scholarly journals Impact of Blood Transfusion During Definitive Stabilization Surgeries on Pelvic Fracture Patient Clinical Outcomes

2021 ◽  
Author(s):  
Xiuqiao Xie ◽  
Jie Wang ◽  
Xueyuan Huang ◽  
Rong Gui ◽  
Yuanshuai Huang
Keyword(s):  
Blood Transfusion ◽  
Hemorrhagic Shock ◽  
Clinical Outcomes ◽  
Pelvic Fracture ◽  
Pelvic Injury ◽  
Total Serum Protein ◽  
Total Serum ◽  
Serum Globulin ◽  
Packed Red Blood Cells ◽  
Blood Tests

Abstract Background: Orthopaedic definitive stabilization surgeries are conducted when pelvic fracture patients are stabilized and blood transfusion is usually inevitable for patients undergo major surgeries and few studies provide insight into the influence of the intraoperative transfusion of packed red blood cells (PRBCs) on the outcomes of pelvic patients . As it presents a risk to the recipient by inducing uncertain morbidity and mortality, this study was aiming at the influence of PRBCs during such surgeries on clinical outcomes of pelvic fracture patients.Methods: 300 patients were collected and 103 patients were analyzed after exclusion. According to the units of intraoperative transfused PRBCs, 52 patients were in the <3U PRBCs group, 39 patients were in the 3-6U group and 12 patients were in the >6U group. Their characteristics, blood tests, details during surgeries, and outcomes were evaluated.Results: Patients in the>6U PRBCs group were more likely admitted with hemorrhagic shock, lower blood platelet count (BPC) and higher Abbreviated Injury Scale (AIS) (all p<0.05). Blood tests of them at admission revealed higher levels of serum creatinine (Scr), prothrombin time (PT) and thromboplastin time (APTT), lower level of total serum protein (TSP), serum albumin (SA), and serum globulin (SG) (all p<0.05). They underwent more subsequent surgeries and intensive care unit (ICU) stays (all p<0.001). No significant differences between complications and clinical outcomes were observed among three groups. Increased intraoperative transfusion of PRBCs was an independent factor for increased numbers of subsequent surgeries after orthopaedic surgeries, and prolonged ICU days.Conclusions: More intraoperative transfusion during orthopedic fixation surgeries indicated patients with more possibilities of hemorrhagic shock, severe pelvic injury, renal injury, and coagulopathy at admission. Increased intraoperative blood transfusion was associated with more ICU days and increased re-operations, whereas it wouldn’t increase the risk of more complications or worsen clinical outcomes.

Automated Procedure for Simultaneously Measuring Total Globulin and Total Protein in Serum

1971 ◽  
Vol 17 (4) ◽  
pp. 301-306 ◽  
Author(s):  
John Savory ◽  
M Geraldine Heintges ◽  
Robert E Sobel
Keyword(s):  
Serum Protein ◽  
Total Protein ◽  
Continuous Flow ◽  
Gamma Globulin ◽  
Glyoxylic Acid ◽  
Total Serum Protein ◽  
Total Serum ◽  
Serum Globulin ◽  
Automated Method ◽  
A Minor

Abstract An automated continuous-flow procedure has been developed for simultaneously measuring total serum protein and globulin. The method for total protein is a minor modification of an existing automated method in which the biuret reagent is used. Total globulin is measured by reaction with glyoxylic acid, and standardized with N-acetyltryptophan. An empirical factor relating concentration of N-acetyltryptophan to human globulin has been derived. Values for total serum globulin obtained by this new automated procedure correlate closely with values obtained by electrophoresis, but do not agree with values obtained by use of procedures involving binding of anionic dye. Recovery of gamma globulin added to serum is essentially quantitative; the day-to-day precision (CV) is 4.31%.

Abstract 190: Hybrid Strategy of Damage Control IR (DCIR) and REBOA Would be Feasible for Traumatic Hemorrhagic Shock Patients Suffering From Severe Pelvic Injuries

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_2) ◽  
Author(s):  
Tomohiko Orita ◽  
Shokei Matsumoto ◽  
Tomohiro Funabiki ◽  
Masayuki Shimizu ◽  
Yukitoshi Toyoda ◽  
...  
Keyword(s):  
Survival Rate ◽  
Blood Transfusion ◽  
Hemorrhagic Shock ◽  
Pelvic Fracture ◽  
Damage Control ◽  
Severe Trauma ◽  
Shock State ◽  
Hybrid Strategy ◽  
Crystalloid Infusion ◽  
Traumatic Hemorrhagic Shock

