scholarly journals Epidemiology of acute rubella infection in Zambia during the pre-vaccination period (2005 – 2016) as a baseline for monitoring rubella epidemiology in the post-rubella vaccine introduction era

2019 ◽  
Author(s):  
Mazyanga Lucy Mazaba ◽  
Seter Siziya ◽  
Mwaka Monze ◽  
Daniel Cohen
Keyword(s):  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Laboratory Data ◽  
Health Concern ◽  
Age Group ◽  
Childbearing Age ◽  
Rubella Vaccine ◽  
Vaccine Introduction ◽  
Hot Dry Season ◽  
The Impact

Abstract Background: Rubella is highly under reported in Zambia as in most sub-Saharan countries despite being a disease of major public health concern especially among women of childbearing age. In September 2016, Zambia introduced a combined measles-rubella vaccine in children 0-14 years. In this study, we estimated the proportion positive for acute rubella among suspected but negative measles cases between 2005 and 2016 and determined its correlates for monitoring rubella epidemiology post-rubella vaccine introduction. Methods: In a retrospective study, 4497 measles IgM negative serum samples from 5686 clinically suspected measles cases were examined for rubella IgM antibodies using the Siemens, Enzygnost® ELISA kit at the national measles laboratory. Data on demographics, year and month of onset were extracted from the surveillance data. Multivariate logistic regression analysis using backward variable selection was conducted to determine independent predictors for acute rubella. The magnitude of association was estimated using adjusted odds ratio with a 95% confidence interval. Results: Overall, a proportion of 29.2% (1313/4497) affecting mostly those between 5 and 24 years was determined. Only age, province, month and year were independently associated with acute rubella. The regional proportions varied from 21.8 – 37.3% peaking in the month of October. Persons in the age group 10-14 years (Adjusted Odds Ratio [AOR]=2.43; 95% CI [2.01 - 2.95]) were more likely while those aged <1 year less likely (AOR=0.31; 95% CI [021 - 0.48]) to have acute rubella compared to those aged 25 years or older. Persons in 2010 were less likely (AOR=0.12; CI [0.05, 0.28]) to have acute rubella compared to those in 2016. While acute rubella was more likely to occur between July and November compared to December, it was less likely to occur between February and May. Conclusions: Rubella virus was circulating in Zambia between 2005 and 2016 affecting mostly persons in the age group 5-24 years peaking in the hot dry season month of October. Although vaccination against rubella has been launched, these baseline data are important to provide a reference point when determining the impact of the vaccination program implemented. Keywords: Rubella, Acute, Proportion, Correlates, Zambia, Pre vaccination era, Immunisation

scholarly journals Epidemiology of acute rubella infection in Zambia during the pre-vaccination period (2005 – 2016) as a baseline for monitoring rubella epidemiology in the post-rubella vaccine  introduction era.

2019 ◽  
Author(s):  
Mazyanga Lucy Mazaba ◽  
Seter Siziya ◽  
Mwaka Monze ◽  
Daniel Cohen
Keyword(s):  
Laboratory Data ◽  
Multivariate Logistic Regression Analysis ◽  
Vaccination Strategy ◽  
Health Concern ◽  
Age Group ◽  
Childbearing Age ◽  
Serum Samples ◽  
Rubella Vaccine ◽  
Vaccine Introduction ◽  
Hot Dry Season

