scholarly journals Association Between Maternal Weight Gain in Different Periods of Pregnancy and the Risk of Venous Thromboembolism: A Retrospective Matched Case-Control Study

Author(s):  
Yuelin Wu ◽  
Jindan Pei ◽  
Lingling Dong ◽  
Zheying Zhou ◽  
Tianfan Zhou ◽  
...  

Abstract Background Although the rate of maternal mortality has declined over the past few decades, pulmonary embolus (PE) remains an important cause of maternal deaths. Little is known about the associations of specific periods of gestational weight gain with detailed PE and deep venous thrombosis (DVT). We explored the incidence of pregnancy-related venous thromboembolism (VTE) in China and assessed the associations of maternal weight gain in different periods of pregnancy with VTE.Methods In a retrospective case-control study conducted in in Shanghai First Maternity and Infant Hospital from January 1st, 2017 to July 31th, 2021, 151 cases (11.7 per 10000) of venous thromboembolism (VTE) within pregnancy or the first 6 postnatal weeks were identified. 302 controls without VTE who gave birth at the same time as the cases were selected. Maternal pre-pregnancy weight, weight in early, mid and late pregnancy and other maternal pregnancy and newborn characteristics were obtained. GWG was standardized into gestational age-specific z-scores stratified by body mass index (BMI) and categorized as low (z score <-1), normal (-1 to 1), and high (>1). The adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated through log-binomial regression models. Interaction effects between gestational weight gain (GWG) and some other adjustment factors were tested, further stratified analyses were performed separately where interaction terms were significant. Results There were 65.6% (99 of 151) of pulmonary embolus (PE) alone and 34.4% (52 of 151) of deep venous thrombosis (DVT) alone or combined with PE. For all pre-pregnancy BMI categories (underweight, normal weight, overweight and obese), there was no statistical association between maternal weight gain of all gestational intervals and DVT or all VTE in this study. However, for PE, there was observed protective effects of low weight gain (aOR 0.79; 95% CI 0.37–1.68) and significantly increased risks of high weight gain (aOR=1.47; 95% CI: 1.03-2.09) among normal-weight women in early pregnancy. Similarly, a tendency towards decreased risk at lower weight gain throughout pregnancy (aOR 0.79; 95% CI 0.37–1.68) and significantly increased risk at higher values (aOR=1.52; 95% CI: 1.01-2.31) for PE was observed in normal-weight women. As for underweight and overweight women, results from the categorical model for early, late or total pregnancy weight gain indicated an increased risk in PE at both low and high weight gain, but confidence intervals were wide.Conclusion Chinese women have a higher risk of PE than the foreigner counterparts. Maternal weight gain in total or early pregnancy is an important risk factor for PE. In order to effectively improve maternal and child outcomes, intensive weight management that continues through pregnancy may be indispensable.

2012 ◽  
Vol 130 (4) ◽  
pp. 242-247 ◽  
Author(s):  
Bárbara Miranda Ferreira Costa ◽  
Régis Resende Paulinelli ◽  
Maria Alves Barbosa

CONTEXT AND OBJECTIVE: Excessive gestational weight gain is related to many complications (both maternal and fetal), such as macrosomia. The most common complications in macrosomic fetuses include: increased risk of intrauterine death, need for intensive care, fractures, neonatal hyperbilirubinemia, paralysis of the brachial plexus and obesity in childhood and adulthood. The aim of this study was to evaluate the association between gestational and fetal weight gain and the incidence of macrosomia in two maternity hospitals. DESIGN AND SETTING: Cohort study in two public maternity hospitals in Goiânia, Brazil. METHODS: This was a cohort study on 200 healthy pregnant women with normal body mass index, divided into two groups: one with normal weight gain and the other with excessive weight gain during pregnancy. RESULTS: The cohorts were similar regarding maternal age, per capita income, schooling level and reproductive behavior. The fetal weight was greater in the cohort with excessive maternal weight gain (3,388.83 g ± 514.44 g) than in the cohort with normal weight (3,175.86 g ± 413.70 g) (P < 0.01). The general incidence of macrosomia was 6.5%: 13.0% (13 cases) in the cohort with excessive maternal weight gain and 0.0% (0 cases) in the cohort with adequate weight gain. CONCLUSION: Excessive maternal weight gain was associated with increased fetal birth weight and incidence of macrosomia.


