Analysis of Transmission of Hepatitis C Viruses: Dental vs. Surgical Procedures

2021 ◽  
Author(s):  
Fawad Ahmad ◽  
Muhammad SAJJAD ◽  
Muhammad Umair Akram ◽  
Rabia Zulfiqar ◽  
Recep Kara ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Surgical Procedures ◽  
Pareto Distribution ◽  
Age Distribution ◽  
Surgical Instruments ◽  
Ann Model ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Dental Procedures ◽  
Hepatitis C Viruses

Abstract Objectives: The primary purpose of the present study is to evaluate the cause of HCV transmission either by dental or surgical procedures in Pakistan. It will reveal the standards of current practices and knowledge of surgical instrument sterilization in Pakistan. Methods:The contemporary study design was cross-sectional. A total of 7097 patients were included in the study that was the confirmed cases of Hepatitis C from four districts of Punjab, Pakistan, during the period of three years from Jul 1, 2018, to Jun 30, 2021. The ANN model simulates a discrete Pareto distribution; descriptive statistics were applied by using SPSS 23.Results:In age distribution, most patients were aged 26-37 from the 2020- 2021 year of study with 45.6%age. The total mean ± SD was 2.42 ± .935 with 0.000P-values. Results show that high-risk variables are strongly associated with the surgical history, such as sector analysis (public and private) with 0.000 P-values. Analysis of these variables indicated that inquiry about surgical instruments sterilization and age groups(100%)were the most vital variable in the ANN model. Pareto distribution values of surgical procedures that are transmitting hepatitis C viruses more than the dental procedures. Conclusion: Surgical procedures are high transmission source of hepatitis C viruses than dental procedures. Clinical Significance: More care should be taken, and more severe sterilization measures should be taken to prevent the transmission of hepatitis C infection, especially in dental and general surgery procedures in Pakistan.

scholarly journals Reporting the Undiagnosed Cases of Hepatitis B and Hepatitis C Viruses among Patients Undergoing Elective Eye Surgery in a Specialized Eye Hospital in Egypt

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Ahmed A. Dahab ◽  
Maha Mohamed Youssef ◽  
Hany Mohamed Eid ◽  
Khaled W. Elsadi
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Eye Surgery ◽  
B Virus ◽  
High Prevalence ◽  
Hepatitis C Viruses

Introduction. Hepatitis B virus (HBV) and hepatitis C virus (HCV) and their long-term sequelae are considered a major health issue in Egypt. The aim of this study is to determine the prevalence of undiagnosed hepatitis B virus (HBV) and hepatitis C virus (HCV) among patients admitted for elective eye surgery in a specialized eye hospital in Cairo, Egypt. Materials and Methods. This cross-sectional study was conducted in a specialized eye hospital, Cairo, Egypt. The study included consecutive patients admitted for elective eye surgery in the period from April 2015 to June 2016. Age, sex, and procedure done were recorded for all patients. All the subjects were screened for HBV and HCV by rapid chromatography immunoassay; if positive, the results had to be confirmed by ELISA. Results. 3067 patients admitted for elective eye surgery were included in the study. The mean age of the patients was 50.85 ± 19.77 years. There were 1592 (51.9%) males and 1475 (48.1%) females. The prevalence of preoperative positive HBV and HCV was 7/3067 (0.2%) and 381/3067 (12.4%), respectively. Conclusion. Given the high prevalence of HBV and HCV infection in our population in general and in this study specifically, all patients admitted for surgery should be screened for both viruses.

scholarly journals Hepatitis C Core Antigen Testing to Diagnose Active Hepatitis C Infection Among Haemodialysis Patients

2020 ◽  
Author(s):  
XZ Wong ◽  
CC Gan ◽  
R M ◽  
R Y ◽  
S G ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Predictive Value ◽  
Hcv Infection ◽  
Core Antigen ◽  
Hcv Rna ◽  
Hepatitis C Infection ◽  
Hcv Treatment ◽  
Serological Screening ◽  
Cross Sectional ◽  
Spearman Test