Introduction: Massive hemorrhage with pelvic injury is sometimes lethal. So, success or failure of hemostatic intervention in the hyperacute phase leads to survival of patients directly. Recently, a hybrid strategy with Operative Management (OM) and Interventional Radiology (IR) and/or Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for torso or pelvic severe trauma has been recognized world-widely. But, awareness of Damage control IR (DCIR) which is conscious of time and coagulopathy as Damage control surgery (DCS) is still not enough. So, we studied the possibility of the hybrid strategy with DCIR and REBOA for traumatic hemorrhagic shock patients with pelvic fracture. Methods: This study included patients who underwent traditional IR or DCIR with REBOA, if it were needed, for a traumatic shock state mainly due to pelvic fracture, at our emergency and trauma center. They were sorted into traditional IR group (group IR) and DCIR group (group DCIR). The primary endpoint was a survival rate in the first 30 days after injured. Secondary endpoints were fluid factors such as total amount of crystalloid infusion and blood transfusion within the first 24 hours, and for the duration of the recovery from shock state. Results: 64 trauma shock patients were sorted into group IR (n=38) and group DCIR (n=26). All REBOA patients (n=18) were in group DCIR. Initial systolic BP (group IR vs DCIR; 75mmHg vs. 54), RTS (5.66 vs. 4.12) and Ps (0.61 vs. 0.39) were significantly lower in group DCIR. ISS (32.8 vs. 41.5) and initial Shock Index (1.9 vs. 2.4) were higher in group DCIR significantly. There were no significant differences in the amount of total crystalloid infusion (7353+/-3152ml vs. 7140+/-5342ml) and blood transfusion (4183+/-3485ml vs. 3972+/-3188ml), and the survival rate (30/38 (79%) vs. 16/28 (62%)). But the required time to recovery from shock state was significantly shorter in group DCIR (65min vs. 43min). Conclusion: The hybrid strategy with DCIR and REBOA did not increase any amount of blood transfusion or crystalloid infusion or the mortality rate. But it could shorten the duration of shock state compared with traditional IR treatment. Thus, this hybrid strategy would be feasible for hemorrhage shock patients suffering from pelvic severe trauma.

scholarly journals Relation of the red blood globulin precipitation reaction to blood globulins. Salomon (Zeit. f. klin. Med, Bd. 99)

1925 ◽  
Vol 21 (2) ◽  
pp. 204-204
Author(s):  
J. Daikhovsky
Keyword(s):  
Red Blood Cells ◽  
Protein Content ◽  
Serum Protein ◽  
Sedimentation Rate ◽  
Blood Cells ◽  
Total Serum Protein ◽  
Total Serum ◽  
Precipitation Reaction ◽  
Healthy Individuals ◽  
Serum Globulin

After examining the serum globulin content of several sick and healthy individuals while determining the sedimentation rate of red blood cells (SR), Salomon found that in cases with normal SR the amount of globulin in the serum was about 30% of the total serum protein content; in patients with moderately accelerated SR the globulin content ranged between 36% and 51%; finally in cases with significantly accelerated SR the globulin content ranged between 37% and 70%.

Milk Protein Quantity and Quality in Low-Birthweight Infants: I. Metabolic Responses and Effects on Growth

PEDIATRICS ◽  
1976 ◽  
Vol 57 (5) ◽  
pp. 659-674 ◽  
Author(s):  
Niels C. R. Räihä ◽  
Kirsti Heinonen ◽  
David K. Rassin ◽  
Gerald E. Gaull
Keyword(s):  
Human Milk ◽  
Gestational Age ◽  
Low Birthweight ◽  
Caloric Intake ◽  
Ammonia Concentration ◽  
Total Serum Protein ◽  
Total Serum ◽  
Serum Globulin ◽  
Crown Rump Length

The optimal quantity and quality of protein for low-birthweight infants is undefined. In this study, 106 well, appropriate-for-gestational age, low-birthweight infants weighing 2,100 gm or less were grouped in three gestational age categories: T1 = 28 to 30 weeks; T2 = 31 to 33 weeks; T3 = 34 to 36 weeks. Each group was assigned randomly to either banked human milk (BM) or to one of four isocaloric formulas varying in quantity and quality of protein but not in mineral content or in fat content: formula 1 = 1.5 gm of protein per 100 ml, 60 parts bovine whey proteins to 40 parts bovine caseins: formula 2 = 3.0 gm of protein per 100 ml, 60:40; formula 3 = 1.5 gm of protein per 100 ml, 18:82; formula 4 = 3.0 gm of protein per 100 ml, 18:82. Caloric intake was 117 kcal/150 ml/kg/day for the formulas. Human milk was fed at 170 ml/kg/day in order to attain a caloric intake approximately equal to that of the formulas. No significant differences were found in the rate of growth in crown-rump length, in femoral length, in head circumference, or in rate of gain in weight from time of regaining birthweight to time of discharge at 2,400 gm. Blood urea nitrogen, urine osmolarity, total serum protein, serum albumin, aiud serum globulin varied directly with the quantity of protein in the diet: F2, F4 &gt; F1, F3 &gt; BM. Blood ammonia concentration varied with both quantity and qualtiy of protein in the diet: F2, F3, F4 &gt; F1, BM. Metabolic acidosis was more frequent, more severe, and more prolonged in the infants fed the casein-predominant formulas (F3, F4) than in those fed the whey protein-predominant formulas (Fl, F2).

