scholarly journals The immunosenescence and lipotoxicity in thyrotoxicosis mice

2022 ◽  
Author(s):  
Qin Feng
Keyword(s):  
Elderly Patients ◽  
Accelerated Aging ◽  
Cholesterol Levels ◽  
Age Related ◽  
Ifn Γ ◽  
Aging Models ◽  
High Level ◽  
The Relationship ◽  
Worse Prognosis ◽  
Biochemical Examination

Abstract COVID-19 is a worldwide outbreak now, and it is found to be age-related. Immunosenescence may be a predisposing and severe factor for COVID-19. Besides, many infectious diseases in clinic are age-related, and elderly patients have longer hospitalization and worse prognosis. Therefore, finding suitable aging models is of great significance for fighting aging related diseases and promoting the prognosis of elderly patients. In this study, the relationship between thyrotoxicosis and aging was investigated by routine detection and serum metabonomics in mice. The results of routine blood test and flow cytometry showed significant decrease in neutrophils, lymphocytes, CD4+/CD8+ and CD4+IFN-γ + lymphocytes in thyrotoxicosis mice. Biochemical examination combined with serum metabolomics analysis showed that serious disorder of lipid metabolism may be one of the causes of immunosenescence, including lower cholesterol levels, lower levels of VD and bile acids, high level of glucocorticoids, triglycerides, free fatty acids, Sphingolipids and decrease of Docosanoids, especially DPA. This study proves that thyrotoxicosis mice are an accelerated aging model. In present study, the main performance is immunosenescence, which may be due to lipotoxicity, suggesting that the immunosenescence state can be adjusted by improving lipotoxicity, whether anti thyroxine or not. However, there are other manifestations of thyroid toxicity mouse model simulating aging, such as organ aging, which need to continue to be studied by means of system biology to provide more comprehensive evidence.

scholarly journals Laboratory findings in SARS-CoV-2 infections: State of the art

2020 ◽  
Vol 66 (8) ◽  
pp. 1152-1156 ◽  
Author(s):  
Miguel Augusto Martins Pereira ◽  
Isabella Carolina de Almeida Barros ◽  
Ana Luiza Veríssimo Jacob ◽  
Mayara Lopes de Assis ◽  
Salim Kanaan ◽  
...  
Keyword(s):  
State Of The Art ◽  
Case Definitions ◽  
Laboratory Findings ◽  
Laboratory Markers ◽  
Tnf Α ◽  
The Subject ◽  
Ifn Γ ◽  
High Level ◽  
Laboratory Changes ◽  
Worse Prognosis

SUMMARY OBJECTIVE The scientific community is constantly assessing the clinical and laboratory manifestations of COVID-19 in the organism. In view of the fragmentation of the large amount of information, knowledge gaps in relation to laboratory markers, and scarcity of papers in Portuguese, we propose a Literature review on laboratory changes observed in patients infected with SARS-CoV-2. METHODS Analysis of articles published between December 2019 and May 2020 on the PubMed and SciELO databases. The articles were identified, filtered, and evaluated based on the approach to the subject, language, and impact. Then, the articles were subjected to a thorough reading, in full, by 4 (four) independent researchers. RESULTS Leukopenia and lymphopenia were included in most studies, even in case definitions. Platelet count and platelet-lymphocyte ratio, at peak platelet, were associated with advanced age and longer hospital stay. Eosinopenia showed a sensitivity of 74.7% and specificity of 68.7% and, together with increased CRP, these are one of the future prospects for screening for disease. A high level of procalcitonin may indicate bacterial co-infection, leading to a worse prognosis. COVID-19 manifests itself with increased levels of many inflammatory markers such as IL-1, IL-2, IL-6, IL-7, IL-12, IP10, IFN-γ, MIP1A, MCP1, GSCF, TNF-α, and MCP1/CCL2, as well as LDH, ESR, D-dimer, CK, ALT, and AST. CONCLUSION There is a need for further studies on the new SARS-CoV-2. So far, there is no consensus regarding laboratory findings and their usefulness, whether as a prognostic marker, mortality, or disease severity.

