scholarly journals Does obesity affect cognitive functions in middle-aged adulthood? A comparative study in Sri Lanka

2019 ◽  
Author(s):  
Pushpika Ariyasinghe ◽  
Ruwan Kumara ◽  
Daham Alexander ◽  
Harsha Senarathna ◽  
Sunethra Kasthuri ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Cognitive Functions ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Obese People ◽  
Cross Sectional ◽  
Neuropsychological Functions ◽  
Remedial Actions ◽  
Middle Aged Adults

Abstract Background Cognition is the collection of an intellectual process, such as perception, thinking, reasoning and remembering for goal-directed behaviors. Recent studies have shown that obesity associated with poor cognitive functions (CFs). However, this association is not known in the Sri Lankan context. The objective was to determine the association of cognitive function and obesity among middle-aged adults in Colombo district, Sri LankaMethods A comparative cross-sectional study was conducted among 166 middle-aged adults aged 50-60 years in a selected MOH division in Colombo District, Sri Lanka. Generalized and central obesity were determined using the WHO cutoff of Body Mass Index (BMI) and Waist Hip Ratio (WHR) values. CFs were assessed using validated Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) tools.Results The study sample consisted 83 subjects of each obese and normal weight categories while 50% were females. Obese middle-aged adults showed significantly lower CF scores in both MoCA and MMSE compared to the normal-weight adults. In addition, lower MMSE scores were significantly associated with high WHR values. Education level of the obese people was a significant predictor of the cognitive functions.Conclusion Obese middle-aged adults had poor cognition compared with their normal-weight subjects. Therefore, remedial actions need to be taken to overcome adulthood obesity for better neuropsychological functions in the brain.

scholarly journals Cystatin C in healthy middle-aged adults: A relationship with anthropometric and cardiometabolic parameters

2016 ◽  
Vol 6 (2) ◽  
pp. 105-111
Author(s):  
Milovan Jovanovic ◽  
Nebojsa Kavaric ◽  
Najdana Gligorovic-Barhanovic ◽  
Verica Skerovic ◽  
Aleksandra Klisic
Keyword(s):  
Cystatin C ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Serum Cystatin C ◽  
Cross Sectional ◽  
Potential Association ◽  
Middle Aged Adults

Introduction: Data suggesting that cystatin C levels are linked to obesity, apart from renal pathology, are conflicting. The aim of the study was to explore the potential association between serum cystatin C levels, anthropometric, and cardiometabolic parameters in healthy middle-aged adults.Methods: A total of 132 participants (mean age 56.2 ± 6.73 years, 69% females) were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained.Results: Obese participants displayed higher cystatin C levels than normal-weight participants (p < 0.001). Multiple linear regression analysis revealed that waist circumference (WC) (Beta = 0.376, p < 0.001) and estimated glomerular filtration rate (Beta = -0.484, p < 0.001) were independently associated with cystatin C levels (R2 = 0.447; p < 0.001).Conclusions: Cystatin C is associated with abdominal obesity independent of renal function. Its relationship with changes in other target organs  should be determined.

scholarly journals Association of the level of cognition and obesity among middle-aged adults in Sri Lanka

2021 ◽  
Vol 9 (6) ◽  
pp. 1546
Author(s):  
Pushpika Ariyasinghe ◽  
Ruwan Kumara ◽  
Dham Alexander ◽  
Harsha Senarathna ◽  
Sunethra Kasthuri ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Cognitive Functions ◽  
Cognitive Assessment ◽  
Mini Mental State Examination ◽  
Descriptive Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Level Of Education ◽  
Middle Aged Adults ◽  
State Examination

Background: Cognition is the collection of an intellectual process, such as perception, thinking, and reasoning for goal-directed behaviours. The obesity-associated cognitive functions (CFs) was varied due to inconsistency of the findings and it is also context bounded. The objective was to assess the association between cognitive function and obesity among middle-aged adults in Sri Lanka.Methods: A descriptive study was conducted among middle-aged adults aged between 50-60 years in Colombo District, Sri Lanka. While Generalized obesity was estimated by the WHO cutoff of body mass index (BMI) while the central obesity was determined using and waist hip ratio (WHR). CFs was assessed using a validated Montreal cognitive assessment (MoCA) and the Mini-mental state examination (MMSE) tools.Results: The study sample consisted of 83 subjects of each obese and normal weight categories, while 50% were females. Middle-aged adults with obesity showed significantly lower CF scores in both MoCA and MMSE compared to the normal-weight adults (p<0.01). In addition, lower MMSE scores were significantly associated with high WHR values (p<0.05). The level of education of adults was a significant predictor of cognitive functions among middle-aged adults (p<0.05).Conclusions: Therefore, the results further confirmed that obesity-associated cognitive impairment among middle-aged adults and further research is warranted to clarify the cause and effect relationship between obesity and body composition.  

scholarly journals Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?