2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Ana Beatriz Franco‐Sena ◽  
Fernanda Rebelo ◽  
Thatiana Pinto ◽  
Dayana Farias ◽  
Roberta Mendes ◽  
...  

2018 ◽  
Vol 36 (06) ◽  
pp. 615-623 ◽  
Author(s):  
Han-Yang Chen ◽  
Suneet Chauhan

Objectives To estimate the prevalence of gestational weight gain (GWG) adequacy according to the 2009 guidelines, and to examine the association between GWG adequacy and the adverse outcomes, stratified by prepregnancy body mass index (BMI). Study Design A retrospective cohort study, using the 2011 to 2013 U.S. linked birth/infant death datasets, restricted to nonanomalous singleton live births at 37 to 41 weeks. The adverse outcomes included composite maternal morbidity (CMM), composite neonatal morbidity (CNM), and neonatal and infant mortalities. We used multivariable Poisson's regression models with robust error variance to examine the association between GWG adequacy and adverse outcomes. Results Of 8,656,791 singleton live births, 20, 32, and 48% had inadequate, adequate, and excessive GWG, respectively. After multivariable regression adjustment, compared with adequate GWG, excessive GWG had 1.10 (1.08–1.13) and 1.12 (1.10–1.14) times higher risk of CMM and CNM, respectively; similar findings were observed in BMI subgroups. Compared with adequate GWG, inadequate GWG had 1.14 (1.03–1.26) and 1.12 (1.07–1.18) times higher risk of neonatal and infant mortalities, respectively. Similar results were noted among women with normal weight. Conclusion Excessive GWG was associated with an increased risk of CMM and CNM, while inadequate GWG was associated with a higher risk of neonatal and infant mortalities.


Author(s):  
Noriko Motoki ◽  
Yuji Inaba ◽  
Takumi Shibazaki ◽  
Yuka Misawa ◽  
Satoshi Ohira ◽  
...  

AbstractAbnormal maternal gestational weight gain (GWG) increases the risk of obstetric-related complications. This investigation examined the impact of GWG on infant neurodevelopmental abnormalities at 12 months of age using the data of a nationwide Japanese cohort study. Questionnaire data were obtained from the ongoing Japan Environment and Children’s Study cohort study. Maternal GWG was subdivided as below, within, or above the reference values of the Institution of Medicine pregnancy weight guidelines. The Ages and Stages Questionnaire, third edition (ASQ-3) is a parent-reported developmental screening instrument for children across five domains: communication, gross motor, fine motor, problem-solving, and personal–social. Multiple logistic regression analysis was employed to identify correlations between GWG and developmental delay defined as ASQ-3 scores of less than two standard deviations below the mean. A total of 30,694 mothers with singleton live births and partners who completed the questionnaire were analyzed. The prevalence of mothers below, within, and above the GWG guidelines was 60.4% (18,527), 32.1% (9850), and 7.5% (2317), respectively. We recorded 10,943 infants (35.7%) who were outliers in at least one ASQ-3 domain. After controlling for covariates, GWG below established guidelines was associated with a significantly higher risk of developmental delay for the communication (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.09–1.34), gross motor (OR 1.14, 95% CI 1.05–1.24), fine motor (OR 1.13, 95% CI 1.04–1.24), problem-solving (OR 1.09, 95% CI 1.01–1.18), and personal–social (OR 1.15, 95% CI 1.07–1.24) domains.Conclusion: This large survey revealed a possible deleterious effect of insufficient maternal GWG on infant neurodevelopment.Trial registration: The Japan Environment and Children’s Study (JECS) was registered in the UMIN Clinical Trials Registry on January 15, 2018 (number UMIN000030786). What is Known:• Inappropriate maternal gestational weight gain may cause obstetric complications and adverse birth outcomes.• Excess maternal weight gain may result in gestational diabetes, hypertension, eclampsia, caesarean delivery, and macrosomia, while insufficient maternal weight gain has been associated with pre-term birth and small for gestational age. What is New:• This study provides important information on a possible adverse effect of insufficient maternal gestational weight gain on offspring neurodevelopment at 12 months of age.• Our findings indicate a need to reconsider the optimal body mass index and gestational weight gain for women desiring pregnancy.


