Case Study and Lessons Learnt for the 1St Fully Integrated Hwu Well Abandonment at Field a Offshore Malaysia

2021 ◽  
Author(s):  
Shahril Yang Shahril Shahril ◽  
Tengku Khairul Izwan Tengku Ahmad Tengku Khairul Tengku Khairul ◽  
Khalieff Fathiee Lokman Zakey Khalieff Fathiee Khalieff
Keyword(s):  
Early Stage ◽  
Low Cost ◽  
Project Planning ◽  
Lessons Learned ◽  
Point Of View ◽  
Fully Integrated ◽  
Practical Experiences ◽  
Well Abandonment ◽  
Technical Operation ◽  
Drilling Rigs

Abstract Uzma was awarded with 1st integrated well abandonment under Provision of Well Abandonment Integrated Services (WAISE) in 2018. Total of 22 wells were plug & abandonment with average 10 to 20 days per well were spent to complete the work. The scope of works is inclusive providing Project Management Team, Hydraulic Workover Unit, Accommodation Work Boat, Supply Vessels, and P&A services. This paper will highlight the practical experiences and capture the lessons learned obtained executing 1st integrated well abandonment campaign in Field A Offshore Malaysia. This paper presents the overall project lesson learnt for 1st integrated well abandonment embarked from early stage of project planning, preparation, acceptance, technical, operation & project close out. The lesson learnt will be beneficial for all Operator & Contractor Company involving with integrated well abandonment. This paper also presents capability of hydraulic workover unit and recommendation for future of low-cost well's plug and abandonment. Plug and abandonment operations with conventional hydraulic workover units have an enormous impact on low-cost plug and abandonment campaign in Malaysia compared with conventional drilling rigs. In essence, the lessons learned and insights gained throughout abandonment campaigns will keep accumulating with time to feed into the knowledge and experience vault. With proper project lesson learnt, many success cases and best practices can be emulated both from technical and commercial point of view. This lesson learnt will be beneficial for all Operator & Contractor Company involving with integrated well abandonment.

scholarly journals Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer

Sensors ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 1317 ◽  
Author(s):  
Jessica Sierra ◽  
José Marrugo-Ramírez ◽  
Romen Rodriguez-Trujillo ◽  
Mònica Mir ◽  
Josep Samitier
Keyword(s):  
Lower Risk ◽  
Causes Of Death ◽  
Histological Analysis ◽  
Early Stage ◽  
Low Cost ◽  
Liquid Biopsies ◽  
Fully Integrated ◽  
Minimal Invasiveness ◽  
Molecular Information ◽  
Detection Technologies

Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular information of the solid tumors via a body fluid draw. This fluid-based diagnostic method displays relevant advantages, including its minimal invasiveness, lower risk, use as often as required, it can be analyzed with the use of microfluidic-based platforms with low consumption of reagent, and it does not require specialized personnel and expensive equipment for the diagnosis. In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), circulating tumor cells (CTCs) and exosomes. The improvements in isolation and detection technologies offer increasingly sensitive and selective equipment’s, and the integration in microfluidic devices provides a better characterization and analysis of these biomarkers. These fully integrated systems will facilitate the generation of fully automatized platforms at low-cost for compact cancer diagnosis systems at an early stage and for the prediction and prognosis of cancer treatment through the biomarkers for personalized tumor analysis.

Cosmobio: a universe of certified organic cosmetics

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Stefania Mariano
Keyword(s):  
Early Stage ◽  
Traditional Approach ◽  
Low Cost ◽  
Subject Area ◽  
Lessons Learned ◽  
Business Failure ◽  
Initial Assessment ◽  
Content Type ◽  
Business Opportunity ◽  
Certified Organic

Study level/applicability This case is appropriate for early-stage postgraduate courses in entrepreneurship or business modeling. Subject area Entrepreneurship. Case overview Cosmobio case study presents the journey of Antonella Bognanni, founder and CEO of Cosmobio, along seven years of operations, from the initial assessment of the business opportunity to the launch, relaunch and closure of the business. Expected learning outcomes 1. To establish whether or not a business idea is a business opportunity. 2. To articulate aspects related to management prowess and liability of newness. 3. To differentiate between a lean versus a more traditional approach to business planning. 4. To discuss the potential bias of preliminary research. 5. To apply definitions of first-mover advantage. 6. To discuss how to conduct an environmental analysis; identify industry and target markets; and perform a competitor analysis. 7. To compare low-cost strategies to differentiation strategies. 8. To discuss marketing mix and marketing strategy. 9. To illustrate challenges related to being a solopreneur and related leadership styles or gender issues implications. 10. To illustrate implications related to business failure, past mistakes and lessons learned. Supplementary materials Teaching notes are available for educators only. Subject code CCS 3 Entrepreneurship.