Metabolites ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 771
Author(s):  
Lourdes Balcázar-Hernandez ◽  
Lourdes Basurto ◽  
Leticia Manuel-Apolinar ◽  
Sara Vega-García ◽  
Norma Basurto-Acevedo ◽  
...  
Keyword(s):  
Body Size ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
The Body ◽  
Metabolic Phenotype ◽  
Obese Women ◽  
Middle Aged ◽  
Cross Sectional ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy

Variations in levels of some adipokines, myokines, osteokines, hepatokines and inflammatory cytokines contribute to abnormal glucose and lipid metabolism. The aim of this study was to determine the pattern of adiponectin, osteocalcin (OCN), irisin, FGF-21, and MCP-1 according to the body size phenotype of middle-aged women, and their associations with BMI, visceral adipose tissue (VAT), and HOMA-IR. A cross-sectional study in 265 women aged from 40 to 65 years was performed. The biochemical characteristics were evaluated in metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy obese, and metabolically unhealthy obese women. There was an association of OCN with BMI (r = −0.107; p = 0.047); adiponectin with BMI (r = −0.217; p = 0.001), insulin (r = −0.415; p = 0.0001), HOMA-IR (r = −0.429; p = 0.0001), and VAT (r = −0.134; p = 0.025); irisin with BMI (r = 0.604; p = 0.001), insulin (r = 0.446; p = 0.0001), HOMA-IR (r = 0.452; p = 0.0001), and VAT (r = 0.645; p = 0.0001); FGF−21 with insulin (r = −0.337; p= 0.030) and HOMA-IR (r = −0.341; p = 0.03); and MCP-1 with BMI (r = 0.481; p = 0.0001), VAT (r = 0.497; p = 0.001), insulin (r = 0.298; p= 0.001), and HOMA-IR (r = 0.255; p = 0.004). A multivariate analysis showed that an elevation of OCN (OR 1.4 (95%CI 1.06–1.81)) and a reduction of adiponectin (OR 0.9 (0.84–0.96)) were associated factors for a metabolic unhealthy phenotype in normal weight participants. Likewise, higher irisin (OR 1.007 (1.003–1.011)) and MCP-1 (1.044 (1.008–1.083)) were risk factors for a metabolic unhealthy phenotype in woman with obesity. OCN, adiponectin, irisin, FGF-21, and MCP-1 are associated with some metabolic parameters such as BMI, HOMA-IR, and VAT, and could be possible biomarkers of an unhealthy metabolic phenotype in middle-aged women.

Benefits of volunteerism for middle-aged and older adults: comparisons between types of volunteering activities

2021 ◽  
pp. 1-20
Author(s):  
Alfred H. K. Lam ◽  
Dannii Y. Yeung ◽  
Edwin K. H. Chung
Keyword(s):  
Older Adults ◽  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Health And Wellbeing ◽  
Hand Grip ◽  
Middle Aged Adults ◽  
Main Effects

Abstract Volunteering is a popular activity among middle-aged and older adults as means to contribute to the society and to maintain personal health and wellbeing. While the benefits of volunteering have been well-documented in the current literature, it does not tend to distinguish between various types of volunteering activities. This cross-sectional study aims to compare the effects of instrumental (e.g. food preparation, fundraising) and cognitively demanding volunteering activities (e.g. befriending, mentoring) in a sample of 487 middle-aged and older Hong Kong Chinese adults. Participation in instrumental and cognitively demanding volunteering, life satisfaction, depressive symptoms, cognitive functioning and hand-grip strength were measured. The results of two-way between-subject robust analyses of variance demonstrated significant main effects of volunteering type and their interaction effect with age on life satisfaction and depressive symptoms. Comparisons among four volunteering groups (no volunteering, instrumental volunteering, cognitively demanding volunteering and both types) revealed that individuals engaging in instrumental volunteering exhibited lower life satisfaction and more depressive symptoms compared to those who engaged in cognitively demanding volunteering and those who did not volunteer at all. This detrimental pattern of instrumental volunteering was only seen in middle-aged adults, but not in older adults. Findings of this study revealed distinctive effects of two volunteering types, and provide valuable directions for designing future volunteering programmes.