PEDIATRICS ◽  
1993 ◽  
Vol 92 (6) ◽  
pp. 805-809
Author(s):  
Catherine Stevens-Simon ◽  
Elizabeth R. MCAnarney ◽  
Klaus J. Roghmann

Objective. To examine the relationship among maternal age, prepregnancy weight, gestational weight gain, and birth weight in 141 low-income black adolescents and their infants. Study sample. One hundred forty-one consecutively enrolled, low-income, black adolescents who entered prenatal care prior to their 23rd week of gestation, were free of chronic diseases, took no regular medications, had no known uterine anomalies, and gave birth to one live neonate. Results. After controlling for prepregnancy weight and other potentially confounding variables, we found a significant relationship between gestational weight gain and infant birth weight among younger adolescents (&lt;16 years old at conception), but not among older adolescents (16 through 19 years old at conception); younger adolescents contributed more of their gestational weight gain to their fetuses than did older adolescents. Among younger adolescents the rate of maternal weight gain during the entire gestation was significantly correlated with birth weight (r = .40; P &lt; .01), whereas for older adolescents only maternal weight gain during the second half of gestation was significantly correlated with birth weight (r = .25, P &lt; .05). Conclusions. The data do not support the thesis that younger adolescents compete with their fetuses for nutrients; in fact, younger study adolescents transferred more of their gestational weight gain to their fetuses than did older adolescents.


Author(s):  
Camila Honorato A Torres ◽  
Lidiane F Schultz ◽  
Paul J Veugelers ◽  
Silmara S B S Mastroeni ◽  
Marco F Mastroeni

Abstract Background We evaluated the effect of maternal gestational weight gain (GWG) and pre-pregnancy weight on blood pressure (BP) of children 6 years after delivery. Methods Cross-sectional study that compared the anthropometric measurements of 181 mothers and their children’s BP 6 years after delivery. The BP was measured by the auscultatory method. We used log-binomial regression to investigate the association of pre-pregnancy body mass index (BMI) and GWG categories with BP in mid-childhood. Results The prevalence of elevated BP in children was 26.5%. Maternal pre-pregnancy overweight and concurrent excessive GWG were positively associated with elevated BP at 6 years of age. Mothers with pre-pregnancy overweight and excessive GWG were more likely to have children with elevated BP at 6 years of age (OR = 2.05; P = 0.018) compared to mothers who were of normal weight pre-pregnancy and experienced appropriate GWG. We also found that mothers with pre-pregnancy BMI ≥25 kg/m2 and concurrent excessive GWG were more likely to have children with elevated diastolic blood pressure (OR = 2.72; P = 0.005). Conclusions Pre-pregnancy overweight/obesity had impact on BP in mid-childhood. Interventions aimed at reducing cardiovascular diseases in children should promote weight loss in women of reproductive age rather than in pregnant women.


2019 ◽  
pp. 377-384

Background. Maternal weight during pregnancy may affect both, the course of pregnancy and the anthropometric parameters of the newborn. The steadily growing problem of excessive weight in reproductive-age women is associated with the risk for gestational obesity and its negative consequences for the infant. Objectives. The aims of the study were to analyze the following: (i) maternal weight gain as compared to the pre-pregnancy BMI, and (ii) the link between maternal weight and other environmental factors versus neonatal size. Material and methods. The study was conducted among 94 women in singleton term pregnancy, who delivered at the Department of Obstetrics, Gynecology and Oncology, Medical University of Warsaw. The American Institute of Medicine criteria for the recommended weight gain were followed. Multivariate logistic regression model and multiple regression analysis were used for statistical analysis. Results. Normal weight gain was observed in only one-third of the subjects, while excess weight gain was detected in as many as 42.5% of the women. Active smokers were at a 4-fold higher risk for excess weight gain as compared to nonsmokers (OR 4.13, 95% CI 1.19 - 14.34, p = 0.026). Infants born to mothers with insufficient weight gain (24.5% of the mothers) were lighter by 302 g (p=0.0405) and shorter by 2.4 cm (p=0.0025) as compared to those born to mothers with normal weight gain. Conclusions. Maternal weight gain in most of our subjects was not compliant with the current recommendations, regardless of the pre-pregnancy BMI. Inadequate pregnancy weight gain negatively affects the anthropometric parameters of the newborn.


