Incidence and Survival Trends of Bladder Rhabdomyosarcoma:A SEER-based Analysis of 125 Cases

Abstract Background To elucidate the bladder rhabdomyosarcoma clinicopathological characteristics and reveal the prognostic factors. Methods We screened data from SEER database (1975-2016) stratified by age group, evaluated the differences between groups with Chi-square and Fisher’s test, conducted the Kaplan-Meier survival analysis and plotted the survival curve. The significant factors were brought into Cox regression analysis and calculated the HR(95%CI). Results About half of the patients who develop bladder RMS will be younger than 2 years of age. Embryonal RMS account for 76% of all histopathology types. Age at diagnosis more than 16-y (HR=6.595,95%CI:3.62-12.01, p=7.04e-10), NOT embryonal rhabdomyosarcoma (HR=3.61, 95%CI:1.99-6.549, p =4.1e-06), without radiotherapy combined or surgery alone (HR=4.382, 95%CI:1.99-6.549, p =2.4e-05) and not performed the surgery (HR=2.982,95%CI:1.263-7.039, p =0.0126) were negatively correlated with 5-year survival time, while race( p =0.341), whether performed the lymphadenectomy( p =0.722) showed no influence on survival time. Cox regression results show that age, histology, SEER stage, treatment combined or alone influence the clinical outcomes. Conclusions We demonstrated the demographic and characteristic of bladder rhabdomyosarcoma, identified and excluded the prognostic factors for the 5-year overall survival and clinical outcomes.

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Factors predicting recurrence after curative resection for rectal cancer: a 16-year study

World Journal of Surgical Oncology ◽

10.1186/s12957-019-1718-1 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 4

Author(s):

Waad Farhat ◽

Mohamed Azzaza ◽

Abdelkader Mizouni ◽

Houssem Ammar ◽

Mahdi ben Ltaifa ◽

...

Keyword(s):

Prognostic Factors ◽

Recurrence Rate ◽

Cox Regression ◽

Survival Curve ◽

Rectal Adenocarcinoma ◽

Distal Margin ◽

Curative Surgery ◽

Factors Affecting ◽

Cox Regression Analysis ◽

Kaplan Meier

Abstract Background The recurrence after curative surgery of the rectal adenocarcinoma is a serious complication, considered as a failure of the therapeutic strategy. The aim of this study was to identify the different prognostic factors affecting the recurrence of adenocarcinoma of the rectum. Methods A retrospective analysis of patients operated for adenocarcinoma of the rectum between January 2000 and December 2015 was conducted. The study of the recurrence rate and prognostic factors was performed through the Kaplan Meier survival curve and the Cox regression analysis. Results During the study period, 188 patients underwent curative surgery for rectal adenocarcinoma, among which 53 had a recurrence. The recurrence rate was 44.6% at 5 years. The multivariate analysis identified four parameters independently associated with the risk of recurrence after curative surgery: a distal margin ≤ 2 cm (HR = 6.8, 95% CI 2.7–16.6, 6), extracapsular invasion of lymph node metastasis (HR = 4.4, 95% CI 1.3–14), tumor stenosis (HR = 4.3, 95% CI 1.2–15.2), and parietal invasion (pT3/T4 disease) (HR = 3, 95% CI 1.1–9.4). Conclusion The determination of the prognostic factors affecting the recurrence of rectal adenocarcinoma after curative surgery allows us to define the high-risk patients for recurrence. Trial registration ClinicalTrials.gov Identifier: NCT03899870. Registered on 2 February 2019, retrospectively registered.

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P-Cresyl Sulfate Is a Valuable Predictor of Clinical Outcomes in Pre-ESRD Patients

BioMed Research International ◽

10.1155/2014/526932 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Cheng-Jui Lin ◽

Chi-Feng Pan ◽

Chih-Kuang Chuang ◽

Fang-Ju Sun ◽

Duen-Jen Wang ◽

...

