MRI Volumetric Changes in Hippocampal Subfields in Psychosis: a Protocol for a Systematic Review and Meta-analysis

Abstract Background: The hippocampus has for long been known for its abilities to form new, declarative memory. However, emerging findings across conditions in the psychosis spectrum also implicate its role in emotional regulation. Systematic reviews have demonstrated consistent volume atrophic changes in the hippocampus. The aim of the systematic review and metanalysis which will follow from this protocol will be to investigate the volume-based neuroimaging findings across each of the subfields of the hippocampus in psychosis independent of diagnosis.Methods: Volume changes across subfields of the hippocampus in psychotic illnesses will be assessed by systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). MRI neuroimaging studies of patients with a definitive diagnosis of psychosis (including brief pre diagnostic states) will be included. Studies lacking adequate controls, illicit drug use, medical psychosis, history of other significant psychiatric comorbidities or emphasis on age groups above 65 or below 16 will be excluded. Subfields investigated will include the CA1, CA2/3, CA4, subiculum, presubiculum, dentate gyrus, stratum, molecular layer, granular cell layer, entorhinal cortex and fimbria. Two researchers will independently conduct the search and selection procedures to gather suitable studies. One reviewer will independently perform all the data extraction, and another reviewer will then systemically check all the extracted information using the original articles to ensure accuracy. Statistical analysis will be performed using the metafor and meta packages in R Studio with application of the random effects model.Discussion: This study will provide insight into the volumetric changes in psychosis of the subfields of the hippocampus, independent of diagnosis. This may shed light on the intricate neural pathology which encompasses psychosis and will open avenues for further exploration of the structures identified as potential drivers of volume change.Systematic review registration: PROSPERO CRD42020199558

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Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis

BMJ ◽

10.1136/bmj.l6373 ◽

2019 ◽

pp. l6373 ◽

Cited By ~ 9

Author(s):

Shannon M Fernando ◽

Alexandre Tran ◽

Wei Cheng ◽

Bram Rochwerg ◽

Monica Taljaard ◽

...

Keyword(s):

Systematic Review ◽

Cardiac Arrest ◽

Prognostic Factors ◽

Systematic Reviews ◽

English Language ◽

Data Extraction ◽

Meta Analysis ◽

Research Strategy ◽

Primary Analysis ◽

Hospital Cardiac Arrest

Abstract Objective To determine associations between important pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest. Design Systematic review and meta-analysis. Data sources Medline, PubMed, Embase, Scopus, Web of Science, and the Cochrane Database of Systematic Reviews from inception to 4 February 2019. Primary, unpublished data from the United Kingdom National Cardiac Arrest Audit database. Study selection criteria English language studies that investigated pre-arrest and intra-arrest prognostic factors and survival after in-hospital cardiac arrest. Data extraction PROGRESS (prognosis research strategy group) recommendations and the CHARMS (critical appraisal and data extraction for systematic reviews of prediction modelling studies) checklist were followed. Risk of bias was assessed by using the QUIPS tool (quality in prognosis studies). The primary analysis pooled associations only if they were adjusted for relevant confounders. The GRADE approach (grading of recommendations assessment, development, and evaluation) was used to rate certainty in the evidence. Results The primary analysis included 23 cohort studies. Of the pre-arrest factors, male sex (odds ratio 0.84, 95% confidence interval 0.73 to 0.95, moderate certainty), age 60 or older (0.50, 0.40 to 0.62, low certainty), active malignancy (0.57, 0.45 to 0.71, high certainty), and history of chronic kidney disease (0.56, 0.40 to 0.78, high certainty) were associated with reduced odds of survival after in-hospital cardiac arrest. Of the intra-arrest factors, witnessed arrest (2.71, 2.17 to 3.38, high certainty), monitored arrest (2.23, 1.41 to 3.52, high certainty), arrest during daytime hours (1.41, 1.20 to 1.66, high certainty), and initial shockable rhythm (5.28, 3.78 to 7.39, high certainty) were associated with increased odds of survival. Intubation during arrest (0.54, 0.42 to 0.70, moderate certainty) and duration of resuscitation of at least 15 minutes (0.12, 0.07 to 0.19, high certainty) were associated with reduced odds of survival. Conclusion Moderate to high certainty evidence was found for associations of pre-arrest and intra-arrest prognostic factors with survival after in-hospital cardiac arrest. Systematic review registration PROSPERO CRD42018104795

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Assessment of humoral and cell-mediated immune responses to pertussis vaccination: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2018-028109 ◽

2019 ◽

Vol 9 (6) ◽

pp. e028109 ◽

Cited By ~ 1

Author(s):

Funbi Akinola ◽

Rudzani Muloiwa ◽

Gregory, D Hussey ◽

Violette Dirix ◽

Benjamin Kagina ◽

...