Abstract Background: Rubella is highly under reported in Zambia as in most sub-Saharan countries despite being a disease of major public health concern especially among women of childbearing age. In September 2016, Zambia introduced a combined measles-rubella vaccine in children aged 0-14 years. In this study, we estimated the proportion of acute rubella among suspected cases during the pre Measles-Rubella vaccine introduction era (2005-2016) and determined its correlates for monitoring rubella epidemiology post-rubella vaccine introduction. Methods: In a retrospective study, 4497 measles IgM negative serum samples from 5686 clinically suspected measles cases were examined for rubella IgM antibodies using the Siemens, Enzygnost® ELISA kit at the national measles laboratory. Data on demographics, year and month of onset were extracted from the surveillance data. Multivariate logistic regression analysis using backward variable selection was conducted to determine independent predictors for acute rubella. Results: Overall, a proportion of 29.2% (1313/4497) affecting mostly those between 5 and 24 years was determined. Only age, province, month and year were independently associated with acute rubella. The regional proportions varied from 21.8 – 37.3% peaking in the hot dry month of October. Persons in the age group 10-14 years (Adjusted Odds Ratio [AOR]=2.43; 95% CI [2.01 - 2.95]) were more likely while those aged <1 year less likely (AOR=0.31; 95% CI [021 - 0.48]) to have acute rubella compared to those aged 25 years or older. Persons in 2010 were less likely (AOR=0.12; CI [0.05, 0.28]) to have acute rubella compared to those in 2016. While acute rubella was more likely to occur between July and November compared to December, it was less likely to occur between February and May. Conclusions: R ubella virus was circulating in Zambia between 2005 and 2016 affecting mostly persons in the age group 5-24 years peaking in the month of October during the hot dry season. It is important that Zambia has introduced a rubella containing vaccine, however, establishing the baseline epidemiological profile of rubella prior to MR vaccine introduction is important for monitoring the success of the preventative vaccination strategy employed. Keywords: Rubella, Acute, Proportion, Correlates, Zambia, Pre vaccination era, Immunisation

scholarly journals Epidemiology of acute rubella infection in Zambia during the pre-vaccination period (2005 – 2016) as a baseline for monitoring rubella epidemiology in the post-rubella vaccine  introduction era.

2019 ◽  
Author(s):  
Mazyanga Lucy Mazaba ◽  
Seter Siziya ◽  
Mwaka Monze ◽  
Daniel Cohen
Keyword(s):  
Laboratory Data ◽  
Multivariate Logistic Regression Analysis ◽  
Vaccination Strategy ◽  
Health Concern ◽  
Age Group ◽  
Childbearing Age ◽  
Serum Samples ◽  
Rubella Vaccine ◽  
Vaccine Introduction ◽  
Hot Dry Season

Abstract Background: Rubella is highly under reported in Zambia as in most sub-Saharan countries despite being a disease of major public health concern especially among women of childbearing age. In September 2016, Zambia introduced a combined measles-rubella vaccine in children aged 0-14 years. In this study, we estimated the proportion of acute rubella among suspected cases during the pre Measles-Rubella vaccine introduction era (2005-2016) and determined its correlates for monitoring rubella epidemiology post-rubella vaccine introduction. Methods: In a retrospective study, 4497 measles IgM negative serum samples from 5686 clinically suspected measles cases were examined for rubella IgM antibodies using the Siemens, Enzygnost® ELISA kit at the national measles laboratory. Data on demographics, year and month of onset were extracted from the surveillance data. Multivariate logistic regression analysis using backward variable selection was conducted to determine independent predictors for acute rubella. Results: Overall, a proportion of 29.2% (1313/4497) affecting mostly those between 5 and 24 years was determined. Only age, province, month and year were independently associated with acute rubella. The regional proportions varied from 21.8 – 37.3% peaking in the hot dry month of October. Persons in the age group 10-14 years (Adjusted Odds Ratio [AOR]=2.43; 95% CI [2.01 - 2.95]) were more likely while those aged <1 year less likely (AOR=0.31; 95% CI [021 - 0.48]) to have acute rubella compared to those aged 25 years or older. Persons in 2010 were less likely (AOR=0.12; CI [0.05, 0.28]) to have acute rubella compared to those in 2016. While acute rubella was more likely to occur between July and November compared to December, it was less likely to occur between February and May. Conclusions: R ubella virus was circulating in Zambia between 2005 and 2016 affecting mostly persons in the age group 5-24 years peaking in the month of October during the hot dry season. It is important that Zambia has introduced a rubella containing vaccine, however, establishing the baseline epidemiological profile of rubella prior to MR vaccine introduction is important for monitoring the success of the preventative vaccination strategy employed. Keywords: Rubella, Acute, Proportion, Correlates, Zambia, Pre vaccination era, Immunisation

scholarly journals Sero-epidemiology of rubella in Zambia in the pre-vaccination period (2005 – 2016) as baseline for evaluation of introduction of rubella vaccine into the national immunization program

2019 ◽  
Author(s):  
Mazyanga Lucy Mazaba ◽  
Seter Siziya ◽  
Mwaka Monze ◽  
Daniel Cohen
Keyword(s):  
Virus Transmission ◽  
Health Concern ◽  
Surveillance Program ◽  
Age Group ◽  
Childbearing Age ◽  
Serum Samples ◽  
Rubella Vaccine ◽  
Rubella Infection ◽  
Logistics Regression ◽  
Hot Dry Season