Keyword(s):

Clinical Outcomes ◽

Cardiovascular Event ◽

Cox Regression ◽

Medical Center ◽

Serum Biochemistry ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Valuable Marker ◽

Valuable Predictor

Background/Aims. Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study.Methods. 72 predialysis patients were enrolled from a single medical center. Serum biochemistry data and PCS were measured. The clinical outcomes including cardiovascular event, all-cause mortality, and dialysis event were recorded during a 3-year follow-up.Results. After adjusting other independent variables, multivariate Cox regression analysis showed age (HR: 1.12,P=0.01), cardiovascular disease history (HR: 6.28,P=0.02), and PCS (HR: 1.12,P=0.02) were independently associated with cardiovascular event; age (HR: 0.91,P<0.01), serum albumin (HR: 0.03,P<0.01), and PCS level (HR: 1.17,P<0.01) reached significant correlation with dialysis event. Kaplan-Meier analysis revealed that patients with higher serum p-cresyl sulfate (>6 mg/L) were significantly associated with cardiovascular and dialysis event (log rankP=0.03, log rankP<0.01, resp.).Conclusion. Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis.

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NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma

Bioscience Reports ◽

10.1042/bsr20180907 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 1

Author(s):

Ji-sheng Jing ◽

Hongbo Li ◽

Shun-cai Wang ◽

Jiu-ming Ma ◽

La-qing Yu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cox Regression ◽

Survival Curve ◽

Disease Free Survival ◽

Prognostic Indicator ◽

Clinicopathological Characteristics ◽

Pcr Analysis ◽

Kaplan Meier ◽

Tumor Tissues ◽

The Relationship

N-myc downstream-regulated gene 3 (NDRG3), an important member of the NDRG family, is involved in cell proliferation, differentiation, and other biological processes. The present study analyzed NDRG3 expression in hepatocellular carcinoma (HCC) and explored the relationship between expression of NDRG3 in HCC patients and their clinicopathological characteristics. We performed quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) analysis and immunohistochemistry (IHC) analyses on HCC tissues to elucidate NDRG3 expression characteristics in HCC patients. Kaplan–Meier survival curve and Cox regression analyses were used to evaluate the prognoses of 102 patients with HCC. The results revealed that compared with non-tumor tissues, HCC tissues showed significantly higher NDRG3 expression. In addition, our analyses showed that NDRG3 expression was statistically associated with tumor size (P=0.048) and pathological grade (P=0.001). Survival analysis and Kaplan–Meier curves revealed that NDRG3 expression is an independent prognostic indicator for disease-free survival (P=0.002) and overall survival (P=0.005) in HCC patients. The data indicate that NDRG3 expression may be considered as a oncogenic biomarker and a novel predictor for HCC prognosis.

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CIP4 Expression is Associated With The Prognosis in Colorectal Cancer

10.21203/rs.3.rs-95046/v1 ◽

2020 ◽

Author(s):

Keqian Zhang ◽

Tianqi Mao ◽

Zhicheng He ◽

Xiaojiao Wu ◽

Yu Peng ◽

...

Keyword(s):

Colorectal Cancer ◽

Cox Regression ◽

Prognostic Significance ◽

Lymphatic Invasion ◽

Chi Square ◽

Interacting Protein ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Chi Square Test ◽

Student’S T

Abstract Background: This study was conducted to detect the expression of Cdc42 interacting protein 4 (CIP4) in patients with colorectal cancer (CRC), and explore the role of CIP4 in prognosis of CRC patients.Methods: The expression of CIP4 mRNA was determined by quantitative real-time PCR (qRT-CPR) and compared by student’s t-test between groups. Relationships of clinical characteristics and CIP4 expression were analyzed by Chi-square test. Kaplan-Meier curves were used to estimate the overall survival of CRC patients. And Cox regression analysis was conducted to identify the prognostic biomarkers for CRC patients.Results: The qRT-PCR results showed that CRC tissues were detected with significantly high CIP4 mRNA expression compared with adjacent normal controls (P<0.0001). The overexpression of CIP4 in CRC tissues was influenced by distant metastasis (P=0.021), lymphatic invasion (P=0.012) and TNM stage (P=0.006). But, other clinical factors including age, gender, differentiation and tumor site were proved to have no obvious effects on CIP4 expression (all, P>0.05). The survival curves showed that patients with high CIP4 expression generally lived shorter than those with low CIP4 expression (P<0.001). In addition, the multivariate analysis revealed that differentiation (P=0.044, HR=1.631, 95%CI=1.013-2.626) and CIP4 expression (P=0.000, HR=5.283, 95%CI=3.138-8.893) were of great prognostic significance for CRC patients.Conclusion: Taken together, up-regulation of CIP4 in CRC tissues represented poor prognosis for patients.