Keyword(s):

Systematic Review ◽

Immune Response ◽

Immune Responses ◽

Public Space ◽

Systematic Reviews ◽

Data Extraction ◽

Meta Analysis ◽

Grey Literature ◽

Assessment Tools ◽

Population Type

IntroductionGlobally, some studies show a resurgence of pertussis. The risks and benefits of using whole-cell pertussis (wP) or acellular pertussis (aP) vaccines in the control of the disease have been widely debated. Better control of pertussis will require improved understanding of the immune response to pertussis vaccines. Improved understanding and assessment of the immunity induced by pertussis vaccines is thus imperative. Several studies have documented different immunological outcomes to pertussis vaccination from an array of assays. We propose to conduct a systematic review of the different immunological assays and outcomes used in the assessment of the humoraland cell-mediated immune response following pertussis vaccination.Methods and analysisThe primary outcomes for consideration are quality and quantity of immune responses (humoral and cell-mediated) post-pertussis vaccination. Of interest as secondary outcomes are types of immunoassays used in assessing immune responses post-pertussis vaccination, types of biological samples used in assessing immune responses post-pertussis vaccination, as well as the types of antigens used to stimulate these samples during post-pertussis vaccination immune response assessments. Different electronic databases (including PubMed, Cochrane, EBSCO Host, Scopus and Web of Science) will be accessed for peer-reviewed published and grey literature evaluating immune responses to pertussis vaccines between 1990 and 2019. The quality of included articles will be assessed using standardised risk and quality assessment tools specific to the study design used in each article. Data extraction will be done using a data extraction form. The extracted data will be analysed using STATA V.14.0 and RevMan V.5.3 software. A subgroup analysis will be conducted based on the study population, type of vaccine (wP or aP) and type of immune response (cell-mediated or humoral). Guidelines for reporting systematic reviews in the revised 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement will be used in this study.Ethics and disseminationEthics approval is not required for this study as it is a systematic review. We will only make use of data already available in the public space. Findings will be reported via publication in a peer-reviewed journal and presented at scientific meetings and workshops.Trial registration numberCRD42018102455.

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Clinical, laboratory and imaging predictors for critical illness and mortality in patients with COVID-19: protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2020-039813 ◽

2020 ◽

Vol 10 (12) ◽

pp. e039813

Author(s):

Xinxing Lai ◽

Jian Liu ◽

Tianyi Zhang ◽

Luda Feng ◽

Ping Jiang ◽

...

Keyword(s):

Systematic Review ◽

Prognostic Factors ◽

Critical Illness ◽

Systematic Reviews ◽

Clinical Laboratory ◽

Data Extraction ◽

Meta Analysis ◽

Cochrane Library ◽

Early Management ◽

Modifiable Factors

IntroductionWith the threat of a worldwide pandemic of COVID-19, it is important to identify the prognostic factors for critical conditions among patients with non-critical COVID-19. Prognostic factors and models may assist front-line clinicians in rapid identification of high-risk patients, early management of modifiable factors, appropriate triaging and optimising the use of limited healthcare resources. We aim to systematically assess the clinical, laboratory and imaging predictors as well as prediction models for severe or critical illness and mortality in patients with COVID-19.Methods and analysisAll peer-reviewed and preprint primary articles with a longitudinal design that focused on prognostic factors or models for critical illness and mortality related to COVID-19 will be eligible for inclusion. A systematic search of 11 databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, VIP, Wanfang Data, SinoMed, bioRxiv, Arxiv and MedRxiv will be conducted. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data extraction will be performed using the modified version of the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies checklist and quality will be evaluated using the Newcastle-Ottawa Scale and the Quality In Prognosis Studies tool. The association between prognostic factors and outcomes of interest will be synthesised and a meta-analysis will be conducted with three or more studies reporting a particular factor in a consistent manner.Ethics and disseminationEthical approval was not required for this systematic review. We will disseminate our findings through publication in a peer-reviewed journal.PROSPERO registration numberCRD 42020178798.

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Effectiveness of interventions on early neurodevelopment of preterm infants: a systematic review and meta-analysis

BMC Pediatrics ◽

10.1186/s12887-021-02559-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Marilyn Aita ◽

Gwenaëlle De Clifford Faugère ◽

Andréane Lavallée ◽

Nancy Feeley ◽

Robyn Stremler ◽

...

