scholarly journals Estimating the Risk of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study

2020 ◽  
Author(s):  
Khalaf Kridin ◽  
Giovanni Damiani ◽  
Ralf J Ludwig ◽  
Dana Tzur Bitan ◽  
Arnon D. Cohen
Keyword(s):  
Ulcerative Colitis ◽  
Pyoderma Gangrenosum ◽  
Case Control Study ◽  
Statistical Significance ◽  
Subsequent Development ◽  
Fold Increase ◽  
Population Based ◽  
Case Control ◽  
Control Subjects ◽  
Control Study

Abstract BackgroundUlcerative colitis (UC) is a well-known underlying comorbidity in pyoderma gangrenosum (PG). However, the relative risk conferred by UC for the subsequent development of PG is yet to be explicated.ObjectiveTo estimate the magnitude of the association between UC and the subsequent occurrence of PG, thus enabling to assess the PG risk with UC.MethodsA population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex- and ethnicity-matched control subjects (n = 1,497) regarding the presence of UC. Logistic regression models were utilized for univariate and multivariate analyses.ResultsThe prevalence of UC was greater in patients with PG than in control subjects (7.3% vs. 0.5%, respectively; P < 0.001). A 15-fold increase in the odds of PG with UC (OR, 14.62 95% CI, 6.45–33.18) was observed. This association retained its statistical significance following a sensitivity analysis excluding UC cases diagnosed up to 2 years prior to PG (OR, 9.88; 95% CI, 3.91–24.97), and after adjusting for confounding factors (adjusted OR, 10.78; 95% CI, 4.55–25.52). The median latency between the diagnosis of UC and the development of PG was 4.59 years. Patients with both PG and UC were younger and had a lower prevalence of smoking when compared to the remaining patients with PG.ConclusionsUC increases the odds of developing PG by 15-folds. Physicians managing patients with UC should be aware of this increased burden. Patients with UC may be advised to avoid additional precipitating factors of PG.

Estimating the Odds of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study

Dermatology ◽  
2021 ◽  
Vol 237 (3) ◽  
pp. 323-329
Author(s):  
Khalaf Kridin ◽  
Giovanni Damiani ◽  
Ralf J. Ludwig ◽  
Dana Tzur Bitan ◽  
Arnon D. Cohen
Keyword(s):  
Ulcerative Colitis ◽  
Pyoderma Gangrenosum ◽  
Case Control Study ◽  
Statistical Significance ◽  
Subsequent Development ◽  
Fold Increase ◽  
Population Based ◽  
Case Control ◽  
Logistic Regression Models ◽  
Control Study

<b><i>Background:</i></b> Ulcerative colitis (UC) is a well-known underlying comorbidity of pyoderma gangrenosum (PG). However, the risk conferred by UC for the subsequent development of PG is yet to be elucidated. We aimed to estimate the magnitude of the association between UC and the subsequent occurrence of PG, which would enable us to assess the odds of PG developing in individuals with a history of UC. <b><i>Methods:</i></b> A population-based case-control study was conducted to compare PG patients (<i>n</i> = 302) and age-, sex- and ethnicity-matched control subjects (<i>n</i> = 1,497) regarding the presence of UC. Logistic regression models were utilized for univariate and multivariate analyses. <b><i>Results:</i></b> The prevalence of preexisting UC was greater in patients with PG than in controls (7.3 vs. 0.5%; <i>p</i> &#x3c; 0.001). A 15-fold increase in the odds of PG in individuals with preexisting UC was observed (OR 14.62, 95% CI 6.45–33.18). The greatest risk of developing PG occurred in the first years following the diagnosis of UC (OR 35.50, 95% CI 4.35–289.60), and decreased thereafter to 10.03 (95% CI 1.83–55.03), 6.69 (95% CI 1.49–30.02), and 10.03 (95% CI 1.83–55.03) at 1–5, 5–10, and 10–15 years after the diagnosis of UC, respectively. This association retained its statistical significance following the adjustment for confounding factors (adjusted OR 10.78, 95% CI 4.55–25.52). Patients with both PG and UC were younger and had a lower prevalence of smoking than the remaining patients with PG. <b><i>Conclusions:</i></b> UC increases the odds of developing PG by 15-fold, with the highest probability of developing PG occurring within the first year after the diagnosis of UC. Patients with UC may be advised to avoid additional precipitating factors for the development of PG.

