scholarly journals SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Author(s):  
Jean-Claude Perez

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and « 2 mutations » IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. 9/ Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? Particularly, we suggest the following conjecture at mRNA folding level : CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.. Particularly, using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the 2 vaccines Moderna and Phizer, we conclude a very probable difference in stability and shelf life of the 2 respective mRNAs of these 2 vaccines. However, the “State of the Art” will tell you that their 2 protein sequences are strictly identical. However, by having modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the 2 cases. We can only note the great ADAPTATION power - at the global scale of their genomes - of the most infectious VARIANTS such as the BRAZIL 20J / 501Y.V3 variant (P.1). This is very worrying for the VACCINES <==> VARIANTS run: We demonstrate how the Brazilian variant P.1 which becomes uncontrollable in Brazil in April 2021 has a level of organization of long metastructures of 17,711 bases covering the genome which is 3.6 more important than that of the 2 reference genomes SARS-CoV2 Wuhan and worldwide D614G. We suggest that this high level of overall structure of this variant contributes to the stability of this genome and, possibly, to its greater contagiousness.

2021 ◽  
Vol 9 (6) ◽  
pp. 349-396
Author(s):  
Jean Claude Perez

In this paper, we suggest a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS currently circulating within the world population. The 10 main results proposed to be reproduced by peers are: SARS-CoV2 genome and spike evolution in one year 2020-2021. SARS-CoV2 Origins. Comparing 11 reference variants spikes. Analysing 32 CAL.20C California variant patients’ spikes. Toward a meta mRNA Fibonacci gene end message code. Analysing S501 UK, S484 South Africa and « 2 mutations » INDIA variants. Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectiousness. Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? The exceptional case of the Brazilian variant P.1. Particularly, we suggest the following conjecture at mRNA folding level: CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Africa, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that these kinds of Fibonacci matastructures disapear TOTALLY by analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the two mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine. This is because their designers by seeking greater stability, have doped to build CG rich sequences   which, as soon as they are inserted into the human host, will, paradoxically, seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve their STABILITY and LIFETIME. We conclude using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the two vaccines Moderna and Pfizer, that there will be very probable differences in stability and shelf life of the two respective mRNAs vaccines. However, “State of the Art” analyzes will disclose that their two protein sequences are strictly identical. By modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the two cases. We wish to draw attention to the great ADAPTATION power - at the global scale of their genomes - of the most infectious VARIANTS, such as the BRAZIL 20J / 501Y.V3 variant (P.1). This is very worrying for the VACCINES <==> VARIANTS run: We demonstrate how the Brazilian variant P.1 which becomes uncontrollable in Brazil in April 2021 has a level of organization of long metastructures of 17,711 bases covering the genome which is 3.6 more important than that of the 2 reference genomes SARS-CoV2  and worldwide D614G. We suggest that this high level of overall structure of this variant contributes to the stability of this genome and, might explain its greater contagiousness. To complete this article, an ADDENDUM by Nobelprizewinner Luc Montagnier vas added at the end of this paper.


Author(s):  
Jean-Claude Perez

ABSTRACT. In this paper, we suggest a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS currently circulating within the world population. The 10 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C California variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ Analysing S501 UK, S484 South Africa and &laquo; 2 mutations &raquo; INDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectiousness. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. 9/ Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? 10/ The exceptional case of the Brazilian variant P.1. Particularly, we suggest the following conjecture at mRNA folding level : CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Africa, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that these kinds of Fibonacci matastructures disapear TOTALLY by analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the two mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine. This is because their designers by seeking greater stability, have doped to build CG rich sequences which, as soon as they are inserted into the human host, will, paradoxically, seek to mutate, like SARS-CoV2 variants, towards CG ==&gt; UA forms in order to improve their STABILITY and LIFETIME. We conclude using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the two vaccines Moderna and Pfizer, that there will be very probable differences in stability and shelf life of the two respective mRNAs vaccines. However, &ldquo;State of the Art&rdquo; analyzes will disclose that their two protein sequences are strictly identical. By modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the two cases. We wish to draw attention to the great ADAPTATION power - at the global scale of their genomes - of the most infectious VARIANTS, such as the BRAZIL 20J / 501Y.V3 variant (P.1). This is very worrying for the VACCINES &lt;==&gt; VARIANTS run: We demonstrate how the Brazilian variant P.1 which becomes uncontrollable in Brazil in April 2021 has a level of organization of long metastructures of 17,711 bases covering the genome which is 3.6 more important than that of the 2 reference genomes SARS-CoV2 and worldwide D614G. We suggest that this high level of overall structure of this variant contributes to the stability of this genome and, might explain its greater contagiousness.