scholarly journals Age-related decrements in cycling and running performance

2004 ◽  
Vol 16 (2) ◽  
pp. 8 ◽  
Author(s):  
A St Clair Gibson ◽  
Ni Lambert ◽  
TD Noakes
Keyword(s):  
Athletic Performance ◽  
Sports Medicine ◽  
Weight Bearing ◽  
Accelerated Aging ◽  
Age Related ◽  
Endurance Cycling ◽  
Order Polynomial ◽  
Bearing Stress ◽  
Rate Of Decline ◽  
The Relationship

Objective. This study examined age-related decrements in athletic performance during running and cycling activities. Design. The age group winning times for males aged between 18 and 70 years competing in the 1999 Argus cycle tour (103 km) and 1999 Comrades running marathon (90 km), South Africa's premier endurance cycling and running events respectively, were examined. Main outcome measures. The relationship between speed (cycling and running respectively) and age was calculated using a 4th order polynomial function. The derivative of each of these functions was determined and then the slope of the function corresponding to each age was calculated. Results. The rate of decline in running speed occurred at an earlier age (~ 32 years) during the running race compared with the cycling tour (~ 55 years). Conclusions. These findings establish a trend that there is ‘accelerated' aging during running which can perhaps be attributed to the increased weight-bearing stress on the muscles during running compared with cycling. SA Sports Medicine Vol.16(2) 2004: 8-11

scholarly journals Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-19 ◽  
Author(s):  
Ana L. Santos ◽  
Ariel B. Lindner
Keyword(s):  
Posttranslational Modifications ◽  
Molecular Mechanisms ◽  
Molecular Processes ◽  
Progressive Decline ◽  
Age Related ◽  
Evolutionarily Conserved ◽  
Protein Posttranslational Modifications ◽  
Aging Models ◽  
The Relationship

Aging is characterized by the progressive decline of biochemical and physiological function in an individual. Consequently, aging is a major risk factor for diseases like cancer, obesity, and type 2 diabetes. The cellular and molecular mechanisms of aging are not well understood, nor is the relationship between aging and the onset of diseases. One of the hallmarks of aging is a decrease in cellular proteome homeostasis, allowing abnormal proteins to accumulate. This phenomenon is observed in both eukaryotes and prokaryotes, suggesting that the underlying molecular processes are evolutionarily conserved. Similar protein aggregation occurs in the pathogenesis of diseases like Alzheimer’s and Parkinson’s. Further, protein posttranslational modifications (PTMs), either spontaneous or physiological/pathological, are emerging as important markers of aging and aging-related diseases, though clear causality has not yet been firmly established. This review presents an overview of the interplay of PTMs in aging-associated molecular processes in eukaryotic aging models. Understanding PTM roles in aging could facilitate targeted therapies or interventions for age-related diseases. In addition, the study of PTMs in prokaryotes is highlighted, revealing the potential of simple prokaryotic models to uncover complex aging-associated molecular processes in the emerging field of microbiogerontology.

scholarly journals Relationship Between Sarcopenia and Cardiovascular Diseases in the Elderly: An Overview

2021 ◽  
Vol 8 ◽  
Author(s):  
Nana He ◽  
Yuelin Zhang ◽  
Lu Zhang ◽  
Shun Zhang ◽  
Honghua Ye
Keyword(s):  
Cardiovascular Diseases ◽  
Elderly Patients ◽  
Population Aging ◽  
Strength Function ◽  
The Elderly ◽  
Clinical Syndrome ◽  
Age Related ◽  
The Relationship ◽  
Insight Into ◽  
Shed Light

With the advent of population aging, aging-related diseases have become a challenge for governments worldwide. Sarcopenia has defined as a clinical syndrome associated with age-related loss such as skeletal muscle mass, strength, function, and physical performance. It is commonly seen in elderly patients with chronic diseases. Changes in lean mass are common critical determinants in the pathophysiology and progression of cardiovascular diseases (CVDs). Sarcopenia may be one of the most important causes of poor physical function and decreased cardiopulmonary function in elderly patients with CVDs. Sarcopenia may induce CVDs through common pathogenic pathways such as malnutrition, physical inactivity, insulin resistance, inflammation; these mechanisms interact. In this study, we aimed to investigate the relationship between sarcopenia and CVDs in the elderly. Further research is urgently needed to understand better the relationship, pathophysiology, clinical presentation, diagnostic criteria, and mechanisms of sarcopenia and CVDs, which may shed light on potential interventions to improve clinical outcomes and provide greater insight into the disorders above.

