scholarly journals Neocarya macrophylla (Sabine) Prance: Review on Taxonomy, Ethnobotany, Phytochemistry and Biological Activities

2021 ◽  
Author(s):  
Amina Jega Yusuf ◽  
Musa Ismail Abdullahi ◽  
Abubakar Alhaji Muhammad ◽  
Kasimu Ghandi Ibrahim
Keyword(s):  
Acute Toxicity ◽  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Structural Materials ◽  
Traditional Healers ◽  
Pharmaceutical Products ◽  
Bioactive Constituents ◽  
Pharmacological Activities ◽  
Toxicity Studies

Neocarya macrophylla (Sabine) Prance (Nm, Chrysobalanaceae) is used traditionally as food, for medicinal spiritual and industrial purposes. It is also used as soap, dye, glue, fodder, termite repellent, firewood and for structural materials. Few studies on the physicochemical, nutritional contents, phytochemical and pharmacological activities have validated the benefits of Nm to humanity as food, in cosmetics and pharmaceutical products. The major bioactive constituents identified in the plant so far are steroids and flavonoids (such as stigmasterol, quercetin, catechin and its related glycosides). Extracts of the plant have shown good antivenom, antimicrobial, analgesic, anti-inflammatory, antimycobacterial, anthelmintic and antioxidant activities. Acute toxicity studies conducted have confirmed the plant to be toxic. More studies on the plant are required in order to exploit other biological activities as claimed by traditional healers and also to isolate more bioactive compounds. In addition, the safety and tolerability assessment of Nm should be undertaken due to its widespread usage.

scholarly journals Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

2021 ◽  
Vol 11 (21) ◽  
pp. 10205
Author(s):  
Hari Prasad Devkota ◽  
Keshav Raj Paudel ◽  
Md. Mahadi Hassan ◽  
Amina Ibrahim Dirar ◽  
Niranjan Das ◽  
...  
Keyword(s):  
Essential Oils ◽  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Scientific Information ◽  
Pharmaceutical Products ◽  
Active Components ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Anti Inflammatory ◽  
Promising Source

The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of Z. montanum with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from Z. montanum. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. Z. montanum could be a promising source for the development of pharmaceutical products and functional foods.

scholarly journals Revue bibliographique sur la composition chimique et les activités biologiques de Guiera senegalensis J.F. Gmel. (Combretaceae)

2020 ◽  
Vol 13 (7) ◽  
pp. 3449-3462
Author(s):  
Yoro Tine ◽  
Moussa Diop ◽  
Idrissa Ndoye ◽  
Alioune Diallo ◽  
Alassane Wele
Keyword(s):  
Chemical Composition ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Chemical Characterization ◽  
Traditional Healers ◽  
Composition Chimique ◽  
Toxicity Studies ◽  
Chemical Variability ◽  
Chemical Studies ◽  
Guiera Senegalensis

Cette étude avait pour objectif de faire le point sur la composition chimique et les activités biologiques de G. senegalensis, une plante médicinale  largement utilisée en Afrique par les guérisseurs traditionnels pour le  traitement de divers troubles. La plupart de ces études chimiques ont porté sur le criblage phytochimique des extraits de feuilles, de racines, de tiges et de galles. Elles ont montré la présence d'hydrates de carbone, de  stéroïdes, de saponines, de flavonoïdes, d’alcaloïdes, de tanins, de  saponines, de glycosides cardiaques, de coumarines, d’anthraquinones, d’acide ascorbique, d’hétérosides cardiotoniques, de cyanogènes et de terpénoïdes. Les potentialités thérapeutiques des extraits de G.  senegalensis rapportées dans plusieurs travaux scientifiques ont porté sur les activités antibactériennes, antitussives, antidiarrhéiques, cytotoxiques, anti-inflammatoires antipaludiques, antitrypanosomiques,  antihelminthiques, antivirales et antioxydantes. Des études de toxicité sur ces extraits ont été aussi réalisées. Ainsi, des études de caractérisation chimique (variabilité chimique), de formulation galénique et aussi de toxicité clinique sur G. senegalensis doivent être menées afin de mettre en place des produits de phytothérapie moderne.Mots clés: Phytochimie, pharmacologie, feuilles, Guiera senegalensis. English Title: Review on the chemical composition and biological activities of Guiera senegalensis J.F. Gmel. (Combretaceae)The aim of this study was to review the chemical composition and biological activities of G. senegalensis, a medicinal plant widely used in Africa by  traditional healers for the treatment of various disorders. Most of these chemical studies have focused on the phytochemical screening of leaf, root, stem and gall extracts. They showed the presence of carbohydrate,  steroids, saponins, flavonoids, alkaloids, tannins, saponins, cardiac  glycosides, coumarins, anthraquinones, ascorbic acid, cardiotonic  glycosides, cyanogens and terpenoids. The therapeutic potentialities of extracts of G. senegalensis reported in several scientific studies have  focused on antibacterial, antitussive, antidiarrheal, cytotoxic, anti-inflammatory, antimicrobial, antitrypanosomal, anthelmintic, antiviral and antioxidant activities. Toxicity studies on these extracts have also been carried out. Thus, chemical characterization studies (chemical variability), galenic formulation and clinical toxicity studies on G. senegalensis must be carried out in order to implement modern phytotherapy products.Keywords: Phytochemistry, pharmacology, leaves, Guiera senegalensis.