THE LAPBOOK AS A DIDACTIC TOOL TO IMPLEMENT INTEGRATED TRAINING IN NATURAL SCIENCE AND TECHNOLOGY AND ENTREPRENEURSHIP AT PRIMARY SCHOOL LEVEL

2018 ◽  
Vol 28 (3) ◽  
pp. 959-963 ◽  
Author(s):  
Yordanka Peycheva ◽  
Snezhana Lazarova
Keyword(s):  
Natural Science ◽  
Lessons Learned ◽  
Point Of View ◽  
School Level ◽  
Integrative Approach ◽  
Educational Goals ◽  
Knowledge And Skills ◽  
Global Issues ◽  
Highly Active ◽  
The World

The formation of comprehensive and in-depth notions of objects and phenomena in the world can be achieved when the mastery of knowledge and skills is carried out in a system realized in the context of integration of different scientific directions. One of the main issues in modern education is related to the contradiction - on one hand between the need to form the skills necessary for the orientation and adaptation of the personality in the dynamics of the globalizing world and on the other - the education which is largely based on unilateral acquiring of knowledge and skills within the different subject areas. This influences the development of a worldview and the formation of an adequate attitude towards the problems under consideration and the world as a whole. The knowledge and skills acquired today are often “locked” in the respective direction. The cross-curricular unity in the curriculum is of a recommended nature, but even if it is realized, it does not fully meet the need for a comprehensive and multifaceted consideration of global issues, as a result of which the student not only understands, reflects, but also applies the lessons learned in the process of creating a product - ideal or material. Combining the intellectual nature of the cognitive process with the practice activity are conditions in which the students are highly active and achieve better learning outcomes. Therefore, it is expedient for the different directions to correspond more closely to each other and to carry out effective cross-curricular integration. The concept of applying an integrative approach in the current paper is based on the idea of creating pedagogical conditions for reconciling the goals and expected outcomes of technology and entrepreneurship and natural sciences studied at the initial stage of the primary education. Integration can take place on two levels - knowledge and skills. We believe that the lapbook as an innovative didactic tool contains the necessary potential for effective realization of the educational goals in both directions in terms of achieving the expected results. In the course of its elaboration, new information is acquired in the field of engineering and technology, specific skills underlying the curricula of technology and entrepreneurship programs are developed. At the same time, a number of subjects from the learning content, which are considered from the natural science point of view, are enriched and perceived in a technological way, after which they find place in an attractive book - a lapbook, made by the students themselves. Its utilitarian value is multiplied by the personal contribution to its creation - not only as an object but also as content. The main topics that are of interest to the students are exploring and preserving nature, jobs, modern technical achievements, holidays and customs. As a result of the adequate integration of competences, tailored to curricula, a number of skills are formed, such as: skills for searching on their own, systematization and presentation of information, and application of the lessons learned in a new situation.

scholarly journals Automation of absolute protein-ligand binding free energy calculations for docking refinement and compound evaluation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Germano Heinzelmann ◽  
Michael K. Gilson
Keyword(s):  
Free Energy ◽  
Early Stage ◽  
Binding Free Energy ◽  
Low Cost ◽  
Free Energy Calculations ◽  
Free Energies ◽  
Energy Calculations ◽  
Drug Candidates ◽  
Binding Free Energy Calculations ◽  
Binding Free Energies

AbstractAbsolute binding free energy calculations with explicit solvent molecular simulations can provide estimates of protein-ligand affinities, and thus reduce the time and costs needed to find new drug candidates. However, these calculations can be complex to implement and perform. Here, we introduce the software BAT.py, a Python tool that invokes the AMBER simulation package to automate the calculation of binding free energies for a protein with a series of ligands. The software supports the attach-pull-release (APR) and double decoupling (DD) binding free energy methods, as well as the simultaneous decoupling-recoupling (SDR) method, a variant of double decoupling that avoids numerical artifacts associated with charged ligands. We report encouraging initial test applications of this software both to re-rank docked poses and to estimate overall binding free energies. We also show that it is practical to carry out these calculations cheaply by using graphical processing units in common machines that can be built for this purpose. The combination of automation and low cost positions this procedure to be applied in a relatively high-throughput mode and thus stands to enable new applications in early-stage drug discovery.

