scholarly journals Evaluation of The Food Effect On a Drospirenone Only Contraceptive Containing 4 mg Administered With and Without High-Fat Breakfast

2022 ◽  
Author(s):  
Pedro-Antonio Regidor ◽  
W. H. Richter ◽  
R. Koytchev ◽  
V. Kirkovd ◽  
E. Colli
Keyword(s):  
Single Dose ◽  
Food Intake ◽  
Real Life ◽  
Oral Formulation ◽  
Relative Bioavailability ◽  
Ratio Test ◽  
Healthy Female ◽  
Rate Of Absorption ◽  
The Difference ◽  
Present Trial

Abstract Background:The objective of the present trial was to assess the difference in pharmacokinetics of an oral test preparation containing 4 mg drospirenone. under fasting conditions compared to food intake after single dose administration.Methods:Open label, single centre, two-treatment, two-sequence, crossover study in 24 healthy female volunteers, with duration of 1 day per sequence and with a real wash-out period of 14 days to investigate the relative bioavailability of DRSP with both forms of administration. The 90% confidence intervals were calculated for the intra-individual ratio (test with food vs. without food) of the pharmacokinetic endpoints AUC(0-72h) and Cmax of drospirenone. Results:The 90% CI calculated by means of ANOVA-log for the endpoint, intra-individual ratio (Test ‘A’ = with food intake) vs. Test ‘B’ = without food intake) of AUC(0-72h) of drospirenone was between 104.72% and 111.36%. The 90% CI calculated by means of ANOVA- log for the endpoint intra-individual ratio (Test ‘A’ vs. Test ‘B’) of Cmax of drospirenone was between 118.58% and 141.10%.The mean relative bioavailability of the Test with food ‘A’ compared to the Test without food ‘B’ after single dose administration based on the endpoints AUC(0-72h) was 107.99%; for the endpoint Cmax it was 129.35%.Conclusions:The rate of absorption, based on the endpoint Cmax of drospirenone was increased by about 30% under fed conditions which differs to a COC containing 0,02 mg EE and 3 mg drospirenone in a 24/4 regimen where the rate of absorption was reduced by about 40% for both components. Implications: Our results suggest that the food intake has no impact on the absorption of 4 mg drospirenone in the management for contraception.This raises up the contraceptive efficacy as no interference with food is expected in real life use when consuming the oral formulation

Administration of Single-Dose Antibiotic Does Not Decrease Oronasal Fistula Rates After Primary Palatoplasty

2021 ◽  
pp. 105566562199265
Author(s):  
Ishwarya Shradha Mamidi ◽  
Esperanza Mantilla-Rivas ◽  
Brynne A. Ichiuji ◽  
Md Sohel Rana ◽  
Karen I. Ramirez ◽  
...  
Keyword(s):  
Single Dose ◽  
Fistula Formation ◽  
Readmission Rates ◽  
Oronasal Fistula ◽  
Inadequate Sample Size ◽  
Perioperative Antibiotics ◽  
The Difference ◽  
Group 2 ◽  
National Databases ◽  
Group 1

Objective: Oronasal fistula (ONF) is a known complication after primary palatoplasty (PP). Studies investigating the effect of perioperative antibiotics on fistula rates after PP are limited by inadequate sample size or reliance on self-reporting through national databases. In this study, the authors evaluated the association between single-dose perioperative antibiotics and postoperative fistula rates after PP at a single institution. Design: A retrospective study. Participants: Children younger than 2 years who underwent PP from April 2009 to September 2019 were included. Interventions: Patients were divided into 2 categories: Group 1 received a single intraoperative dose of IV antibiotic, while group 2 did not. Main Outcome Measure(s): Outcome measures included ONF formation, length of stay (LOS), and 30-day readmission rates. Multivariable firth logistic regression, quantile regression, and χ2 tests were performed. Results: Of the 424 patients, 215 and 209 patients were in groups 1 and 2, respectively. The overall ONF rate was 1.9% among all patients. Patients in group 1 experienced an ONF rate of 3.3%, while patients in group 2 had an ONF rate of 0.5%. After correcting for confounding variables, the difference in ONF rates was not statistically different ( P = .68). Median LOS was 35.7 hours and 35.5 hours ( P = .17), while the rate of readmission within 30 days was 4.7% and 2.4% for group 1 and 2, respectively ( P = .96). Conclusions: Administration of a single-dose perioperative antibiotic did not decrease fistula formation after PP, nor did it affect the patient’s LOS or 30-day readmission rate.