Abstract Background Rubella is highly under-reported in Zambia as in most sub-Saharan countries despite being a disease of major public health concern especially among women of childbearing age. In September 2016, Zambia introduced a combined measles-rubella vaccine in children aged 0-14 years. In this study, we estimated the rubella sero-prevalence and its correlates between 2005 and 2016, a period prior to the introduction of Measles-Rubella vaccine in Zambia to provide baseline reference data for the future evaluation of its impact. Methods In a retrospective study, serum samples collected through the national measles surveillance program that tested negative for measles were examined for rubella IgM antibodies using the Siemens, Enzygnost® ELISA kit at the national measles laboratory accredited by WHO. Data on age, sex, province, year and month of onset were extracted from the surveillance data. Logistics regression analysis was conducted to determine independent predictors of rubella infection. Results Overall, a sero-prevalence of 29.2% (1313/4497) affecting mostly those between 5 and 24 years was determined. Logistics regression results indicated that only age, province, year and month were independently associated with rubella infection. The regional sero-prevalence varied from 21.8 – 37.3% peaking in the hot dry month of October. Logistics regression indicated that those in the age group 10-14 years (AOR=2.43; 95% CI [2.01 - 2.95]) were more likely while those aged <1 year less likely (AOR=0.31; 95% CI [021 - 0.48]) to have rubella compared to those aged 25 years or older. Persons in 2010 were less likely (AOR=0.12; CI [0.05, 0.28]) to have rubella infection compared to those in 2016. While rubella infections were more likely to occur between July and November compared to December, they were less likely to occur between February and May. Conclusions There is evidence that rubella virus was circulating in Zambia between 2005 and 2016 affecting more females than males and persons in the age group 5-24 years with a peak in the hot dry season. It is recommended that immunisation campaigns be targeted in months of lower virus transmission between February and May and in a situation of limited resources to those aged 5-24 years.

Self-Reported Vision Impairment and Frailty among Older People with Low Cognitive Performance in Central Africa: EPIDEMCA Population-Based Study

2021 ◽  
pp. 1-7
Author(s):  
Antoine Gbessemehlan ◽  
Gilles Kehoua ◽  
Catherine Helmer ◽  
Cécile Delcourt ◽  
Achille Tchalla ◽  
...  
Keyword(s):  
Older People ◽  
Cognitive Performance ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Central Africa ◽  
Population Based ◽  
Vision Impairment ◽  
Sub Saharan Africa ◽  
Population Based Study ◽  
The Impact

<b><i>Introduction:</i></b> Very little is known about the impact of vision impairment (VI) on physical health in late-life in sub-Saharan Africa populations, whereas many older people experience it. We investigated the association between self-reported VI and frailty in Central African older people with low cognitive performance. <b><i>Methods:</i></b> It was cross-sectional analysis of data from the Epidemiology of Dementia in Central Africa (EPIDEMCA) population-based study. After screening for cognitive impairment, older people with low cognitive performance were selected. Frailty was assessed using the Study of Osteoporotic Fracture index. Participants who met one of the 3 parameters assessed (unintentional weight loss, inability to do 5 chair stands, and low energy level) were considered as pre-frail, and those who met 2 or more parameters were considered as frail. VI was self-reported. Associations were investigated using multinomial logistic regression models. <b><i>Results:</i></b> Out of 2,002 older people enrolled in EPIDEMCA, 775 (38.7%) had low cognitive performance on the screening test. Of them, 514 participants (sex ratio: 0.25) had available data on VI and frailty and were included in the analyses. In total, 360 (70%) self-reported VI. Prevalence of frailty was estimated at 64.9% [95% confidence interval: 60.9%–69.1%] and 23.7% [95% CI: 20.1%–27.4%] for pre-frailty. After full adjustment, self-reported VI was associated with frailty (adjusted odds ratio = 2.2; 95% CI: 1.1–4.3) but not with pre-frailty (adjusted odds ratio = 1.8; 95% CI: 0.9–3.7). <b><i>Conclusion:</i></b> In Central African older people with low cognitive performance, those who self-reported VI were more likely to experience frailty. Our findings suggest that greater attention should be devoted to VI among this vulnerable population in order to identify early frailty onset and provide adequate care management.