scholarly journals Age-related decrements in cycling and running performance

2004 ◽  
Vol 16 (2) ◽  
pp. 8 ◽  
Author(s):  
A St Clair Gibson ◽  
Ni Lambert ◽  
TD Noakes
Keyword(s):  
Athletic Performance ◽  
Sports Medicine ◽  
Weight Bearing ◽  
Accelerated Aging ◽  
Age Related ◽  
Endurance Cycling ◽  
Order Polynomial ◽  
Bearing Stress ◽  
Rate Of Decline ◽  
The Relationship

Objective. This study examined age-related decrements in athletic performance during running and cycling activities. Design. The age group winning times for males aged between 18 and 70 years competing in the 1999 Argus cycle tour (103 km) and 1999 Comrades running marathon (90 km), South Africa's premier endurance cycling and running events respectively, were examined. Main outcome measures. The relationship between speed (cycling and running respectively) and age was calculated using a 4th order polynomial function. The derivative of each of these functions was determined and then the slope of the function corresponding to each age was calculated. Results. The rate of decline in running speed occurred at an earlier age (~ 32 years) during the running race compared with the cycling tour (~ 55 years). Conclusions. These findings establish a trend that there is ‘accelerated' aging during running which can perhaps be attributed to the increased weight-bearing stress on the muscles during running compared with cycling. SA Sports Medicine Vol.16(2) 2004: 8-11

Prognosis, Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer

2019 ◽  
Vol 19 (11) ◽  
pp. 1359-1367 ◽  
Author(s):  
Xinyu Shao ◽  
Zhengwu Cheng ◽  
Menglin Xu ◽  
Jiading Mao ◽  
Junfeng Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Targeted Therapy ◽  
Tissue Samples ◽  
Normal Tissues ◽  
Positive Expression ◽  
Gli1 Expression ◽  
Single Positive ◽  
High Level ◽  
The Relationship ◽  
Worse Prognosis

Background:Gastric Cancer (GC) is a frequently common malignancy. Recent studies have reported Rab1A as an activator of mTORC1, and the mTOR1 pathway is involved in regulating Gli1 expression in several cancers. Only a few studies have been performed to explore the relationship between Rab1A and p-S6K/Gli1in GC.Methods:Immunohistochemistry (IHC) was performed to explore the association of Rab1A/p-S6K/Gli1 expression and prognosis in 117 GC tissue samples and adjacent normal tissues.Results:Our results indicated that Rab1A/p-S6K/Gli1 was significantly overexpressed in GC tissues. High expression of Rab1A was closely related to the tumor size and the depth of tumor invasion. In addition, Rab1A expression was closely related with p-S6K/Gli1 expression in GC, and high level of Rab1A/p-S6K/Gli1 caused worse prognosis of GC patients. The univariate and multivariate analysis indicated that the expression of Rab1A was an independent prognostic factor. Moreover, both high Rab1A and p-S6K expression led to a worse prognosis when compared to a single positive expression as well as both high Rab1A/Gli1 expression also led to a worse prognosis than the single positive expression of Rab1A/Gli1. Strikingly, the overexpression of p-S6K also led to a worse prognosis in Rab1A positive patients, as did Gli1.Conclusion:Our results indicate that Rab1A/mTOR/S6K/Gli1 axis played a crucial role in GC, which may provide a novel field on targeted therapy of GC, especially for mTORC1-targeted therapy-resistant cancers.

scholarly journals Impact of Beliefs about Medicines on the Level of Intentional Non-Adherence to the Recommendations of Elderly Patients with Hypertension

2021 ◽  
Vol 18 (6) ◽  
pp. 2825
Author(s):  
Natalia Świątoniowska-Lonc ◽  
Jacek Polański ◽  
Grzegorz Mazur ◽  
Beata Jankowska-Polańska
Keyword(s):  
Elderly Patients ◽  
Uncontrolled Hypertension ◽  
Elderly Age ◽  
Multiple Factor Analysis ◽  
Beliefs About Medicines ◽  
Common Causes ◽  
Adherence Scale ◽  
The Mean ◽  
High Level ◽  
The Relationship

