutical industry to support health. Various species of pine tree contain different compositions of bioactive compounds. Regardless of the solvent, method, pine species and plant part used, all pine extracts contain a high number of polyphenols. Pine tree extracts exhibit several described biological activities that may be beneficial to human health. The available examples of the application of pine elements in food are promising. The reuse of residual pine elements is still limited compared to its potential. In this case, it is necessary to conduct more research to find and develop new products and applications of pine residues and by-products.

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