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

scholarly journals Natural Product Repertoire of the Genus Amphimedon

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 19 ◽  
Author(s):  
Nourhan Shady ◽  
Mostafa Fouad ◽  
Mohamed Salah Kamel ◽  
Tanja Schirmeister ◽  
Usama Abdelmohsen
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Marine Sponges ◽  
Rich Source ◽  
Undescribed Species ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Complete Survey

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.

scholarly journals A REVIEW ON MARINE ALGAE AND ITS APPLICATIONS

2020 ◽  
pp. 21-27
Author(s):  
CHANDRA VELUCHAMY ◽  
RADHA PALANISWAMY
Keyword(s):  
Bioactive Compounds ◽  
Marine Algae ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
The Novel ◽  
Marine Microbes ◽  
Pharmacological Activities ◽  
Nutritional Values ◽  
Other Substances ◽  
Living Organisms

The ocean is the major essential source of structurally unique natural products that are mainly present in living organisms. The essential products extracted from marine microbes and marine algae are highly analyzed areas in instinctive product research. Marine algae are the novel food with potential nutritional values used for multiple purposes in industry and medicine. They show pharmacological activities which are helpful for the invention of bioactive compounds. Furthermore, marine algae have shown to provide an abundant source of natural bioactive compounds with antidiabetic, anti-inflammatory, antiviral, antifungal, hypolipidemic, antioxidant, anti-hypercholesterolemia, antibacterial, and antineoplastic properties. They produce new secondary metabolites that possess biological activities and have the potential to be developed as therapeutic agents. Macroalgal lectins, fucoidans, kainoids, and other substances have been routinely used in the research of biomedical and also have biological activities. The potential pharmaceutical, medicinal, and research applications of these compounds are discussed.

Hydroxycinnamic Acids and Their Related Synthetic Analogs: An Update of Pharmacological Activities

2021 ◽  
Vol 21 ◽  
Author(s):  
Ayyoub Selka ◽  
Fanta J. Ndongou Moutombi ◽  
Jacques Jean-François ◽  
Mohamed Touaibia
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Hydroxycinnamic Acid ◽  
Hydroxycinnamic Acids ◽  
Pharmacological Activities ◽  
Synthetic Analogs ◽  
Anti Cancer ◽  
Anti Inflammatory

: The hydroxycinnamic acid scaffold is extremely versatile with various biological activities. This review will highlight the progress of the biological activities of hydroxycinnamic acids and their related synthetic analogs, including recently reported anti-cancer, anti-inflammatory, and antioxidant activities.

scholarly journals Algae Bioactive Constituents and Possible Role During COVID-19 Pandemic (A review)

2021 ◽  
Vol 30 (2) ◽  
pp. 16-22
Author(s):  
Sayed Rashad ◽  
Ghadir El-Chaghaby
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Bioactive Constituents ◽  
Algae Biomass ◽  
Synthetic Drugs ◽  
Pharmaceutical Applications ◽  
Active Chemical ◽  
Wide Range ◽  
Algal Products

Nowadays, the use of natural bio-products in pharmaceuticals is gaining popularity as safe alternatives to chemicals and synthetic drugs. Algal products are offering a pure, healthy and sustainable choice for pharmaceutical applications. Algae are photosynthetic microorganisms that can survive in different environmental conditions. Algae have many outstanding properties that make them excellent candidate for use in therapeutics. Algae grow in fresh and marine waters and produce in their cells a wide range of biologically active chemical compounds. These bioactive compounds are offering a great source of highly economic bio-products. The present review discusses the phytochemical and bioactive compounds present in algae biomass and their potent biological activities. The review focuses on the use of alga in therapy and their pharmaceutical applications with special reference to the possible preventive and therapeutic role of algae against COVID-19.

scholarly journals Alterations in Herbage Yield, Antioxidant Activities, Phytochemical Contents, and Bioactive Compounds of Sabah Snake Grass (Clinacanthus Nutans L.) with Regards to Harvesting Age and Harvesting Frequency

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2833
Author(s):  
Nur Mardhiati Afifa Abd Samat ◽  
Syahida Ahmad ◽  
Yahya Awang ◽  
Ros Azrinawati Hana Bakar ◽  
Mansor Hakiman
Keyword(s):  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Block Design ◽  
Economic Benefits ◽  
Total Phenolic ◽  
Bioactive Constituents ◽  
Antioxidant Power ◽  
Main Compound ◽  
Clinacanthus Nutans ◽  
Phytochemical Contents

