scholarly journals Peptic Ulcer Does Not Increase the Risk of Stroke: a Longitudinal Follow-up Study Using a National Sample Cohort

2021 ◽  
Author(s):  
Hyo Geun Choi ◽  
Jae Seung Soh ◽  
Jae Sung Lim ◽  
Song Yong Sim ◽  
Suk Woo Lee
Keyword(s):  
Peptic Ulcer ◽  
Ischemic Stroke ◽  
Subgroup Analysis ◽  
Gastrointestinal Diseases ◽  
National Sample ◽  
Control Group ◽  
Ulcer Disease ◽  
Hazard Ratios ◽  
Korean National Health Insurance ◽  
Age And Sex

Abstract Background: Studies have reported that several gastrointestinal diseases increase the risk of stroke. We aimed to evaluate the risk of stroke in patients with peptic ulcer disease (PUD) using a national sample cohort from South Korea. Methods: We extracted data entered into the Korean National Health Insurance Service for patients with PUD (n = 129,531) and for 1:1 matched control participants (n = 129,531) and analyzed the risk of stroke using Cox proportional hazard model. Subgroup analyses were performed based on age and sex.Results: The rates of hemorrhagic and ischemic stroke were lower in the PUD group than in the control group. In a subgroup analysis according to age, the adjusted hazard ratios (HRs) of PUD for hemorrhagic and ischemic stroke were 0.76 (95% CI = 0.63-0.90) and 0.85 (95% CI = 0.73-0.98) in the < 50-year-old group and 0.72 (95% CI = 0.65-0.80) and 0.84 (95% CI = 0.80-0.89) in the ≥ 50-year-old group, respectively (each p < 0.05). In a subgroup analysis according to sex, the adjusted HRs of PUD were 0.71 (95% CI = 0.63-0.81) and 0.81 (95% CI = 0.5-0.87) in men and 0.75 (95% CI = 0.66-0.86) and 0.88 (95% CI = 0.82-0.95) in women, respectively (each p < 0.05).Conclusions: Our study concluded that PUD does not increase the risk of ischemic or hemorrhagic stroke regardless of age and sex.

scholarly journals Increased Risk of Sudden Sensory Neural Hearing Loss in Osteoporosis: A Longitudinal Follow-Up Study

2018 ◽  
Vol 103 (8) ◽  
pp. 3103-3109 ◽  
Author(s):  
So Young Kim ◽  
Il Gyu Kong ◽  
Hyun Lim ◽  
Hyo Geun Choi
Keyword(s):  
Hearing Loss ◽  
The Elderly ◽  
National Sample ◽  
Control Group ◽  
Cox Proportional Hazard ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Korean National Health Insurance ◽  
Sensory Neural ◽  
Sensory Neural Hearing Loss

Abstract Context The results of a previous population cohort study suggested an association between osteoporosis and sudden sensory neural hearing loss (SSNHL). Objectives To use a nationwide cohort in the Korean population to investigate the risk of SSNHL in patients with osteoporosis. Design, Setting, and Participants Data entered from 2002 to 2013 were collected from the Korean National Health Insurance Service-National Sample Cohort. A total of 68,241 patients with osteoporosis aged ≥50 years were matched with 68,241 control individuals. The crude (simple) and adjusted hazard ratios (HRs) of SSNHL in those with osteoporosis were analyzed using the Cox proportional hazard model. A subgroup analysis was performed according to age and sex. Results The risk of SSNHL was greater in the osteoporosis group than in the control group (adjusted HR, 1.56; 95% CI, 1.37 to 1.78; P &lt; 0.001). The risk of SSNHL in those with osteoporosis was greater in patients aged &lt;60 years, regardless of sex. Women aged ≥60 years had a higher HR for SSNHL in the presence of osteoporosis (women aged 60 to 69 years: adjusted HR, 1.67; 95% CI, 1.34 to 2.08; P &lt; 0.001; women aged ≥70 years: adjusted HR, 1.90; 95% CI, 1.29 to 2.79; P &lt; 0.001). Conclusions The risk of SSNHL was greater for patients with osteoporosis aged ≥50 years. Middle-age adults, as well as the elderly, are at an increased risk of SSNHL in the presence of osteoporosis.

scholarly journals Association between ischemic stroke and seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251851
Author(s):  
Dong Hyun Lee ◽  
Seung Hun Sheen ◽  
Dong-Geun Lee ◽  
Jae-Won Jang ◽  
Dong Chan Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ischemic Stroke ◽  
Hazard Ratio ◽  
Control Group ◽  
Medical Disorders ◽  
Seropositive Rheumatoid Arthritis ◽  
Hazard Ratios ◽  
Increased Risk ◽  
Age And Sex