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Prognostic factors in the persistence of posttraumatic epilepsy after penetrating head injuries sustained in war

Journal of Neurosurgery ◽

10.3171/2008.4.17519 ◽

2009 ◽

Vol 110 (2) ◽

pp. 319-326 ◽

Cited By ~ 24

Author(s):

Behzad Eftekhar ◽

Mohammad Ali Sahraian ◽

Banafsheh Nouralishahi ◽

Ali Khaji ◽

Zahra Vahabi ◽

...

Keyword(s):

Prognostic Factors ◽

Cox Regression ◽

Head Injuries ◽

Clinical Findings ◽

Term Outcome ◽

Long Term Outcome ◽

Cox Regression Analysis ◽

Posttraumatic Epilepsy ◽

Kaplan Meier

Object The goal of this paper was to investigate the long-term outcome and the possible prognostic factors that might have influenced the persistence of posttraumatic epilepsy after penetrating head injuries sustained during the Iraq–Iran war (1980–1988). Methods In this retrospective study, the authors evaluated 189 patients who sustained penetrating head injury and suffered posttraumatic epilepsy during the Iraq–Iran war (mean 18.6 ± 4.7 years after injury). The probabilities of persistent seizures (seizure occurrence in the past 2 years) in different periods after injury were estimated using the Kaplan-Meier method. The possible prognostic factors (patients and injury characteristics, clinical findings, and seizure characteristics) were studied using log-rank and Cox regression analysis. Results The probability of persistent seizures was 86.4% after 16 years and 74.7% after 21 years. In patients with < 3 pieces of shrapnel or no sphincter disturbances during seizure attacks, the probability of being seizure free after these 16 and 21 years was significantly higher. Conclusions Early seizures, prophylactic antiepileptics drugs, and surgical intervention did not significantly affect long-term outcome in regard to persistence of seizures.

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The Identification and Analysis of a Novel Model Based on Ferroptosis-Related Genes for Predicting the Prognosis of Diffuse Large B-Cell Lymphomas

10.21203/rs.3.rs-1119694/v1 ◽

2021 ◽

Author(s):

Jiayi Wang ◽

Hongling Peng ◽

Guangsen Zhang ◽

Yunxiao Xu ◽

Wenzhe Yan

Keyword(s):

B Cell ◽

Prognostic Model ◽

Cox Regression ◽

Survival Curve ◽

B Cell Lymphoma ◽

B Cell Lymphomas ◽

Roc Curve Analysis ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Large B Cell

Abstract Background Diffuse large B-cell lymphomas (DLBCLs) are the most common B-cell lymphoma featured as phenotypically and genetically heterogeneous. Ferroptosis is a new found programmed cell death and have a crucial role in the chemoresistance of tumor. We aim to build a ferroptosis-related genes (FRGs) prognostic signature to predict the outcome of DLBCLs. Methods Our study retrospectively investigated the mRNA expression level and clinical data of 604 DLBCL patients from 3 GEO public datasets. A series of bioinformatic approaches including Cox regression analysis, function enrich analysis, immune infiltration analysis, ROC curve analysis, Kaplan–Meier survival curve and the least absolute shrinkage and selection operator (LASSO) method by the corresponding R packages in R statistical software were combined to explored the heterogenicity of FRG based clusters and to build prognostic model. Immunohistochemistry was used to exam the protein expression of six FRGs in different molecular type of DLBCL. Results We first identified 19 FRGs with potential prognostic values and classfied the patients into cluster 1 and cluster 2, Results indicated that cluster 1 tend to have a shorter overall survival (OS) time, while patients in the two clusters have different patterns of infiltrating immune cells among. Furthermore, the LASSO was used to generated a six-genes (GCLC, LPCAT3, NFE2L2, ABCC1, SLC1A5, and GOT1) risk signature which constructed a risk score formula and prognostic model for the OS of DLBCL patients. Kaplan–Meier survival analysis proved that poorer OS was exhibited in higher risk patients stratified by the prognostic model in both the training cohort and test cohort. In addition, we constructed nomograms to predict the OS of DLBCL patients. Both the decision curve(DCA) and the calibration plots showed that the nomogram had good agreement between predicted results and actual observation. Finally, the validation by immunohistochemistry indicated the GCLC, LPCAT3, ABCC1, SLC1A5, and GOT1 were high expressed in DLBCL with various prognostic adverse molecular factor. Conclusion In sum, we built a new FRG-based prognostic model which will help improve diagnosis and treatment for DLBCL patients.

