scholarly journals Synthesis of some Heterocyclic Compounds Derived from

2013 ◽  
Vol 10 (3) ◽  
pp. 525-536
Author(s):  
Baghdad Science Journal
Keyword(s):  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Sulfonyl Chloride ◽  
Starting Material ◽  
Amino Group ◽  
Thiazole Derivatives ◽  
Ft Ir ◽  
Bromo Compound

The 4-(?-bromo acetyl)-4?-toluene sulfonanilide (2) was used as key intermediate to synthesize new heterocyclic compounds. This bromo compound was synthesized via sulfonation of amino group of p-amino acetophenone using Hinsburg method with 4-toluene sulfonyl chloride to form 4-acetyl-4?-toluene sulfonanilide (1) which is used as a starting material in this work. This compound was brominated to yield compound (2) which is used as a precursor to synthesize new five and seven membered heterocyclic compounds such as substituted 1,3-oxazoles (3,4), 1,3-thiazole derivatives (5-7), thiourea compounds (8a,b), 1,3-Thiazoline-2-thione compounds (9a-f) and 1,2,5-triazepine compounds (11a-d). The synthesized compounds were identified depending upon physical, FT-IR and UV spectroscopic data.

Synthesis and Optical Properties of Dipolar Thiazole Derivatives Incorporating Nitro and Amino Substituents

2018 ◽  
Vol 773 ◽  
pp. 157-161
Author(s):  
Ahmad Shah Noor Aisyah ◽  
Nur Farahin Pairan ◽  
Noor Azilah Mohd Kasim ◽  
Bohari Mohd Yamin
Keyword(s):  
Thermal Stability ◽  
Optical Properties ◽  
Electron Acceptor ◽  
Decomposition Temperature ◽  
Amino Group ◽  
Thiazole Derivatives ◽  
Good Thermal Stability ◽  
H Nmr ◽  
Ft Ir ◽  
C Nmr

We report the synthesis of two dipolar thiazole derivatives functionalized with nitro group as electron acceptor and amino group as electron donor, in order to study their optical properties in the UV-vis range. Their structures were verified by 1H NMR, 13C NMR, HRMS and FT-IR. The resulted thiazole derivatives have good thermal stability with decomposition temperature, Td of 320.20 °C and 284 °C for compounds 1 and 2 respectively. The absorbance bands of compound 2 in the UV-vis range are more red-shifted than that of compound 1 which made compound 2 could have high potential as a great organic NLO material.

scholarly journals Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed El Fal ◽  
Youssef Ramli ◽  
Abdelfettah Zerzouf ◽  
Ahmed Talbaoui ◽  
Youssef Bakri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloaddition ◽  
Bacterial Strains ◽  
Pyrimidine Derivatives ◽  
H Nmr ◽  
Biological Interest ◽  
Mic Value

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

scholarly journals Green Synthesis andIn VitroBiological Evaluation of Heteroaryl Chalcones and Pyrazolines of Medicinal Interest

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Vishal Banewar
Keyword(s):  
Green Synthesis ◽  
Elemental Analysis ◽  
Broad Spectrum ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Active Compounds

Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds. In the present investigation, a series of various heteroaryl chalcones and pyrazolines were synthesized by condensing formylquinolines with diverse ketones. The newly synthesized 2-pyrazolines were characterized on the basis of elemental analysis and spectroscopic data. All of the newly synthesized target compounds were selected by the NCI forin vitrobiological evaluation. These active compounds exhibited broad spectrum of various biological activities. Most of the compounds showed potent activity.

scholarly journals Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

2017 ◽  
Vol 13 (2) ◽  
pp. 6006-6020
Author(s):  
Amira A. El-Sayed ◽  
Maher El-HAshash ◽  
Sameh Rizk
Keyword(s):  
Antimicrobial Activity ◽  
Green Synthesis ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Antimicrobial Properties ◽  
One Pot ◽  
One Pot Synthesis ◽  
Electrophilic Reagents

One pot synthesis and reaction of triazinthione and triazinohydrazide derivatives with different electrophilic reagents in ordered to synthesis of some interesting non-mixed heterocyclic compounds. Structures of thiazolotriazine, triazolotriazine, pyrimidinyltriazine, and triazinotriazine derivatives were established via spectroscopic data and elemental analysis. The synthesized compounds were screened for their antimicrobial activity.