Author(s):  
Jean-Claude Perez

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and &laquo; 2 mutations &raquo; IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. 9/ Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? Particularly, we suggest the following conjecture at mRNA folding level : CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==&gt; UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.. Particularly, using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the 2 vaccines Moderna and Phizer, we conclude a very probable difference in stability and shelf life of the 2 respective mRNAs of these 2 vaccines. However, the &ldquo;State of the Art&rdquo; will tell you that their 2 protein sequences are strictly identical. However, by having modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the 2 cases.


1984 ◽  
Vol 44 ◽  
Author(s):  
Eberhard Freude ◽  
Bernd Grambow ◽  
Werner Lutze ◽  
Harald Rabe ◽  
Rodney C. Ewing

During the past ten years extensive data have been determined for the corrosion of nuclear waste forms in short-term laboratory experiments (usually less than one year). The long-term behavior of glass has been inferred by: (1) the acceleration of corrosion rates at high temperatures [1]; (2) the use of high surface areas of the glass to small volumes of solution [1]; and the analysis of natural glasses altered over long periods of geologic time [2, 3]. The most recent efforts have concentrated on understanding the mechanisms of corrosion [1, 4, 5]. The corrosion mechanism may be used to make long-term extrapolations of the “stability” of the waste form. In this paper, we consider a linear time dependence for the corrosion under near saturation conditions and use a rate equation in the QTERM code [6, 7, 8] to model the long-term behavior of the German glass, C-31−3EC [9], JSS A [10, 11] and SRL TDS 131 [1]. The data base for C-31−3EC has been published elsewhere [9, 12, 13, 14], and we include experimental work completed by Rabe for boron and silica, at 200°C.


Author(s):  
Jean-Claude Perez

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and 2 mutations IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFITZER and MODERNA. Particularly, we suggest the following conjecture at mRNA folding level: CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of podiums for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a hairpin, which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFITZER and MODERNA vaccines.


Clay Minerals ◽  
2013 ◽  
Vol 48 (2) ◽  
pp. 199-213 ◽  
Author(s):  
S. Kaufhold ◽  
R. Dohrmann ◽  
T. Sandén ◽  
P. Sellin ◽  
D. Svensson

AbstractBentonite, which is envisaged as a promising engineered barrier material for the safe disposal of highly radioactive waste, was and is investigated in different large scale tests. The main focus was and is on the stability (or durability) of the bentonite. However, most countries concentrated on one or a few different bentonites only, regardless of the fact that bentonite performance in different applications is highly variable. Therefore, SKB (Svensk Kärnbränslehantering) set up the first large scale test which aimed at a direct comparison of different bentonites. This test was termed the ‘alternative buffer material test’ and considers eleven different clays which were either compacted (blocks) or put into cages to keep the material together. One so-called package consisted of thirty different blocks placed on top of each other. These blocks surrounded a heated iron tube 10 cm in diameter. Altogether three packages were installed in the underground test laboratory Äspö, Sweden. The first package was terminated 28 months after installation and the bentonite had been exposed for the maximum temperature (130°C) for about one year.Almost all geochemical and mineralogical alterations of the different bentonites (apart from exchangeable cations) were restricted to the contact between iron and bentonite. The increase of the Fe2O3 content was attributed to corrosion of the tube. However, the typical 7 or 14 Å smectite alteration product was not found. At the contact of one sample, siderite was precipitated. Some samples showed anhydrite and organic carbon accumulation and some showed dissolution of clinoptilolite and cristobalite. IR spectroscopy, XRD, and XRF data indicated the formation of trioctahedral minerals/domains in the case of some bentonites. Even more data has to be collected before unambiguous conclusions concerning both alteration mechanisms and bentonite differences can be drawn.