scholarly journals Impact of Intimate Partner violence on ever married women and utilization of antenatal care services in Tanzania

2018 ◽  
Vol 14 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Russell Kabir ◽  
Anwarul Azim Majumder ◽  
SM Yasir Arafat ◽  
Rocky Khan Chodwhury ◽  
Shireen Sultana ◽  
...  
Keyword(s):  
Intimate Partner Violence ◽  
Antenatal Care ◽  
Partner Violence ◽  
Odds Ratio ◽  
Intimate Partner ◽  
Adult Women ◽  
Age Group ◽  
Care Services ◽  
Main Challenge ◽  
The Impact

Background and Objectives:Sub Saharan Africa region is considered as one of the deprived regions of this world and women from this part of the world are suffering from intimate partner violence. This study was undertaken to assess the impact of intimate partner violence on utilization of antenatal care services among the ever married women.Materials and Methods:This is a descriptive cross-sectional study design. The data used in this research was extracted from the Tanzania Demographic Health Survey 2015-16. A total of 13, 266 women were interviewed.Results:The mean age of the respondents is 28.69 years. About 74% women visited antenatal care services more than 4 times. Logistic regression results indicate that the middle-aged adult women (35-49 years age group) were identified having lower odds (Odds ratio: 0.807, 95% CI: 0.693-0.940, P<0.001) than women in younger age group. Women who did not complete their secondary education were less likelihood to experience IPV (Odds ratio: 0.705, 95% CI: 0.540-0.922, P<0.010).Conclusion:Intimate partner violence is one main challenge to women’s health and wellbeing during pregnancy period. Proper implementation and community based interventions to support pregnant women to seek antenatal care services and to raise awareness regarding intimate partner violence are advocated. 

scholarly journals Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study

Critical Care ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
François Dépret ◽  
Clément Hoffmann ◽  
Laura Daoud ◽  
Camille Thieffry ◽  
Laure Monplaisir ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Retrospective Study ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Kidney Injury ◽  
Smoke Inhalation ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
The Impact

Abstract Background The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study. The impact of hydroxocobalamin on the risk of acute kidney injury (AKI) and survival after smoke inhalation in a multicenter setting remains unexplored. Methods We conducted a multicenter retrospective study in 21 intensive care units (ICUs) in France. We included patients admitted to an ICU for smoke inhalation between January 2011 and December 2017. We excluded patients discharged at home alive within 24 h of admission. We assessed the risk of AKI (primary endpoint), severe AKI, major adverse kidney (MAKE) events, and survival (secondary endpoints) after administration of hydroxocobalamin using logistic regression models. Results Among 854 patients screened, 739 patients were included. Three hundred six and 386 (55.2%) patients received hydroxocobalamin. Mortality in ICU was 32.9% (n = 243). Two hundred eighty-eight (39%) patients developed AKI, including 186 (25.2%) who developed severe AKI during the first week. Patients who received hydroxocobalamin were more severe and had higher mortality (38.1% vs 27.2%, p = 0.0022). The adjusted odds ratio (95% confidence interval) of AKI after intravenous hydroxocobalamin was 1.597 (1.055, 2.419) and 1.772 (1.137, 2.762) for severe AKI; intravenous hydroxocobalamin was not associated with survival or MAKE with an adjusted odds ratio (95% confidence interval) of 1.114 (0.691, 1.797) and 0.784 (0.456, 1.349) respectively. Conclusion Hydroxocobalamin was associated with an increased risk of AKI and severe AKI but was not associated with survival after smoke inhalation. Trial registration ClinicalTrials.gov, NCT03558646

Impact of simplified therapeutic guidelines on antibiotic prescriptions: a prospective multicentre comparative study

2019 ◽  
Vol 75 (3) ◽  
pp. 747-755
Author(s):  
Pierre-Marie Roger ◽  
Ingrid Peyraud ◽  
Michel Vitris ◽  
Valérie Romain ◽  
Laura Bestman ◽  
...  
Keyword(s):  
Clavulanic Acid ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Antibiotic Use ◽  
Antibiotic Consumption ◽  
Third Generation ◽  
Therapeutic Guidelines ◽  
Amoxicillin Clavulanic Acid ◽  
The Impact ◽  
Third Generation Cephalosporins