scholarly journals Neonatal outcome of term deliveries in Sri Lanka

2018 ◽  
Vol 7 (2) ◽  
pp. 34-39
Author(s):  
Damitha Asanga Gunawardane ◽  
Samath D Dharmaratne ◽  
Dhammica S Rowel
Keyword(s):  
Sri Lanka ◽  
High Volume ◽  
Cross Sectional Study ◽  
Neonatal Care ◽  
Normal Weight ◽  
Neonatal Outcomes ◽  
Bacterial Sepsis ◽  
Cross Sectional ◽  
Term Neonates ◽  
Gestational Age At Delivery

Major proportion (40-70%) of neonatal mortality is among ‘term neonates’. Even though, information on neonatal outcomes of term neonates is scarce. The high volume of term neonatal admissions to neonatal care units signify the importance of studying the neonatal outcomes among term neonates. The aim of this study is to describe the neonatal outcomes, of term neonates following term deliveries (37 completed weeks - 41 completed weeks and 6 days) at Teaching Hospital (TH) Kandy, Sri Lanka. A descriptive cross-sectional study was conducted to describe neonatal outcomes of term neonates before the initial hospital discharge point. A sample of 1,105 neonates, delivered at term were studied during the study period. Mean gestational age at delivery is 38.85 weeks and 41% of term neonates are delivered before completion of 39 weeks of Period of Amenorrhoea (POA). The mean birth weight of the term neo-nates is 2925.24 grams. Out of all term neonates, 15.84% (n=175) were admitted to Neonatal Care Unit (NCU) and 23.3% (n=257) had at least one diagnosed neonatal condition. The commonest neonatal condition was bacterial sepsis of newborn (n=138, 12.48%), followed by neonatal jaundice from other and unspecified causes (n=84, 7.6%), and respiratory distress of newborn (n=44, 3.94%). Median hospital stay of term neonates is 3 days. Majority of term neo-nates admitted to NCU are normal weight term neonates. Nearly one-fourth of term neonates had at least one diag-nosed neonatal condition. Prevention and control of infection from the time of birth to the time of discharge from the hospital should be given due attention to reducing bacterial sepsis among term neonates.South East Asia Journal of Public Health Vol.7(2) 2017: 34-39

scholarly journals Sex Differences in the Influence of Sleep on Body Mass Index and Risk of Metabolic Syndrome in Middle-Aged Adults

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 561
Author(s):  
Hyun-E Yeom ◽  
Jungmin Lee
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Middle Aged ◽  
Cross Sectional ◽  
Aged People ◽  
Middle Aged Adults ◽  
The Impact

Poor sleep and obesity are intimately related to cardiovascular diseases. We aimed to examine whether the influence of sleep and body mass index (BMI) on the risk of metabolic syndrome (MetS) differed by sex in middle-aged people. It is a cross-sectional study of 458 Korean participants who completed self-administered surveys; the data were analyzed using the PROCESS macro for SPSS. We found that both sleep and BMI were significant predictors of MetS risk in women, particularly by the role of BMI connecting the impact of sleep to MetS risk. However, the association was not found in men, showing that BMI, but not sleep, was a significant predictor of MetS. This sex-related difference was due to different relationships between sleep and BMI, indicating that BMI was more dependent on sleep quality for women than for men. Therefore, a sex-specific approach to decrease the risk of MetS is warranted.

scholarly journals Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

2019 ◽  
Author(s):  
Takako Shirasawa ◽  
Hirotaka Ochiai ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Central Obesity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Cross Sectional ◽  
Men And Women ◽  
Japanese Adults

Abstract Background Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40-64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m 2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5-24.9 kg/m 2 ) without (NW; WHtR <0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid >7.0 and ≥6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4% and 11.0%, and of participants with NWCO respectively 15.6% and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03-2.21; women: OR, 3.54; 95%CI, 3.21-3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36-1.52; women: OR, 1.41; 95%CI, 1.27-1.57). The results were similar regardless of alcohol consumption. Conclusions We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

scholarly journals Influence of Body Composition on Arterial Stiffness in Middle-Aged Adults: Healthy UAL Cross-Sectional Study