Cholecystokinin octapeptide analogues suppress food intake via central CCK-A receptors in mice

1993 ◽  
Vol 265 (3) ◽  
pp. R481-R486 ◽  
Author(s):  
Y. Hirosue ◽  
A. Inui ◽  
A. Teranishi ◽  
M. Miura ◽  
M. Nakajima ◽  
...  
Keyword(s):  
Food Intake ◽  
Receptor Antagonist ◽  
Rank Order ◽  
Peripheral Circulation ◽  
Inhibitory Effect ◽  
Peripheral Tissues ◽  
Cholecystokinin Octapeptide ◽  
The Central Nervous System ◽  
The Difference ◽  
The Brain

To examine the mechanism of the satiety-producing effect of cholecystokinin (CCK) in the central nervous system, we compared the potency of intraperitoneally (ip) or intracerebroventricularly (icv) administered CCK-8 and its analogues on food intake in fasted mice. The icv administration of a small dose of CCK-8 (0.03 nmol/brain) or of Suc-(Thr28, Leu29, MePhe33)-CCK-7 (0.001 nmol/brain) suppressed food intake for 20 min, whereas CCK-8 (1 nmol/kg, which is equivalent to 0.03 nmol/brain) or Suc-(Thr28, Leu29, MePhe33)-CCK-7 (1 nmol/kg) had satiety effect after ip administration. Dose-response studies indicated the following rank order of potency: Suc-CCK-7 > or = Suc-(Thr28, Leu29, MePhe33)-CCK-7 > or = CCK-8 > or = (Nle28,31)-CCK-8 >> desulfated CCK-8 = CCK-4 = 0 in the case of ip administration and Suc-(Thr28, Leu29, MePhe33)-CCK-7 >> Suc-CCK-7 > or = CCK-8 > or = (Nle28,31)-CCK-8 >> desulfated CCK-8 = CCK-4 = 0 in the case of icv administration. The selective CCK-A receptor antagonist MK-329 reversed the inhibitory effect of the centrally as well as peripherally administered CCK-8, or of Suc-(Thr28, Leu29, MePhe33)-CCK-7, whereas the selective CCK-B receptor antagonist L-365260 did not. The icv administered CCK-8 did not appear in the peripheral circulation. These findings suggest the participation of CCK-A receptors in the brain in mediating the satiety effect of CCK and the difference in CCK-A receptors in the brain and peripheral tissues.

Association Between the CDC6 G1321A Polymorphism and the Risk of Cervical Cancer

2010 ◽  
Vol 20 (5) ◽  
pp. 856-861 ◽  
Author(s):  
Xing-Dong Xiong ◽  
Li-Qin Zeng ◽  
Qing-Yuan Xiong ◽  
Sheng-Xiang Lu ◽  
Zhi-Zhen Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Statistical Significance ◽  
Biological Significance ◽  
Brdu Incorporation ◽  
General Validity ◽  
Cervical Cancer Risk ◽  
Healthy Female ◽  
The Difference ◽  
Incorporation Assay

Introduction:Cell division cycle protein 6 (CDC6) plays critical roles in DNA replication and carcinogenesis. The biological significance of the CDC6 G1321A polymorphism (V441I, rs13706) on cervical carcinogenesis is still unknown. Here, we examined the potential influence of this polymorphism on cell proliferation and the individual's susceptibility to cervical cancer.Methods:We genotyped the CDC6 G1321A polymorphism in 87 cervical cancer cases and 110 healthy female subjects. Unconditional logistic regression analysis was used to estimate the association between the genotypes and the risk of cervical cancer. The BrdU incorporation assay was applied to analyze the effect of this polymorphism on cell proliferation.Results:Compared with the GG homozygotes, the cervical cancer risk was significantly reduced in the individuals with the heterozygous AG genotype (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.28-0.98; P = 0.042) or the homozygous AA genotype (OR, 0.29; 95% CI, 0.09-0.89; P = 0.030). Further stratified analyses showed that the decreased risk of cervical cancer was more evident among younger subjects (≤44 years old) with the AG or AA genotypes (OR, 0.44; 95% CI, 0.21-0.92; P = 0.029 and OR, 0.12; 95% CI, 0.03-0.61; P = 0.010, respectively). The BrdU incorporation assay showed that 293T cells transfected with CDC6-441I (1321A) had a lower proliferation rate in comparison with those transfected with CDC6-441V (1321G), although the difference did not reach statistical significance at the 0.05 level.Conclusions:The CDC6 G1321A polymorphism may contribute to the risk of cervical cancer. Further studies with more subjects and in diverse ethnic populations are necessary to confirm the general validity of our findings.

scholarly journals The Gender Factor Effect on Saudi Learners’ Perceptions of Using Social Media on Their Social Interaction

2018 ◽  
Vol 11 (10) ◽  
pp. 30
Author(s):  
Boushra Abdul-Aziz AlGhamdi ◽  
Shorouq Ali AL-Garni ◽  
Maysa M. Qutob
Keyword(s):  
Social Media ◽  
Social Interaction ◽  
Time Management ◽  
Real Life ◽  
Point Of View ◽  
Factor Effect ◽  
Males And Females ◽  
The Difference ◽  
Gender Factor ◽  
Positive Point

This study compares males and females perception of the effect of social media on their social interaction to understand the difference between both genders. The study follows a mixed-method methodology using a questionnaire with closed-ended items and open-ended questions. Responses to the questionnaire are collected form 207 male and female students from a public university in Saudi Arabia. In general, the results of the questionnaire are insignificant which indicate that there are no differences between both genders. However, the results of the open-ended questions show that females have a negative view of the effect of social media on human relations while males have a positive point of view. However, both genders have a positive point of view regarding balancing between friends and family in real life and virtual world through time management.

