scholarly journals Characteristics of the Epidemiological Situation on Cholera in the World and in the Russian Federation in 2020 and Forecast for 2021

2021 ◽  
pp. 43-51
Author(s):  
A. K. Noskov ◽  
V. D. Kruglikov ◽  
E. A. Moskvitina ◽  
E. V. Monakhova ◽  
D. A. Levchenko ◽  
...  
Keyword(s):  
Russian Federation ◽  
Biological Properties ◽  
Epidemiological Surveillance ◽  
Snp Analysis ◽  
Phylogenetic Relations ◽  
Environmental Objects ◽  
The World ◽  
The Russian Federation ◽  
Toxigenic Strains ◽  
Epidemiological Situation

Aim of the work – to assess the epidemiological situation on cholera in 2020 and to make a forecast for 2021 based on the monitoring data and analysis of morbidity around the world for the period of 2011–2020. During the period between 2011 and 2020, 4 413 988 cases of cholera were recorded in 97 countries of the world with a general trend towards a decrease in the incidence (coefficient of accuracy of approximation R2  – 0.5705). However, due to the continuing epidemic manifestations of cholera in the endemic countries of Asia, Africa and America, the epidemiological situation on cholera on these continents was characterized as unfavorable in 2020. The emergence of a new “post-Haitian” lineage was observed among epidemically hazardous strains of Vibrio cholerae O1. In 2020, no epidemically dangerous strains of V. cholerae O1, O139 were isolated from humans on the territory of the Russian Federation. 25 non-toxigenic V. cholerae O1 El Tor strains were isolated from environmental objects, eight out of which (ctxA-, tcpA+), according to PCR-INDEL typing and SNP analysis of sequences, belonged to the clonal complex. The results of the analysis of biological properties and phylogenetic relations between the isolated non-toxigenic strains provided the basis for considering the epidemiological situation on cholera in Russia in 2020 as a stable one and a similar forecast of its development in 2021. At the same time, the possibility of importation of this infection from endemic countries cannot be ruled out, as well as the need to carry out a complex of differentiated anti-epidemic (preventive) measures within the framework of the state sanitary-epidemiological surveillance in order to localize and eliminate the imported focus and avoid the spread of the infection.

scholarly journals Analysis of the Current Epidemiological Situation in Natural Plague Foci around the World. Enhancement of the Effectiveness of Epidemiological Surveillance in Natural Plague Foci of the Russian Federation and Forecast of their Epizootic Activity for 2019

2019 ◽  
pp. 81-88 ◽  
Author(s):  
N. V. Popov ◽  
I. G. Karnaukhov ◽  
N. D. Pakskina ◽  
G. A. Eroshenko ◽  
A. A. Kuznetsov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Ground Squirrels ◽  
Epidemiological Surveillance ◽  
High Mountain ◽  
Mountain Areas ◽  
Coverage Area ◽  
The World ◽  
The Russian Federation ◽  
The Republic ◽  
Epidemiological Situation

The paper presents the analysis of epidemic activity of natural plague foci around the world, including in CIS and the Russian Federation, over the period of 2000–2018. It was established that in 2010–2018, epidemic manifestations took place in natural plague foci where the main carriers are synanthropic (black, multinippled rats) and commercial (marmots, souslik, ground squirrels) species of rodents. Retaining of low epizootic activity of lowland natural plague foci in the territory of the Russian Federation is observed. In 2018, plague epizooties were detected in the territory of the Gorno-Altai high-mountain and Tuva mountain natural foci, the total coverage area being 2641 km2. 13 strains of the main subspecies and 6 strains of Altaic subspecies of plague microbe were isolated. Demonstrated were the prospects of GIS-technology usage for the enhancement of epidemiological surveillance over plague in Russia. Epizootiological forecast for persisting challenging epidemiological situation in Kosh-Agach district of the Republic of Altai and Mongun-Taiginsky, Ovyursky and Tes-Khemsky Kozhuuns of the Republic of Tuva was substantiated. Recorded was high probability of retention of strained epizootic and epidemiological situation in the south and central parts of the desert zone in the Republic of Kazakhstan, high-mountain areas of the Republic of Kyrgyzstan. Also conservation of epidemic risks for the territories of the countries in Africa (Republic of Madagascar), South (Peru, Bolivia), and North (USA) America, China, and Mongolia was noted. 

scholarly journals LICENSED ANTHRAX VACCINES AND EXPERIMENTAL PREPARATIONS AT THE STAGE OF CLINICAL TRIALS

2017 ◽  
pp. 112-126
Author(s):  
N. I. Mikshis ◽  
P. Yu. Popova ◽  
A. P. Semakova ◽  
V. V. Kutyrev
Keyword(s):  
Clinical Trials ◽  
Russian Federation ◽  
Large Scale ◽  
Next Generation ◽  
The World ◽  
High Pathogenicity ◽  
The Russian Federation ◽  
Manufacturing Technologies ◽  
Anthrax Vaccines ◽  
Epidemiological Situation