Keyword(s):

Systematic Review ◽

Preterm Infants ◽

Systematic Reviews ◽

Standard Care ◽

Data Extraction ◽

Meta Analysis ◽

Sensory Stimulation ◽

Related Factors ◽

Quality Of Evidence

Abstract Background As preterm infants’ neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this specific time. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of interventions initiated during NICU hospitalization on preterm infants’ early neurodevelopment during their hospitalization and up to two weeks corrected age (CA). Methods This systematic review referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] guidelines and was registered in PROSPERO (CRD42017047072). We searched CINAHL, MEDLINE, PubMed, EMBASE (OVID), Cochrane Systematic Reviews, CENTRAL, and Web of Science from 2002 to February 2020 and included randomized controlled/clinical trials conducted with preterm infants born between 24 and 366/7 weeks of gestation. All types of interventions instigated during NICU hospitalization were included. Two independent reviewers performed the study selection, data extraction, assessment of risks of bias and quality of evidence. Results Findings of 12 studies involving 901 preterm infants were synthesized. We combined three studies in a meta-analysis showing that compared to standard care, the NIDCAP intervention is effective in improving preterm infants’ neurobehavioral and neurological development at two weeks CA. We also combined two other studies in a meta-analysis indicating that parental participation did not significantly improve preterm infants’ neurobehavioral development during NICU hospitalization. For all other interventions (i.e., developmental care, sensory stimulation, music and physical therapy), the synthesis of results shows that compared to standard care or other types of comparators, the effectiveness was either controversial or partially effective. Conclusions The overall quality of evidence was rated low to very low. Future studies are needed to identify interventions that are the most effective in promoting preterm infants’ early neurodevelopment during NICU hospitalization or close to term age. Interventions should be appropriately designed to allow comparison with previous studies and a combination of different instruments could provide a more global assessment of preterm infants’ neurodevelopment and thus allow for comparisons across studies. Trial registration Prospero CRD42017047072.

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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis

Pain Research and Management ◽

10.1155/2021/6656863 ◽

2021 ◽

Vol 2021 ◽

pp. 1-13

Author(s):

Giulia Di Stefano ◽

Andrea Di Lionardo ◽

Giuseppe Di Pietro ◽

Giorgio Cruccu ◽

Andrea Truini

Keyword(s):

Systematic Review ◽

Neuropathic Pain ◽

Systematic Reviews ◽

Randomised Controlled Trials ◽

Fatty Acid Amide Hydrolase ◽

Data Extraction ◽

Meta Analysis ◽

Acid Amide ◽

Controlled Trials ◽

Randomised Controlled

Despite an increasing number of available therapies, the treatment of neuropathic pain remains a major issue. Systematic reviews and meta-analyses indicate that only a minority of patients with neuropathic pain have an adequate response to pharmacological treatment and that most drugs have dose-limiting side effects. We conducted a systematic review and meta-analysis of randomised controlled trials published in the last five years. We searched for relevant papers within PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and the Clinical Trials database (ClinicalTrials.gov). Two authors independently selected studies for inclusion, data extraction, and bias assessment. We identified 39 randomised controlled trials and included 16 in the meta-analysis. Trial outcomes were generally modest even for first-line drugs such as tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, and gabapentinoids. Many drugs acting on new pain targets are currently under development. Clinical data are currently available for sodium channel isoform-specific antagonists, anti-nerve growth factor molecules, and fatty acid amide hydrolase inhibitors.

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Effectiveness of Interventions on Early Neurodevelopment of Preterm Infants: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-36651/v2 ◽

2020 ◽

Author(s):

Marilyn Aita ◽

Gwenaëlle De Clifford-Faugère ◽

Andréane Lavallée ◽

Nancy Feeley ◽

Robyn Stremler ◽

...

Keyword(s):