The purpose of this longitudinal follow-up study was to investigate the risk of ischemic stroke nationwide in patients with seropositive rheumatoid arthritis (RA) and controls who were matched in age and sex. Patient data were collected from the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. Using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD), RA was identified. A total of 2,765 patients and 13,825 control subjects were included in our study. The 12-year incidence of ischemic stroke in each group was calculated using the Kaplan–Meier method. The risk ratio of ischemic stroke was estimated using Cox proportional hazards regression. Sixty-four patients (2.31%) in the seropositive RA group and 512 (3.70%) in the control group experienced ischemic stroke (P < 0.001) during the follow-up period. The hazard ratio of ischemic stroke in the seropositive RA group was 1.32 (95% confidence interval (CI), 1.02–1.73) after adjusting for age and sex. The adjusted hazard ratio of ischemic stroke in the seropositive RA group was 1.40 (95% CI, 1.07–1.82) after adjusting for demographics and comorbid medical disorders. According to the subgroup analysis, the hazard ratios of ischemic stroke risks in the female and hypertensive subgroups were 1.44 (95% CI, 1.05–1.97) and 1.66 (95% CI, 1.16–2.38), respectively. In the non-diabetes and non-dyslipidemia subgroups, the corresponding hazard ratios of ischemic stroke were 1.47 (95% CI, 1.11–1.95) and 1.43 (95% CI, 1.07–1.91). Seropositive RA patients have an increased risk of ischemic stroke. In female, hypertension, non-diabetes, and non-dyslipidemia RA subgroups, even without the traditional risk factors for stroke (except for hypertension), increased the risk, which could be potentially attributed to RA.

ANTICYTOKINE ACTIVITY OF THE PROTOZOA BLASTOCYSTIS SPP

2020 ◽  
pp. 44-48
Author(s):  
Bugero N.V. ◽  
Ilyina N.A. ◽  
Aleksandrova S.M.
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Diseases ◽  
Control Group ◽  
Ulcer Disease ◽  
Cytokine Balance ◽  
High Prevalence ◽  
Blastocystis Spp ◽  
High Level ◽  
Eukaryotic Organisms ◽  
High Degree

In addition to the classical pathogens, which are well understood and well identified, new pathogens with the potential to spread epidemiologically are being identified. Some of these little-known organisms are the simplest Blastocystis spp. blastocystostosis. The clinical significance of Blastocystis spp. and its pathogenicity are still under discussion. This parasite belongs to a group of single-celled eukaryotic organisms living in the colon of the human intestine. Blastocystis spp. is known to be found both in people with reduced immune status and in individuals without any clinical manifestation. It has been established that a sufficiently high degree of invasiveness is observed in persons with gastrointestinal tract diseases, dermatosis, allergic reactions, in patients with carriers of the human immunodeficiency virus, etc. Possessing persistence factors, protozoa blastocysts contribute to the inactivation of host defensive mechanisms, providing a stable anthogonistic effect. In recent years, many works have been devoted to the characteristics of the persistent properties of Blastocystis spr., however, individual properties of blastocysts, in particular, anticytokine activity (ACA), have not yet been studied. In this regard, the work studied the anticytokine activity of microorganisms isolated from healthy subjects and patients with gastrointestinal tract diseases. A high prevalence of the studied characteristic in the subjects was shown. The expression of anticytokine activity in the obtained isolates of blastocysts was the highest in the group of persons with gastric ulcer disease, which decreased in the order of duodenal ulcer, chronic cholecystitis, chronic gastritis, etc. The data obtained in this work on the high level of ACA expression in blastocyst isolates obtained from individuals with gastrointestinal diseases as compared with the control group enables to conclude that their exometabolites may influence the local cytokine balance [1], which supports the inflammatory process.

scholarly journals The Association Between Peptic Ulcer Disease and Ischemic Stroke

Medicine ◽  
2016 ◽  
Vol 95 (22) ◽  
pp. e3797 ◽  
Author(s):  
Tain-Junn Cheng ◽  
How-Ran Guo ◽  
Chia-Yu Chang ◽  
Shih-Feng Weng ◽  
Pi-I Li ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Ischemic Stroke ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease

scholarly journals Association between Skin Cancer and Systemic and Ocular Comorbidities in South Korea