Background: Non-adherence to pharmaceutical treatment is one of the most common causes of uncontrolled hypertension. Non-adherence may be intentional or unintentional. In the case of intentional non-adherence, it is crucial to understand the reasons behind it. The literature increasingly addresses the issue of beliefs and concerns about medication, but studies on this subject performed in a Polish population of hypertensive patients are still lacking. The aim of the study was to assess the level of intentional non-adherence among patients with hypertension, and to determine the relationship between beliefs about medication and the level of intentional non-adherence to treatment in elderly patients with hypertension. Material and methods: The study included 300 patients (106 of whom were male, mean age (SD) 71.71 (8.12) years) with hypertension, treated at a hypertension clinic. The following instruments were used: the Intentional Non-Adherence Scale (INAS) for evaluating intentional non-adherence, and the Beliefs about Medicines Questionnaire (BMQ) for evaluating patients’ beliefs and opinions regarding medication. Socio-demographic and clinical data were obtained from patients’ medical records. Results: The mean (SD) INAS score in the study was 47.28 (19.12). Patients were most concerned about the harm caused by medication, and least concerned about the necessity to take medication (mean score per item 3.49 vs. 2.14). Correlation analysis demonstrated weak correlations between BMQ and INAS: higher scores for necessity were associated with more intentional non-adherence (r = 0.174, p = 0.003), while higher scores for overuse, harm, and concerns were associated with less intentional non-adherence (respectively: r = −0.253, p < 0.001 vs. r = −0.336, p < 0.001 vs. r = −0.351, p < 0.001). In multiple-factor analysis, factors increasing the level of intentional non-adherence were elderly age (β = −0.352, p = 0.009), multimorbidity (β = −2.374, p = 0.035), and a higher BMQ concerns score (β = −1.376, p < 0.001), while being single was an independent predictor decreasing intentional non-adherence (β = 5.646, p = 0.013). Conclusions: The overall level of intentional non-adherence among patients with hypertension is moderate, but approximately one third of patients with hypertension demonstrate a high level of non-adherence. Independent determinants of intentional non-adherence include concerns, elderly age, multimorbidity, and being single.

scholarly journals Bronchial obstruction and resistance to hypoxia in elderly patients with COPD

2020 ◽  
pp. 8-9
Author(s):  
E.O. Asanov ◽  
Yu.I. Holubova ◽  
I.A. Diba ◽  
S.O. Asanova ◽  
G.P. Voynarovskaya
Keyword(s):  
Elderly Patients ◽  
Pulmonary Ventilation ◽  
The Elderly ◽  
Tissue Hypoxia ◽  
The Body ◽  
Bronchial Obstruction ◽  
Resistance To Hypoxia ◽  
Arterial Hypoxemia ◽  
Age Related ◽  
The Relationship

Background. Age-related morphofunctional changes in the body lead to the development of arterial hypoxemia, tissue hypoxia and hypoxic changes. All this causes a decrease in the body’s resistance to hypoxia and contributes to the development of lung diseases, in particular, chronic obstructive pulmonary disease (COPD) in the elderly. With the development of COPD in the elderly due to bronchial obstruction and disorders of pulmonary gas exchange, age-related hypoxic shifts, arterial hypoxemia, tissue hypoxia and resistance to hypoxia are further reduced. However, the relationship between bronchial obstruction and resistance to hypoxia in elderly patients with COPD has not been studied. Objective. To identify the relationship between bronchial patency and resistance to hypoxia in elderly patients with COPD. Materials and methods. The study included 30 patients with COPD in the elderly (60-74 years), I-II stage, without exacerbation, with a disease duration of 7 to 26 years, risk groups A and B. The type and severity of pulmonary ventilation were assessed indicators of spirometry and the curve “flow/volume” of forced exhalation on the device Spirobank (Mir, Italy). To determine the body’s resistance to hypoxia, a hypoxic test with 12 % oxygen content was performed for 12 min with monitoring of blood saturation using the automated software and hardware complex Hypotron (Ukraine). Results. Researches have shown that under hypoxic exposure, blood saturation in elderly patients with COPD is reduced, on average, by 18.23±0.26 %. This decrease in blood saturation can be regarded as severe arterial hypoxemia. At the same time, in elderly patients with COPD with an increase in bronchial patency disorders, the saturation shifts in hypoxia, on average, also increase. There was a significant correlation (r=0.50; p=0.006) of blood saturation shifts in hypoxia with bronchial obstruction. Conclusions. In elderly patients with COPD, resistance to hypoxia is determined by bronchial obstruction.