Abstract BACKGROUNDHepatitis C virus (HCV) infects more than 71 million people worldwide and chronic HCV infection increases the risk of liver cirrhosis and failure. Haemodialysis (HD) is one of the renal replacement therapies with risk of HCV transmission. Anti-HCV antibodies are the serological screening test for HCV infection that does not detect active phase of infection. Majority HCV infected HD patients in Malaysia do not have further HCV RNA performed due to high cost and thus HCV treatment is less frequently offered. HCV Core Antigen (HCV Ag) can potentially be used to diagnose active HCV infection in HD population in comparison to HCV RNA, at lower cost. METHODS We conducted a cross-sectional study to assess the correlation between HCV Ag and HCV RNA and to identify the prevalence of active HCV infection among HCV seropositive HD patients from dialysis centres across West Malaysia from July 2019 to May 2020. Pre-dialysis blood was taken and tested for both HCV Ag and HCV RNA tests. HCV Ag was tested with Abbott ARCHITECT HCV Ag test.RESULTS We recruited 112 seropositive HD patients from 17 centres with mean age of 54.04±11.62 years, HD vintage of 14.1±9.7 years, and male constitute 59.8% (67) of the study population. HCV Ag correlates well with HCV RNA (Spearman test coefficient 0.833, p<0.001). The sensitivity was 90.7%, specificity 100%, positive predictive value (PPV) 100%, negative predictive value (NPV) 76.5%, and accuracy 92.9%. For HCV RNA level >3000 IU/mL, HCV Ag had a higher sensitivity of 95.1% and greater correlation (Spearman test coefficient 0.897, p<0.001). The prevalence of active HCV infection was 76.8% among HCV seropositive HD patients. CONCLUSIONS Although HCV Ag is less sensitive, it shows an excellent correlation with HCV RNA and has 100% PPV. HCV Ag can be considered as an alternative diagnostic tool for chronic active HCV infection among HD cohort, who can then be considered for HCV treatment. For seropositive HD patient with negative HCV Ag, we recommend to follow-up with HCV RNA test.

scholarly journals Perceptions about Hepatitis C, its Myths, Misconceptions and Association with Health-Related Behavior among People of District Layyah, Punjab, Pakistan

2018 ◽  
Vol 2 (1) ◽  
pp. 15-23
Author(s):  
Muhammad Imran ◽  
Ayesha Baber Kawish ◽  
Aamira Hashmi ◽  
Muzammil Irshad ◽  
Naila Azam
Keyword(s):  
Hepatitis C ◽  
General Population ◽  
Personal Characteristics ◽  
Cross Sectional Study ◽  
Common Source ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Health Related ◽  
Unsafe Injection ◽  
The Right

Background: Hepatitis C virus is a blood-borne virus where the most common modes of its transmission are unsafe injection practices, inadequate sterilization of medical equipment, and transfusion of unscreened blood and blood products. Approximately, 130–150 million people globally are suffering from chronic hepatitis C infection. A significant number of these chronically infected will develop liver cirrhosis or liver cancer subsequently. Approximately 500,000 people die of hepatitis C related liver diseases every year. This study aimed to describe personal characteristics, knowledge of respondents and to find out association of these factors with perceptions about Hepatitis C. The study also aimed to focus on perceptions (perceived susceptibility, severity and cues to action) of general population and finding association between their perceptions and health-related behaviors.Methods: A cross sectional study was conducted in Layyah city situated in Punjab province. Total of 423 male participants were selected through multistage sampling from general population of district Layyah. Structured questionnaire was used to collect data.Results: Out of 423 respondents, participants with the poor level of knowledge had right perceptions about hepatitis C (16.8%). 82.7% of the respondents were aware about the availability of hepatitis C treatment. Highest perceptions were observed in age group of 21-25 years old (39.7%), unmarried (73.0%), Saraiki (58.2%) and unemployed population (45.9%). People with less myth had the right perceptions about the hepatitis C.Conclusion: Increasing age, unmarried status and ethnicity were associated with right perceptions shown by respondents. Knowledge remained significant in showing association with perceptions about hepatitis C. General population perceived their susceptibility, severity of consequences and cues to actions were connecting them to show right perceptions overall. Relatives, colleagues and TV were common source of information about hepatitis C respectively.

scholarly journals CROSS SECTIONAL STUDY OF PREVALENCE AND RISK FACTORS OF HEPATITIS B AND HEPATITIS C INFECTION IN A RURAL VILLAGE OF INDIA

2015 ◽  
Vol 52 (4) ◽  
pp. 321-324 ◽  
Author(s):  
Prasad BHATE ◽  
Naimish SARAF ◽  
Pathik PARIKH ◽  
Meghraj INGLE ◽  
Aniruddha PHADKE ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Cross Sectional Study ◽  
Blood Product Transfusion ◽  
Sectional Study ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Hbsag Positivity

Background - Hepatitis B virus and hepatitis C virus are among the principal causes of severe liver disease. There is limited data of epidemiology of Hepatitis B in community, more so in rural population. Objective - To find the prevalence of hepatitis B and C infection in community and study the risk factors for their transmission. Methods - This was a community based cross sectional study. A total of 1833 randomly selected subjects from a rural area were interviewed for risk factors for transmission and tested for markers of hepatitis B and hepatitis C infection. All the positive card tests were confirmed by ELISA. Results - Out of 2400 subjects, rate for participation was 76.38%. None of the subjects was positive for anti hepatitis C virus antibody. Point prevalence for HBsAg positivity was 0.92. Being healthcare worker and having tattoo were significantly associated with HBsAg positive results. Nose and ear piercing was reported by almost. History of blood or blood product transfusion, I/V drug abuse, multiple sexual partners, unsafe Injections, hemodialysis and any h/o surgery was not associated with HBsAg positivity. Conclusion - Health care workers are at high risk for transmission of hepatitis B. Educating common people regarding mode of transmission of Hepatitis B and C will help to reduce their transmission.