The ethics of pandemic preparedness revisited - autonomy, quarantine, transferability and trust

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
P Schröder-Bäck ◽  
T Schloemer ◽  
K Martakis ◽  
C Brall
Keyword(s):  
Crisis Management ◽  
Ethical Issues ◽  
Lessons Learned ◽  
Point Of View ◽  
Ethical Challenges ◽  
Pandemic Preparedness ◽  
Ethical Aspects ◽  
Outbreak Management ◽  
Ethics Framework ◽  
Ethical Point

Abstract Background The outbreak of SARS in 2002 lead to a public health ethics discourse. The crisis management of that time was ethically analysed and lessons to be learned discussed. Scholarship and WHO, among others, developed an ethics of pandemic preparedness. The current “corona crisis” also faces us with ethical challenges. This presentation is comparing the two crises from an ethical point of view and a focus on Europe. Methods An ethics framework for pandemic preparedness (Schröder et al. 2006 and Schröder-Bäck 2014) is used to make a synopsis of ethical issues. Ethical aspects of 2002 and 2020 that were discussed in the literature and in the media are compared. For 2020, the focus is on interventions in Italy, Germany, Switzerland, and the Netherlands. Results Topics that emerged from the 2002 crisis were, among others, revolving around aspects of stigmatisation and fair distribution of scarce resources (esp. vaccines, antivirals). Currently, most urgent and ethically challenging aspects relate to social distancing vs. autonomy: Isolation and quarantine are handled differently across Europe and the EU. Questions of transferability of such interventions prevail. Contexts vary vertically over time (2002 vs. 2020) and horizontally (e.g. between Italy and Germany at the same time). Furthermore, trust in authorities, media and health information is a key issue. Conclusions Ethical aspects are key for good pandemic preparedness and management. The context of the crises between 2002 and 2020 has slightly changed, also based on “lessons learned” from 2002. This has implications on ethical issues that are being discussed. New lessons will have to be learned from the 2020 crisis. Key messages Pandemic preparedness and outbreak management entail many ethical tensions that need to be addressed. Currently, questions of trust and transferability are key to the crisis management, further ethical issues could still emerge.

scholarly journals In-Plane Monolithic Integration of Scaled III-V Photonic Devices

2021 ◽  
Vol 11 (4) ◽  
pp. 1887
Author(s):  
Markus Scherrer ◽  
Noelia Vico Triviño ◽  
Svenja Mauthe ◽  
Preksha Tiwari ◽  
Heinz Schmid ◽  
...  
Keyword(s):  
Integrated Circuits ◽  
High Speed ◽  
Low Cost ◽  
Photonic Devices ◽  
Monolithic Integration ◽  
Light Emitters ◽  
Fully Integrated ◽  
Large Lattice ◽  
Hybrid Iii ◽  
Gain Material

It is a long-standing goal to leverage silicon photonics through the combination of a low-cost advanced silicon platform with III-V-based active gain material. The monolithic integration of the III-V material is ultimately desirable for scalable integrated circuits but inherently challenging due to the large lattice and thermal mismatch with Si. Here, we briefly review different approaches to monolithic III-V integration while focusing on discussing the results achieved using an integration technique called template-assisted selective epitaxy (TASE), which provides some unique opportunities compared to existing state-of-the-art approaches. This method relies on the selective replacement of a prepatterned silicon structure with III-V material and thereby achieves the self-aligned in-plane monolithic integration of III-Vs on silicon. In our group, we have realized several embodiments of TASE for different applications; here, we will focus specifically on in-plane integrated photonic structures due to the ease with which these can be coupled to SOI waveguides and the inherent in-plane doping orientation, which is beneficial to waveguide-coupled architectures. In particular, we will discuss light emitters based on hybrid III-V/Si photonic crystal structures and high-speed InGaAs detectors, both covering the entire telecom wavelength spectral range. This opens a new path towards the realization of fully integrated, densely packed, and scalable photonic integrated circuits.