P2525Relationship of Charlson Comorbidity Index with adverse events in elderly patients with Acute Coronary Syndromes: an analysis from LONGEVO-SCA Registry

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M A Esteve Pastor ◽  
E Martin ◽  
O Alegre ◽  
J C Castillo Dominguez ◽  
F Formiga ◽  
...  
Keyword(s):  
Adverse Events ◽  
Elderly Patients ◽  
Acute Coronary Syndromes ◽  
Risk Of Mortality ◽  
All Cause Mortality ◽  
Coronary Syndromes ◽  
Comorbidity Index ◽  
The Relationship ◽  
Worse Prognosis

Abstract Background Elderly patients with Acute Coronary Syndromes (ACS) are under-represented in clinical trials and they have higher risk of new due their comorbidities. Charlson Comorbidity Index (CCI) is an established tool for evaluating the burden of comorbidity status and a high score of CCI is related with an increased risk of death. Purpose The aim of this study was to analyze the relationship of CCI in adverse outcomes at short-term follow-up in elderly patients admitted by an ACS. Methods The prospective multicenter LONGEVO-SCA included unselected elderly patients (≥80 years old) hospitalized after non-STACS. In this substudy, we analyze the influence of comorbidities, comparing the relationship between quartiles of CCI and adverse events at 6 months follow-up of CCI. Results We analyzed 520 patients (mean age 84.4±3.6 years; 320 (61.5%) male). 196 (37.6%) were classified into Q1, 105 (20.2%) into Q2, 93 (17.9%) into Q3 and 126 (24.2%) into Q4. No differences were observed in treatment at discharge across different quartiles for aspirin (p=0.648), beta-blockers (p=0.908) or statins (p=0.756). We observed a significant increase for all-cause mortality [9 (4.8%) vs 10 (10.2%) vs 11 (12.0%) vs 32 (26.0%); p<0.001] and readmissions [36 (18.4%) vs 21 (20%) vs 33 (35.5%) vs 48 (38.1%); p<0.001] respectively from Q1 to Q4. After Cox multivariate regression analysis, CCI was independently associated with mortality or readmissions [HR 1.15, 95% CI (1.06–1.26); p=0.001] and patients into high quartile had 6-fold risk of mortality [HR 6.19, 95% CI (2.95–12.99); p<0.001]. Kaplan Meier analysis showed that patients in the highest quartiles had significantly worse prognosis during the follow-up with high risk of all-cause mortality and readmissions (both p<0.001). Event Free Survival according Charlson Conclusions In LONGEVO-SCA registry, we validated for the first time CCI as an independent factor related with adverse events. Patients into high quartiles of CCI had significantly worse prognosis during the follow-up and elderly patients into Q4 had 6-fold risk of mortality compared to Q1 patients.

Cognitive Factors Mediate the Relation Between Age and Flight Path Maintenance in General Aviation

2016 ◽  
Vol 6 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Kathleen Van Benthem ◽  
Chris M. Herdman
Keyword(s):  
Cognitive Functioning ◽  
Flight Path ◽  
General Aviation ◽  
Cognitive Factors ◽  
Pilot Performance ◽  
Pilot Error ◽  
Age Related ◽  
And Performance ◽  
Relationship Of ◽  
The Relationship

Abstract. Identifying pilot attributes associated with risk is important, especially in general aviation where pilot error is implicated in most accidents. This research examined the relationship of pilot age, expertise, and cognitive functioning to deviations from an ideal circuit trajectory. In all, 54 pilots, of varying age, flew a Cessna 172 simulator. Cognitive measures were obtained using the CogScreen-AE ( Kay, 1995 ). Older age and lower levels of expertise and cognitive functioning were associated with significantly greater flight path deviations. The relationship between age and performance was fully mediated by a cluster of cognitive factors: speed and working memory, visual attention, and cognitive flexibility. These findings add to the literature showing that age-related changes in cognition may impact pilot performance.

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