Abstract Objectives We studied the impact of simplified therapeutic guidelines (STGs) associated with accompanied self-antibiotic reassessment (ASAR) on antibiotic use. Methods Prospective antibiotic audits and feedback took place at 15 hospitals for 12 months, allowing STGs with ≤15 drugs to be devised. STGs were explained to prescribers through sessions referred to as ASAR. Optimal therapy was defined by the conjunction of a diagnosis and the drug specified in the STGs. Analysis of consumption focused on critical drugs: amoxicillin/clavulanic acid, third-generation cephalosporins and fluoroquinolones. Results We compared prescriptions in five hospitals before (n = 179) and after (n = 168) the implementation of STGs + ASAR. These tools were associated with optimal therapies and amoxicillin/clavulanic acid prescriptions [adjusted odds ratio (AOR) 3.28, 95% CI 1.82–5.92 and 2.18, 95% CI 1.38–3.44, respectively] and fewer prescriptions for urine colonization [AOR 0.20 (95% CI 0.06–0.61)]. Comparison of prescriptions (n = 1221) from 10 departments of three clinics with STGs + ASAR for the first quarters of 2018 and 2019 revealed that the prescriptions by 23 ASAR participants more often complied with STGs than those by 28 other doctors (71% versus 60%, P = 0.003). STGs alone were adopted by 10 clinics; comparing the prescriptions (n = 311) with the 5 clinics with both tools, we observed fewer unnecessary therapies in the latter [AOR 0.52 (95% CI 0.34–0.80)]. The variation in critical antibiotic consumption between 2017 and 2018 was −16% for the 5 clinics with both tools and +20% for the other 10 (P = 0.020). Conclusions STGs + ASAR promote optimal antibiotic therapy and reduce antibiotic use.

scholarly journals Characteristics of hospitalizations with influenza diagnosis, France, 2012-2017

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Pivette ◽  
V de Lauzun ◽  
N Nicolay ◽  
A Scanff ◽  
B Hubert
Keyword(s):  
Length Of Stay ◽  
Diagnosis Related Groups ◽  
Laboratory Data ◽  
Incidence Rates ◽  
H3n2 Virus ◽  
Influenza Surveillance ◽  
Surveillance Systems ◽  
Age Group ◽  
Hospital System ◽  
The Impact

Abstract Background Seasonal influenza surveillance in France is based on several data sources (ambulatory data, emergency department and intensive care unit (ICU) admissions, laboratory data, mortality). However, the data do not provide a complete measure of the impact of the epidemics on the hospital system. The objective of the study was to describe the characteristics of influenza hospitalizations from the French national hospital discharge database (PMSI) between 2012 and 2017 and to precise the burden of influenza by age group and by season. Methods All hospitalizations in metropolitan France with at least one ICD-10 code related to influenza (J09, J10, J11) as a principal, related or associated diagnosis between 1 July 2012 to 30 June 2017 were extracted from the PMSI. For each season, the total number of hospitalizations, admissions to ICU, incidence and lethality rates, lengths of stay and classification in diagnosis-related groups were described by age group. Results During the 5 seasons, 91 255 hospitalizations with an influenza-diagnosis were identified. The incidence varied significantly between seasons, from 12.7/100 000 in 2013-2014 to 45.9/100 000 in 2016-2017. A high number of cases was observed in elderlies in 2014-2015 and 2016-2017, marked by the circulation of A (H3N2) virus. The proportion of hospitalizations with an admission in ICU was 10%, and was higher in the 40-79 age group (19%). Lethality increased steadily with age, from 0.5% under 20 years to 10% in 80 years and older. Length of stay also increased with age. Significant regional disparities were observed, with higher incidence rates in South-Eastern France each season. Conclusions The analysis of influenza hospitalizations from the PMSI provides important elements on influenza burden, not available in the current surveillance systems. An annual analysis, stratified by age group, would provide an indicator of the impact of the epidemics on hospital system at the end of each influenza season. Key messages Important influenza incidence variations were observed between seasons by age groups. Severity and impact of influenza (mortality, ICU, length of stay) varied significantly by age group.

Targeted therapy at the end of life and the impact on health care utilization.