scholarly journals Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study

2020 ◽  
Vol 9 (6) ◽  
pp. 1626 ◽  
Author(s):  
Khalaf Kridin ◽  
Ralf J. Ludwig ◽  
Dana Tzur Bitan ◽  
Mouhammad Kridin ◽  
Giovanni Damiani ◽  
...  
Keyword(s):  
Pyoderma Gangrenosum ◽  
Regression Models ◽  
Case Control Study ◽  
Matched Control ◽  
Population Based ◽  
Case Control ◽  
Significant Independent Predictor ◽  
Logistic Regression Models ◽  
Control Subjects ◽  
Control Study

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex-, and ethnicity-matched control subjects (n = 1497) with respect to the presence of preceding gout. Logistic regression models were utilized for univariate and multivariate analyses. The prevalence of preceding gout was greater in patients with PG than in control subjects (3.7% vs. 0.7%, respectively; p < 0.001). Gout was associated with a more than fivefold increase in the risk of PG (OR, 5.15; 95% CI, 2.21–11.98). After adjusting for confounding factors, gout emerged as a significant independent predictor of PG (adjusted OR, 4.08; 95% CI, 1.69–9.80). Gout preceded the diagnosis of PG by a median latency of 4.6 years. Patients with gout-associated PG were older, predominantly male, and had a higher prevalence of metabolic syndrome than other patients with PG. In conclusion, gout increases the risk of developing PG by more than fivefold. Physicians managing patients with gout and PG should be aware of this emerging association.

scholarly journals Is colonoscopic surveillance reducing colorectal cancer mortality in ulcerative colitis? A population based case control study

Gut ◽  
1998 ◽  
Vol 42 (5) ◽  
pp. 711-714 ◽  
Author(s):  
P Karlén ◽  
D Kornfeld ◽  
O Broström ◽  
R Löfberg ◽  
P-G Persson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Confidence Interval ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Colonoscopic Surveillance ◽  
Colorectal Cancer Mortality ◽  
Control Study

Background—Colonoscopic surveillance is a standard procedure in many patients with long standing, extensive ulcerative colitis (UC), in order to avoid death from colorectal cancer. No conclusive proof of its benefits has been presented however.Aims—To evaluate the association between colonoscopic surveillance and colorectal cancer mortality in patients with UC.Patients—A population based, nested case control study comprising 142 patients with a definite UC diagnosis, derived from a study population of 4664 patients with UC, was conducted.Methods—Colonoscopic surveillance in all patients with UC who had died from colorectal cancer after 1975 was compared with that in controls matched for age, sex, extent, and duration of the disease. Information on colonoscopic surveillance was obtained from the medical records.Results—Two of 40 patients with UC and 18 of 102 controls had undergone at least one surveillance colonoscopy (relative risk (RR) 0.29, 95% confidence interval 0.06 to 1.31). Twelve controls but only one patient with UC had undergone two or more surveillance colonoscopies (RR 0.22, 95% confidence interval 0.03 to 1.74), indicating a protective dose response relation.Conclusion—Colonoscopic surveillance may be associated with a decreased risk of death from colorectal cancer in patients with long standing UC.

scholarly journals Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case–Control Study

2017 ◽  
Vol 15 (9) ◽  
pp. 1405-1412.e3 ◽  
Author(s):  
M. Ellen Kuenzig ◽  
Cheryl Barnabe ◽  
Cynthia H. Seow ◽  
Bertus Eksteen ◽  
Maria E. Negron ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Case Control Study ◽  
Subsequent Development ◽  
Population Based ◽  
Case Control ◽  
Inflammatory Bowel ◽  
Control Study

scholarly journals Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study.