scholarly journals Post- Modern elements in the novels of Chetan Bhagat

2018 ◽  
Vol 6 (8) ◽  
pp. 11
Author(s):  
Dr. Radha ◽  
Dr. Premalatha. C 
Keyword(s):  
20Th Century ◽  
Real Life ◽  
16Th Century ◽  
Western Philosophy ◽  
Economic Power ◽  
Late 20Th Century ◽  
Distant Observer ◽  
Post Modernism ◽  
The Difference

Postmodernism is a Western philosophy, a late 20th-century movement characterized by broad skepticism, subjectivism, or relativism; a general suspicion of reason; and an acute sensitivity to the role of ideology in asserting and maintaining political and economic power”.Post-Modernists are independent while expressing their ideas, they never drop their statements and theory. It is more personal than identify with some other categories. The post-modernism was started in America around 16th century later it extended to Europe and other countries.Post-modern civilization fails to accept the modification between high and low class. There is a little place for modernism, originality or individual thinking. Bhagat has concentrated on the preconceptions of toppers, however there is more to life than these things your family, your friends, your internal desires and goals and the grades you get in dealing with each of these areas will define you as a person.The post-modernism has defused the difference between good and bad, moral and immoral, right and wrong. If there is a choice to select modern generation would not hesitate to go for one which is traditionally named as bad. Bhagat imbibed all these qualities in his writing. His characters go against the traditional customs and values. Bhagat represents intricate, deeply engrained socio-cultural complications of multicultural India, light-heartedly. He wishes readers to giggle at themselves, at their stupidities, their partialities, and their wrong-actions; not as a member but as a distant observer. He doesn’t bout them directly, but through fiction he attempts to understand their errors and gives a chance to rectify in the real life. Bhagat’s linking story telling method and the funny situations appeal readers.

scholarly journals Impact of Stem Education on Academic Achievement of Elementary School Students‟ of Delhi

2019 ◽  
Vol 9 (2) ◽  
pp. 3275-3278
Keyword(s):  
Academic Achievement ◽  
Stem Education ◽  
Teaching Methods ◽  
Life Experiences ◽  
Real Life ◽  
Traditional Teaching ◽  
School Students ◽  
Traditional Teaching Methods ◽  
Before And After ◽  
The Difference

STEM education does not follow traditional teaching methods but is based on interesting and critical thinking activities. It is important to increase students' interest and awareness of STEM educational activities to encourage them to learn STEM. STEM-based education can help students or children learn and participate in activities based on real-life experiences. We need to let them know that what they learned in STEM today is not only building their own future, but also the cornerstone of the country. Since no study has been done to know the difference in the academic achievement and basic attitude of the students towards this approach based on gender school types (government and private); before and after the conduction of STEM programme this study will give STEM practitioners strategies to design and integrate STEM content purposefully for the students ; so that students can develop a positive attitude towards STEM programme which will in turn help them to acquire higher academic achievement and make study more effective. This study will also through light on the teachers to make STEM programme more effective. This study will also be of immense help to the school authorities while opting for better STEM programme

scholarly journals HOW TO OBTAIN A GLOBAL REFERENCE THRESHOLD IN AHP/ANP

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Claudio Garuti
Keyword(s):  
Real Life ◽  
Absolute Measurement ◽  
Threshold Value ◽  
Rate Of Change ◽  
Current Status ◽  
Medical Diagnoses ◽  
Specific Objective ◽  
Global Threshold ◽  
Disaster Assessment ◽  
The Difference

This paper has two main objectives. The first objective is to provide a mathematically grounded technique to construct local and global thresholds using the well-known rate of change method. The next objective, which is secondary, is to show the relevance and possibilities of applying the AHP/ANP in absolute measurement (AM) compared to the relative measurement (RM) mode, which is currently widely used in the AHP/ANP community. The ability to construct a global threshold would help increase the use of AHP/ANP in the AM mode (rating mode) in the AHP/ANP community. Therefore, if the first specific objective is achieved, it would facilitate reaching the second, more general objective.   For this purpose, a real-life example based on the construction of a multi-criteria index and threshold will be described. The index measures the degree of lag of a neighborhood through the Urban and Social Deterioration Index (USDI) based on an AHP risks model. The global threshold represents the tolerable lag value for the specific neighborhood. The difference or gap between the neighborhood’s current status (actual USDI value) and this threshold represents the level of neighborhood deterioration that must be addressed to close the gap from a social and urban standpoint. The global threshold value is a composition of 45 terminal criteria with their own local threshold that must be evaluated for the specific neighborhood. This example is the most recent in a large list of AHP applications in AM mode in vastly different decision making fields, such as risk disaster assessment, environmental assessment, the problem of medical diagnoses, social responsibility problems, BOCR analysis for the evolution of nuclear energy in Chile in the next 20 years and many others. (See list of projects in Appendix).

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