2019 ◽  
Vol 4 (2) ◽  
pp. 34
Author(s):  
Dewi Andriani

ABSTRAK Kenaikan berat badan ibu hamil merupakan adanya adaptasi ibu terhadap pertumbuhan janin, sedangkan berat badan bayi baru lahir merupakan bagian dari hasil pertumbuhan janin yang dapat dipengaruhi oleh kenaikan berat badan ibu selama hamil. Tujuan penelitian ini adalah untuk mengetahui hubungan serta badan ibu hamil trimester 3 dengan berat badan bayi baru lahir di Puskesmas Tanah KaliKedinding Surabaya.Jenis penelitian ini adalah korelasi dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah ibu post partum yang melahirkan di Puskesmas Tanah KaliKedinding Surabaya dengan populasi 35 responden sampel sebanyak 32 responden. Teknik pengambilan sampling menggunakan Quota Sampling. Instrument penelitian ini menggunakan lembar observasi. Hasil yang didapat dari 32 responden terdapat berat badan ibu hamil yang normal sebanyak 17 orang (53,1%). Berat badan bayi baru lahir dengan berat sedang sebanyak 23 orang (71,9). Hasil analisis uji statistic Spierman Rho menunjukkan bahwa signifikan rho value sebesar 0,003 (α≤ 0,05) maka dengan ini H0 ditolak dan H1 diterima. Artinya terdapat Hubungan Berat Badan Ibu Hamil Trimester 3 Dengan Berat Badan Bayi Baru Lahir di Puskesmas Tanah KaliKedinding Surabaya. Pemantauan berat badan ibu hamil penting untuk mengetahui tumbuh kembang janin. ANC secara teratur merupakan upaya pemantauan yang efektif sehingga mengurangi resiko gangguan dalam persalinan.   Kata kunci :berat badan ibu hamil, berat badan bayi baru lahir, trimester 3   ABSTRACT Maternal weight gain is a maternal adaptation of fetal growth, while newborn weight is part of fetal growth that may be affected by maternal weight gain during pregnancy. The purpose of this study was to determine the relationship between body trimester pregnant mother 3 with newborn weight at Puskesmas Tanah KaliKedinding Surabaya. This research type is correlation with csoss sectional approach. The population in this research is post partum mother who gave birth at Puskesmas Tanah Kali Kedinding Surabaya with population of 35 sample respondents as many as 32 respondents. Sampling technique uses Sampling Quota. This research instrument uses observation sheet. Results obtained from 32 respondents had normal weight of pregnant women as many as 17 people (53.1%). Newborn weight with moderate weight as many as 23 people (71,9). The result of Spierman Rho statistic test shows that the significant rho value is 0,003 (α≤ 0,05) hence H0 is rejected and H1 accepted. This means that there is a Weight Pregnancy Trimester 3 Pregnant Wife With New Baby Weight Born in Puskesmas Tanah KaliKedinding Surabaya. Monitoring the weight of pregnant women is important to know the growth of fetal growth. ANCs are regularly an effective monitoring effort thus reducing the risk of impairment in labor.   Keywords: maternal weight, weight of newborn baby, trimester 3.


F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1138 ◽  
Author(s):  
Latsamy Oulay ◽  
Wongsa Laohasiriwong ◽  
Teerasak Phajan ◽  
Supat Assana ◽  
Kritkantorn Suwannaphant

Background: Low Birth Weight (LBW) is a worldwide public health problem, which subsequently may affect the health status of the child. Lao PDR has high incidence of LBW.  Antenatal care (ANC) is provided to improve maternal and child health outcomes. The aim of this study was to identify the effect ANC on LBW prevention in Lao PDR. Methods: This case control study was conducted in tertiary hospitals of Lao PDR. The ratio of case: control was 1:3, of which there were 52 cases and 156 controls that passed the inclusion criteria included in the study. In our analysis information on pregnancy and ANC including height of mother, maternal weight gain during pregnancy, maternal gestational age at delivery, type of delivery, supplementary vitamins, and other covariates including age, marital status, educational attainment, occupation, family income, health insurance, family size and living condition were described and determine their association with LBW using multiple logistic regression analysis. Results: There were only 32.69 % of complete ANC among cases and 57.69% in control.  Incomplete ANC (<4 times) were significant increased the odds of having LBW (adj. OR=2.97; 95%CI: 1.48 to 5.93; p-value =0.002). Other covariates which also influenced LBW were having maternal weight gain during pregnancy less than 10 kg. (adj.OR=2.28; 95%CI: 1.16 to 4.49; p-value = 0.017), maternal gestation age at delivery less than 40 weeks (adj. OR=3.33; 95%CI: 1.52 to 7.32; p-value =0.003).  Conclusion: Complete ANC could help both mother and child in term of weight gain and full term delivery which may effect on LBW reduction.


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