High pathogenicity of anthrax agent combined with unique insensitivity of its spore forms to environmental stresses class it among extremely dangerous biological agents. Registered and effectively used anthrax vaccines made invaluable contribution to the improvement of epidemiological situation around the world. Nevertheless, neglect of non-specific prophylaxis may result in dramatic scenarios and require large-scale measures on rectification of the consequences. Efforts on the development of next-generation vaccines are aimed at safety build-up, decrease in frequency of administration, and enhancement of manufacturing technologies. The review contains the key information on licensed anthrax vaccines designed for medical use, both in the territory of the Russian Federation and abroad. Among multiple experimental developments emphasized have been preparations manufactured by various biopharmaceutical companies in compliance with GMP standards, at different phases of clinical trials in 2016.

scholarly journals Review of the Current Epidemiological Situation on the Incidence of Hemorrhagic Fever with Renal Syndrome in the World and Forecast of the Incidence for the Territory of the Russian Federation in 2019

2019 ◽  
pp. 30-36 ◽  
Author(s):  
T. A. Savitskaya ◽  
V. A. Trifonov ◽  
G. Sh. Isaeva ◽  
I. D. Reshetnikova ◽  
N. D. Pakskina ◽  
...  
Keyword(s):  
Russian Federation ◽  
Hemorrhagic Fever ◽  
Federal District ◽  
Incidence Rates ◽  
Downward Trend ◽  
Average Level ◽  
The World ◽  
The Russian Federation ◽  
Autonomous Regions ◽  
Epidemiological Situation

The paper presents analysis of epidemiological situation on hemorrhagic fever with renal syndrome around the world and in the Russian Federation over the period of 2009–2018. 5855 cases of hemorrhagic fever with renal syndrome were registered in Russia in 2018 (3.99 per one hundred thousand of the population). Downward trend is observed as compared to 2017 (by 29.6 %). Cases of cluster infection were not reported. It is established that the highest level of morbidity, exceeding the average level across Russia 3.9 times, was noted in the Volga Federal District, where 77.5% of the total cases occurred. The territory of the Russian Federation was differentiated by the HFRS incidence rates. The areas with high levels of morbidity included the entities of the Russian Federation with intensive index range between 9.08 and 41.39 per one hundred thousand of the population, among them Republics of Bashkortostan, Mari El, Tatarstan, and Mordovia, Udmurt and Chuvashi Republics, Kirov, Nizhny Novgorod, Penza, Samara, Ulyanovsk, Kostroma, Yaroslavl, and Jewish Autonomous Regions. The forecast for preservation of tense epidemiological situation on HFRS incidence in the territory of the Volga Federal District was substantiated.

scholarly journals Review of Hantavirus Infections in the World, Epidemiological Situation on Hemorrhagic Fever with Renal Syndrome in the Russian Federation in 2020 and a Forecast for 2021

2021 ◽  
pp. 62-70
Author(s):  
T. A. Savitskaya ◽  
A. V. Ivanova ◽  
G. Sh. Isaeva ◽  
I. D. Reshetnikova ◽  
E. Kabve ◽  
...  
Keyword(s):  
Russian Federation ◽  
Far East ◽  
Statistical Processing ◽  
Federal District ◽  
European Part ◽  
The Past ◽  
Central Federal District ◽  
The World ◽  
The Russian Federation ◽  
Epidemiological Situation

The review used the data from operational monitoring carried out by the Reference Center for Monitoring over HFRS – “Kazan Research Institute of Epidemiology and Microbiology of the Rospotrebnadzor”, based on official data provided by the Rospotrebnadzor institutions in the constituent entities of the Russian Federation. Statistical processing was conducted using conventional methods of variation statistics applying the Excel program. Over the past decades, hantavirus diseases have become very relevant and spread throughout the world. In the territory of the Russian Federation, natural foci of HFRS are located in the European part of the country, Western Siberia and Far East. The most epidemically active foci are situated in the European part of Russia. Over the past decade, the intensive incidence rate of HFRS in the Russian Federation stayed within the range of 3.0–9.5 per 100 thousand of the population, the long-term average annual indicator – 5.2 per 100 thousand of the population. In 2020, 3845 cases of HFRS were registered (2.62 per 100,000 of the population). There was a decrease in the incidence of HFRS by 3.6 times, compared with the indicators of 2019. A factor that may have influenced the decrease in the incidence of HFRS was the depression of the epizootic process among small mammals, the main carriers of HFRS pathogens, due to natural and climatic factors. The nature of the distribution of HFRS incidence across the territory of the Russian Federation in 2020 was heterogeneous. Statistical processing of the data made it possible to identify 5 groups of territories that differ in the level of HFRS incidence. Almost all constituent entities of the Volga Federal District and the Kostroma Region belonging to the Central Federal District were classified as groups of territories with high and very high incidence rates. In 2021, the deterioration of the epidemiological situation is predicted in the summer-autumn period of the year in the Volga Federal District and four entities of the Central Federal District. 