2021 ◽  
Vol 10 (11) ◽  
pp. 2451
Author(s):  
Sul Hee Lee ◽  
Jun-Soo Ro ◽  
Kee Yang Chung ◽  
Sang Hoon Lee ◽  
Young Lip Park ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Macular Degeneration ◽  
Propensity Scores ◽  
Multivariate Logistic Regression Analysis ◽  
National Sample ◽  
Control Group ◽  
South Korean ◽  
Non Melanoma Skin Cancer ◽  
Korean National Health Insurance ◽  
Melanoma Skin

Background: In this study, we investigated the associations between various systemic and ocular comorbidities and skin cancer, in a nationwide cohort of South Koreans. Method: We reviewed the data of 1,103,302 individuals in the South Korean National Health Insurance Service-National Sample Cohort database from 2002 to 2015. Of these, 1202 individuals diagnosed with skin cancer from 2004 were included in the study group. The control group was matched in a 1:5 ratio based on propensity scores. Results: The prevalence rates of melanoma and non-melanoma skin cancer increased from 2004 to 2015. Multivariate logistic regression analysis revealed that, among the various systemic conditions, hypertension was significantly associated with skin cancer, while among ocular comorbidities, macular degeneration showed a significant association with skin cancer. Conclusions: This is the first study to demonstrate associations between skin cancer and various systemic and ocular comorbidities. The results suggest that hypertension and macular degeneration may increase the risk of skin cancer development, or vice versa. Further studies are needed to evaluate the causal relationships between these conditions.

scholarly journals Evaluation of the increased risk of spine fracture in patients with mood disorder compared with matched controls: a longitudinal follow-up study using a national sample cohort in Korea

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e027581
Author(s):  
So Young Kim ◽  
Chanyang Min ◽  
Bumjung Park ◽  
Miyoung Kim ◽  
Hyo Geun Choi
Keyword(s):  
Mood Disorder ◽  
National Sample ◽  
Spine Fracture ◽  
Secondary Outcome ◽  
Control Group ◽  
Follow Up Study ◽  
Increased Risk ◽  
History Of ◽  
Age And Sex

ObjectiveTo evaluate the risk of spine fracture in patients with mood disorder using a nationwide cohort.DesignA longitudinal follow-up study.SettingClaims data for the population ≥20 years of age were collected from 2002 to 2013 for the Korean National Health Insurance Service-National Sample Cohort.ParticipantsA total of 60 140 individuals with mood disorder were matched with 240 560 individuals (control group) for age, sex, income, region of residence and osteoporosis.InterventionsIn both the mood disorder and control groups, the history of spine fracture was evaluated. The International Classification of Diseases 10th Revision codes for mood disorder (F31–F39) and spine fracture (S220 and S320) were included.Primary and secondary outcome measuresThe univariable and multivariable HRs and 95% CIs of spine fracture for patients with mood disorder were analysed using a stratified Cox proportional hazards model. Subgroup analyses were conducted according to the history of osteoporosis, age and sex.ResultsApproximately 3.3% (2011/60 140) of patients in the mood disorder group and 2.8% (6795/240 560) of individuals in the control group had spine fracture (p<0.001). The mood disorder group demonstrated a higher adjusted HR for spine fracture than the control group (multivariable HR=1.10, 95% CI 1.04 to 1.15, p<0.001). The participants without osteoporosis showed a higher HR of mood disorder for spine fracture than the control participants (multivariable HR=1.25, 95% CI 1.14 to 1.37, p<0.001). According to age and sex, this result was consistent in subgroups of women aged 20–39 and 40–59 years and men aged ≥60 years.ConclusionThe risk of spine fracture was increased in patients with mood disorder. The potential risk of spine fracture needs to be evaluated when managing patients with mood disorder.

scholarly journals Association between Herpes Zoster and Osteoporosis: A Nested Case-Control Study Using a National Sample Cohort

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Chanyang Min ◽  
Woo Jin Bang ◽  
Dong Jun Oh ◽  
Songyong Sim ◽  
Hyo Geun Choi
Keyword(s):  
Herpes Zoster ◽  
Conditional Logistic Regression ◽  
National Sample ◽  
Chronic Inflammatory Disease ◽  
Control Group ◽  
Subgroup Analyses ◽  
Region Of Residence ◽  
Icd 10 ◽  
Nested Case Control ◽  
Age And Sex

