Coagulation indicators and their association with apoptosis ,flammatory indicators and Sharp scores of rheumatoid arthritis
Abstract Background Recent studies have shown that coagulations indicators hava a strong correlation with apoptosis ,flammatory indexes.In the present study, we measured coagulation indicators such PAF,PGI2 and TXB2 in patients with RA and investigated their association with apoptosis,flammatory indicators and Sharp scores of rheumatoid arthritis (RA). Methods A total of 90 patients diagnosed with rheumatoid arthritis were enrolled for comparisons. The clinical and laboratory data of patients were retrospectively reviewed. The X-ray findings of both hands were scored according to Sharp's criteria. In addition, the statistics of patients with apoptosis indicator,coagulation indicator and flammatory indicator. Explored the relationship between coagulation indiccators and the above indicators. Results In this study,there was a strong correlation between the abnormal increase of apoptosis parameters,immune inflammation indicators,Sharp Score and the increase of coagulation indicator in patients with rheumatoid arthritis, and the increase of Sharp Scores,Caspase-3,FasL indexes or the decrease of C-reactive protein (CRP)could be risk factors for the development of RA. The higher the coagulation indicator, the higher the Sharp score,and the high parameters of hypercoagulable state RA. Conclusions Higher coagulation indicators are associated with RA disease activity, as well as apoptosis ,flammatory indicators and decreased physical activity. Moreover, coagulation indicator are associated with Sharp scores.Coagulation indicator are important for the diagnosis of rheumatoid arthritis and are potential markers of activity and hypercoagulable state in RA patients.