Systematic Review ◽

Preterm Infants ◽

Systematic Reviews ◽

Standard Care ◽

Data Extraction ◽

Meta Analysis ◽

Primary Objective ◽

Related Factors ◽

Quality Of Evidence

Abstract Background : As preterm infants’ neurodevelopment is shaped by NICU-related factors during their hospitalization, it is essential to evaluate which interventions are more beneficial for their neurodevelopment at this specific time. The primary objective of this systematic review and meta-analysis was to evaluate the effectiveness of interventions initiated during NICU hospitalization on preterm infants’ early neurodevelopment during their hospitalization and up to two weeks corrected age (CA). Methods: This systematic review referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] guidelines and was registered in PROSPERO (CRD42017047072). We searched CINAHL, MEDLINE, PubMed, EMBASE (OVID), Cochrane Systematic Reviews, CENTRAL, and Web of Science from 2002 to February 2020. Two independent reviewers performed the study selection, data extraction, assessment of risks of bias and quality of evidence. Results: Findings of 12 studies involving 901 preterm infants were synthesized. We combined three studies in a meta-analysis showing that compared to standard care, NIDCAP intervention is effective in improving preterm infants’ neurobehavioral and neurological development at two weeks CA. We also combined two other studies in a meta-analysis indicating that parental participation did not significantly improve preterm infants’ neurobehavioral development during NICU hospitalization. For all other interventions (i.e., developmental care, sensory stimulation, music and physical therapy), the synthesis of results shows that compared to standard care or other types of comparators, the effectiveness was either controversial or partially effective. Conclusions: The overall quality of evidence was rated low to very low. Future studies are needed to identify interventions that are the most effective in promoting preterm infants’ neurodevelopment during NICU hospitalization or close to term age. Interventions should be appropriately designed to allow comparison with previous studies and a combination of different instruments could provide a more global assessment of preterm infants’ neurodevelopment and thus allow for comparisons across studies. Systematic Review Protocol Registration: Prospero CRD42017047072

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Effectiveness of Home and Community Exercise Interventions in Improving Indices of Adiposity and Health Outcomes in Adults Living With HIV: a Protocol for a Systematic Review.

10.21203/rs.3.rs-186428/v1 ◽

2021 ◽

Author(s):

Jeannine Anyingu Aminde ◽

Neil Harris ◽

Caroline Thng ◽

Ben Desbrow

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Data Extraction ◽

Meta Analysis ◽

Home Exercise ◽

People Living With Hiv ◽

Cochrane Central Register ◽

Exercise Interventions ◽

Supervised Exercise ◽

Living With Hiv

Abstract Background: Disorders of adipose distribution in people living with the human immunodeficiency virus (HIV) have been associated with significant metabolic derangements that increase their risk of cardiovascular and other chronic diseases. Systematic reviews focusing on centre-based supervised exercise interventions demonstrate that these interventions improve adipose distribution in people living with HIV (PLWH). However, there is need to examine the effectiveness of more flexible home/community self-managed exercise. The aim of this review will be to synthesize existing evidence on the effectiveness of home and community exercise interventions to improve adiposity indices in PLWH.Methods: The following databases will be searched from inception; PubMed, Embase, Scopus, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database, SPORTDiscus, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Clinicaltrials.gov. In addition, reference lists searching and forward citation searching will be performed. Screening of studies and data extraction will be conducted by two independent reviewers using a pre-established checklist and no language restrictions will be applied. The quality of included studies will be evaluated with the Cochrane Effective Practice and Organisation of Care Risk of bias tool for controlled and uncontrolled before-after studies. A random-effects meta-analysis will be used to pool effect estimates for primary outcomes (measures of total body adiposity, adipose distribution, and regional adiposity). However, if pooling is deemed inappropriate due to substantial differences between studies, a narrative synthesis will be performed. This protocol is written according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols 2015 statement (see Additional file 1).Discussion: This review shall provide evidence to support or disapprove the prescription of self-managed home exercise interventions in a particularly vulnerable population. We will equally explore the potential impact of technology in improving adherence. Our findings could help guide clinicians involved in the care of PLWH in prescribing exercise and inform the design of future trials and research. Systematic review registration: This protocol was submitted with the International Prospective Register of Systematic Reviews (PROSPERO) on 11/01/2021.

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Effect and safety of gemtuzumab ozogamicin for the treatment of patients with acute myeloid leukaemia: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2019-032503 ◽

2020 ◽

Vol 10 (6) ◽

pp. e032503

Author(s):

Nor A Muhamad ◽

Nor S Mohd Dali ◽

Aliza Mohd Yacob ◽

Mohd S A Kassim ◽

Noor A Lodz ◽

...