scholarly journals Epidemiological and Epizootiological Situation on Tularemia in Russia and Neighboring Countries in 2019, the Forecast for 2020

2020 ◽  
pp. 21-32
Author(s):  
T. Yu. Kudryavtseva ◽  
V. P. Popov ◽  
A. N. Mokrievich ◽  
A. V. Kholin ◽  
A. V. Mazepa ◽  
...  
Keyword(s):  
Russian Federation ◽  
Preventive Measures ◽  
Human Infection ◽  
Altai Republic ◽  
Environmental Objects ◽  
The World ◽  
Federal Districts ◽  
Sporadic Cases ◽  
The Russian Federation ◽  
North Western

The review provides the data on the epidemic condition of tularemia foci in countries neighboring Russia and ongoing preventive measures in these territories. The highest tularemia incidence in the stated countries and in the world as a whole is observed in Finland. In 2019, 42 cases of human infection with tularemia pathogen were recorded in the territory of the Russian Federation, 85 % of which occur in three Federal Districts: North-Western, Central, and Siberian. Epizootic manifestations of infection of varying degrees of intensity were detected in 51 entities of the Federation. Against this background, sporadic cases of tularemia are registered in 17 regions of the country. The most severe epidemic complications continue in Karelia – 9 patients. Seventeen Francisella tularensis cultures were isolated from environmental objects in the Tver, Yaroslavl, Vologda Regions, in the Altai Territory and the Altai Republic. The paper gives an opinion on the regions in which epidemic complications of tularemia are most likely to occur in 2020.

scholarly journals Epizootiological and Epidemiological Situation on Brucellosis around the World in 2011–2020 and Forecast for the Russian Federation for 2021

2021 ◽  
pp. 41-51
Author(s):  
D. G. Ponomarenko ◽  
O. N. Skudareva ◽  
A. A. Khachaturova ◽  
A. N. Germanova ◽  
D. E. Lukashevich ◽  
...  
Keyword(s):  
Russian Federation ◽  
Current Trend ◽  
Farm Animals ◽  
Human Brucellosis ◽  
The North ◽  
The World ◽  
Federal Districts ◽  
The Russian Federation ◽  
Epidemiological Situation

Analysis of the incidence of human brucellosis in the world in 2011–2020 is presented in the paper. An assessment of the epizootiological-epidemiological situation on brucellosis in the Russian Federation in 2020 is performed. It is outlined that the epidemiological situation on brucellosis in Russia over the past decade was characterized as unfavorable with downward trend in the incidence rate against the background of persistent epizootiological insecurity among cattle and small ruminants. Between 2011 and 2020, 3507 first identified human cases of brucellosis were registered. The long-term average number of cases is 350 per year, including 28 cases among children under 17 years old. The average long-term intensive morbidity rate per 100 000 people was 0.24, among children under 17 – 0.1. In 2020, 119 human cases of brucellosis were detected in Russia (0.08), which indicates that the trend towards an improvement in the epidemiological situation on brucellosis continues. The largest number of brucellosis cases among people was registered in the North-Caucasian (77.1 % of the total incidence across Russia) and the Southern Federal District (13.5 %). In the period of 2010–2020 (9 months), 4610 areas potentially hazardous as regards bovine brucellosis and 422 – as regards brucellosis in sheep and goats were registered in the Russian Federation. Analysis of the development of brucellosis situation in Russia indicates that in the medium term, with the current trend maintained, there is a real risk of widespread brucellosis distribution among farm animals in the constituent entities of the Central, Volga, Far Eastern and Siberian Federal Districts, as well as the persistence of epizootiological insecurity in the North Caucasus and Southern Federal Districts. Taking into account the current epizootiological-epidemiological situation and the long-term dynamics of the development in the Russian Federation, one can predict the incidence of brucellosis in people at a level below the longterm average values – 0.13–0.18 per 100000 of the population in 2021.

scholarly journals Modern Stage of Development of the Epidemiological Surveillance and Prospects of its Improvement

2017 ◽  
Vol 16 (4) ◽  
pp. 4-7 ◽  
Author(s):  
E. G. Simonova
Keyword(s):  
Russian Federation ◽  
Rapid Development ◽  
Diagnostic Methods ◽  
Epidemiological Surveillance ◽  
Parasitic Diseases ◽  
Historical Aspects ◽  
Stage Of Development ◽  
The World ◽  
The Russian Federation