Author(s):  
Jean-Claude Perez

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and 2 mutations IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFITZER and MODERNA. Particularly, we suggest the following conjecture at mRNA folding level: CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of podiums for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a hairpin, which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==&gt; UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME..


Author(s):  
Jogendra Singh ◽  
Amit Kumar ◽  
Abdul Fiyaz R ◽  
Muneendra Kumar Singh

Twenty one genotypes of pigeon pea were evaluated in a randomized complete block design during the Kharif season of 2007-08, 2008-09 and 2009-10 based upon number of primary branches per plant, pod length, number of grains per pod, 100-seed weight and seed yield per plant. The stability was studied by deploying AMMI (additive main effects and multiplicative interaction) model. The significant differences among the years were observed and measured more than 50% of the treatment sum of squares. First principal component axis (PCA1) of the interaction captured more than 60% of the interaction sum of squares for almost all the traits studied. The mean seed yield per plant was found highest (39.15 g) and at par similar in all the three years. Nine stable and high yielding genotypes viz., PUSA 2003-1; CORG-2001-5; WREG- 28; PANT-A-286; H-94-6; GT 101; ICPL-99004; ICPL-85010 and UPAS-120 exhibited stable performance under the rainfed environmental conditions for more than one traits studied and also under more than one year.


2021 ◽  
Author(s):  
Tristan S Yates ◽  
Lena J Skalaban ◽  
Cameron T Ellis ◽  
Angelika J Bracher ◽  
Christopher Baldassano ◽  
...  

Although sensory input is continuous, we perceive and remember discrete events. Event segmentation has been studied extensively in adults, but little is known about how the youngest minds experience the world. The main impediment to studying event segmentation in infants has been a reliance on explicit parsing tasks that are not possible at this age. fMRI has recently proven successful at measuring adult event segmentation during task-free, naturalistic perception. Applied to infants, this could reveal the nature of their event segmentation, from low-level sensory transients to high-level cognitive boundaries. We collected fMRI data from 25 adults and 25 infants less than one year of age watching the same short movie. Neural events were defined by the stability of voxel activity patterns. In adults, we replicated a hierarchical gradient of event timescales, from shorter events in early visual regions to longer events in later visual and narrative regions. In infants, however, longer events were found throughout the brain, including in a second dataset. Infant event structure fit adult data and vice versa, but adult behavioral boundaries were differently expressed in adult and infant brains. These findings have implications for the nature of infant experience and cognition.


Author(s):  
Jie Wen ◽  
Zheng Zhang ◽  
Yong Xu ◽  
Bob Zhang ◽  
Lunke Fei ◽  
...  

In recent years, incomplete multi-view clustering, which studies the challenging multi-view clustering problem on missing views, has received growing research interests. Although a series of methods have been proposed to address this issue, the following problems still exist: 1) Almost all of the existing methods are based on shallow models, which is difficult to obtain discriminative common representations. 2) These methods are generally sensitive to noise or outliers since the negative samples are treated equally as the important samples. In this paper, we propose a novel incomplete multi-view clustering network, called Cognitive Deep Incomplete Multi-view Clustering Network (CDIMC-net), to address these issues. Specifically, it captures the high-level features and local structure of each view by incorporating the view-specific deep encoders and graph embedding strategy into a framework. Moreover, based on the human cognition, \emph{i.e.}, learning from easy to hard, it introduces a self-paced strategy to select the most confident samples for model training, which can reduce the negative influence of outliers. Experimental results on several incomplete datasets show that CDIMC-net outperforms the state-of-the-art incomplete multi-view clustering methods.


Sign in / Sign up

Export Citation Format

Share Document