Gut ◽  
1991 ◽  
Vol 32 (12) ◽  
pp. 1526-1530 ◽  
Author(s):  
S M Samuelsson ◽  
A Ekbom ◽  
M Zack ◽  
C G Helmick ◽  
H O Adami
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Ulcerative Proctitis ◽  
Control Study

Risk of congenital abnormalities in children born to women with ulcerative colitis: a population-based, case-control study

2003 ◽  
Vol 98 (9) ◽  
pp. 2006-2010 ◽  
Author(s):  
Bente Norgard ◽  
Erzsebet Puho ◽  
Lars Pedersen ◽  
Andrew E. Czeizel ◽  
Henrik T. Sorensen
Keyword(s):  
Ulcerative Colitis ◽  
Case Control Study ◽  
Congenital Abnormalities ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals Association Between Inflammatory Potential of the Diet and Ulcerative Colitis: A Case-Control Study

2021 ◽  
Vol 7 ◽  
Author(s):  
Zeinab Khademi ◽  
Parvane Saneei ◽  
Ammar Hassanzadeh-Keshteli ◽  
Hamed Daghaghzadeh ◽  
Hamid Tavakkoli ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Case Control Study ◽  
Dietary Habits ◽  
Large Population ◽  
Population Based ◽  
Case Control ◽  
Dietary Intakes ◽  
Health And Nutrition ◽  
Study Participants ◽  
Control Study

Background/Aim: Despite the inflammatory nature of inflammatory bowel disease (IBD), limited data are available on the association of inflammatory potential of the diet and risk of ulcerative colitis (UC). We aimed to investigate the association of inflammatory potential of the diet (IPD) score and odds of UC in a case-control study.Methods: Patients with UC were enrolled from Iranian IBD registry, whose disease was confirmed by a gastroenterologist. Controls were selected randomly from the Study of the Epidemiology of Psycho Alimentary Health and Nutrition (SEPAHAN) study, a large population-based study on more than 8,000 apparently healthy individuals. Dietary intakes of 28 food items obtained from a validated dish-based food frequency questionnaire (FFQ), were used to compute IPD score.Results: This case-control study was carried out among 109 cases and 218 randomly chosen controls. Mean age of cases and controls was 39.5 ± 10.0 and 41.5 ± 11.8 y, respectively. Totally, 52% of study participants were female and 48% were male. After controlling for age, sex, and body mass index (BMI), we found that the patients with UC were more likely to be in the highest quartile of IPD score compared with controls (OR: 2.83; 95% CI: 1.41–5.69, P-trend &lt; 0.001). This association strengthened after additional adjustment for education, smoking, medical history, and physical activity (OR: 3.48; 95% CI: 1.32–9.10, P-trend = 0.003). When we took dietary habits into account, the association was slightly attenuated (OR: 3.33; 95% CI: 1.20–9.20, P-trend = 0.005).Conclusions: We found that adherence to a pro-inflammatory diet was positively associated with greater odds of UC. Further studies are required to confirm these findings.

scholarly journals Obesity and Breast Cancer Risk in Men: A National Case-Control Study in England and Wales

2021 ◽  
Author(s):  
Anthony J Swerdlow ◽  
Cydney Bruce ◽  
Rosie Cooke ◽  
Penny Coulson ◽  
James Griffin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Statistical Significance ◽  
Growth Factor Receptor ◽  
Population Based ◽  
Case Control ◽  
Her2 Positive ◽  
England And Wales ◽  
Breast Cancer In Men ◽  
Control Study

Abstract Background Breast cancer is rare in men, and information on its causes is very limited, from studies that have generally been small. Adult obesity has been shown as a risk factor but more detailed anthropometric relations have not been investigated. Methods We conducted an interview population-based case-control study of breast cancer in men in England and Wales including 1,998 cases incident during 2005–2017 at ages under 80 years and 1,597 male controls, with questions asked about a range of anthropometric variables at several ages. All tests of statistical significance were two-sided. Results Risk of breast cancer statistically significantly increased with increasing body mass index (BMI) at ages 20 (odds ratio [OR]=1.07, 95% confidence interval [CI] = 1.02 to 1.12 per 2-unit change in BMI), 40 (OR = 1.11, 95% CI = 1.07 to 1.16), and 60 (OR = 1.14, 95% CI = 1.09 to 1.19) years but there was also an indication of raised risk for the lowest BMIs. Large waist circumference 5 years before interview was more strongly associated than was BMI with risk, and each showed independent associations. Associations were similar for invasive and in situ tumors separately and stronger for human epidermal growth factor receptor 2 (HER2)-positive than HER2-negativetumors. Ninety-nine percent of tumors were estrogen receptor-positive. Conclusions Obesity at all adult ages, particularly recent abdominal obesity, is associated with raised risk of breast cancer in men, probably because of conversion of testosterone to estrogens by aromatase in adipose tissue. The association is particularly strong for HER2-expressingtumors.

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