scholarly journals A Feasibility Study of the Use of Smartwatches in Wearable Fall Detection Systems

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2254
Author(s):  
Francisco Javier González-Cañete ◽  
Eduardo Casilari
Keyword(s):  
Low Cost ◽  
Fall Detection ◽  
The Elderly ◽  
Point Of View ◽  
False Alarms ◽  
Battery Life ◽  
Area Network ◽  
Battery Lifetime ◽  
Detection Systems ◽  
Operational Aspects

Over the last few years, the use of smartwatches in automatic Fall Detection Systems (FDSs) has aroused great interest in the research of new wearable telemonitoring systems for the elderly. In contrast with other approaches to the problem of fall detection, smartwatch-based FDSs can benefit from the widespread acceptance, ergonomics, low cost, networking interfaces, and sensors that these devices provide. However, the scientific literature has shown that, due to the freedom of movement of the arms, the wrist is usually not the most appropriate position to unambiguously characterize the dynamics of the human body during falls, as many conventional activities of daily living that involve a vigorous motion of the hands may be easily misinterpreted as falls. As also stated by the literature, sensor-fusion and multi-point measurements are required to define a robust and reliable method for a wearable FDS. Thus, to avoid false alarms, it may be necessary to combine the analysis of the signals captured by the smartwatch with those collected by some other low-power sensor placed at a point closer to the body’s center of gravity (e.g., on the waist). Under this architecture of Body Area Network (BAN), these external sensing nodes must be wirelessly connected to the smartwatch to transmit their measurements. Nonetheless, the deployment of this networking solution, in which the smartwatch is in charge of processing the sensed data and generating the alarm in case of detecting a fall, may severely impact on the performance of the wearable. Unlike many other works (which often neglect the operational aspects of real fall detectors), this paper analyzes the actual feasibility of putting into effect a BAN intended for fall detection on present commercial smartwatches. In particular, the study is focused on evaluating the reduction of the battery life may cause in the watch that works as the core of the BAN. To this end, we thoroughly assess the energy drain in a prototype of an FDS consisting of a smartwatch and several external Bluetooth-enabled sensing units. In order to identify those scenarios in which the use of the smartwatch could be viable from a practical point of view, the testbed is studied with diverse commercial devices and under different configurations of those elements that may significantly hamper the battery lifetime.

Development of a Low-Cost Insulin Infusion Pump: Lessons Learned from an Industry Case

2015 ◽  
Author(s):  
Luiz Eduardo G. Martins ◽  
Hanniere de Faria ◽  
Lucas Vecchete ◽  
Tatiana Cunha ◽  
Tiago de Oliveira ◽  
...  
Keyword(s):  
Insulin Infusion ◽  
Low Cost ◽  
Infusion Pump ◽  
Lessons Learned

Functional Requirements for Effective Decision Making in Humanrobot Teams: Lessons Learned from Operational Settings

2005 ◽  
Vol 49 (3) ◽  
pp. 452-456
Author(s):  
James Tittle ◽  
William Elm ◽  
Scott Potter
Keyword(s):  
Decision Making ◽  
Information Seeking ◽  
Reference Frames ◽  
Broad Class ◽  
Design Guidelines ◽  
Lessons Learned ◽  
Point Of View ◽  
Functional Requirements ◽  
Urban Search And Rescue ◽  
Robot Teams

Many environments require humans and robots operating together to accomplish complex and dangerous tasks, but technology-centered designs often support robot navigation but not the mission goals of the organization using the robot. Urban Search and Rescue (USAR) is a particularly valuable domain to identify general functional requirements for effective HRI, and our purpose in this paper is to demonstrate how a CSE approach can lead to valuable design guidelines that more effectively support decision making within Human-Robot teams. Our analysis of HRI in USAR lead us to identify several important guidelines for supporting effective coordination for Human-Robot teams: including (i) enable individual problem holders to have direct control over point-of-view to facilitate active information seeking, and (ii) create common reference frames on shared imagery so different problem holders can remotely coordinate information and actions. Designs based on these guidelines will support a broad class of coordinated activities between team members.

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