Effect of Replacing Bone Ash with Fresh Water Snail (Pila Ampullacea) Shell Ash on Serum Biochemical Indices of Weaned Rabbits

2021 ◽  
pp. 1-6
Author(s):  
F. B. P. Abang ◽  
S. S. Emmanuel ◽  
S. Attah
Keyword(s):  
Fresh Water ◽  
Total Serum Protein ◽  
Total Serum ◽  
Security Measures ◽  
Serum Globulin ◽  
Bone Ash ◽  
Fresh Water Snail ◽  
Serum Biochemical ◽  
Biochemical Indices ◽  
Dietary Treatments

Twenty five (25) mixed breed weaned rabbits were utilized in 84-days experiment to investigate the effect of replacing bone ash with fresh water snail (Pila ampullacea) shell ash on the serum biochemical composition of weaned rabbits. The experiment was conducted at the Teaching and Research Farm, University of Agriculture, Makurdi, Benue State, Nigeria for a period of 12 weeks. The rabbits were randomly assigned to the five dietary treatments and replicated five times giving a total of one rabbit per replicate in a completely randomized design (CRD).   Rabbits were raised intensively in hutches of about 4ft × 4ft. Five experimental diets tagged T1 to T5 were formulated  such that fresh water snail (Pila ampullacea) shell ash replaced bone ash at 0%, 25%, 50%, 75% and 100%. Feed and water were served ad libitum. Bio sanitary and bio security measures were strictly adhered to. At the end of the feeding trial, three rabbits per treatment were selected for the evaluation of serum biochemistry. The parameters assayed for were: total serum protein, serum globulin, serum albumin, cholesterol, serum calcium, and serum phosphorus. The study showed that the serum biochemical indices were not influenced (P˃0.05) by the dietary treatments except for calcium which was significantly (P<0.05) influenced, however, calcium values were within the normal reference values for rabbits. This study had shown that fresh water snail (Pila ampullacea) shell ash can serve as a substitute for bone ash in weaned rabbit diet up to 100% inclusion levels without adverse effect on the serum biochemical indices.

scholarly journals Haematologic and biochemical changes in bitchs with clinical and subclinical mastitis

2016 ◽  
Vol 73 (2) ◽  
pp. 248 ◽  
Author(s):  
Iosif Vasiu ◽  
Orsolya Sarpataki ◽  
Ioana Bedecean ◽  
Raul Alexandru Pop ◽  
Florinel Gheorghe Brudașcă
Keyword(s):  
Serum Protein ◽  
Blood Count ◽  
Complete Blood Count ◽  
Subclinical Mastitis ◽  
Total Serum Protein ◽  
Total Serum ◽  
Total Proteins ◽  
Great Flexibility ◽  
Protein Levels ◽  
Blood Tests

Abstract Mastitis in bitch is in general superficially researched and evaluated. Data regarding blood tests during bitch glandular tissue inflammation is scarcely documented, therefore this paper aims to assess blood response in such cases. A total of 74 blood samples were obtained from lactating dams.These included females with Lactatio sine graviditate, with or without overt signs of mammary gland illness and with or without other signs of disease. Routine complete blood count and serum total proteins were evaluated. Complete blood count and total serum protein levels showed great flexibility, thus making it very difficult to establish and describe a clear and common haematological and biochemical pathway during mastitis inflammatory response. Clincians shoulds not relay only on blood tests whenever dealing with such pathology. Complete blood count and total serum protein levels should only be used as complementary tests, alongside other assays such as milk microbiology or cytology.

scholarly journals The Physical Activity-Dependent Hematological and Biochemical Changes in School Horses in Comparison to Blood Profiles in Endurance and Race Horses

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1128
Author(s):  
Małgorzata Maśko ◽  
Małgorzata Domino ◽  
Tomasz Jasiński ◽  
Olga Witkowska-Piłaszewicz
Keyword(s):  
Physical Activity ◽  
Blood Parameters ◽  
Total Serum Protein ◽  
Total Serum ◽  
Improve Performance ◽  
Blood Profile ◽  
Hematological And Biochemical Parameters ◽  
Activity Dependent ◽  
Race Horses ◽  
Blood Profiles

Blood testing is one of the most important ways to improve performance, facilitate recovery and monitor the training of endurance and race horses. However, little is known about the physical activity-dependent changes of blood parameters in horses used for pleasure and in riding schools. This study aimed to perform routine blood tests for training monitoring of sport horses in three different horse types of use. Then the values of blood indicators were compared between school, endurance and race horses to find similarities in the physical activity-dependent profile. The study was carried out on 15 endurance, 15 race and 15 school healthy horses who underwent the typical effort for their disciplines. The hemogram parameters, creatine phosphokinase (CPK), aspartate aminotransferase (AST), blood lactate (LAC), and total serum protein (TSP) concentrations were measured using the same protocol and equipment. Measurements of main hematological and biochemical physical activity-dependent parameters were conducted before, immediately after and 30 min after training. In school horses, the physical activity-dependent increase of WBC (40.9%) and CPK (76.4%) was similar to endurance horses, whereas an increase of RBC (19.1%), HGB (18.6%) and HCT (19.4%) were more similar to race horses. The moderate effort-dependent increase of LAC concentration (2775%) was lower than in race horses (7526%) and higher than in endurance horses (390%). Limiting the training or work monitoring assessment of school horses to only the endurance or racing blood profile may result in the omission of significant changes in hematological and biochemical parameters.

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