Objectives. Chronic inflammatory disease might affect osteoporosis; however, few studies have reported the association between herpes zoster and osteoporosis. The goal of this study was to estimate the association between herpes zoster and osteoporosis in Korean residents. Methods. The Korean National Health Insurance Service-National Sample Cohort, which includes individuals aged ≥ 50 years, was assessed from 2002 to 2013. In total, 68,492 osteoporosis participants were matched with 68,492 control participants at a ratio of 1:1 by age, sex, income, and region of residence. We assayed the prior histories of herpes zoster in the osteoporosis and control groups. The diagnoses of herpes zoster and osteoporosis were based on ICD-10 codes and claim codes. Crude and adjusted models of odds ratios (ORs) were explored using conditional logistic regression analyses, and the 95% confidence intervals (CIs) were computed. The participants were stratified according to age, sex, income, and region of residence. Subgroup analyses were performed to investigate the role of age and sex. Results. The rate of herpes zoster in the osteoporosis group (5.1% [3,487/68,492]) was higher than that in the control group (4.0% [2,738/68,492]). The adjusted OR of herpes zoster in the osteoporosis group was 1.17 (95% CI = 1.11-1.24). In the subgroup analyses, the adjusted OR was 1.34 (95% CI = 1.01-1.78) among males aged < 65 years, 1.20 (95% CI = 1.12-1.29) among females aged < 65 years, and 1.19 (95% CI = 1.04-1.36) among males aged ≥ 65 years. Conclusion. The ORs of herpes zoster were increased among the osteoporosis patients. This correlation was reliable in all subgroups by age and sex except group of women ≥ 65 years old.

scholarly journals The Associations of Tonsillectomy with Adenoidectomy with Pneumonia and Appendicitis Based on National Sample Cohort Data from the Korean National Health Insurance Service

2021 ◽  
Author(s):  
Junhui Jeong ◽  
Jung Kyu Choi ◽  
Hyun Seung Choi ◽  
Chang Eui Hong ◽  
Hyang Ae Shin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Insurance ◽  
National Health Insurance ◽  
National Health ◽  
Significant Risk ◽  
National Sample ◽  
Population Based ◽  
Control Group ◽  
Number Of Patients ◽  
Korean National Health Insurance

Abstract Introduction The association between tonsillectomy with adenoidectomy (T&A) with appendicitis is controversial, and the association of T&A with pneumonia has not been investigated. Objective To investigate the associations of T&A with pneumonia and appendicitis using data from the Korean National Health Insurance Service National Sample Cohort. Methods We selected patients between the ages of 3 and 10 years who had undergone T&A in 2005 and were monitored since the performance of the T&A until 2013. The control group was established to have similar propensities for demographic characteristics compared to the T&A group. For eight years after the T&A, the number of patients with a diagnosis of pneumonia, patients who were admitted due to pneumonia, and those who underwent appendectomy were analyzed. The risk factors for pneumonia and appendectomy were analyzed. Results The number of pneumonia diagnoses was significantly higher in the T&A group than in the control group (p = 0.023), but there were no significant differences in the number of admissions due to pneumonia between the 2 groups (p = 0.155). Younger age and T&A were significant risk factors for the development of pneumonia. There were no significant differences in the number of appendectomies between the T&A and the control groups (p = 0.425), neither were there significant risk factors for appendectomy. Conclusion Tonsillectomy with adenoidectomy was associated with an increase in pneumonia diagnoses, but it was not associated with the number of appendectomies. The associations of T&A with pneumonia and appendicitis were analyzed in this population-based study.

scholarly journals The comparative effects of oral famotidine and lansoprazole in prophylaxis of aspirin induced peptic ulcer in albino rat

2021 ◽  
Vol 9 (4) ◽  
pp. 1047
Author(s):  
Rabi Bhushan ◽  
Ratan Kumar ◽  
Akash Chandra ◽  
Haribansh Kumar Singh
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Experimental Work ◽  
Control Group ◽  
Albino Rats ◽  
Epithelial Layer ◽  
Albino Rat ◽  
Ulcer Disease

Background: Peptic ulcer is defined as any break in the continuity of gastric or duodenal epithelial layer. There are mainly three factors which are responsible for peptic ulcer disease which are Helicobacter pylori infections, NSAIDs and stress. Famotidine is H2 receptor blocker and Lansoprazole is proton pump inhibitor which are used prophylactically in aspirin induced peptic ulcer.Methods: The experimental work was carried out on albino rat. Experiment was carried out with two ulcer protecting agents e.g-famotidine, lansoprazole and one ulcer producing agent Aspirin. Each ulcer protecting drug was used separately but simultaneously with aspirin to see their ulcer protecting efficacy. There was three groups of animals each consisting of ten albino rats. Ist group was control group which was given aspirin only.2nd group was given aspirin+famotidine, 3rd group was given aspirin+lansoprazole.Results: The prophylactically ulcer preventing activity was the most with lansoprazole and least with famotidine.Conclusions: Finally, all the two drugs like famotidine, lansoprazole prevented the ulcerogenic effects of Aspirin effectively, although not completely.

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