The article presents historical aspects of the development of epidemiological surveillance in the world and in the Russian Federation. The contribution of outstanding researchers to the development of theoretical bases for epidemiological surveillance of infectious and parasitic diseases is shown. The directions of improving epidemiological surveillance in modern conditions are considered in connection with the trends in the development of the epidemic situation, the emergence of «new» and the return of «old» infections, the rapid development of means and diagnostic methods, as well as taking into account the existing limitations.

scholarly journals Results of cholera monitoring in administrative territories of Russia from 2013 to 2019

2021 ◽  
Author(s):  
A. K. Noskov ◽  
V. D. Kruglikov ◽  
A. A. Lopatin ◽  
O. S. Chemisova ◽  
D. A. Levchenko ◽  
...  
Keyword(s):  
Russian Federation ◽  
Khabarovsk Krai ◽  
Rostov Region ◽  
Intestinal Infections ◽  
Irkutsk Region ◽  
The Russian Federation ◽  
Toxigenic Strains ◽  
El Tor ◽  
Further Development ◽  
Epidemiological Situation

Purpose. A dynamic comparative analysis of the results of identification ofVibrio cholerae(V. cholera) isolates from water and human specimens isolated during the monitoring of cholera throughout the Russian Federation in 2013–2019.Materials and methods. Total 385 strains ofV. choleraeO1 serogroup (including one toxigenicV. choleraeO1 El Tor Inaba — Rostov region, 2014) and the R-variant from environment objects were identified in the territory of 21 regions of the Russian Federation.Results. It was found that 91% of the strains were isolated in 7 regions of the Russian Federation: Republic of Kalmykia, Krasnodar Krai, Transbaikal Krai, Khabarovsk Krai, Primorsky Krai, Rostov region and Irkutsk region. 2.3% of strains were atypical in their agglutinability, and 75.3% of strains had atypical phagosensitivity. Phagotypes were identified for 13.2% of strains isolated in 11 administrative territories. Phageotype 11 included 48.8% of the strains isolated mainly in the Transbaikal Krai. Non-toxigenic strains ofV. choleraenonО1/nonO139 (n = 46) were isolated from 43 patients with acute intestinal infections and otitis in 8 regions of Russia. PCR-typing of 377 non-toxigenicV. choleraestrains demonstrated that they belong to 13 clusters and 71 genotypes. Strains with unique genotypes (probable cases of importation) and with the same genotypes repeatedly isolated in different years in one or several territories of the Russian Federation were identified, indicating the prevalence of strains in environment throughout the country.Conclusion. The results allowed us to characterize the epidemiological situation of cholera in Russia (in terms of the environment contamination withV. choleraeO1) as unstable, but not significantly changed over the past 7-year period. These data are important for substantiating the forecast for further development of the epidemiological situation.

scholarly journals Cholera: Monitoring of Epidemiological Situation around the World and in Russia (2010–2019). Forecast for 2020

2020 ◽  
pp. 38-47 ◽  
Author(s):  
E. A. Moskvitina ◽  
E. G. Yanovich ◽  
M. I. Kurilenko ◽  
V. D. Kruglikov ◽  
S. V. Titova ◽  
...  
Keyword(s):  
Russian Federation ◽  
Large Scale ◽  
Epidemiological Surveillance ◽  
Epidemic Process ◽  
The World ◽  
Imported Cases ◽  
The Russian Federation ◽  
Cis Countries ◽  
High Degree ◽  
Social And Environmental Risks

Objective of the study was to monitor the spread of cholera in the world, in the CIS countries and in Russia with an assessment of risks and emergencies that contribute to the activation of the epidemic process. Despite the downward trend in the global incidence rate of cholera during the period between 2010 and 2019, epidemics and major outbreaks occurred in 96 countries. WHO has reported 2013 imported cases of cholera to countries in Asia, the Americas, including the Caribbean, Europe, and Australia with Oceania; cholera-endemic administrative territories are identified in 24 countries. According to WHO, cholera burden reduction in Asia and Africa is associated with large-scale vaccination. During epidemiological surveillance of cholera, 705 strains of V. cholerae O1 and O139 serogroups were isolated from surface reservoirs in 26 constituent entities of the Russian Federation, including 10 strains of V. cholerae O1 ctxA+tcpA+, 35 strains of V. cholerae O1 ctxA–tcpA+, 655 strains of V. cholerae O1 ctxA–tcpA– , and five strains of V. cholerae O139 ctxA–tcpA–. Identification of strains with unique, previously unknown INDEL genotypes testifies to their imported nature. The forecast for cholera in the world for 2020, given the proven high degree of epidemic process activation at the expense of social and environmental risks caused by emergencies of different origin, the presence of endemic foci, infection import and other risk factors is unfavorable. For Russia, the forecast for cholera will be determined by the presence of external risks created by the ongoing 7-th pandemic, possible importation of infection to constituent entities of the Russian Federation that differ by the types of epidemic manifestations.

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