scholarly journals Studies on the prevalence of Hepatitis C virus infection in diabetic patients attending a tertiary health-care facility South-west Nigeria

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
James A. Ndako ◽  
Akinyomade O. Owolabi ◽  
Joseph A. Olisa ◽  
Jeremiah A. Akinwumi ◽  
Victor T. Dojumo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Age Distribution ◽  
Care Facility ◽  
Health Care Facility ◽  
Hcv Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Hepatitis C Infection

Abstract Background Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) are two major public health problems associated with increasing complications and mortality rates worldwide. The objective of this study is to evaluate the prevalence of hepatitis C virus (HCV) infection in diabetic patients and to investigate the influence of several epidemiological and clinical factors on HCV infection. Method A total number of one hundred and eighty diabetic patients were recruited for this study. Consented subjects made up of 71(39.4%) males and 109(60.56%) females were recruited for the study. While one-Hundred (100) Non-Diabetics (Controls) were also recruited for the study. Structured questionnaires were administered to the consented participants to obtain relevant data. Sera samples were assayed for antibodies to HCV using an enzyme linked immunosorbent assay [Inteco Diagnostic Limited]. ELISA technique. Result Overall prevalence of HCV infection among diabetes patients assayed was 13.3% out of which 8(11.3%) was obtained from the male subjects compared to 16 (14.7%) seropositivity recorded among the females (P = 0.511; P > 0.05). Considering age distribution, Subjects aged 41–50 years recorded, 9 (22.5%) positivity (P = 0.238; P > 0.05).Considering educational status of subjects screened, 22 (14.9%) positivity was rescored among subjects who have attained tertiary status of education.(P = 0.574;P > 0.05).Risk factors considered showed that, 7 (18.9%) seropositive subject were alcoholic consumers(P value = 0.2621;P > 0.05) while 5 (8.9%) recorded history of sharing sharp objects P = 0.2427;P > 0.05). Conclusion Our study shows a slightly higher prevalence of hepatitis C infection in type 2 diabetics. This call for urgent routine screening exercise among diabetic patients for HCV infection. This study also emphasizes the need for public enlightenment on the association between HCV infection and T2DM, to avert possible complications among diabetic patients.

scholarly journals Fatigue in chronic hepatitis C infection a mixed method study

2021 ◽  
Author(s):  
Dora Marta Zalai
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Sleep Disorders ◽  
Chronic Hepatitis C ◽  
Hcv Infection ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
Severe Fatigue ◽  
Patient Reported ◽  
Clinically Significant

Fatigue is a main patient reported outcome of chronic hepatitis C (HCV) infection; yet its contributors are unknown. Objectives: The study (1) evaluated fatigue predictors, (2) tested the mediating role of fatigue cognitions, (3) screened for sleep disorders, and (4) explored fatigue from patients’ perspectives. Participants: Both sexes (age>18 years, N = 115) with chronic HCV infection. Design: Cross-sectional. Results: Sixty percent reported severe fatigue (FSS≥4). Fatigue perceptions were the main predictors of fatigue (ß=.58, bias corrected CI = .070-.163). Fatigue perceptions mediated the relationship between comorbidities and fatigue. Half of the sample reported clinically significant symptoms of insomnia and/or sleep apnea. Eight main fatigue themes were endorsed by the participants. Conclusions: Fatigue and sleep disorders were clinically significant issues. Fatigue cognitions may contribute to severe fatigue outcomes. Significance: Integrating the findings into existing sleep and fatigue treatments could improve clinical outcomes.

scholarly journals HEPATITIS C INFECTION

2015 ◽  
Vol 22 (10) ◽  
pp. 1278-1283
Author(s):  
Shabnam Naveed ◽  
Syed Masroor Ahmed ◽  
Zeeshan Ali ◽  
Romana Awan ◽  
Humaira Zakir ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Cross Sectional Study ◽  
Study Data ◽  
Diabetic Patients ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Cross Sectional ◽  
History Of ◽  
Associated Risk Factors ◽  
Insulin Use

Objectives: To determine the prevalence of Hepatitis C virus infection in Type IIDiabetes Mellitus patients and its associated risk factors in our population. Duration and Placeof Study: Study was conducted in Jinnah Post graduate Medical Centre, Karachi betweenDecember 2013 to December 2014.Study Design: It is a Cross-sectional study. Data collectionand Results: Data was collected from registered diabetic patients, 355 diagnosed Type IIdiabetes mellitus patients including 128(36.1%) males and 227(63.9%) females were selectedand their Hepatitis C screening was done by ICT method. The bio-data of the patients, history andduration of diabetes mellitus, history of blood transfusion, previous surgery, accidents, shavingfrom barber, tattooing, nose piercing, acupuncture,insulin use were recorded on a proforma.Out of the 355 diabetes mellituspatients tested, 33 were positive for anti-HCV antibodies givinga prevalence of 9.3%. Conclusion:There is increased prevalence of HCV infectionin diabeticpatients when compared with general prevalence of HCV in Pakistan.

Sign in / Sign up

Export Citation Format

Share Document