Synthesis, spectroscopic (FT–IR and UV–Vis), crystallographic and theoretical studies, and a molecular docking simulation of an imatinib-like template

2019 ◽  
Vol 75 (12) ◽  
pp. 1681-1689
Author(s):  
Rodolfo Moreno-Fuquen ◽  
Kevin Arango-Daraviña ◽  
Esteban Garcia ◽  
Juan-C. Tenorio ◽  
Javier Ellena
Keyword(s):  
Crystal Growth ◽  
Hydrogen Bonds ◽  
Docking Simulation ◽  
Myelogenous Leukemia ◽  
Amino Group ◽  
Protein Residues ◽  
Function Analyzer ◽  
Stretching Vibration ◽  
Donor Acceptor ◽  
Ft Ir

The aim of the present study was to report the crystal structure and spectroscopic, electronic, supramolecular and electrostatic properties of a new polymorph of 4-(pyridin-2-yl)pyrimidin-2-amine (C9H8N4). The compound was synthesized under microwave irradiation. The single-crystal X-ray structure analysis revealed an angle of 13.36 (8)° between the planes of the rings, as well as molecules linked by Nsp 2—H...N hydrogen bonds forming dimers along the crystal. The material was analyzed by FT–IR vibrational spectroscopy, while a computational approach was used to elucidate the vibrational frequency couplings. The existence of Nsp 2—H...N hydrogen bonds in the crystal was confirmed spectroscopically by the IR peaks from the N—H stretching vibration shifting to lower wavenumbers in the solid state relative to those in the gas phase. The supramolecular studies confirmed the formation of centrosymmetric R 2 2(8) rings, which correspond to the formation of dimers that stack parallel to the b direction. Other weak C—H...π interactions, essential for crystal growth, were found. The UV–Vis spectroscopic analysis showed a donor–acceptor process, where the amino group acts as a donor and the pyridine and pyrimidine rings act as acceptors. The reactive sites of the molecule were identified and their quantitative values were defined using the electrostatic potential model proposed in the multifunctional wave function analyzer multiwfn. The calculated interaction energies between pairs of molecules were used to visualize the electrostatic terms as the leading factors against the dispersion factors in the crystal-growth process. The docking results showed that the amino group of the pyrimidine moiety was simultaneously anchored by hydrogen-bonding interactions with the Asp427 and His407 protein residues. This compound could be key for the realization of a series of syntheses of molecules that could be used as possible inhibitors of chronic myelogenous leukemia.

scholarly journals Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines

2021 ◽  
Vol 13 (1) ◽  
pp. 183-194
Author(s):  
T. Saroja ◽  
R. M. Ezhilarasi ◽  
V. Selvamani ◽  
S. Mahalakshmi
Keyword(s):  
Acetic Acid ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Mass Spectra ◽  
Acid Hydrazide ◽  
In Silico Analysis ◽  
Pharmacological Activities ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Silico Analysis

Heterocyclic compounds such as pyrazolines, pyrimidines, oxazole and isoxazole exhibit different pharmacological activities. The current study involves synthesis of new 2-pyrazolines. The synthesis involves the cyclocondensation reaction of substituted chalcones with (4-fluorophenylthio)acetic acid hydrazide (FTAH) under reflux. The chalcones (C1-C7 / 1a-1g) were synthesized from the reaction of substituted acetophenone with substituted benzaldehyde and FTAH was prepared from 4-fluro thiophenol. New 2-pyrazolines were obtained in good yields (60-70 %). All the compounds were characterized by FT-IR, 1H, 13C NMR and mass spectra. PASS analysis was carried out for the 2-pyrazolines synthesized (P1-P7 / 3a-3g).

Sign in / Sign up

Export Citation Format

Share Document