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Role of nicergoline in corneal wound healing in diabetic rats

BMC Ophthalmology ◽

10.1186/s12886-021-01835-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Amanda Lemos Barros Martins Portela ◽

Rafael Neves Moreno ◽

Maria Helena Madruga Lima Ribeiro ◽

Fernanda Miguel de Andrade ◽

Yale Viana Alves ◽

...

Keyword(s):

Wound Healing ◽

Cox Regression ◽

Survival Curve ◽

Diabetic Rats ◽

Rank Test ◽

Control Group ◽

Cox Regression Analysis ◽

Corneal Epithelial Defect ◽

Kaplan Meier ◽

Diabetic Keratopathy

Abstract Background To investigate the effect of nicergoline on the rate of complete corneal ulcer reepithelialization (CCUR) in diabetic rats with diabetic keratopathy. Methods Forty-eight streptozotocin-induced diabetic rats were randomly divided into two groups. The experimental group (n = 24) received nicergoline (10 mg.kg− 1.day− 1), while the control group (n = 24) received a placebo. A corneal epithelial defect was induced using a corneal diamond burr, and defect area was compared at time points of 0, 12, 24, 48 and 72 h after the injury using image analysis software. The probability of CCUR within 72 h was assessed using the Kaplan–Meier survival analysis log-rank test. Results When compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72 h (log-rank = 0.027). Cox regression analysis found no effect of the covariates blood glucose (P = 0.601) or weight (P = 0.322) on the corneal reepithelialization (survival) curve. Conclusions Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.

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Abstract 11737: Heart Failure Patients Who Have Knowledge About Their Disease but Don’t Perform Self-Care Have Worse Clinical Outcomes

Circulation ◽

10.1161/circ.130.suppl_2.11737 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Naoko Kato ◽

Koichiro Kinugawa ◽

Tiny Jaarsma

Keyword(s):

Heart Failure ◽

Clinical Outcomes ◽

Risk Score ◽

Help Seeking ◽

Cox Regression ◽

Self Care ◽

Knowledge Score ◽

Chi Square ◽

Cox Regression Analysis ◽

The Mean

Introduction: Both knowledge and self-care are related to outcomes of heart failure (HF) patients. Some HF patients do not perform self-care even if they have knowledge about the disease and might be in need for special interventions. We aimed at describing characteristics of those patients and assessing their clinical outcomes. Methods: A total of 163 HF outpatients were enrolled (age 64, 70% male, NYHA I or II, 95%) and followed for 2 years. HF self-care risk score was calculated by counting the number of poor adherence to five self-care behaviors (medication, a low-sodium diet, exercise, daily weighing, and help-seeking behavior) (range, 0-6). Knowledge was assessed with a Japanese HF knowledge scale (range, 0-15). Subsequently, we classified patients into 4 groups (A-D) as shown in figure. We analyzed patient’s characteristics in group C (poor self-care but good knowledge) by ANOVA and Chi-square test. To assess clinical outcomes we used Kaplan-Meier method and Cox regression analysis. Results: The mean HF self-care risk score was 3.1±1.6 and the mean knowledge score was 10.9±2.9. In total, 45 patients (28%) were classified into Group C [76% male, mean B-type natriuretic peptide (BNP) levels, 164 pg/mL]. Compared with other groups, patients in Group C were likely to be younger (61±13 vs. 65±11 years, p=0.059). Their self-care scores did not correlate with their knowledge scores (p=0.99). During a 2-year follow-up period, 29 patients (18%) had HF hospitalization and/or cardiac death, with a significant higher rate in Group C (30%, Fig, p=0.04). After adjustment for age, BNP, and medical therapy, patients in Group C had 2.8 times higher risk of poor outcomes than other groups (hazard ratio=2.80, p=0.01). Conclusions: One-third of patients have HF knowledge but they do not perform self-care, and they have worse outcomes compared with other groups. Further study is necessary to examine those patients in more detail and to provide support for them to put knowledge into action.