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 116-116
Author(s):  
Heidi Yeung ◽  
Parsa Salehi ◽  
James Don Murphy
Keyword(s):  
Targeted Therapy ◽  
End Of Life ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Large Population ◽  
Metastatic Breast ◽  
Care Utilization ◽  
Study Cohort ◽  
Ed Visits ◽  
The Impact

116 Background: The use of targeted therapy has steadily increased over the past decade, though the impact of targeted agents on patterns of care at the end-of-life life remains unknown. The purpose of this study was to explore the influence of targeted therapy on end-of-life care in a large population-based database. Methods: We identified 14,398 patients from the SEER-Medicare linked database with metastatic breast, lung, or colorectal cancer diagnosed between 2000 and 2009 who received conventional cytotoxic chemotherapy or targeted therapy in the last 3 months of life. Multivariate logistic and linear regression models were used to determine the impact of targeted therapy on the following endpoints in the last 3 months of life: emergency department (ED) visits, hospitalizations, and hospice utilization. Analyses were adjusted for differences in patient age, gender, race, comorbidity, socioeconomic status, and geography. Results: Among the whole study cohort 83% of patients received chemotherapy alone, 12% received chemotherapy with targeted therapy, and 5% received targeted therapy alone. The delivery of any targeted therapy in the last 3 months increased across the study period, from 1.5% in 2000 to 28% in 2009. Compared to patients treated with chemotherapy alone, those treated with targeted therapy alone had lower rates of ED visits (adjusted odds ratio [aOR]=0.81, p=0.01), lower rates of hospitalization (adjusted odds ratio [aOR]=0.69, p<0.0001), no difference in overall hospice utilization rates, though had longer stays on hospice (5.1 days longer, p<0.0001). Compared to patients treated with chemotherapy alone, those treated with both chemotherapy and targeted therapy had no difference in ED visits or hospitalization admission rates, though had decreased rates of hospice utilization (aOR = 0.79, p<0.0001), and shorter stays on hospice (2.7 days longer, p<0.0001). Conclusions: This study found that targeted therapy was associated with varying patterns of healthcare utilization at the end-of-life, though these differences could be influenced by unknown confounding variables. Future research should focus on defining the specific impact of targeted therapy on quality of life at the end-of-life.

scholarly journals Trends of central obesity and associations with nutrients intake and daily behaviors among women of childbearing age in China

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zichong Long ◽  
Lili Huang ◽  
Jiajun Lyu ◽  
Yuanqing Xia ◽  
Yiting Chen ◽  
...  
Keyword(s):  
Protein Intake ◽  
Central Obesity ◽  
Linear Mixed Model ◽  
Leisure Time Physical Activity ◽  
Chinese Women ◽  
Health Concern ◽  
Age Group ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Nutrients Intake

Abstract Background Obesity among women of childbearing age has becoming an important public health concern. We aimed to describe the trends of central obesity among Chinese women of childbearing age from 2004 to 2011 and to examine its associations with nutrients intake and daily behaviors. Methods Longitudinal data were derived from the China Health and Nutrition Survey. Participants consisted of 2481 women aged 15–44 years old. WC (Waist circumference) and WHtR (Waist to height ratio) were adopted as indicators of central obesity. Generalized linear mixed model was performed to analyze the associations of nutrients intake and daily behaviors with central obesity. Results From 2004 to 2011, the prevalence of central obesity among Chinese women of childbearing age increased from 21.6 to 30.7% (WC as indice) or from 22.8 to 32.6% (WHtR as indice) (both p < 0.001). Protein intake above the AMDR (Acceptable macronutrient distribution range) (OR = 1.21, 95% CI 1.05–1.39, p < 0.01) and non-participation in LTPA (Leisure time physical activity) (OR = 1.45, 95% CI 1.17–1.80, p < 0.001) were risk factors for high WC, and the latter was also associated with high WHtR (OR = 1.36, 95% CI 1.10–1.67, p < 0.01). For those women who had high WC & high WHtR, the impacts of protein intake and LTPA became stronger, especial LTPA (OR = 1.53, 95% CI 1.21–1.94, p < 0.001). Age-stratified analyses found that non-participation in LTPA was key factor for central obesity in 15–34 age group, while protein intake above the AMDR was pronounced in the 35–44 age group. Conclusions Non-participation in LTPA and protein intake above the AMDR were significant contributors of central obesity, which could be intervention targets to deal with the growing trend of central obesity among women of childbearing age.

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