Keyword(s):

Systematic Review ◽

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Systematic Reviews ◽

Data Extraction ◽

Meta Analysis ◽

Gemtuzumab Ozogamicin ◽

Data Extraction Form ◽

Randomised Controlled ◽

Acute Myeloid

IntroductionAcute myeloid leukaemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells or platelets. Gemtuzumab ozogamicin (GO) holds promise as a new agent that also could be efficacious in newly diagnosed AML with acceptable toxicity. This paper describes the design of a protocol to conduct a systematic review of published studies assessing GO for the treatment of AML.Method and analysisWe will conduct a systematic review of randomised controlled trials that investigate the effect and safety of GO for the treatment of patients with AML. We will search for any eligible articles from selected electronic databases. We will follow the Preferred Reporting Items for Systematic reviews and Meta-Analysis for study selection and reporting. We will use The Cochrane Handbook for Systematic Reviews of Interventions and Meta-Analysis as guidance to select eligible studies. All data will be extracted using a standardised data extraction form.Ethics and disseminationThere was no patient involved in this study, therefore no ethical consideration is needed. The findings of this study will be disseminated in a peer-reviewed journal and any relevant conference presentation.PROSPERO registration numberCRD42019123286.

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New meniscal tears after ACL injury: what is the risk? A systematic review protocol

British Journal of Sports Medicine ◽

10.1136/bjsports-2017-097728 ◽

2017 ◽

Vol 52 (6) ◽

pp. 386-386 ◽

Cited By ~ 10

Author(s):

Guri Ranum Ekås ◽

Clare Ardern ◽

Hege Grindem ◽

Lars Engebretsen

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Data Extraction ◽

Evidence Synthesis ◽

Meta Analysis ◽

Demographic Data ◽

Acl Injury ◽

Risk Of Bias ◽

Meniscal Tears ◽

Best Evidence Synthesis

BackgroundSecondary meniscal tears after ACL injuries increase the risk of knee osteoarthritis. The current literature on secondary meniscal injuries after ACL injury is not consistent and may have methodological shortcomings. This protocol describes the methods of a systematic review investigating the rate of secondary meniscal injuries in children and adults after treatment (operative or non-operative) for ACL injury.MethodsWe will search electronic databases (Embase, Ovid Medline, Cochrane, CINAHL (Cumulative Index to Nursing and Allied Health Literature), SPORTDiscus, PEDro and Google Scholar) from database inception. Extracted data will include demographic data, methodology, intervention details and patient outcomes. Risk of bias will be assessed using the Newcastle Ottawa checklist for cohort studies. Article screening, eligibility assessment, risk of bias assessment and data extraction will be performed in duplicate by independent reviewers. A proportion meta-analysis will be performed if studies are homogeneous (I2<75%). If meta-analysis is precluded, data will be synthesised descriptively using best-evidence synthesis. The strength of recommendations and quality of evidence will be assessed using the Grading of Recommendations Assessment Development and Evaluation working group methodology.Ethics and disseminationThis protocol is written according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses, and was registered in the International Prospective Register of Systematic Reviews on 22 March 2016.Trial registration numberCRD42016036788.

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Sweet Solutions for Analgesia in Neonates in China: A Systematic Review and Meta-Analysis

Canadian Journal of Nursing Research ◽

10.1177/0844562118803756 ◽

2018 ◽

Vol 51 (2) ◽

pp. 116-127 ◽

Cited By ~ 2

Author(s):

Rui-Rui Huang ◽

Ri-Hua Xie ◽

Shi Wu Wen ◽

Shao-Lin Chen ◽

Qin She ◽

...

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Systematic Reviews ◽

Chinese Literature ◽

Data Extraction ◽

Meta Analysis ◽

Sweet Taste ◽

Heart Rate Change ◽

Biomedical Literature ◽

China National Knowledge Infrastructure

Introduction High-quality synthesized evidence of sweet taste analgesia in neonates exists. However, Chinese databases have never been included in previous systematic reviews of sweet solutions for procedural pain. Objective To conduct a systematic review of Chinese literature evaluating analgesic effects of sweet solutions for neonates. Data sources: Wang Fang, China National Knowledge Infrastructure and Chinese Biomedical Literature Database. Data extraction and analysis: Two authors screened studies for inclusion and conducted risk of bias ratings and data extraction. A third author resolved any conflicts. Meta-analyses were performed using RevMan 5.2 software, on mean differences in pain outcomes using random effects models. Results Thirty-one trials (4999 neonates) were included; 26 trials used glucose, 4 used sucrose, and 1 trial evaluated both solutions. Sweet solutions reduced standardized mean pain scores (n = 21 studies; −1.68, 95% confidence interval −2.08, −1.27) and cry duration (n = 6 studies; −25.60, 95% confidence interval −36.47, −14.72 s) but not heart rate change (n = 7 studies; −17.64, 95% confidence interval −52.71, 17.43). No included studies cited the previously published systematic reviews of sweet solutions. Conclusions This systematic review of Chinese databases showed the same results as previously published systematic reviews. No trials included in this review cited the English systematic reviews, highlighting a parallel research agenda.

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