Exposure Factors Associated With SARS-CoV-2 Seroprevalence During the First Eight Months of the COVID-19 Pandemic in the Netherlands: A Cross-sectional Study
Abstract BackgroundThe availability of valid SARS-CoV-2 serological tests overcome the problem of underestimated cumulative COVID-19 cases during the first months of the pandemic in The Netherlands. This enabled us to study a wide variety of demographic, behavioural and social exposure factors associated with seropositivity during the first eight months of the pandemic in Limburg, The Netherlands. MethodsSARS-CoV-2 point-seroprevalence was determined cross-sectionally to indicate previous infection in a convenience sample of 10,000 inhabitants of the study province. Possible exposure factors were mapped by means of an extensive questionnaire. Associated exposure factors were determined using uni- and multivariable logistic regression models.ResultsSeropositivity was established in 19.5% (n=1,948) of the 10,001 participants (on average 49 years old (SD=15; range 18-90 years), majority women (n=5,829; 58.3%). Exposure factors associated with seropositivity included current education, working in healthcare and not working from home, and being a member of three or four associations or clubs. Specifically for February-March 2020, visiting an après-ski bar during winter sports in Austria, travelling to Spain, celebrating carnival, and participating in a singing activity or ball sport were associated with seropositivity. ConclusionsOur results confirm that relevant COVID-19 exposure factors generally reflected circumstances where social distancing was impossible, and the number and duration of contacts was high, in particular for indoor activities.