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 334 ◽  
Author(s):  
Alba Hernandez-Martinez ◽  
Elena Martinez-Rosales ◽  
Manuel Alcaraz-Ibañez ◽  
Alberto Soriano-Maldonado ◽  
Enrique G. Artero
Keyword(s):  
Body Composition ◽  
Arterial Stiffness ◽  
Metabolic Diseases ◽  
Cross Sectional Study ◽  
Neck Circumference ◽  
Fat Free Mass ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Middle Aged Adults

Background and objectives: Several anthropometric and body composition parameters have been linked to arterial stiffness (AS) as a biomarker of cardiovascular disease. However, little is known about which of these closely related factors is more strongly associated with AS. The aim of the present study was to analyze the relationship of different anthropometric and body composition parameters with AS in middle-aged adults. Materials and Methods: This cross-sectional study included 186 middle-aged participants (85 women, 101 men; age = 42.8 ± 12.6 years) evaluated as part of the Healthy UAL study, a population study conducted at the University of Almería with the main purpose of analyzing the etiology and risk factors associated with cardio-metabolic diseases. Anthropometric measures included neck, waist, and hip circumferences, as well as the waist-to-height ratio (WHtr). Bioimpedance-derived parameters included fat-free mass index (FFMI), fat mass index (FMI), and percent of body fat (%BF). AS was measured by pulse wave velocity (PWV). The relationships of interest were examined through stepwise regression analyses in which age and sex were also introduced as potential confounders. Results: Neck circumference (in the anthropometric model; R 2: 0.889; β: age = 0.855, neck = 0.204) and FFMI (in the bio-impedance model; R2: 0.891; β: age = 0.906, FFMI = 0.199) emerged as significant cross-sectional predictors of AS. When all parameters were included together (both anthropometry and bio-impedance), both neck circumference and FFMI appeared again as being significantly associated with AS (R2: 0.894; β: age = 0.882, FFMI = 0.126, neck = 0.093). Conclusion: It was concluded that FFMI and neck circumference are correlated with AS regardless of potential confounders and other anthropometric and bioimpedance-derived parameters in middle-aged adults.

scholarly journals Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Takako Shirasawa ◽  
Hirotaka Ochiai ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Central Obesity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Middle Aged ◽  
Cross Sectional ◽  
Men And Women ◽  
Japanese Adults

Abstract Background Several studies have shown that normal weight with central obesity (NWCO) is associated with cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO and hyperuricemia has not been studied in detail. Methods We investigated the association between NWCO and hyperuricemia among Japanese adults aged 40–64 years who had undergone periodic health examinations between April 2013 and March 2014. Obesity was defined as a body mass index (BMI) ≥25 kg/m2 and central obesity was determined as a waist-to-height ratio (WHtR) ≥0.5. We classified the participants into the following groups based according to having obesity and central obesity: normal weight (BMI 18.5–24.9 kg/m2) without (NW; WHtR < 0.5) and with (NWCO) central obesity, and obesity without (OB) and with (OBCO) central obesity. Hyperuricemia was defined as serum uric acid > 7.0 and ≥ 6.0 mg/dL in men and women, respectively, or under medical treatment for hyperuricemia. Alcohol intake was classified as yes (daily and occasional consumption) and none (no alcohol consumption). Odds ratios (OR) and 95% confidence intervals (CI) for hyperuricemia were calculated using a logistic regression model. Results We analyzed data derived from 96,863 participants (69,241 men and 27,622 women). The prevalences of hyperuricemia in men and women were respectively, 21.4 and 11.0%, and of participants with NWCO respectively 15.6 and 30.0%. The adjusted OR for hyperuricemia was significantly increased in OBCO compared with NW, regardless of sex (men: OR, 2.12; 95%CI; 2.03–2.21; women: OR, 3.54; 95%CI, 3.21–3.90) and were statistically significant in NWCO compared with NW (men: OR, 1.44; 95%CI, 1.36–1.52; women: OR, 1.41; 95%CI, 1.27–1.57). The results were similar regardless of alcohol consumption. Conclusions We found that NWCO and OBCO were associated with hyperuricemia in middle-aged Japanese men and women. Middle-aged Japanese adults with normal weight but having central obesity should be screened using a combination of BMI and WHtR and educated about how to prevent hyperuricemia.

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