Sabah snake grass or Clinacanthus nutans has drawn public interest having significant economic benefits attributable to the presence of phytochemicals and several interesting bioactive constituents that may differ according to harvesting age and harvesting frequency. The current study was aimed to evaluate the effect of harvesting age and harvesting frequency towards herbal yield, antioxidant activities, phytochemicals synthesis, and bioactive compounds of C. nutans. A factorial randomized completely block design with five replications was used to illustrate the relationship between herbal yield, DPPH (2, 2-diphenyl-1-picrylhydrazyl) and ferric reducing antioxidant power (FRAP) assays, total phenolic and flavonoid content affected by harvesting age (week 8, 12, and 16 after transplanting), and harvesting frequency (harvest 1, 2, and 3). The bioactive compounds by HPLC were also determined to describe the interaction effect between both harvesting age and harvesting frequency. The yield, antioxidant activities, and phytochemical contents were gradually increased as the plant grew, with the highest recorded during week 16. However, the synthesis and activities of phytochemicals were reduced in subsequent harvests despite the increment of the herbal yield. All bioactive compounds were found to be influenced insignificantly and significantly by harvesting age and harvesting frequency, respectively, specifically to shaftoside, iso-orientin, and orientin. Among all constituents, shaftoside was the main compound at various harvesting ages and harvesting frequencies. These results indicated that harvesting at week 16 with 1st harvest frequency might enhance the yield while sustaining the high synthesis of polyphenols and antioxidant activities of C. nutans.

scholarly journals Enhanced Recovery of Phenolic and Tocopherolic Compounds from Walnut (Juglans Regia L.) Male Flowers Based on Process Optimization of Ultrasonic Assisted-Extraction: Phytochemical Profile and Biological Activities

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 607
Author(s):  
Anca Pop ◽  
Ionel Fizeșan ◽  
Laurian Vlase ◽  
Marius Emil Rusu ◽  
Julien Cherfan ◽  
...  
Keyword(s):  
Water Content ◽  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Juglans Regia ◽  
Total Tocopherol ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Male Flowers

The extraction of bioactive compounds present in walnut (Juglans regia L.) male flowers (WMFs) was performed based on an experimental design using ultrasonic-assisted extraction. Solvent nature, extraction time, and water content were selected as experimental variables, and phenolic, flavonoidic, and condensed tannins contents and antioxidant properties were evaluated. Acetone was the solvent with the highest extraction performance, with the extracts obtained using this solvent displaying an increased concentration of bioactive compounds and increased antioxidant activities. For several extracts with high bioactive content, individual polyphenolic and tocopherolic compounds were evaluated by means of LC-MS and LC-MS/MS. The best extraction conditions for polyphenolic (2.86 mg gallic acid equivalents/g WMF) and tocopherolic compounds (29.4 µg/g WMF) were acetone with 40% water content (N20) and acetone with 20% water content (N15), respectively. Although the total tocopherol concentrations were lower than in other Juglans regia parts, most of the total tocopherol quantity was provided by the highly biologically active δ-tocopherol (84%). Significant quantities of quercetin (101.9 µg/g), hyperoside (2662.9 µg/g), quercitrin (405.7 µg/g), and isoquercitrin (1293.7 µg/g) were determined in WMF (N20). Both extracts inhibited the enzymatic activity of α-glucosidase and tyrosinase; however, an increased inhibition was observed for N20, the extract with the higher polyphenolic content. Conversely, N15 had higher anticancerous activity on the cell lines used, with a moderate selectivity towards the cancerous phenotype being observed for both extracts. At non-cytotoxic concentrations, both extracts displayed good antioxidant activities in cellular cultures, decreasing basal and H2O2-induced oxidative stress. This is the first characterization of both hydrophilic and lipophilic phytochemicals in WMF extracts. The outcomes of our study reveal that walnut male flowers have strong biological activities, thus justifying further research to demonstrate their usefulness in the food, pharmaceutical, and/or cosmetic industries.

scholarly journals Pharmacological activities and potential use of bovine colostrum for peptide-based radiopharmaceuticals: A review

Pharmacia ◽  
2021 ◽  
Vol 68 (2) ◽  
pp. 471-477
Author(s):  
Crhisterra Ellen Kusumaningrum ◽  
Eva Maria Widyasari ◽  
Maula Eka Sriyani ◽  
Hendris Wongso
Keyword(s):  
Nuclear Medicine ◽  
Bioactive Peptides ◽  
Biological Activities ◽  
Bovine Colostrum ◽  
Human Diseases ◽  
Bovine Lactoferrin ◽  
Bioactive Constituents ◽  
Short Term ◽  
Pharmacological Activities ◽  
Potential Use

Bovine colostrum (BC) is the initial milk produced by cows after giving birth. It has been used to treat human diseases, such as infections, inflammations, and cancers. Accumulating evidence suggests that bovine lactoferrin and bovine antibodies seem to be the most important bioactive constituents in BC. Thus, BC has also been reviewed for its potential to deliver short-term protection against coronavirus disease 2019 (COVID-19). In addition, it can potentially be explored as a precursor for peptide-based radiopharmaceuticals. To date, several bioactive peptides have been isolated from BC, including casocidin-1, casecidin 15 and 17, isracidin, caseicin A, B, and C. Like other peptides, bioactive peptides derived from BC could be used as a valuable precursor for radiopharmaceuticals either for diagnosis or therapy purposes. This review provides bovine colostrum’s biological activities and a perspective on the potential use of peptides from BC for developing radiopharmaceuticals in nuclear medicine.

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