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NCOG-02. SURVIVAL AND TREATMENT OUTCOMES OF NEOPLASTIC MENINGITIS (NM)

Neuro-Oncology ◽

10.1093/neuonc/noab196.595 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi152-vi152

Author(s):

Taylor Perison ◽

Kayla Wheat ◽

Salim Gnabode ◽

Lori Lyn Price ◽

Suriya Jeyapalan

Keyword(s):

Prognostic Factors ◽

Cancer Patients ◽

Cox Regression ◽

Neoplastic Meningitis ◽

Tissue Type ◽

Tumor Type ◽

Primary Tumors ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Number Of Patients

Abstract INTRODUCTION NM occurs in 5 - 15% of cancer patients and Overall Survival (OS) in treated patients ranges from 2-6 months. The purpose of this study was to analyze the effect of prognostic factors on OS and calculate a graded prognostic assessment (GPA) score based on tissue type, similar to the index score created for cancer patients with brain metastases (BM). METHODS We conducted a single center, retrospective analysis of 118 patients diagnosed between 2006 and 2018 at TMC. The prognostic factors analyzed were: Age (< = 50yo =1pt), Karnofsky Performance Status (KPS > =60 =1 pt), and no extracranial metastases (1pt). The GPA score was calculated from 0.0 - 3.0 by adding the points together. Kaplan Meier curves were used to estimate OS for primary tumors with 10 or more patients (breast, lung, leukemia, lymphoma). Cox regression analysis was used to evaluate the association of the GPA with OS. RESULTS The GPA analysis by tumor type included 76% of the patient population. The median OS was 5 months (breast), 2 months (lung), 7 months (leukemia), and 2 months (lymphoma). We found that leukemia (p =0.008, N = 20) and lung cancer (p =0.002, N = 20) patients showed distinct separation between GPA groups on their Kaplan Meier curves. Higher KPS was associated with increased OS (p < 0.0001) using Cox regression. DISCUSSION: The GPA algorithm was only partially successful in our NM population, which may reflect the smaller number of patients in our study compared to the studies used to create the BM GPA. TMC is a contributing institution to a large, multi-institutional, multi-national registry of patients with NM disease (Neoplastic Meningitis Registry - NeMeRe). We plan to use this larger dataset to validate our GPA score as a useful tool for predicting OS in NM patients.

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Role of the TGFβ/PDCD4/AP-1 Signaling Pathway in Nasopharyngeal Carcinoma and Its Relationship to Prognosis

Cellular Physiology and Biochemistry ◽

10.1159/000481871 ◽

2017 ◽

Vol 43 (4) ◽

pp. 1392-1401 ◽

Cited By ~ 6

Author(s):

Jie Ma ◽

Shu-Hong Xuan ◽

Yan Li ◽

Zhi-Ping Zhang ◽

Xin-Hua Li

Keyword(s):

Regression Analysis ◽

Prognostic Factors ◽

Nasopharyngeal Carcinoma ◽

Cox Regression ◽

Advanced Tumor Stage ◽

Cox Regression Analysis ◽

Normal Tissues ◽

Kaplan Meier ◽

Low Expression

Background: The objective of the present study was to evaluate the role of the TGFβ/PDCD4/AP-1 pathway in nasopharyngeal carcinoma (NPC) and its relationship to NPC prognosis. Methods: NPC tissues collected from 66 NPC patients were compared to 17 nasopharyngeal mucosa biopsy specimens collected as normal tissues. Immunohistochemical staining was performed to assess expression of transforming growth factor-β receptor I (TGFβRI), programmed cell death 4 (PDCD4) and activator protein-1 (AP-1). The Kaplan-Meier method was applied to evaluate NPC patient overall survival (OS) and progression-free-survival (PFS). Cox regression analysis was used to estimate independent prognostic factors for NPC. The human NPC cell line CNE2 was selected and treated with SB431542, an inhibitor of TGFβRI; expression of TGFβRI and PDCD4 in CNE2 cells was determined by western blotting. NPC tissues showed higher expression of TGFβRI and AP-1 but lower expression of PDCD4 than normal tissues (all P < 0.05). Results: The results of Kaplan-Meier analysis showed that TGFβRI-positive patients and AP-1-positive patients had shorter OS and PFS than TGFβRI-negative patients and AP-1-negative patients; additionally, PDCD4-positive patients had higher OS and PFS than PDCD4-negative patients. Cox regression analysis revealed that advanced tumor stage, overexpression of TGFβRI and AP-1, and low expression of PDCD4 were unfavorable factors influencing OS and PFS in NPC patients. Compared with the control group, expression of TGFβRI decreased and that of PDCD4 increased significantly in CNE2 cells treated with the inhibitor (all P < 0.05). These findings indicate that the TGFβ/PDCD4/AP-1 pathway may be associated with NPC development and progression. Conclusion: High expression of TGFβRI and AP-1 and low expression of PDCD4 may be unfavorable prognostic factors for NPC.

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